All Stories

  1. Piezo1 in intestinal smooth muscle cells: Emerging perspectives

    Article • The Journal of Physiology, November 2025, Wiley

    Distinguished Professor L. Fernando Santana

  2. Microvascular Rarefaction in the Sinoatrial Node

    Article • JACC Clinical Electrophysiology, October 2025, Elsevier

    Distinguished Professor L. Fernando Santana

  3. Large-scale synthetic data enable digital twins of human excitable cells

    Article • September 2025, openRxiv

    Distinguished Professor L. Fernando Santana

  4. Beat-locked ATP microdomains in the sinoatrial node map a Ca 2+ -timed energetic hierarchy and regional pacemaker roles

    Article • August 2025, openRxiv

    Distinguished Professor L. Fernando Santana

  5. Demonstration of Beat-to-Beat, On-Demand ATP Synthesis in Ventricular Myocytes Reveals Sex-Specific Mitochondrial and Cytosolic Dynamics

    Article • July 2025, openRxiv

    Distinguished Professor L. Fernando Santana

  6. Parameter Optimization of Biochemical Models for Precision Medicine: A Case Study in PI(4,5)P 2 Synthesis

    Article • July 2025, openRxiv

    Distinguished Professor L. Fernando Santana

  7. A new conceptual framework for preclinical departments in schools of medicine: Maximizing groundbreaking work through thematic breadth

    Article • The FASEB Journal, March 2025, Wiley

    Distinguished Professor L. Fernando Santana

  8. Electrifying the brain capillary Ca 2+ signal

    Article • Proceedings of the National Academy of Sciences, January 2025, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  9. α1 C S1928 Phosphorylation of Ca V 1.2 Channel Controls Vascular Reactivity and Blood Pressure

    Article • Journal of the American Heart Association, October 2024, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  10. The life cycle of a capillary: Mechanisms of angiogenesis and rarefaction in microvascular physiology and pathologies

    Article • Vascular Pharmacology, September 2024, Elsevier

    Distinguished Professor L. Fernando Santana

  11. Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications

    Article • The Journal of Physiology, July 2024, Wiley

    Distinguished Professor L. Fernando Santana

  12. How the Heart Generates and Uses Energy to Keep Beating

    Article • Proceedings of the National Academy of Sciences, June 2024, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  13. SanPy: Software for the analysis and visualization of whole-cell current-clamp recordings

    Article • Biophysical Journal, April 2024, Elsevier

    Distinguished Professor L. Fernando Santana

  14. Sorbs2 Modulation of BK Channels in Arterial Myocytes: Implications for Diabetes

    Article • Circulation Research, March 2024, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  15. A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

    Article • eLife, February 2024, eLife

    Distinguished Professor L. Fernando Santana

  16. A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

    Article • eLife, February 2024, eLife

    Distinguished Professor L. Fernando Santana

  17. Toward Digital Twin Technology for Precision Pharmacology

    Article • JACC Clinical Electrophysiology, February 2024, Elsevier

    Distinguished Professor L. Fernando Santana

  18. A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

    Article • December 2023, eLife

    Distinguished Professor L. Fernando Santana

  19. Interstitial cells of Cajal – pacemakers of the gastrointestinal tract

    Article • The Journal of Physiology, November 2023, Wiley

    Distinguished Professor L. Fernando Santana

  20. A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

    Article • September 2023, eLife

    Distinguished Professor L. Fernando Santana

  21. Abstract P3008: A Computational Model Predicts Sex-specific Responses To Calcium Channel Blockers In Mesenteric Vascular Smooth Muscle

    Article • Circulation Research, August 2023, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  22. A multiscale predictive digital twin for neurocardiac modulation

    Article • The Journal of Physiology, August 2023, Wiley

    Distinguished Professor L. Fernando Santana

  23. The formation of K V 2.1 macro-clusters is required for sex-specific differences in L-type Ca V 1.2 clustering and function in arterial myocytes

    Article • June 2023, openRxiv

    Distinguished Professor L. Fernando Santana

  24. A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

    Article • June 2023, openRxiv

    Distinguished Professor L. Fernando Santana

  25. Remodeled connexin 43 hemichannels alter cardiac excitability and promote arrhythmias

    Article • Journal of General Physiology, May 2023, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  26. Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor

    Article • Basic & Clinical Pharmacology & Toxicology, May 2023, Wiley

    Distinguished Professor L. Fernando Santana

  27. SanPy: A whole-cell electrophysiology analysis pipeline

    Article • May 2023, openRxiv

    Distinguished Professor L. Fernando Santana

  28. Regulating voltage-gated ion channels with nanobodies

    Article • Nature Communications, December 2022, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  29. Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains

    Article • JCI Insight, November 2022, American Society for Clinical Investigation

    Distinguished Professor L. Fernando Santana

  30. The Inferior Sinoatrial Node Suffers the Most During Heart Failure

    Article • JACC Clinical Electrophysiology, November 2022, Elsevier

    Distinguished Professor L. Fernando Santana

  31. The Central Brain of the Heart

    Article • JACC Clinical Electrophysiology, October 2022, Elsevier

    Distinguished Professor L. Fernando Santana

  32. Mechanisms and physiological implications of cooperative gating of clustered ion channels

    Article • Physiological Reviews, July 2022, American Physiological Society

    Distinguished Professor L. Fernando Santana

  33. Aging reduces the number and function of L-type calcium channels in the membrane of cardiac pacemaker cells

    Article • June 2022, openRxiv

    Distinguished Professor L. Fernando Santana

  34. Piezo1 Tunes Blood Flow in the Central Nervous System

    Article • Circulation Research, May 2022, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  35. Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling

    Article • Journal of General Physiology, April 2022, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  36. The physiological sensor channels TRP and piezo: Nobel Prize in Physiology or Medicine 2021

    Article • Physiological Reviews, April 2022, American Physiological Society

    Distinguished Professor L. Fernando Santana

  37. Regulation of neuronal excitation–transcription coupling by Kv2.1-induced clustering of somatic L-type Ca 2+ channels at ER-PM junctions

    Article • Proceedings of the National Academy of Sciences, November 2021, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  38. IP 3 R-driven increases in mitochondrial Ca 2+ promote neuronal death in NPC disease

    Article • Proceedings of the National Academy of Sciences, September 2021, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  39. Author response: Genetically engineered mice for combinatorial cardiovascular optobiology

    Article • September 2021, eLife

    Distinguished Professor L. Fernando Santana

  40. Genetically Engineered Mice for Combinatorial Cardiovascular Optobiology

    Article • January 2021, openRxiv

    Distinguished Professor L. Fernando Santana

  41. The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability

    Article • Function, January 2021, American Physiological Society

    Distinguished Professor L. Fernando Santana

  42. AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2

    Article • Nature Communications, October 2020, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  43. Evolving Discovery of the Origin of the Heartbeat

    Article • JACC Clinical Electrophysiology, August 2020, Elsevier

    Distinguished Professor L. Fernando Santana

  44. Maladaptive response of arterial myocytes to chronic exposure to Ca 2+ channel blockers

    Article • Proceedings of the National Academy of Sciences, July 2020, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  45. TRPML1ng on sparks

    Article • Science Signaling, June 2020, American Association for the Advancement of Science

    Distinguished Professor L. Fernando Santana

  46. Metabolic–electrical control of coronary blood flow

    Article • Proceedings of the National Academy of Sciences, April 2020, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  47. Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes

    Article • AJP Cell Physiology, March 2020, American Physiological Society

    Distinguished Professor L. Fernando Santana

  48. Kv2.1 channels play opposing roles in regulating membrane potential, Ca 2+ channel function, and myogenic tone in arterial smooth muscle

    Article • Proceedings of the National Academy of Sciences, February 2020, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  49. Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

    Article • eLife, October 2019, eLife

    Distinguished Professor L. Fernando Santana

  50. Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity

    Article • Journal of Cell Biology, October 2019, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  51. A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

    Article • eLife, September 2019, eLife

    Distinguished Professor L. Fernando Santana

  52. A stochastic model of ion channel cluster formation in the plasma membrane

    Article • Journal of General Physiology, August 2019, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  53. Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in neurons

    Article • July 2019, openRxiv

    Distinguished Professor L. Fernando Santana

  54. Adenylyl cyclase 5–generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia

    Article • Journal of Clinical Investigation, July 2019, American Society for Clinical Investigation

