All Stories

  1. Diabetic nephropathy: Role of nitric oxide

    Article • Nitric Oxide, December 2025, Elsevier

    Dr Khosrow Kashfi

  2. NOSH-aspirin (NBS-1120) attenuates motor defects and dopaminergic neuron degeneration in a rat model of Parkinson's disease

    Article • European Journal of Pharmacology, September 2025, Elsevier

    Dr Khosrow Kashfi

  3. Reprogramming inflammation: Mechanisms and therapeutic targeting of eicosanoids and pro-resolving mediators

    Article • European Journal of Pharmacology, September 2025, Elsevier

    Dr Khosrow Kashfi

  4. Research Hypothesis: A Brief History, Central Role in Scientific Inquiry, and Characteristics

    Article • Addiction and Health, August 2025, MaadRayan Publishing Company

    Dr Khosrow Kashfi

  5. Hormetic association between sodium nitrate and liver enzymes: a study in female and male rats

    Article • Toxicology Research, July 2025, Oxford University Press (OUP)

    Dr Khosrow Kashfi

  6. Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms

    Article • Pharmacological Research, June 2025, Elsevier

    Dr Khosrow Kashfi

  7. Current Approaches and Innovations in Managing Preeclampsia: Highlighting Maternal Health Disparities

    Article • Journal of Clinical Medicine, February 2025, MDPI AG

    Dr Khosrow Kashfi

  8. NOSH-aspirin (NBS-1120) inhibits estrogen receptor–negative breast cancer in vitro and in vivo by modulating redox-sensitive signaling pathways

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2025, Elsevier

    Dr Khosrow Kashfi

  9. Advances in Preeclampsia Management: Addressing Racial Disparities and Improving Outcomes

    Article • December 2024, MDPI AG

    Dr Khosrow Kashfi

  10. NO- and H2S- releasing nanomaterials: A crosstalk signaling pathway in cancer

    Article • Nitric Oxide, October 2024, Elsevier

    Dr Khosrow Kashfi

  11. Nitric oxide-based treatments improve wound healing associated with diabetes mellitus

    Article • Medical Gas Research, July 2024, Wolters Kluwer Health

    Dr Khosrow Kashfi

  12. Effect of long-term inorganic nitrate administration on myocardial ischemia-reperfusion injury in ovariectomized rats

    Article • Frontiers in Pharmacology, March 2024, Frontiers

    Dr Khosrow Kashfi

  13. Anti-obesity and anti-diabetic effects of L-citrulline are sex-dependent

    Article • Life Sciences, February 2024, Elsevier

    Dr Khosrow Kashfi

  14. Dissolving sodium hydrosulfide in drinking water is not a good source of hydrogen sulfide for animal studies

    Article • Scientific Reports, December 2023, Springer Science + Business Media

    Dr Khosrow Kashfi

  15. Type 1 Diabetes and COVID-19: A Literature Review and Possible Management

    Article • International Journal of Endocrinology and Metabolism, October 2023, Kowsar Medical Institute

    Dr Khosrow Kashfi

  16. The Triple Crown: NO, CO, and H2S in cancer cell biology

    Article • Pharmacology & Therapeutics, September 2023, Elsevier

    Dr Khosrow Kashfi

  17. Long-term inorganic nitrate administration protects against myocardial ischemia-reperfusion injury in female rats

    Article • BMC Cardiovascular Disorders, August 2023, Springer Science + Business Media

    Dr Khosrow Kashfi

  18. Vascular nitric oxide resistance in type 2 diabetes

    Article • Cell Death and Disease, July 2023, Springer Science + Business Media

    Dr Khosrow Kashfi

  19. Type1 Diabetes and COVID-19: A Systematic Review and Possible Management

    Article • June 2023, MDPI AG

    Dr Khosrow Kashfi

  20. Protective effects of long-term nitrate administration against ovariectomy-induced kidney dysfunction in rats

    Article • Pharmacological Reports, June 2023, Springer Science + Business Media

    Dr Khosrow Kashfi

  21. The evolving landscape of PCSK9 inhibition in cancer

    Article • European Journal of Pharmacology, June 2023, Elsevier

    Dr Khosrow Kashfi

  22. Heat shock proteins and cancer: The FoxM1 connection

    Article • Biochemical Pharmacology, May 2023, Elsevier

    Dr Khosrow Kashfi

  23. Altered sialin mRNA gene expression in type 2 diabetic male Wistar rats: implications for nitric oxide deficiency

    Article • Scientific Reports, March 2023, Springer Science + Business Media

    Dr Khosrow Kashfi

  24. Why Don’t the Mutant Cells That Evade DNA Repair Cause Cancer More Frequently? Importance of the Innate Immune System in the Tumor Microenvironment

