All Stories

  1. Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

    Article • Pharmacological Reviews, March 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Lawrence Toll

  2. Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001

    Article • Neuropharmacology, June 2015, Elsevier

    Dr Lawrence Toll

  3. Activation of β2-adrenergic receptor by (R,R′)-4′-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells

    Article • Cellular Signalling, May 2015, Elsevier

    Dr Lawrence Toll

  4. AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology

    Article • British Journal of Pharmacology, January 2015, Wiley

    Dr Lawrence Toll

  5. BU08073 a buprenorphine analogue with partial agonist activity at μ-receptorsin vitrobut long-lasting opioid antagonist activityin vivoin mice

    Article • British Journal of Pharmacology, November 2014, Wiley

    Dr Lawrence Toll

  6. Challenges for opioid receptor nomenclature: IUPHAR Review 9

    Article • British Journal of Pharmacology, July 2014, Wiley

    Dr Lawrence Toll, Brian Cox

  7. Tyrosine 308 Is Necessary for Ligand-directed G s Protein-biased Signaling of β 2 -Adrenoceptor

    Article • Journal of Biological Chemistry, May 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Lawrence Toll

  8. Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library

    Article • Journal of Medicinal Chemistry, April 2014, American Chemical Society (ACS)

    Dr Lawrence Toll

  9. [125I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors

    Article • Neuropharmacology, February 2014, Elsevier

    Dr Lawrence Toll

  10. Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β2-adrenergic receptor

    Article • Bioorganic & Medicinal Chemistry, January 2014, Elsevier

    Dr Lawrence Toll

  11. Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies

    Article • Journal of Medicinal Chemistry, December 2013, American Chemical Society (ACS)

    Dr Lawrence Toll

  12. Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.

    Article • Bioorganic & Medicinal Chemistry Letters, June 2013, Elsevier

    Dr Lawrence Toll

  13. The Use of Bifunctional NOP/Mu and NOP Receptor Selective Compounds for the Treatment of Pain, Drug Abuse, and Psychiatric Disorders

    Article • Current Pharmaceutical Design, March 2013, Bentham Science Publishers

    Dr Lawrence Toll

  14. Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity

    Article • European Journal of Pharmacology, January 2013, Elsevier

    Dr Lawrence Toll

  15. Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

    Article • European Journal of Pharmacology, January 2013, Elsevier

    Dr Lawrence Toll

  16. Pharmacology of Mixed NOP/Mu Ligands

    Article • January 2013, American Chemical Society (ACS)

    Dr Lawrence Toll

  17. Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies

    Article • Journal of Peptide Science, November 2012, Wiley

    Dr Lawrence Toll

  18. Rodent motor and neuropsychological behaviour measured in home cages using the integrated modular platform SmartCage™

    Article • Clinical and Experimental Pharmacology and Physiology, June 2012, Wiley

    Dr Lawrence Toll

  19. Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis

    Article • European Journal of Pharmacology, May 2012, Elsevier

    Dr Lawrence Toll

  20. Radiosynthesis of a 125I analog of a highly selective alpha3beta4 nicotinic acetylcholine receptor antagonist ligand for use in autoradiography studies

    Article • Journal of Labelled Compounds and Radiopharmaceuticals, April 2012, Wiley

    Dr Lawrence Toll

  21. AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats

    Article • Neuropsychopharmacology, January 2012, Springer Science + Business Media

    Dr Lawrence Toll

  22. Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Dr Lawrence Toll

  23. Orphanin FQ/Nociceptin Activates Nuclear Factor Kappa B

    Article • Journal of Neuroimmune Pharmacology, May 2011, Springer Science + Business Media

    Dr Lawrence Toll

  24. Novel ligands interacting with opioid receptors

    Article • Pharmacological Reports, January 2011, Elsevier

    Dr Lawrence Toll

  25. Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: Ligand-directed chiral recognition

    Article • Chirality, January 2011, Wiley

    Dr Lawrence Toll

  26. Novel α3β4 Nicotinic Acetylcholine Receptor-Selective Ligands. Discovery, Structure−Activity Studies, and Pharmacological Evaluation

    Article • Journal of Medicinal Chemistry, November 2010, American Chemical Society (ACS)

    Dr Lawrence Toll

  27. The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the β2-adrenoceptor

    Article • Biochemical Pharmacology, June 2010, Elsevier

    Dr Lawrence Toll

  28. Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective β2-adrenergic receptor agonists

    Article • Bioorganic & Medicinal Chemistry, January 2010, Elsevier

    Dr Lawrence Toll

  29. Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: Potentiation of morphine anti-allodynic activity by NOP receptor antagonists

    Article • European Journal of Pharmacology, May 2009, Elsevier

    Dr Lawrence Toll

  30. Synthesis of Isohasubanan Alkaloids via Enantioselective Ketone Allylation and Discovery of an Unexpected Rearrangement

    Article • The Journal of Organic Chemistry, February 2009, American Chemical Society (ACS)

