All Stories

  1. Subjective and neurocognitive profiling of clinical doses of 3,4-methylenedioxymethamphetamine (MDMA) in healthy volunteers: implications for therapeutic use

    Article • Molecular Psychiatry, April 2026, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  2. Comparative effects of ayahuasca and breathwork on self-reported cognitive flexibility, emotion regulation, positive affect, and sleep quality

    Article • Journal of Psychedelic Studies, September 2025, Akademiai Kiado

    Dr Kim P. C. Kuypers

  3. Between Enhancement and Risk: A Critical Review of Psychedelic Microdosing

    Article • Current Opinion in Psychology, August 2025, Elsevier

    Dr Kim P. C. Kuypers

  4. Use of psychedelic treatments in psychiatric clinical practice: an EPA policy paper

    Article • European Psychiatry, January 2025, Royal College of Psychiatrists

    Dr Kim P. C. Kuypers

  5. Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study

    Article • Neuropsychopharmacology, December 2024, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  6. Inter-individual variability in neural response to low doses of LSD

    Article • Translational Psychiatry, July 2024, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  7. Self-Rated Effectiveness of Ayahuasca and Breathwork on Well-Being, Psychological Resilience, Self-Compassion, and Personality: An Observational Comparison Study

    Article • Psychoactives, March 2024, MDPI AG

    Dr Kim P. C. Kuypers

  8. Effects of psychedelic microdosing versus conventional ADHD medication use on emotion regulation, empathy, and ADHD symptoms in adults with severe ADHD symptoms: A naturalistic prospective comparison study

    Article • European Psychiatry, January 2024, Royal College of Psychiatrists

    Dr Kim P. C. Kuypers

  9. A Preliminary Inventory of Kratom (Mitragyna Speciosa) Products and Vendors on the Darknet and Cryptomarkets

    Article • Journal of Psychoactive Drugs, September 2023, Taylor & Francis

    Dr Kim P. C. Kuypers

  10. Assessment of the Acute Effects of 2C‐B vs. Psilocybin on Subjective Experience, Mood, and Cognition

    Article • Clinical Pharmacology & Therapeutics, June 2023, Wiley

    Dr Kim P. C. Kuypers

  11. Investigation of self-treatment with lysergic acid diethylamide and psilocybin mushrooms: Findings from the Global Drug Survey 2020

    Article • Journal of Psychopharmacology, March 2023, SAGE Publications

    Dr Kim P. C. Kuypers, James Rucker

  12. Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Dr Kim P. C. Kuypers

  13. Psilocybin induces acute and persisting alterations in immune status and the stress response in healthy volunteers

    Article • November 2022, Cold Spring Harbor Laboratory Press

    Dr Kim P. C. Kuypers

  14. Microdosing with psychedelics to self-medicate for ADHD symptoms in adults: A prospective naturalistic study

    Article • Neuroscience Applied, January 2022, Elsevier

    Dr Kim P. C. Kuypers

  15. A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans

    Article • Human Psychopharmacology Clinical and Experimental, July 2021, Wiley

    Dr Kim P. C. Kuypers

  16. Spontaneous and deliberate creative cognition during and after psilocybin exposure

    Article • Translational Psychiatry, April 2021, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  17. Exploring the use of Kratom (Mitragyna speciosa) via the YouTube data tool: A novel netnographic analysis

    Article • Emerging Trends in Drugs Addictions and Health, January 2021, Elsevier

    Dr Kim P. C. Kuypers

  18. A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers

    Article • Journal of Psychopharmacology, August 2020, SAGE Publications

    Dr Kim P. C. Kuypers

  19. Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

    Article • Neuropsychopharmacology, May 2020, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  20. The therapeutic potential of microdosing psychedelics in depression

    Article • Therapeutic Advances in Psychopharmacology, January 2020, SAGE Publications

    Dr Kim P. C. Kuypers

  21. Motives for Classical and Novel Psychoactive Substances Use in Psychedelic Polydrug Users

    Article • Contemporary Drug Problems, September 2019, SAGE Publications

    Dr Kim P. C. Kuypers

  22. Microdosing psychedelics: More questions than answers? An overview and suggestions for future research

    Article • Journal of Psychopharmacology, July 2019, SAGE Publications

    Dr Kim P. C. Kuypers

  23. Psychedelic medicine: The biology underlying the persisting psychedelic effects

    Article • Medical Hypotheses, April 2019, Elsevier

    Dr Kim P. C. Kuypers

  24. Sub-Acute Effects of Psilocybin on Empathy, Creative Thinking, and Subjective Well-Being

    Article • Journal of Psychoactive Drugs, February 2019, Taylor & Francis

    Dr Kim P. C. Kuypers

  25. A First-in-Man Study with 4-Fluoroamphetamine Demonstrates it Produces a Mild Psychedelic State

    Article • Journal of Psychoactive Drugs, January 2019, Taylor & Francis

    Dr Kim P. C. Kuypers

  26. Increased Temporal Discounting in Social Anxiety Disorder Normalizes after Oxytocin Treatment

    Article • Psychotherapy and Psychosomatics, January 2019, Karger Publishers

    Dr Kim P. C. Kuypers, Thomas Kinfe

  27. Independent elevation of peripheral oxytocin concentrations and reduction in cognitive empathy during 4-fluoroamphetamine intoxication