    Distinguished Professor L. Fernando Santana

  55. A Gs-coupled purinergic receptor boosts Ca2+ influx and vascular contractility during diabetic hyperglycemia

    Article • eLife, March 2019, eLife

    Distinguished Professor L. Fernando Santana

  56. A Novel Stochastic Self-Assembly Model for Ion Channel Trafficking and Clustering in Excitable Cells

    Article • Biophysical Journal, February 2019, Elsevier

    Distinguished Professor L. Fernando Santana

  57. BIN1 Induces the Formation of T-Tubules and Adult-Like Ca2+ Release Units in Developing Cardiomyocytes

    Article • Stem Cells, November 2018, Oxford University Press (OUP)

    Distinguished Professor L. Fernando Santana

  58. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins

    Article • Proceedings of the National Academy of Sciences, November 2018, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  59. Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 2018, Elsevier

    Distinguished Professor L. Fernando Santana

  60. Abstract 105: Tuning EC-Coupling: β -Adrenergic Receptor Activation Stimulates Dynamic Augmentation of Ca V 1.2 Channel Sarcolemmal Abundance and Cooperativity

    Article • Circulation Research, August 2018, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  61. A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics

    Article • PLoS Computational Biology, January 2018, PLOS

    Distinguished Professor L. Fernando Santana

  62. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  63. A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade

    Article • Journal of Neuropathology & Experimental Neurology, July 2017, Oxford University Press (OUP)

    Distinguished Professor L. Fernando Santana

  64. Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

    Article • eLife, June 2017, eLife

    Distinguished Professor L. Fernando Santana

  65. Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes

    Article • Journal of General Physiology, May 2017, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  66. Calcium Channels in Vascular Smooth Muscle

    Article • January 2017, Elsevier

    Distinguished Professor L. Fernando Santana

  67. Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve

    Article • Cardiovascular Research, November 2016, European Society of Cardiology

    Distinguished Professor L. Fernando Santana

  68. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction

    Article • Cellular Signalling, July 2016, Elsevier

    Distinguished Professor L. Fernando Santana

  69. Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels

    Article • eLife, May 2016, eLife

    Distinguished Professor L. Fernando Santana

  70. Oxidative stress decreases microtubule growth and stability in ventricular myocytes

    Article • Journal of Molecular and Cellular Cardiology, April 2016, Elsevier

    Linda Wordeman, Distinguished Professor L. Fernando Santana

  71. Oxidative Stress in Myocardial Infarction Disrupts Microtubule Trafficking, Reducing Transient Outward Current Density

    Article • Biophysical Journal, February 2016, Elsevier

    Linda Wordeman, Distinguished Professor L. Fernando Santana

  72. BK and CaV1.3 Channels Organize in Clusters that Control Excitability in Neurons

    Article • Biophysical Journal, February 2016, Elsevier

    Distinguished Professor L. Fernando Santana

  73. Bin1 Regulates CaV1.2 Channel Clustering in Ventricular Myocytes

    Article • Biophysical Journal, February 2016, Elsevier

    Distinguished Professor L. Fernando Santana

  74. A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

    Article • eLife, September 2015, eLife

    Linda Wordeman, Distinguished Professor L. Fernando Santana

  75. The long and winding road home: How junctin and triadin find their way to the junctional SR

    Article • Journal of Molecular and Cellular Cardiology, April 2015, Elsevier

    Distinguished Professor L. Fernando Santana

  76. Graded Ca 2+ /calmodulin-dependent coupling of voltage-gated Ca V 1.2 channels

    Article • eLife, February 2015, eLife

    Distinguished Professor L. Fernando Santana

  77. AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension

    Article • Science Signaling, July 2014, American Association for the Advancement of Science

    Distinguished Professor L. Fernando Santana

  78. Evaluation of clinical safety and anthelmintic efficacy of aurixazole administed orally at 24 mg/kg in cattle

    Article • Research in Veterinary Science, June 2014, Elsevier

    Distinguished Professor L. Fernando Santana

  79. Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Heart Failure

    Article • Circulation, April 2014, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  80. Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle

    Article • Journal of General Physiology, April 2014, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  81. Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery

    Article • Stem Cell Research, March 2014, Elsevier

    Distinguished Professor L. Fernando Santana

  82. AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca 2+ -Activated K + Channel Remodeling in Hyperglycemia and Diabetes Mellitus

    Article • Circulation Research, February 2014, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  83. Super-Resolution Imaging of Cav1.2 Channel Clusters

