All Stories

  1. Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors

    Article • International Journal of Molecular Sciences, June 2021, MDPI AG

    Koichiro Kawashima

  2. Minireview: Divergent roles of α7 nicotinic acetylcholine receptors expressed on antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation

    Article • International Immunopharmacology, May 2020, Elsevier

    Koichiro Kawashima

  3. α7 nAChRs expressed on antigen presenting cells are insensitive to the conventional antagonists α-bungarotoxin and methyllycaconitine

    Article • International Immunopharmacology, April 2020, Elsevier

    Koichiro Kawashima

  4. A historic perspective on the current progress in elucidation of the biologic significance of non-neuronal acetylcholine

    Article • International Immunopharmacology, April 2020, Elsevier

    Koichiro Kawashima

  5. Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation

    Article • Frontiers in Immunology, May 2019, Frontiers

    Koichiro Kawashima

  6. Expression and Function of the Cholinergic System in Immune Cells

    Article • Frontiers in Immunology, September 2017, Frontiers

    Koichiro Kawashima

  7. Physiological functions of the cholinergic system in immune cells

    Article • Journal of Pharmacological Sciences, May 2017, Elsevier

    Koichiro Kawashima

  8. Acetylcholine released from T cells regulates intracellular Ca 2+ , IL-2 secretion and T cell proliferation through nicotinic acetylcholine receptor

    Article • Life Sciences, March 2017, Elsevier

    Koichiro Kawashima

  9. CRAC channels are required for [Ca2+]i oscillations and c-fos gene expression after muscarinic acetylcholine receptor activation in leukemic T cells

    Article • Life Sciences, September 2016, Elsevier

    Koichiro Kawashima

  10. Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs

    Article • International Immunopharmacology, November 2015, Elsevier

    Koichiro Kawashima

  11. Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1

    Article • International Immunopharmacology, November 2015, Elsevier

    Koichiro Kawashima

  12. Recent progress in revealing the biological and medical significance of the non-neuronal cholinergic system

    Article • International Immunopharmacology, November 2015, Elsevier

    Koichiro Kawashima

  13. IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against Staphylococcus aureus

    Article • PLOS One, October 2015, PLOS

    Koichiro Kawashima

  14. SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity

    Article • Journal of Neuroimmunology, February 2014, Elsevier

    Koichiro Kawashima

  15. Effect of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) on airway epithelial cells

    Article • Biochemical and Biophysical Research Communications, August 2013, Elsevier

    Koichiro Kawashima

  16. Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function

    Article • Life Sciences, November 2012, Elsevier

    Koichiro Kawashima

  17. Regulatory mechanisms of acetylcholine synthesis and release by T cells

    Article • Life Sciences, November 2012, Elsevier

    Koichiro Kawashima

  18. The non-neuronal cholinergic system: Basic science, therapeutic implications and new perspectives

    Article • Life Sciences, November 2012, Elsevier

    Koichiro Kawashima

  19. The missing link between long-term stimulation of nicotinic receptors and the increases of acetylcholine release and vasodilation in the cerebral cortex of aged rats

    Article • The Journal of Physiological Sciences, October 2012, Springer Science + Business Media

    Koichiro Kawashima

  20. Localization of Acetylcholine-Related Molecules in the Retina: Implication of the Communication from Photoreceptor to Retinal Pigment Epithelium

    Article • PLOS One, August 2012, PLOS

    Koichiro Kawashima

  21. Non-neuronal acetylcholine derived from immune cells is involved in regulation of immune function.

    Article • Annals of the New York Academy of Sciences, July 2012, Wiley

    Koichiro Kawashima

  22. Mediatophore regulates acetylcholine release from T cells

    Article • Journal of Neuroimmunology, March 2012, Elsevier

    Koichiro Kawashima

  23. Sustained subcutaneous infusion of nicotine enhances cholinergic vasodilation in the cerebral cortex induced by stimulation of the nucleus basalis of Meynert in rats

    Article • European Journal of Pharmacology, March 2011, Elsevier

    Koichiro Kawashima

  24. Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric α7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions

    Article • Biochemical and Biophysical Research Communications, August 2010, Elsevier

    Koichiro Kawashima

  25. Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase

    Article • Journal of Neuroscience Research, October 2009, Wiley

    Koichiro Kawashima

  26. Expression of SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells

    Article • Journal of Neuroscience Research, September 2009, Wiley

    Koichiro Kawashima

  27. Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand

    Article • Neuroscience Research, August 2009, Elsevier

    Koichiro Kawashima

  28. Long-term nicotine treatment reduces cerebral cortical vasodilation mediated by α4β2-like nicotinic acetylcholine receptors in rats

    Article • European Journal of Pharmacology, May 2009, Elsevier

    Koichiro Kawashima

  29. Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice

    Article • European Journal of Neuroscience, June 2008, Wiley

    Koichiro Kawashima

  30. L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner

    Article • Neuroscience Research, May 2008, Elsevier

    Koichiro Kawashima

  31. Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of an Independent, Non-neuronal Cholinergic System in Lymphocytes and Its Clinical Significance in Immunotherapy

    Article • Journal of Pharmacological Sciences, January 2008, Japanese Pharmacological Society

    Koichiro Kawashima

  32. Basic and Clinical Aspects of Non-neuronal Acetylcholine: Overview of Non-neuronal Cholinergic Systems and Their Biological Significance