    Dr Lawrence Toll

  31. Paralytic activity of (des-Glu1)conotoxin GI analogs in the mouse diaphragm

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr Lawrence Toll

  32. Novel μ-selective Met-enkephalinamide analogs with antagonist activity.

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr Lawrence Toll

  33. Evolutionary Sequence Modeling for Discovery of Peptide Hormones

    Article • PLoS Computational Biology, January 2009, PLOS

    Dr Lawrence Toll

  34. F.100. Nociceptin/Orphanin FQ Antagonists Ameliorate the Disease Pathogenesis During Inflammatory Bowel Disease

    Article • Clinical Immunology, January 2009, Elsevier

    Dr Lawrence Toll

  35. Peptidomics ofCpefat/fatmouse brain regions: implications for neuropeptide processing

    Article • Journal of Neurochemistry, December 2008, Wiley

    Dr Lawrence Toll

  36. Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia

    Article • Journal of Clinical Investigation, June 2008, American Society for Clinical Investigation

    Dr Lawrence Toll

  37. Small-Molecule Agonists and Antagonists of the Opioid Receptor-Like Receptor (ORL1, NOP): Ligand-Based Analysis of Structural Factors Influencing Intrinsic Activity at NOP

    Article • January 2008, Springer Science + Business Media

    Dr Lawrence Toll

  38. Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors

    Article • Bioorganic & Medicinal Chemistry Letters, June 2007, Elsevier

    Dr Lawrence Toll

  39. Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents

    Article • European Journal of Pharmacology, March 2007, Elsevier

    Dr Lawrence Toll

  40. Evolutionary Sequence Modeling for Discovery of Peptide Hormones

    Article • January 2007, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Lawrence Toll

  41. Regulation of the prepronociceptin gene and its effect on neuronal differentiation

    Article • Gene, December 2006, Elsevier

    Dr Lawrence Toll

  42. Small-molecule agonists and antagonists of the opioid receptor-like receptor (ORL1, NOP): Ligand-based analysis of structural factors influencing intrinsic activity at NOP

    Article • The AAPS Journal, June 2005, American Association of Pharmaceutical Scientists (AAPS)

    Dr Lawrence Toll

  43. Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide

    Article • Bioorganic & Medicinal Chemistry Letters, March 2005, Elsevier

    Dr Lawrence Toll

  44. Design, Chemical Synthesis, and Biological Evaluation of Thiosaccharide Analogues of Morphine- and Codeine-6-Glucuronide

    Article • Journal of Medicinal Chemistry, November 2004, American Chemical Society (ACS)

    Dr Lawrence Toll

  45. Synthesis and biological evaluation of some 6-arylamidomorphines as analogues of morphine-6-glucuronide

    Article • Bioorganic & Medicinal Chemistry, November 2004, Elsevier

    Dr Lawrence Toll

  46. Synthesis, receptor binding and functional studies of mesoridazine stereoisomers

    Article • Bioorganic & Medicinal Chemistry Letters, September 2004, Elsevier

    Dr Lawrence Toll

  47. A Novel Series of Piperidin-4-yl-1,3-Dihydroindol-2-ones as Agonist and Antagonist Ligands at the Nociceptin Receptor

    Article • Journal of Medicinal Chemistry, June 2004, American Chemical Society (ACS)

    Dr Lawrence Toll

  48. The Design and Synthesis of a Novel Quinolizidine Template for Potent Opioid and Opioid Receptor-Like (ORL1, NOP) Receptor Ligands.

    Article • ChemInform, April 2004, Wiley

    Dr Lawrence Toll

  49. The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands

    Article • Bioorganic & Medicinal Chemistry Letters, January 2004, Elsevier

    Dr Lawrence Toll

  50. Regulation of transcription of the human prepronociceptin gene by Sp1

    Article • Gene, May 2002, Elsevier

    Dr Lawrence Toll

  51. Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors

    Article • European Journal of Pharmacology, September 2001, Elsevier

    Dr Lawrence Toll

  52. Transcriptional Regulation of the Human Prepronociceptin Gene

    Article • Biochemical and Biophysical Research Communications, September 2000, Elsevier

    Dr Lawrence Toll

  53. Species differences in the efficacy of compounds at the nociceptin receptor (ORL1)

    Article • Peptides, July 2000, Elsevier

    Dr Lawrence Toll

  54. Structural Determinants of Opioid Activity in the Orvinols and Related Structures:  Ethers of Orvinol and Isoorvinol

    Article • Journal of Medicinal Chemistry, May 2000, American Chemical Society (ACS)

    Dr Lawrence Toll

  55. Structural Determinants of Opioid Activity in the Orvinols and Related Structures. Ethers of 7,8-Cyclopenta-Fused Analogs of Buprenorphine

    Article • Helvetica Chimica Acta, April 2000, Wiley

    Dr Lawrence Toll

  56. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol- 13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: A potential role fortrans-RA-induced ZBP-89 in ODC inhibition

