All Stories

  1. A Screening Pattern Recognition Method Finds New and Divergent Targets for Drugs and Natural Products

    Article • ACS Chemical Biology, June 2014, American Chemical Society (ACS)

    Dr Laszlo A Urban

  2. Predictive ADMET

    Article • March 2014, Wiley

    Dr Laszlo A Urban

  3. Current Social, Clinical, and Scientific Environment of Pharmaceutical R&D

    Article • March 2014, Wiley

    Dr Laszlo A Urban

  4. Translation of off-target effects: prediction of ADRs by integrated experimental and computational approach

    Article • Toxicology Research, January 2014, Oxford University Press (OUP)

    Dr Laszlo A Urban

  5. Hazard identification and elimination: designing safe medicines

    Article • Toxicology Letters, August 2013, Elsevier

    Dr Laszlo A Urban

  6. Large-scale prediction and testing of drug activity on side-effect targets

    Article • Nature, June 2012, Springer Science + Business Media

    Dr Laszlo A Urban

  7. Screening for Safety-Relevant Off-Target Activities

    Article • February 2012, Wiley

    Dr Laszlo A Urban

  8. Using Full Factorial Design of Experiments on an Automated Patch Clamp Instrument: A Case Study on the Ionworks Quattro and Nav1.5 Channel

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Laszlo A Urban

  9. IonFlux: A Microfluidic Patch Clamp System Evaluated with Human Ether-à-go-go Related Gene Channel Physiology and Pharmacology

    Article • Assay and Drug Development Technologies, December 2011, Mary Ann Liebert Inc

    Dr Laszlo A Urban

  10. Cardiac ion channel safety profiling on the IonWorks Quattro system

    Article • Journal of Pharmacological and Toxicological Methods, July 2011, Elsevier

    Dr Laszlo A Urban

  11. Mechanisms of hERG Potassium Channel Enhancers

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Laszlo A Urban

  12. TRPV1 Function in Health and Disease

    Article • Current Pharmaceutical Biotechnology, January 2011, Bentham Science Publishers

    Dr Laszlo A Urban

  13. Molecular Structure of Transient Receptor Potential Vanilloid Type 1 Ion Channel (TRPV1)

    Article • Current Pharmaceutical Biotechnology, January 2011, Bentham Science Publishers

    Dr Laszlo A Urban

  14. Cardiac Ion Channel Safety Profiling on the IonWorks Quattro Automated Patch Clamp System

    Article • Assay and Drug Development Technologies, December 2010, Mary Ann Liebert Inc

    Dr Laszlo A Urban

  15. Phenotypic screening: Fishing for neuroactive compounds

    Article • March 2010

    Dr Laszlo A Urban

  16. Role of Transient Receptor Potential and Acid-sensing Ion Channels in Peripheral Inflammatory Pain

    Article • Anesthesiology, March 2010, Wolters Kluwer Health

    Dr Laszlo A Urban

  17. Hit and Lead Profiling

    Article • August 2009

    Dr Laszlo A Urban

  18. Integrative Risk Assessment

    Article • August 2009, Wiley

    Dr Laszlo A Urban

  19. SPREAD-exploiting chemical features that cause differential activity behavior

    Article • Statistical Analysis and Data Mining The ASA Data Science Journal, July 2009, Wiley

    Dr Laszlo A Urban

  20. In vitrosafety pharmacology profiling: what else beyond hERG?

    Article • Future Medicinal Chemistry, July 2009, Future Science

    Dr Laszlo A Urban

  21. Mapping Adverse Drug Reactions in Chemical Space

    Article • Journal of Medicinal Chemistry, April 2009, American Chemical Society (ACS)

    Dr Laszlo A Urban

  22. Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis

    Article • Journal of Chemical Information and Modeling, January 2009, American Chemical Society (ACS)

    Dr Laszlo A Urban

  23. Predictive Toxicology in Drug Safety

    Article • January 2009, Cambridge University Press

    Dr Laszlo A Urban

  24. Functional Molecular Biology of the TRPV1 Ion Channel

    Article • January 2008, Springer Science + Business Media

    Dr Laszlo A Urban

  25. Maximising use ofin vitroADMET tools to predictin vivobioavailability and safety

    Article • Expert Opinion on Drug Metabolism & Toxicology, October 2007, Informa Healthcare

