All Stories

  1. Arginines of the CGN codon family are Achilles’ heels of cancer genes
  2. Evolution of termination codons of proteins and the TAG-TGA paradox
  3. Use of Publication Dynamics to Distinguish Cancer Genes and Bystander Genes
  4. Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog
  5. Miguel Llinás and the Structure of the Kringle Fold
  6. Exon Shuffling Played a Decisive Role in the Evolution of the Genetic Toolkit for the Multicellular Body Plan of Metazoa
  7. Use of signals of positive and negative selection to distinguish cancer genes and passenger genes
  8. Fold class and evolutionary mobility of protein modules
  9. The Arg244His missense mutation in SDHB-1 leads to altered metabolism in Caenorhabditis elegans: a new disease model
  10. Exon skipping-rich transcriptomes of animals reflect the significance of exon-shuffling in metazoan proteome evolution
  11. Influence of WFIKKN 1 on BMP 1‐mediated activation of latent myostatin
  12. The Mstn cmpt-Dl1abc mutation impairs secretion of promyostatin
  13. Putative extremely high rate of proteome innovation in lancelets might be explained by high rate of gene prediction errors
  14. Identification and Correction of Erroneous Protein Sequences in Public Databases
  15. Wnts grasp the WIF domain of Wnt Inhibitory Factor 1 at two distinct binding sites
  16. K153R polymorphism in myostatin gene increases the rate of promyostatin activation by furin
  17. FixPred: a resource for correction of erroneous protein sequences
  18. Both LCCL-domains of human CRISPLD2 have high affinity for lipid A
  19. MisPred: a resource for identification of erroneous protein sequences in public databases
  20. Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2
  21. Exons and Protein Modules
  22. Domain Architecture Evolution of Metazoan Proteins
  23. Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1
  24. Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2
  25. Correction: Nagy, A., et al. Reassessing Domain Architecture Evolution of Metazoan Proteins: Major Impact of Gene Prediction Errors. Genes 2011, 2, 449-501.
  26. Reassessing Domain Architecture Evolution of Metazoan Proteins: The Contribution of Different Evolutionary Mechanisms
  27. Reassessing Domain Architecture Evolution of Metazoan Proteins: Major Impact of Errors Caused by Confusing Paralogs and Epaktologs
  28. Reassessing Domain Architecture Evolution of Metazoan Proteins: Major Impact of Gene Prediction Errors
  29. WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity
  30. Agrin Binds BMP2, BMP4 and TGFβ1
  31. Identifying protein-coding genes in genomic sequences
  32. The second von Willebrand type A domain of cochlin has high affinity for type I, type II and type IV collagens
  33. Alternative Splicing: Evolution
  34. Exons: Shuffling
  35. Exons and Protein Modules
  36. Introns: Phase Compatibility
  37. Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion
  38. Identification and correction of abnormal, incomplete and mispredicted proteins in public databases
  39. Quality control of gene predictions
  40. Comment on "Tequila, a Neurotrypsin Ortholog, Regulates Long-Term Memory Formation in Drosophila"
  41. A general theory of gene sharing
  42. Exons: Shuffling
  43. Alternative Splicing: Evolution
  44. Introns: Phase Compatibility
  45. Exons and Protein Modules
  46. Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein
  47. NMR structure of the WIF domain from human WIF-1
  48. NMR Structure of the WIF Domain of the Human Wnt-Inhibitory Factor-1
  49. Modules, multidomain proteins and organismic complexity
  50. Hydroxamate-based peptide inhibitors of matrix metalloprotease 2
  51. Xenolog
  52. Coevolution of Protein Residues
  53. Alignment Score
  54. Protein Domain
  55. Multidomain Protein
  56. DNA-Protein Coevolution
  57. Exon Shuffling
  58. Synonymous Mutation (Silent Mutation)
  59. Gap Penalty
  60. Homology
  61. Protein Module
  62. Module Shuffling
  63. Exon
  64. Homologous Genes
  65. Protein-Protein Coevolution
  66. Modular Protein
  67. Sequence Similarity Search
  68. Non-Synonymous Mutation
  69. BLOSUM (BLOSUM Matrix)
  70. Xenolog (Xenologue)
  71. Epaktolog (Epaktologue)
  72. Pseudoparalog (pseudoparalogue)
  73. BLOSUM Matrix
  74. Horizontal Gene Transfer
  75. Mosaic Protein
  76. Nonsynonymous Mutation
  77. PAM Matrix of Nucleotide Substitutions
  78. Paralog
  79. Homology
  80. Modular Protein
  81. Coevolution (Molecular Coevolution)
