All Stories

  1. A Novel Combinatorial Regimen Using Sorafenib and Uttroside B, A US FDA-designated ‘Orphan Drug’, for the Treatment of Hepatocellular Carcinoma

    Article • Anti-Cancer Agents in Medicinal Chemistry, November 2024, Bentham Science Publishers

    Dr Kuzhuvelil B Harikumar, Induja DK

  2. Targeting acid ceramidase enhances antitumor immune response in colorectal cancer

    Article • Journal of Advanced Research, November 2024, Elsevier

    Dr Kuzhuvelil B Harikumar

  3. Modulatory Role of Phytochemicals/Natural Products in Cancer Immunotherapy

    Article • Current Medicinal Chemistry, October 2024, Bentham Science Publishers

    Dr Kuzhuvelil B Harikumar

  4. Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention

    Article • Archives of Biochemistry and Biophysics, April 2024, Elsevier

    Dr Kuzhuvelil B Harikumar

  5. Data from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  6. Data from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  7. Supplementary Data from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  8. Supplementary Data from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  9. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  10. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  11. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  12. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  13. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  14. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  15. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  16. Supplementary Figure from DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • March 2023, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  17. Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma

    Article • Pharmaceuticals, May 2022, MDPI AG

    Dr Kuzhuvelil B Harikumar

  18. Development and Functional Characterization of a Versatile Radio-/Immunotheranostic Tool for Prostate Cancer Management

    Article • Cancers, April 2022, MDPI AG

    Dr Kuzhuvelil B Harikumar

  19. DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

    Article • Clinical Cancer Research, February 2022, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  20. Augmented efficacy of uttroside B over sorafenib in a murine model of human hepatocellular carcinoma

    Article • February 2022, Cold Spring Harbor Laboratory Press

    Dr Kuzhuvelil B Harikumar

  21. p27 as a Transcriptional Regulator: New Roles in Development and Cancer

    Article • Cancer Research, September 2020, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  22. Regulatory role of SphK1 in TLR7/9‐dependent type I interferon response and autoimmunity

    Article • The FASEB Journal, January 2020, Wiley

    Dr Kuzhuvelil B Harikumar

  23. TAMing pancreatic cancer: combat with a double edged sword

    Article • Molecular Cancer, March 2019, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  24. Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus

    Article • The FASEB Journal, March 2019, Wiley

    Sabira Mohammed, Dr Kuzhuvelil B Harikumar

  25. Corrigendum: Sphingosine 1-Phosphate: A Novel Target for Lung Disorders

    Article • Frontiers in Immunology, July 2018, Frontiers

    Dr Kuzhuvelil B Harikumar

  26. Targeting oncogenic transcription factors by polyphenols: A novel approach for cancer therapy

    Article • Pharmacological Research, April 2018, Elsevier

    Dr Kuzhuvelil B Harikumar

  27. Enhanced expression of histone chaperone APLF associate with breast cancer

    Article • Molecular Cancer, March 2018, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  28. The Origin and Functions of Exosomes in Cancer

    Article • Frontiers in Oncology, March 2018, Frontiers

    Dr Kuzhuvelil B Harikumar

  29. Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine

    Article • Theranostics, January 2018, Ivyspring International Publisher

    Dr Kuzhuvelil B Harikumar

  30. Cardamonin inhibits colonic neoplasia through modulation of MicroRNA expression

    Article • Scientific Reports, October 2017, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  31. Sphingosine 1-Phosphate: A Novel Target for Lung Disorders

    Article • Frontiers in Immunology, March 2017, Frontiers

    Dr Kuzhuvelil B Harikumar

  32. Complementary and Alternative Medicines in Prostate Cancer

    Article • December 2016, Taylor & Francis

    Dr Kuzhuvelil B Harikumar

  33. The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell–dependent acute allergic responses

    Article • Journal of Allergy and Clinical Immunology, April 2015, Elsevier

    Dr Kuzhuvelil B Harikumar

  34. K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5

    Article • Nature Immunology, January 2014, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  35. A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma

    Article • Journal of Allergy and Clinical Immunology, February 2013, Elsevier

    Dr Kuzhuvelil B Harikumar

  36. Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

    Article • Cancer Cell, January 2013, Elsevier

    Dr Kuzhuvelil B Harikumar

  37. Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics

    Article • The FASEB Journal, April 2012, Federation of American Societies For Experimental Biology (FASEB)

    Dr Kuzhuvelil B Harikumar

  38. Sphingosine-1-phosphate signaling and its role in disease

    Article • Trends in Cell Biology, January 2012, Elsevier

    Dr Kuzhuvelil B Harikumar

  39. Extracellular and intracellular sphingosine-1-phosphate in cancer

    Article • Cancer and Metastasis Reviews, October 2011, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  40. Phyllanthus Species

    Article • August 2011, Taylor & Francis

    Dr Kuzhuvelil B Harikumar

  41. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

    Article • Nature, June 2010, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  42. A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

    Article • Molecular Cancer Therapeutics, May 2010, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  43. Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

    Article • Molecular Cancer Research, May 2010, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  44. Erratum

    Article • Integrative Cancer Therapies, March 2010, SAGE Publications

    Dr Kuzhuvelil B Harikumar

  45. Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

    Article • Journal of Biological Chemistry, January 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Kuzhuvelil B Harikumar

  46. Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of Nuclear Factor-κB Signaling Pathway