    Article • Biophysical Journal, January 2014, Elsevier

    Distinguished Professor L. Fernando Santana

  84. Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8)

    Article • Journal of Molecular and Cellular Cardiology, January 2014, Elsevier

    Distinguished Professor L. Fernando Santana

  85. Functional Clustering of L-Type CaV1.3 Channels

    Article • Biophysical Journal, January 2014, Elsevier

    Distinguished Professor L. Fernando Santana

  86. Anthelmintic efficacy of an oral formulation of Aurixazol against gastrointestinal nematodes of naturally and experimentally infected sheep

    Article • Veterinary Parasitology, December 2013, Elsevier

    Distinguished Professor L. Fernando Santana

  87. Down‐regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca2+ into hypertensive arterial smooth muscle

    Article • The Journal of Physiology, November 2013, Wiley

    Distinguished Professor L. Fernando Santana

  88. Evidence of sexual transmission of Toxoplasma gondii in goats

    Article • Small Ruminant Research, October 2013, Elsevier

    Distinguished Professor L. Fernando Santana

  89. Regulation of L-type calcium channel sparklet activity by c-Src and PKC-α

    Article • AJP Cell Physiology, September 2013, American Physiological Society

    Distinguished Professor L. Fernando Santana

  90. CaV1.2 sparklets in heart and vascular smooth muscle

    Article • Journal of Molecular and Cellular Cardiology, May 2013, Elsevier

    Distinguished Professor L. Fernando Santana

  91. A Ca2+- and PKC-driven regulatory network in airway smooth muscle

    Article • Journal of General Physiology, January 2013, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  92. Anchored phosphatases modulate glucose homeostasis

    Article • The EMBO Journal, November 2012, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  93. Adding Accessories for Hypertension

    Article • Hypertension, October 2012, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  94. Anchored phosphatases modulate glucose homeostasis

    Article • The EMBO Journal, August 2012, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  95. Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna−/− Mice

    Article • PLOS One, August 2012, PLOS

    Distinguished Professor L. Fernando Santana

  96. L-Type Ca2+ Channel Function During Timothy Syndrome

    Article • Trends in Cardiovascular Medicine, April 2012, Elsevier

    Distinguished Professor L. Fernando Santana

  97. Ca 2+ signaling amplification by oligomerization of L-type Ca v 1.2 channels

    Article • Proceedings of the National Academy of Sciences, January 2012, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  98. Ca2+ Signaling Amplification by Oligomerization of L-Type Cav1.2 Channels

    Article • Biophysical Journal, January 2012, Elsevier

    Distinguished Professor L. Fernando Santana

  99. Optical Recordings of Ca2+ Influx via TRPV4 and Voltage-Gated L-type Ca2+ Channels in Arterial Smooth Muscle

    Article • Biophysical Journal, January 2012, Elsevier

    Distinguished Professor L. Fernando Santana

  100. Relationship between Ca2+sparklets and sarcoplasmic reticulum Ca2+load and release in rat cerebral arterial smooth muscle

    Article • AJP Heart and Circulatory Physiology, December 2011, American Physiological Society

    Distinguished Professor L. Fernando Santana

  101. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria

    Article • Proceedings of the National Academy of Sciences, November 2011, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  102. Restoration of Normal L-Type Ca 2+ Channel Function During Timothy Syndrome by Ablation of an Anchoring Protein

    Article • Circulation Research, July 2011, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  103. Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

    Article • Journal of the American College of Cardiology, June 2011, Elsevier

    Distinguished Professor L. Fernando Santana

  104. Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

    Article • Circulation Research, April 2011, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  105. Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes

    Article • BioMed Research International, January 2011, Wiley

    Distinguished Professor L. Fernando Santana

  106. Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2 Group X

    Article • Journal of Biological Chemistry, December 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  107. How does the shape of the cardiac action potential control calcium signaling and contraction in the heart?