    Article • Human Psychopharmacology Clinical and Experimental, October 2018, Wiley

    Dr Kim P. C. Kuypers

  28. Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution

    Article • Psychopharmacology, August 2018, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  29. Safety Profile and Neurocognitive Function Following Acute 4-Fluoroamphetamine (4-FA) Administration in Humans

    Article • Frontiers in Pharmacology, July 2018, Frontiers

    Dr Kim P. C. Kuypers

  30. A single dose of cocaine enhances prospective memory performance

    Article • Journal of Psychopharmacology, June 2018, SAGE Publications

    Dr Kim P. C. Kuypers

  31. Self-medication with psychedelics for mental or physical problems occurs amongst psychedelic users

    Article • Journal of Psychedelic Studies, June 2018, Akademiai Kiado

    Dr Kim P. C. Kuypers

  32. Intoxicated aggression: Do alcohol and stimulants cause dose-related aggression? A review

    Article • European Neuropsychopharmacology, June 2018, Elsevier

    Dr Kim P. C. Kuypers

  33. Out of the box: A psychedelic model to study the creative mind

    Article • Medical Hypotheses, June 2018, Elsevier

    Dr Kim P. C. Kuypers

  34. Drug liking and wanting, not impulsive action or reflection is increased by 4-fluoroamphetamine

    Article • Psychopharmacology, May 2018, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  35. Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter

    Article • Scientific Reports, January 2018, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  36. Neurocognition and subjective experience following acute doses of the synthetic cannabinoid JWH‐018: a phase 1, placebo‐controlled, pilot study

    Article • British Journal of Pharmacology, November 2017, Wiley

    Dr Kim P. C. Kuypers

  37. Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication

    Article • Psychopharmacology, November 2017, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  38. Emotional Empathic Responses to Dynamic Negative Affective Stimuli Is Gender-Dependent

    Article • Frontiers in Psychology, August 2017, Frontiers

    Dr Kim P. C. Kuypers

  39. Erratum to: MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor

    Article • Psychopharmacology, August 2017, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  40. MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor

    Article • Psychopharmacology, July 2017, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  41. MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor

    Article • Frontiers in Pharmacology, July 2017, Frontiers

    Dr Kim P. C. Kuypers

  42. Multifaceted empathy of healthy volunteers after single doses of MDMA: A pooled sample of placebo-controlled studies

    Article • Journal of Psychopharmacology, April 2017, SAGE Publications

    Dr Kim P. C. Kuypers

  43. A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., “weaving”) while driving at a blood alcohol concentration of 0.5 g/L

    Article • Psychopharmacology, January 2017, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  44. Neurocognitive performance following acute mephedrone administration, with and without alcohol

    Article • Journal of Psychopharmacology, September 2016, SAGE Publications

    Dr Kim P. C. Kuypers

  45. Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking

    Article • Psychopharmacology, July 2016, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  46. Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure

    Article • Psychopharmacology, July 2016, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  47. Cannabis and tolerance: acute drug impairment as a function of cannabis use history

    Article • Scientific Reports, May 2016, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  48. Verbal Memory Impairment in Polydrug Ecstasy Users: A Clinical Perspective

    Article • PLOS One, February 2016, PLOS

    Dr Kim P. C. Kuypers, Benjamin Schultz

  49. Brain reactivity to alcohol and cannabis marketing during sobriety and intoxication

    Article • Addiction Biology, January 2016, Wiley

    Dr Kim P. C. Kuypers

  50. Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes

    Article • Brain Imaging and Behavior, December 2015, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  51. Emotion recognition during cocaine intoxication

    Article • European Neuropsychopharmacology, November 2015, Elsevier

    Dr Kim P. C. Kuypers

  52. MDMA, cannabis, and cocaine produce acute dissociative symptoms

    Article • Psychiatry Research, August 2015, Elsevier

    Dr Kim P. C. Kuypers

  53. Psychedelic symptoms of cannabis and cocaine use as a function of trait impulsivity

    Article • Journal of Psychopharmacology, January 2015, SAGE Publications

    Dr Kim P. C. Kuypers

  54. Changes in serotonin transporter (5-HTT) gene expression in peripheral blood cells after MDMA intake

    Article • Psychopharmacology, December 2014, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  55. Memory and mood during MDMA intoxication, with and without memantine pretreatment

    Article • Neuropharmacology, December 2014, Elsevier

    Dr Kim P. C. Kuypers

  56. Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans

    Article • Psychopharmacology, July 2014, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  57. No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation

    Article • PLOS One, June 2014, PLOS

    Dr Kim P. C. Kuypers

  58. Single doses of THC and cocaine decrease proficiency of impulse control in heavy cannabis users

    Article • British Journal of Pharmacology, November 2013, Wiley

    Dr Kim P. C. Kuypers

  59. Escitalopram Decreases Cross-Regional Functional Connectivity within the Default-Mode Network

    Article • PLOS One, June 2013, PLOS

    Dr Kim P. C. Kuypers

  60. Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit

    Article • Psychopharmacology, April 2013, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  61. Inhibition of MDMA-induced increase in cortisol does not prevent acute impairment of verbal memory

    Article • British Journal of Pharmacology, January 2013, Wiley

    Dr Kim P. C. Kuypers

  62. Psychomotor Function in Chronic Daily Cannabis Smokers during Sustained Abstinence

    Article • PLOS One, January 2013, PLOS

    Dr Kim P. C. Kuypers

  63. A Case-Control Study Estimating Accident Risk for Alcohol, Medicines and Illegal Drugs

    Article • PLOS One, August 2012, PLOS

    Dr Kim P. C. Kuypers

  64. Medicinal Δ9-tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests

    Article • Addiction, July 2012, Wiley

    Dr Kim P. C. Kuypers

  65. Effects of Acute MDMA Intoxication on Mood and Impulsivity: Role of the 5-HT2 and 5-HT1 Receptors

    Article • PLOS One, July 2012, PLOS

    Dr Kim P. C. Kuypers

  66. Effects of stimulant drugs on actual and simulated driving: perspectives from four experimental studies conducted as part of the DRUID research consortium

    Article • Psychopharmacology, June 2012, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  67. A placebo-controlled study to assess Standardized Field Sobriety Tests performance during alcohol and cannabis intoxication in heavy cannabis users and accuracy of point of collection testing devices for detecting THC in oral fluid

    Article • Psychopharmacology, May 2012, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  68. MDMA (ecstasy) effects on actual driving performance before and after sleep deprivation, as function of dose and concentration in blood and oral fluid

    Article • Psychopharmacology, September 2011, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  69. MDMA intoxication and verbal memory performance: a placebo-controlled pharmaco-MRI study

    Article • Journal of Psychopharmacology, May 2011, SAGE Publications

    Dr Kim P. C. Kuypers

  70. Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

    Article • Neuropsychopharmacology, May 2011, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  71. Dose-related effects of MDMA on psychomotor function and mood before, during, and after a night of sleep loss

    Article • Psychopharmacology, January 2010, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  72. Erratum: Involvement of Inferior Parietal Lobules in Prospective Memory Impairment During Acute MDMA (Ecstasy) Intoxication: An Event-Related fMRI Study

    Article • Neuropsychopharmacology, May 2009, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  73. Involvement of Inferior Parietal Lobules in Prospective Memory Impairment during Acute MDMA (Ecstasy) Intoxication: An Event-Related fMRI Study

    Article • Neuropsychopharmacology, December 2008, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  74. Memory and mood during the night and in the morning after repeated evening doses of MDMA

    Article • Journal of Psychopharmacology, February 2008, SAGE Publications

    Dr Kim P. C. Kuypers

  75. Sustained attention and serotonin: a pharmaco-fMRI study

    Article • Human Psychopharmacology Clinical and Experimental, January 2008, Wiley

    Dr Kim P. C. Kuypers

  76. Acute effects of nocturnal doses of MDMA on measures of impulsivity and psychomotor performance throughout the night

    Article • Psychopharmacology, January 2007, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  77. The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers

    Article • Psychopharmacology, November 2006, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  78. Stimulant effects of 3,4-methylenedioxymethamphetamine (MDMA) 75 mg and methylphenidate 20 mg on actual driving during intoxication and withdrawal

    Article • Addiction, November 2006, Wiley

    Dr Kim P. C. Kuypers

  79. Selective verbal and spatial memory impairment after 5-HT1A and 5-HT2A receptor blockade in healthy volunteers pre-treated with an SSRI

    Article • Journal of Psychopharmacology, August 2006, SAGE Publications

    Dr Kim P. C. Kuypers

  80. MDMA and alcohol effects, combined and alone, on objective and subjective measures of actual driving performance and psychomotor function

    Article • Psychopharmacology, July 2006, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  81. Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected

    Article • Psychopharmacology, March 2006, Springer Science + Business Media

    Dr Kim P. C. Kuypers

  82. Transient memory impairment after acute dose of 75mg 3.4-Methylene-dioxymethamphetamine

    Article • Journal of Psychopharmacology, November 2005, SAGE Publications

    Dr Kim P. C. Kuypers

  83. A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance

    Article • Journal of Psychopharmacology, September 2005, SAGE Publications

    Dr Kim P. C. Kuypers

  84. Acute Effects of 3,4-Methylenedioxymethamphetamine (MDMA) on Behavioral Measures of Impulsivity: Alone and in Combination with Alcohol

    Article • Neuropsychopharmacology, September 2005, Springer Science + Business Media

    Dr Kim P. C. Kuypers