    Dr Laszlo A Urban

  26. Modeling Promiscuity Based on in vitro Safety Pharmacology Profiling Data

    Article • ChemMedChem, June 2007, Wiley

    Dr Laszlo A Urban

  27. Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off-Target Effects from Chemical Structure

    Article • ChemMedChem, June 2007, Wiley

    Dr Laszlo A Urban

  28. Cover Picture: Analysis of Pharmacology Data and the Prediction of Adverse Drug Reactions and Off-Target Effects from Chemical Structure (ChemMedChem 6/2007)

    Article • ChemMedChem, June 2007, Wiley

    Dr Laszlo A Urban

  29. High-throughputinvitroprofiling assays: lessons learnt from experiences at Novartis

    Article • Expert Opinion on Drug Metabolism & Toxicology, November 2006, Informa Healthcare

    Dr Laszlo A Urban

  30. Mechanisms underlying joint pain

    Article • Drug Discovery Today Disease Mechanisms, September 2006, Elsevier

    Dr Laszlo A Urban

  31. Keynote review: In vitro safety pharmacology profiling: an essential tool for successful drug development

    Article • Drug Discovery Today, November 2005, Elsevier

    Dr Laszlo A Urban

  32. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2

    Article • British Journal of Pharmacology, February 2005, Wiley

    Dr Laszlo A Urban

  33. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology

    Article • European Journal of Pharmacology, October 2004, Elsevier

    Dr Laszlo A Urban

  34. Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat

    Article • Pain, January 2004, Wolters Kluwer Health

    Dr Laszlo A Urban

  35. Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1in vitro

    Article • European Journal of Neuroscience, June 2003, Wiley

    Dr Laszlo A Urban

  36. THIS ARTICLE HAS BEEN RETRACTED Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release

    Article • Journal of Neurochemistry, January 2003, Wiley

    Dr Laszlo A Urban

  37. Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain

    Article • Pain, December 2002, Wolters Kluwer Health

    Dr Laszlo A Urban

  38. Spinal Neurokinin NK1 Receptor Down-Regulation and Antinociception: Effects of Spinal NK1 Receptor Antisense Oligonucleotides and NK1 Receptor Occupancy

    Article • Journal of Neurochemistry, November 2002, Wiley

    Dr Laszlo A Urban

  39. The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. (Novartic Institute for Medical Sciences, London, United Kingdom) Pain. 2001;92:91-100.

    Article • Pain Practice, December 2001, Wiley

    Dr Laszlo A Urban

  40. Possible mechanisms of cannabinoid-induced antinociception in the spinal cord

    Article • European Journal of Pharmacology, October 2001, Elsevier

    Dr Laszlo A Urban

  41. The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain

    Article • Pain, May 2001, Wolters Kluwer Health

    Dr Laszlo A Urban

  42. The neurogenic contribution to synovial leucocyte infiltration and other outcome measures in a guinea pig model of arthritis

    Article • Neuroscience Letters, February 2001, Elsevier

    Dr Laszlo A Urban

  43. The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat

    Article • Pain, February 2001, Wolters Kluwer Health

    Dr Laszlo A Urban

  44. “Neuropeptides 2000”

    Article • Regulatory Peptides, December 2000, Elsevier

    Dr Laszlo A Urban

  45. Differential role of neurokinin receptors in human lymphocyte and monocyte chemotaxis

    Article • Regulatory Peptides, December 2000, Elsevier

    Dr Laszlo A Urban

  46. Excitatory effects of galanin in the spinal cord of intact, anaesthetized rats

    Article • Neuroscience Letters, December 2000, Elsevier

    Dr Laszlo A Urban

  47. In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue

    Article • Pain, December 2000, Wolters Kluwer Health

    Dr Laszlo A Urban

  48. Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat

    Article • European Journal of Pain, September 2000, Wiley

    Dr Laszlo A Urban

  49. Oral anti-hyperalgesic and anti-inflammatory activity of NK1 receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig

    Article • Pain, August 2000, Wolters Kluwer Health

    Dr Laszlo A Urban

  50. Repeated administration of systemic gabapentin alleviates allodynia-like behaviors in spinally injured rats

    Article • Neuroscience Letters, February 2000, Elsevier

    Dr Laszlo A Urban

  51. Animal models for pain research

    Article • Molecular Medicine Today, July 1999, Elsevier

    Dr Laszlo A Urban

  52. Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat

    Article • Pain, June 1999, Wolters Kluwer Health

    Dr Laszlo A Urban

  53. Pharmacology of Chronic Pain

    Article • January 1999, Springer Science + Business Media

    Dr Laszlo A Urban

  54. Immunohistochemical localization of neurokinin-1 receptor in the lumbar spinal cord of young rats: morphology and distribution

    Article • Somatosensory & Motor Research, January 1999, Taylor & Francis

    Dr Laszlo A Urban

  55. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord

    Article • Developmental Brain Research, January 1999, Elsevier

    Dr Laszlo A Urban

  56. The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection

    Article • Experimental Brain Research, August 1998, Springer Science + Business Media

    Dr Laszlo A Urban

  57. mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia

    Article • Neuroreport, April 1998, Wolters Kluwer Health

    Dr Laszlo A Urban

  58. Alterations of substance P immunoreactivity in lumbar and thoracic segments of rat spinal cord in ultraviolet irradiation induced hyperalgesia of the hindpaw

    Article • Brain Research, March 1998, Elsevier

    Dr Laszlo A Urban

  59. Sympathetic component of neuropathic pain: Animal models and clinical diagnosis

    Article • Behavioral and Brain Sciences, September 1997, Cambridge University Press

    Dr Laszlo A Urban

  60. Is there a nociceptive carousel?

    Article • Trends in Pharmacological Sciences, July 1997, Elsevier

    Dr Laszlo A Urban

  61. Bradykinin depolarises the rat isolated superior cervical ganglion via B2 receptor activation

    Article • Neuroscience Letters, July 1995, Elsevier

    Dr Laszlo A Urban

  62. Pharmacology of chronic pain

    Article • Trends in Pharmacological Sciences, June 1994, Elsevier

    Dr Laszlo A Urban

  63. Tachykinin induced regulation of excitatory amino acid responses in the rat spinal cord in vitro

    Article • Neuroscience Letters, February 1994, Elsevier

    Dr Laszlo A Urban

  64. Cellular Mechanisms of Sensory Processing

    Article • January 1994, Springer Science + Business Media

    Dr Laszlo A Urban

  65. Hyperexcitabilty in the Spinal Dorsal Horn: Cooperation of Neuropeptides and Excitatory Amino Acids

    Article • January 1994, Springer Science + Business Media

    Dr Laszlo A Urban

  66. The effects of NK-1 and NK-2 receptor antagonists on the capsaicin evoked synaptic response in the rat spinal cord in vitro

    Article • Regulatory Peptides, July 1993, Elsevier

    Dr Laszlo A Urban

  67. Correlation Between Function and Structure in "Epileptic" Human Hippocampal Tissue Maintained In Vitro

    Article • Epilepsia, January 1993, Wiley

    Dr Laszlo A Urban

  68. Effect of capsaicin and resiniferatoxin on peptidergic neurons in cultured dorsal root ganglion

    Article • Regulatory Peptides, June 1992, Elsevier

    Dr Laszlo A Urban

  69. Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro

    Article • Neuroscience Letters, December 1991, Elsevier

    Dr Laszlo A Urban

  70. The responses recorded in vitro of deep dorsal horn neurons to direct and orthodromic stimulation in the young rat spinal cord

    Article • Neuroscience, October 1988, Elsevier

    Dr Laszlo A Urban

  71. Prologue – Predictive toxicology: a new chapter in drug safety evaluation

    Article • Cambridge University Press

    Dr Laszlo A Urban

  72. Integrated approaches to lead optimization: improving the therapeutic index

    Article • Cambridge University Press

    Dr Laszlo A Urban

  73. PREDICTIVE TOXICOLOGY IN DRUG SAFETY

    Article • Cambridge University Press

    Dr Laszlo A Urban