    Article • Journal of Molecular and Cellular Cardiology, December 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  108. Sympathetic Stimulation of Adult Cardiomyocytes Requires Association of AKAP5 With a Subpopulation of L-Type Calcium Channels

    Article • Circulation Research, September 2010, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  109. Detection of Toxoplasma gondii in the reproductive system of male goats

    Article • Revista Brasileira de Parasitologia Veterinária, September 2010, FapUNIFESP (SciELO)

    Distinguished Professor L. Fernando Santana

  110. Phosphodiesterase 8A (PDE8A) regulates excitation–contraction coupling in ventricular myocytes

    Article • Journal of Molecular and Cellular Cardiology, August 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  111. Natural inequalities: why some L-type Ca2+ channels work harder than others

    Article • Journal of General Physiology, July 2010, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  112. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

    Article • AJP Heart and Circulatory Physiology, May 2010, American Physiological Society

    Distinguished Professor L. Fernando Santana

  113. A-Kinase Anchoring Proteins

    Article • Circulation, March 2010, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  114. Increased Coupled Gating of L-Type Ca 2+ Channels During Hypertension and Timothy Syndrome

    Article • Circulation Research, March 2010, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  115. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

    Article • AJP Cell Physiology, February 2010, American Physiological Society

    Distinguished Professor L. Fernando Santana

  116. AKAP150 is Required for NFATC3 Transcriptional Regulation of Kv2.1 and BK Channel Expression in Smooth Muscle

    Article • Biophysical Journal, January 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  117. Activation of PKC-Alpha Increases Ca2+ Sparklet Activity in Cardiac Myocytes

    Article • Biophysical Journal, January 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  118. Developmental Changes of the Sarcoplasmic Reticulum

    Article • Biophysical Journal, January 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  119. Persistent Calcium Sparklet Activity of L-Type Calcium Channels: Link Between PKC and c-Src

    Article • Biophysical Journal, January 2010, Elsevier

    Distinguished Professor L. Fernando Santana

  120. Myostatin represses physiological hypertrophy of the heart and excitation–contraction coupling

    Article • The Journal of Physiology, October 2009, Wiley

    Distinguished Professor L. Fernando Santana

  121. Molecular and biophysical mechanisms of Ca2+ sparklets in smooth muscle

    Article • Journal of Molecular and Cellular Cardiology, October 2009, Elsevier

    Distinguished Professor L. Fernando Santana

  122. Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

    Article • Circulation, June 2009, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  123. Local Control of Excitation-Contraction Coupling in Human Embryonic Stem Cell-Derived Cardiomyocytes

    Article • PLOS One, April 2009, PLOS

    Distinguished Professor L. Fernando Santana

  124. NFATc3-dependent loss of Ito gradient across the left ventricular wall during chronic β adrenergic stimulation

    Article • Journal of Molecular and Cellular Cardiology, February 2009, Elsevier

    Distinguished Professor L. Fernando Santana

  125. Calmodulin Regulates Calcium Sparklet Activity in Vascular Smooth Muscle

    Article • Biophysical Journal, February 2009, Elsevier

    Distinguished Professor L. Fernando Santana

  126. The control of Ca 2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension

    Article • Proceedings of the National Academy of Sciences, October 2008, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  127. NFAT-Dependent Excitation–Transcription Coupling in Heart

    Article • Circulation Research, September 2008, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  128. CALCIUM SPARKLETS IN ARTERIAL SMOOTH MUSCLE

    Article • Clinical and Experimental Pharmacology and Physiology, August 2008, Wiley

    Distinguished Professor L. Fernando Santana

  129. AKAP150 Is Required for Stuttering Persistent Ca 2+ Sparklets and Angiotensin II–Induced Hypertension

    Article • Circulation Research, February 2008, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  130. SMAKing Ca2+ sparks in arterial myocytes

    Article • The Journal of Physiology, September 2007, Wiley

    Distinguished Professor L. Fernando Santana

  131. Cav1.3 channels produce persistent calcium sparklets, but Cav1.2 channels are responsible for sparklets in mouse arterial smooth muscle

    Article • AJP Heart and Circulatory Physiology, September 2007, American Physiological Society

    Distinguished Professor L. Fernando Santana

  132. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle

    Article • The Journal of Physiology, February 2007, Wiley

    Distinguished Professor L. Fernando Santana

  133. Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+ Channels in Arterial Smooth Muscle and Contributes to Hypertension

    Article • Journal of Biological Chemistry, February 2007, Elsevier

    Distinguished Professor L. Fernando Santana

  134. Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane

    Article • Journal of General Physiology, October 2006, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  135. Kv2 channels oppose myogenic constriction of rat cerebral arteries