    Article • International Journal of Molecular Sciences, March 2023, MDPI AG

    Dr Khosrow Kashfi

  25. Prediction of dual NF-κB/IκB inhibitors using an integrative in-silico approaches

    Article • Journal of Biomolecular Structure and Dynamics, February 2023, Taylor & Francis

    Dr Khosrow Kashfi

  26. Metabolic effects of L‐citrulline in type 2 diabetes

    Article • Acta Physiologica, January 2023, Wiley

    Dr Khosrow Kashfi

  27. Khosrow Kashfi Bio

    Article • Critical Reviews™ in Oncogenesis, January 2023, Begell House

    Dr Khosrow Kashfi

  28. Preface

    Article • Critical Reviews™ in Oncogenesis, January 2023, Begell House

    Dr Khosrow Kashfi

  29. Dedication to Dr. Larry K. Keefer at the Sixth International Workshop on Nitric Oxide in Cancer and Beyond

    Article • Critical Reviews™ in Oncogenesis, January 2023, Begell House

    Dr Khosrow Kashfi

  30. Fifty Years of Diazeniumdiolate Research: A Tribute to Dr. Larry K. Keefer

    Article • Critical Reviews™ in Oncogenesis, January 2023, Begell House

    Dr Khosrow Kashfi

  31. Scientific Publishing in Biomedicine: A Brief History of Scientific Journals

    Article • International Journal of Endocrinology and Metabolism, December 2022, Kowsar Medical Institute

    Dr Khosrow Kashfi

  32. Preface

    Article • November 2022, Bentham Science Publishers

    Dr Khosrow Kashfi

  33. The Renin–Angiotensin-Aldosterone System, Nitric Oxide, and Hydrogen Sulfide at the Crossroads of Hypertension and COVID-19: Racial Disparities and Outcomes

    Article • International Journal of Molecular Sciences, November 2022, MDPI AG

    Dr Khosrow Kashfi

  34. Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise

    Article • Nitric Oxide, November 2022, Elsevier

    Dr Khosrow Kashfi

  35. Identification of new small molecules as dual FoxM1 and Hsp70 inhibitors using computational methods

    Article • Research in Pharmaceutical Sciences, November 2022, Medknow

    Dr Khosrow Kashfi

  36. Carbon monoxide in cell signaling and potential therapeutics

    Article • Biochemical Pharmacology, October 2022, Elsevier

    Dr Khosrow Kashfi

  37. Carbon monoxide and its role in human physiology: A brief historical perspective

    Article • Biochemical Pharmacology, October 2022, Elsevier

    Dr Khosrow Kashfi

  38. Chronic nitrate administration increases the expression the genes involved in the browning of white adipose tissue in female rats

    Article • Cell Biochemistry and Function, September 2022, Wiley

    Dr Khosrow Kashfi

  39. Behavioral and Molecular Effects of Thapsigargin-Induced Brain ER- Stress: Encompassing Inflammation, MAPK, and Insulin Signaling Pathway

    Article • Life, September 2022, MDPI AG

    Dr Khosrow Kashfi

  40. Scientific Publishing in Biomedicine: Information Literacy

    Article • International Journal of Endocrinology and Metabolism, August 2022, Kowsar Medical Institute

    Dr Khosrow Kashfi

  41. Carbon monoxide and β-cell function: Implications for type 2 diabetes mellitus

    Article • Biochemical Pharmacology, July 2022, Elsevier

    Dr Khosrow Kashfi

  42. Hydrogen sulfide potentiates the protective effects of nitrite against myocardial ischemia-reperfusion injury in type 2 diabetic rats

    Article • Nitric Oxide, July 2022, Elsevier

    Dr Khosrow Kashfi

  43. Molecular targets of statins and their potential side effects: Not all the glitter is gold

    Article • European Journal of Pharmacology, May 2022, Elsevier

    Dr Khosrow Kashfi

  44. Association between serum hydrogen sulfide concentrations and dysglycemia: a population-based study

    Article • BMC Endocrine Disorders, March 2022, Springer Science + Business Media

    Dr Khosrow Kashfi

  45. Design and Characterization of a Recombinant Brucella abortus RB51 Vaccine That Elicits Enhanced T Cell-Mediated Immune Response