    Article • Molecular Pharmacology, January 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Kuzhuvelil B Harikumar

  47. Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabinein vitroand in orthotopic mouse model of human pancreatic cancer

    Article • International Journal of Cancer, January 2010, Wiley

    Dr Kuzhuvelil B Harikumar

  48. Inhibition of IkB kinase and NF-κB by a novel synthetic compound SK 2009

    Article • Bioorganic & Medicinal Chemistry, January 2010, Elsevier

    Dr Kuzhuvelil B Harikumar

  49. Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

    Article • Science, September 2009, American Association for the Advancement of Science

    Dr Kuzhuvelil B Harikumar

  50. Inhibition of Viral Carcinogenesis by Phyllanthus amarus

    Article • Integrative Cancer Therapies, August 2009, SAGE Publications

    Dr Kuzhuvelil B Harikumar

  51. Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

    Article • Experimental Biology and Medicine, August 2009, SAGE Publications

    Dr Kuzhuvelil B Harikumar

  52. Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

    Article • Annals of the New York Academy of Sciences, August 2009, Wiley

    Dr Kuzhuvelil B Harikumar, Professor Sanjit Dey

  53. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX‐2, MMP‐9, VEGF and CXCR4 expression in an orthotopic mouse model

    Article • International Journal of Cancer, July 2009, Wiley

    Dr Kuzhuvelil B Harikumar

  54. Phyllanthus amarus Inhibits Cell Growth and Induces Apoptosis in Dalton's Lymphoma Ascites Cells Through Activation of Caspase-3 and Downregulation of Bcl-2

    Article • Integrative Cancer Therapies, February 2009, SAGE Publications

    Dr Kuzhuvelil B Harikumar

  55. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

    Article • The International Journal of Biochemistry & Cell Biology, January 2009, Elsevier

    Dr Kuzhuvelil B Harikumar

  56. Resveratrol addiction: To die or not to die

    Article • Molecular Nutrition & Food Research, January 2009, Wiley

    Dr Kuzhuvelil B Harikumar

  57. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

    Article • Biochemical Pharmacology, December 2008, Elsevier

    Dr Kuzhuvelil B Harikumar

  58. Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-κB (NF-κB) by Picroliv Suppresses NF-κB–Regulated Gene Products and Potentiates Apoptosis

    Article • Cancer Research, October 2008, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  59. Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

    Article • Blood, October 2008, American Society of Hematology

    Dr Kuzhuvelil B Harikumar

  60. Neutrophil Gelatinase-Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

    Article • Cancer Research, August 2008, American Association for Cancer Research (AACR)

    Dr Kuzhuvelil B Harikumar

  61. Cancer is a Preventable Disease that Requires Major Lifestyle Changes

    Article • Pharmaceutical Research, July 2008, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  62. Cancer is a Preventable Disease that Requires Major Lifestyle Changes

    Article • Pharmaceutical Research, July 2008, Springer Science + Business Media

    Dr Kuzhuvelil B Harikumar

  63. Potential of Spice-Derived Phytochemicals for Cancer Prevention

    Article • Planta Medica, July 2008, Thieme Publishing Group

    Dr Kuzhuvelil B Harikumar

  64. Resveratrol: A multitargeted agent for age-associated chronic diseases

    Article • Cell Cycle, April 2008, Taylor & Francis

    Dr Kuzhuvelil B Harikumar

  65. Toxicity Profile of Lutein and Lutein Ester Isolated From Marigold Flowers (Tagetes erecta)

    Article • International Journal of Toxicology, January 2008, SAGE Publications

    Dr Kuzhuvelil B Harikumar

  66. An Extract of Phyllanthus amarus Protects Mouse Chromosomes and Intestine from Radiation Induced Damages

    Article • Journal of Radiation Research, January 2007, Oxford University Press (OUP)

    Dr Kuzhuvelil B Harikumar

  67. Proapoptotic and antitumor activities of the HMG-CoA reductase inhibitor, lovastatin, against Dalton's Lymphoma Ascites tumor in mice

    Article • Clinica Chimica Acta, April 2006, Elsevier

    Dr Kuzhuvelil B Harikumar

  68. Inhibition of Drug Metabolizing Enzymes (Cytochrome P450) in Vitro as Well as in Vivo by Phyllanthus amarus SCHUM & THONN

    Article • Biological and Pharmaceutical Bulletin, January 2006, Pharmaceutical Society of Japan

    Dr Kuzhuvelil B Harikumar

  69. Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice

    Article • Phytomedicine, June 2005, Elsevier

    Dr Kuzhuvelil B Harikumar

  70. A Preliminary Assessment of the Acute and Subchronic Toxicity Profile of Phase2: An α-Amylase Inhibitor

    Article • International Journal of Toxicology, March 2005, SAGE Publications

    Dr Kuzhuvelil B Harikumar

  71. Modulation of Haematopoetic System and Antioxidant Enzymes by Emblica Officinalis Gaertn and its Protective Role Against γ-radiation Induced Damages in Mice

    Article • Journal of Radiation Research, January 2004, Oxford University Press (OUP)

    Dr Kuzhuvelil B Harikumar

  72. Protective Effect of an Extract of Phyllanthus amarus against Radiation-induced Damage in Mice

    Article • Journal of Radiation Research, January 2004, Oxford University Press (OUP)

    Dr Kuzhuvelil B Harikumar