    Article • AJP Cell Physiology, August 2006, American Physiological Society

    Distinguished Professor L. Fernando Santana

  136. Differential Calcineurin/NFATc3 Activity Contributes to the I to Transmural Gradient in the Mouse Heart

    Article • Circulation Research, May 2006, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  137. Mechanisms Underlying Heterogeneous Ca2+ Sparklet Activity in Arterial Smooth Muscle

    Article • Journal of General Physiology, May 2006, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  138. Mechanisms underlying variations in excitation–contraction coupling across the mouse left ventricular free wall

    Article • The Journal of Physiology, March 2006, Wiley

    Distinguished Professor L. Fernando Santana

  139. On the Loose: Uncaging Ca2+-induced Ca2+ Release in Smooth Muscle

    Article • Journal of General Physiology, February 2006, Rockefeller University Press

    Distinguished Professor L. Fernando Santana

  140. Constitutively active L-type Ca 2+ channels

    Article • Proceedings of the National Academy of Sciences, July 2005, Proceedings of the National Academy of Sciences

    Distinguished Professor L. Fernando Santana

  141. Sodium Current and Arrhythmogenesis in Heart Failure

    Article • Heart Failure Clinics, July 2005, Elsevier

    Distinguished Professor L. Fernando Santana

  142. Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca 2+ Release

    Article • Circulation Research, March 2005, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  143. NFATc3 Regulates Kv2.1 Expression in Arterial Smooth Muscle

    Article • Journal of Biological Chemistry, November 2004, Elsevier

    Distinguished Professor L. Fernando Santana

  144. NFATc3-Induced Reductions in Voltage-Gated K + Currents After Myocardial Infarction

    Article • Circulation Research, May 2004, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  145. Downregulation of the BK Channel β1 Subunit in Genetic Hypertension

    Article • Circulation Research, November 2003, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana

  146. Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension

    Article • Journal of Clinical Investigation, September 2003, American Society for Clinical Investigation

    Distinguished Professor L. Fernando Santana

  147. Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes

    Article • The Journal of Physiology, October 2002, Wiley

    Distinguished Professor L. Fernando Santana

  148. Local Ca2+ Signaling and EC Coupling in Heart: Ca2+ Sparks and the Regulation of the [Ca2+]i Transient

    Article • Journal of Molecular and Cellular Cardiology, August 2002, Elsevier

    Distinguished Professor L. Fernando Santana

  149. Probing the Effects of Membrane Cholesterol in the Torpedo californica Acetylcholine Receptor and the Novel Lipid-exposed Mutation αC418W in XenopusOocytes

    Article • Journal of Biological Chemistry, December 2001, Elsevier

    Distinguished Professor L. Fernando Santana

  150. Role of phospholamban in the modulation of arterial Ca2+sparks and Ca2+-activated K+channels by cAMP

    Article • AJP Cell Physiology, September 2001, American Physiological Society

    Distinguished Professor L. Fernando Santana

  151. Differential contribution of sialic acid to the function of repolarizing K+ currents in ventricular myocytes

    Article • AJP Cell Physiology, August 2001, American Physiological Society

    Distinguished Professor L. Fernando Santana

  152. Role of Sodium Channel Deglycosylation in the Genesis of Cardiac Arrhythmias in Heart Failure

    Article • Journal of Biological Chemistry, July 2001, Elsevier

    Distinguished Professor L. Fernando Santana

  153. Ca 2+ Flux Through Promiscuous Cardiac Na + Channels: Slip-Mode Conductance

    Article • Science, February 1998, American Association for the Advancement of Science

    Distinguished Professor L. Fernando Santana

  154. Calcium Sparks and Excitation–Contraction Coupling in Phospholamban‐Deficient Mouse Ventricular Myocytes

    Article • The Journal of Physiology, August 1997, Wiley

    Distinguished Professor L. Fernando Santana

  155. Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

    Article • Science, May 1997, American Association for the Advancement of Science

    Distinguished Professor L. Fernando Santana

  156. Two mechanisms of quantized calcium release in skeletal muscle

    Article • Nature, February 1996, Springer Science + Business Media

    Distinguished Professor L. Fernando Santana

  157. Relation Between the Sarcolemmal Ca 2+ Current and Ca 2+ Sparks and Local Control Theories for Cardiac Excitation-Contraction Coupling

    Article • Circulation Research, January 1996, Wolters Kluwer Health

    Distinguished Professor L. Fernando Santana