  82. Sequence Similarity Search
  83. Multidomain Protein
  84. Coevolution of Protein Residues
  85. Module Shuffling
  86. Gap Penalty
  87. Protein Domain
  88. Homologous Genes
  89. Exon Shuffling
  90. Alignment Score
  91. DNA-Protein Coevolution
  92. Protein-Protein Coevolution
  93. Synonymous Mutation (Silent Mutation)
  94. Exon
  95. Protein Module
  96. Protein Family
  97. Dayhoff Amino Acid Substitution Matrix (PAM Matrix, Percent Accepted Mutation Matrix)
  98. PAM Matrix of Nucleotide Substitutions (Point Accepted Mutations)
  99. Paralog (Paralogue)
  100. Protein Family
  101. Dayhoff Amino Acid Substitution Matrix (PAM Matrix, Percent Accepted Mutation Matrix)
  102. Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides
  103. Evidence that human genes of modular proteins have retained significantly more ancestral introns than their fly or worm orthologues
  104. Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere's disease
  105. NMR structure of the NTR domain from human PCOLCE1
  106. Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein
  107. Expression and characterization of the olfactomedin domain of human myocilin
  108. Modular assembly of genes and the evolution of new functions
  109. Structural characterization of the second TSP1-module of human thrombospondin
  110. The First Fibronectin Type II Module from Human Matrix Metalloproteinase 2
  111. Distinct Expression Pattern of Two Related Human Proteins Containing Multiple Types of Protease-Inhibitory Modules
  112. The Col-1 Module of Human Matrix Metalloproteinase-2 (MMP-2): Structural/Functional Relatedness between Gelatin-Binding Fibronectin Type II Modules and Lysine-Binding Kringle Domains
  113. NMR structure of the LCCL domain
  114. Origin of fibronectin type II (FN2) modules: Structural analyses of distantly-related members of the kringle family idey the kringle domain of neurotrypsin as a potential link between FN2 domains and kringles
  115. The Third Fibronectin Type II Module from Human Matrix Metalloproteinase 2
  116. Localization of Disulfide Bonds in the Frizzled Module of Ror1 Receptor Tyrosine Kinase
  117. Were protein internal repeats formed by ‘bricolage’?
  118. Involvement of Fibronectin Type II Repeats in the Efficient Inhibition of Gelatinases A and B by Long-chain Unsaturated Fatty Acids
  119. Unique functional composition of metazoan genomes
  120. The LCCL module
  121. The WIF module
  122. THE SECOND TYPE II MODULE FROM HUMAN MATRIX METALLOPROTEINASE 2
  123. The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins
  124. The second type II module from human matrix metalloproteinase 2: structure, function and dynamics
  125. Genome evolution and the evolution of exon-shuffling — a review
  126. The NTR module: Domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases
  127. The gelatin-binding site of the second type-II domain of gelatinase �A/MMP-2
  128. Amoebapore homologs of Caenorhabditis elegans
  129. A deletion in the myostatin gene causes the compact ( Cmpt ) hypermuscular mutation in mice
  130. Apolipoprotein(a): A Puzzling Evolutionary Story
  131. Exon shuffling and other ways of module exchange
  132. [12] Consensus approaches in detection of distant homologies
  133. The SEA module: A new extracellular domain associated withO-glycosylation
  134. Sequences and topology
  135. Introns and exons
  136. Agrin-like proteins of the neuromuscular junction
  137. REFINED SOLUTION STRUCTURE AND LIGAND-BINDING PROPERTIES OF PDC-109 DOMAIN B. A COLLAGEN-BINDING TYPE II DOMAIN
  138. Significance of exon-shuffling in the evolution of extracellular proteolytic systems
  139. Functions of agrin and agrin-related proteins
  140. [1] Modular design of proteases of coagulation, fibrinolysis, and complement activation: Implications for protein engineering and structure-function studies
  141. Structure, function and evolution of mosaic proteins
  142. A family of laminin-related proteins controlling ectodermal differentiation in Drosophila
  143. Refined solution structure and ligand-binding properties of PDC-109 domain b
  144. Laminin A-related domains in crb protein of Drosophila and their possible role in epithelial polarization
  145. Modular exchange principles in proteins
  146. Evidence for the involvement of type II domains in collagen binding by 72 kDa type IV procollagenase
  147. Conformation of Lys-plasminogen and the kringle 1-3 fragment of plasminogen analyzed by small-angle neutron scattering