    Article • International Journal of Cancer, January 2000, Wiley

    Dr Lawrence Toll

  57. Characterization of the δ-opioid receptor found in SH-SY5Y neuroblastoma cells

    Article • European Journal of Pharmacology, April 1997, Elsevier

    Dr Lawrence Toll

  58. Modulation of enkephalin release by nociceptin (orphanin FQ)

    Article • European Journal of Pharmacology, April 1997, Elsevier

    Dr Lawrence Toll

  59. Synthesis and characterization of substituted benzoylhydrazones of naloxone

    Article • Synapse, October 1996, Wiley

    Dr Lawrence Toll

  60. Desensitization of melanotropin receptors in COS-7 cells

    Article • Life Sciences, March 1996, Elsevier

    Dr Lawrence Toll

  61. Nociceptin in vitro biotransformation in human blood

    Article • Peptides, January 1996, Elsevier

    Dr Lawrence Toll

  62. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

    Article • Nature, October 1995, Springer Science + Business Media

    Dr Lawrence Toll

  63. The in vitro pharmacological characterization of naloxone benzoylhydrazone

    Article • European Journal of Pharmacology, April 1995, Elsevier

    Dr Lawrence Toll

  64. Characterization of the δ receptor subtype in SH-SY5Y neuroblastoma cells

    Article • Regulatory Peptides, November 1994, Elsevier

    Dr Lawrence Toll

  65. Evidence for an NMDA receptor subunit in human keratinocytes and rat cardiocytes

    Article • European Journal of Pharmacology Molecular Pharmacology, August 1994, Elsevier

    Dr Lawrence Toll

  66. Molecular determinants of recognition and activation at the ?-opioid receptor by met-enkephalin-like peptides

    Article • International Journal of Quantum Chemistry, March 1993, Wiley

    Dr Lawrence Toll

  67. Comparison of κ2-opioid receptors in guinea pig brain and guinea pig ileum membranes

    Article • European Journal of Pharmacology, February 1993, Elsevier

    Dr Lawrence Toll

  68. The μ-opioid activity of κ-opioid receptor agonist compounds in the guinea pig ileum

    Article • European Journal of Pharmacology, March 1992, Elsevier

    Dr Lawrence Toll

  69. Development of peptidomimetic inhibitors of a newly isolated atrial peptide-degrading enzyme

    Article • January 1992, Springer Science + Business Media

    Dr Lawrence Toll

  70. Isolation and characterization of a new atrial peptide-degrading enzyme from bovine kidney

    Article • Biochemical and Biophysical Research Communications, March 1991, Elsevier

    Dr Lawrence Toll

  71. μ-Opioid receptor binding in intact SH-SY5Y neuroblastoma cells

    Article • European Journal of Pharmacology, February 1990, Elsevier

    Dr Lawrence Toll

  72. Effects of addition of a 2-methyl group to ethyl nipecotates (.beta.-meperidines) on receptor affinities and opiate agonist/antagonist activities

    Article • Journal of Medicinal Chemistry, October 1988, American Chemical Society (ACS)

    Dr Lawrence Toll

  73. N-Substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines

    Article • Journal of Medicinal Chemistry, April 1986, American Chemical Society (ACS)

    Dr Lawrence Toll

  74. Inhibition of [3H]captopril binding by peptide analog angiotensin converting enzyme inhibitors

    Article • Biochemical and Biophysical Research Communications, March 1986, Elsevier

    Dr Lawrence Toll

  75. The use of computer analysis in describing multiple opiate receptors

    Article • Neuropeptides, December 1984, Elsevier

    Dr Lawrence Toll

  76. Structure-activity studies of β-carboline analogs

    Article • Life Sciences, May 1984, Elsevier

    Dr Lawrence Toll

  77. Computer-assisted determination of benzodiazepine receptor heterogeneity

    Article • European Journal of Pharmacology, March 1984, Elsevier

    Dr Lawrence Toll

  78. Pyrazolo[1,5-a]pyrimidines: Receptor binding and anxiolytic behavioral studies

    Article • Pharmacology Biochemistry and Behavior, March 1984, Elsevier

    Dr Lawrence Toll

  79. Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity

    Article • Journal of Medicinal Chemistry, February 1984, American Chemical Society (ACS)

    Dr Lawrence Toll

  80. Detailed receptor binding studies of a series of N-substituted ethyl 3-arylnipecotates

    Article • Life Sciences, January 1983, Elsevier

    Dr Lawrence Toll

  81. Computer-assisted analysis of receptor-binding studies of [3H]-naloxone and [3H]-DADL: A reinterpretation of the Na+ effect

    Article • Life Sciences, January 1983, Elsevier

    Dr Lawrence Toll

  82. [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig and rat brain homogenates

    Article • European Journal of Pharmacology, April 1981, Elsevier

    Dr Lawrence Toll

  83. Storage of dopamine and acetylcholine in granules of PC12, a clonal pheochromocytoma cell line

    Article • Biochemistry, March 1980, American Chemical Society (ACS)

    Dr Lawrence Toll

  84. Role of Mg 2+ ion-activated ATPase and a pH gradient in the storage of catecholamines in synaptic vesicles

    Article • Biochemistry, June 1978, American Chemical Society (ACS)

    Dr Lawrence Toll

  85. Energy utilization in the uptake of catecholamines by synaptic vesicles and adrenal chromaffin granules

    Article • Brain Research, November 1977, Elsevier

    Dr Lawrence Toll