    Article • Journal of Pharmacological Sciences, January 2008, Japanese Pharmacological Society

    Koichiro Kawashima

  33. Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor α7 subunit gene knockout mice

    Article • Journal of Neuroimmunology, September 2007, Elsevier

    Koichiro Kawashima

  34. Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice

    Article • Journal of Neuroimmunology, August 2007, Elsevier

    Koichiro Kawashima

  35. Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity

    Article • Life Sciences, May 2007, Elsevier

    Koichiro Kawashima

  36. Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands

    Article • Life Sciences, May 2007, Elsevier

    Koichiro Kawashima

  37. Expression and function of genes encoding cholinergic components in murine immune cells

    Article • Life Sciences, May 2007, Elsevier

    Koichiro Kawashima

  38. Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems

    Article • Life Sciences, May 2007, Elsevier

    Koichiro Kawashima

  39. The Non-neuronal Cholinergic System of Human Skin

    Article • Hormone and Metabolic Research, February 2007, Thieme Publishing Group

    Koichiro Kawashima

  40. The lymphocytic cholinergic system and its biological function

    Article • Life Sciences, March 2003, Elsevier

    Koichiro Kawashima

  41. Acetylcholine increase in amniotic fluid of experimental rats for intrauterine growth retardation

    Article • Life Sciences, March 2003, Elsevier

    Koichiro Kawashima

  42. Introduction: The non-neuronal cholinergic system in humans

    Article • Life Sciences, March 2003, Elsevier

    Koichiro Kawashima

  43. An Independent Non-neuronal Cholinergic System in Lymphocytes.

    Article • The Japanese Journal of Pharmacology, January 2001, Japanese Pharmacological Society

    Koichiro Kawashima

  44. The Non-neuronal Cholinergic System

    Article • The Japanese Journal of Pharmacology, January 2001, Japanese Pharmacological Society

    Koichiro Kawashima

  45. Maintenance of constant blood acetylcholine content before and after feeding in young chimpanzees

    Article • Neuroscience Letters, May 1997, Elsevier

    Koichiro Kawashima

  46. 401 AMPA receptor-mediated acetylcholine release in cultured embryonic rat septal cells

    Article • Neuroscience Research, January 1997, Elsevier

    Koichiro Kawashima

  47. 1010 Induction of choline acetyltransferase mRNA in human T-lymphocytes during the immune responses

    Article • Neuroscience Research, January 1996, Elsevier

    Koichiro Kawashima

  48. 1238 Characterization of cholinergic nerve properties of SN49, a neuronal cell line derived from mouse septum

    Article • Neuroscience Research, January 1996, Elsevier

    Koichiro Kawashima

  49. Species differences in the concentration of acetylcholine, a neurotransmitter, in whole blood and plasma

    Article • Neuroscience Letters, December 1995, Elsevier

    Koichiro Kawashima

  50. Does Tacrine Increase Acetylcholine Release from the Hippocampus?

    Article • January 1995, Springer Science + Business Media

    Koichiro Kawashima

  51. Plasma concentration of acetylcholine in young women

    Article • Neuroscience Letters, October 1987, Elsevier

    Koichiro Kawashima

  52. Chronic effects of arotinolol (S-596) in spontaneously hypertensive rats.

    Article • Journal of Pharmacobio-Dynamics, January 1985, Pharmaceutical Society of Japan

    Koichiro Kawashima

  53. Antihypertensive Effects of Arotinolol (S-596) in Spontaneously Hypertensive Rats

    Article • Japanese Heart Journal, January 1984, International Heart Journal (Japanese Heart Journal)

    Koichiro Kawashima

  54. Diurnal Rhythm of Melatonin in Spontaneously Hypertensive Rats

    Article • Japanese Heart Journal, January 1982, International Heart Journal (Japanese Heart Journal)

    Koichiro Kawashima

  55. Variation of Plasma and Kidney Renin Activities Among Substrains of Spontaneously Hypertensive Rats

    Article • January 1980, Taylor & Francis

    Koichiro Kawashima

  56. Radioimmunoassay for reserpine

    Article • Life Sciences, November 1976, Elsevier

    Koichiro Kawashima

  57. Development of radioimmunoassay for chlorpromazine

    Article • European Journal of Pharmacology, June 1975, Elsevier

    Koichiro Kawashima

  58. EFFECTS OF GASTRIC ANTIBODIES ON GASTRIC SECRETION

    Article • The Japanese Journal of Pharmacology, January 1972, Japanese Pharmacological Society

    Koichiro Kawashima

  59. EFFECTS OF GASTRIC ANTIBODIES ON GASTRIC SECRETION

    Article • The Japanese Journal of Pharmacology, January 1972, Japanese Pharmacological Society

    Koichiro Kawashima

  60. Effects of Crude Platycodin on Gastric Secretion and Experimental Ulcerations in Rats

    Article • Chemical and Pharmaceutical Bulletin, January 1972, Pharmaceutical Society of Japan

    Koichiro Kawashima

  61. THE EFFECT OF PROPRANOLOL ON THE STRESS AND SHAY ULCERATIONS IN RATS

    Article • The Japanese Journal of Pharmacology, January 1969, Japanese Pharmacological Society

    Koichiro Kawashima