  148. Exons - original building blocks of proteins?
  149. Sequence-specific proton NMR assignments and structural characterization of bovine seminal fluid protein PDC-109 domain b
  150. The collagen-binding site of type-II units of bovine seminal fluid protein PDC-109 and fibronectin
  151. Evolutionary Assembly of Blood Coagulation Proteins
  152. Homology of a domain of the growth hormone/prolactin receptor family with type III modules of fibronectin
  153. Homology of cytotoxic protein of eosinophilic leukocytes with IgE receptor Fcϵ RII: Implications for its structure and function
  154. Detecting distant homologies of mosaic proteins
  155. Homology of human pancreatic stone protein with animal lectins
  156. 44 Homologies of plasma proteases: Implications for their structure, function and evolution
  157. 245 Different shapes and secondary struture of human glu- and lys-plasminogen
  158. Analysis of the aliphatic 1H-NMR spectrum of plasminogen kringle 4. A comparative study of human, porcine, bovine and chicken homologs
  159. Detecting homology of distantly related proteins with consensus sequences
  160. Intron-dependent evolution: Preferred types of exons and introns
  161. Is lung surfactant protein a lectin–collagen hybrid?
  162. The aromatic 1H-NMR spectrum of plasminogen kringle 4. A comparative study of human, porcine and bovine homologs
  163. The krigle 4 domain of chicken plasminogen
  164. Proximity of the catalytic region and the kringle 2 domain in the closed conformer of plasminogen
  165. Chemical modification and nuclear magnetic resonance studies on human plasminogen kringle 4. Assignment of tyrosine and histidine resonances to specific residues in the sequence
  166. Comments on 'Purification and properties of plasminogen activators from epithelial cells', by A. Electricwala and T. Atkinson
  167. Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules
  168. Analysis and identification of aromatic signals in the proton magnetic resonance spectrum of the kringle 4 fragment from human plasminogen
  169. .beta.(Leu121-Lys122) segment of fibrinogen is in a region essential for plasminogen binding by fibrin fragment E
  170. Common evolutionary origin of the fibrin-binding structures of fibronectin and tissue-type plasminogen activator
  171. Location of plasminogen-binding sites in human fibrin(ogen)
  172. Structure of the omega-aminocarboxylic acid-binding sites of human plasminogen. Arginine 70 and aspartic acid 56 are essential for binding of ligand by kringle 4.
  173. Origin of the Selectivity of alpha-Dicarbonyl Reagents for Arginyl Residues of Anion-Binding Sites
  174. Identification of the C-1-Phosphate-Binding Arginine Residue of Rabbit-Muscle Aldolase. Isolation of 1,2-Cyclohexanedione-Labeled Peptide by Chemisorption Chromatography
  175. Aldolase-catalysed inactivation of glyceraldehyde-3-phosphate dehydrogenase
  176. Role of Nascent alpha-Ketoaldehyde in Substrate-Dependent Oxidative Inactivation of Aldolase
  177. Decreased Heparin Sensitivity of Cyclohexanedione-Modified Thrombin
  178. Histone III. VI. Two forms of calf thymus histone III.
  179. Reversible modification of arginine residues. Application to sequence studies by restriction of tryptic hydrolysis to lysine residues
  180. Identification of functional arginine residues in ribonuclease A and lysozyme
  181. Histone III
  182. Effect of amino acid starvation on constitutive synthesis of histidine mRNA