    Article • Vaccines, March 2022, MDPI AG

    Dr Khosrow Kashfi

  46. Role of nitric oxide in type 1 diabetes-induced osteoporosis

    Article • Biochemical Pharmacology, March 2022, Elsevier

    Dr Khosrow Kashfi

  47. Lipoproteins and cancer: The role of HDL-C, LDL-C, and cholesterol-lowering drugs

    Article • Biochemical Pharmacology, February 2022, Elsevier

    Dr Khosrow Kashfi

  48. Long Term Sodium Nitrate Administration Positively Impacts Metabolic and Obesity Indices in Ovariectomized Rats

    Article • Archives of Medical Research, February 2022, Elsevier

    Dr Khosrow Kashfi

  49. NSAIDs and Cancer Resolution: New Paradigms beyond Cyclooxygenase

    Article • International Journal of Molecular Sciences, January 2022, MDPI AG

    Dr Khosrow Kashfi

  50. Scientific Publishing in Biomedicine: Revising a Peer-reviewed Manuscript

    Article • International Journal of Endocrinology and Metabolism, January 2022, Kowsar Medical Institute

    Dr Khosrow Kashfi

  51. Effect of Nitrate on Gene and Protein Expression of Nitric Oxide Synthase Enzymes in Insulin-Sensitive Tissues of Type 2 Diabetic Male Rats

    Article • Endocrine Metabolic & Immune Disorders - Drug Targets, December 2021, Bentham Science Publishers

    Dr Khosrow Kashfi

  52. Macrophage Reprogramming and Cancer Therapeutics: Role of iNOS-Derived NO

    Article • Cells, November 2021, MDPI AG

    Dr Khosrow Kashfi

  53. Resolution of inflammation: An organizing principle in biology and medicine

    Article • Pharmacology & Therapeutics, November 2021, Elsevier

    Dr Khosrow Kashfi

  54. Sodium hydrosulfide has no additive effects on nitrite-inhibited renal gluconeogenesis in type 2 diabetic rats

    Article • Life Sciences, October 2021, Elsevier

    Dr Khosrow Kashfi

  55. A New Perspective on Cancer Therapy: Changing the Treaded Path?

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Dr Khosrow Kashfi

  56. Hyperuricemia-induced endothelial insulin resistance: the nitric oxide connection

    Article • Pflügers Archiv - European Journal of Physiology, July 2021, Springer Science + Business Media

    Dr Khosrow Kashfi

  57. Scientific Publishing in Biomedicine: How to Write a Cover Letter?

    Article • International Journal of Endocrinology and Metabolism, July 2021, Kowsar Medical Institute

    Dr Khosrow Kashfi

  58. Lost-in-Translation of Metabolic Effects of Inorganic Nitrate in Type 2 Diabetes: Is Ascorbic Acid the Answer?

    Article • International Journal of Molecular Sciences, April 2021, MDPI AG

    Dr Khosrow Kashfi

  59. Acidified Nitrite Accelerates Wound Healing in Type 2 Diabetic Male Rats: A Histological and Stereological Evaluation

    Article • Molecules, March 2021, MDPI AG

    Dr Khosrow Kashfi

  60. Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

    Article • Redox Biology, January 2021, Elsevier

    Dr Khosrow Kashfi

  61. Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts

    Article • Chemical Communications, January 2021, Royal Society of Chemistry

    Dr Khosrow Kashfi

  62. Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway

    Article • Life Sciences, January 2021, Elsevier

    Dr Khosrow Kashfi

  63. SP1-independent inhibition of FOXM1 by modified thiazolidinediones

    Article • European Journal of Medicinal Chemistry, January 2021, Elsevier

    Dr Khosrow Kashfi

  64. Scientific Publishing in Biomedicine: How to Choose a Journal?

    Article • International Journal of Endocrinology and Metabolism, November 2020, Kowsar Medical Institute

    Dr Khosrow Kashfi

  65. Endogenous flux of nitric oxide: Citrulline is preferred to Arginine

    Article • Acta Physiologica, November 2020, Wiley

    Dr Khosrow Kashfi

  66. Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation

    Article • Nitric Oxide, October 2020, Elsevier

    Dr Khosrow Kashfi

  67. Importance of Systematic Reviews and Meta-analyses of Animal Studies: Challenges for Animal-to-Human Translation

    Article • Journal of the American Association for Laboratory Animal Science, September 2020, American Association for Laboratory Animal Science

    Dr Khosrow Kashfi

  68. Protective effect of intermediate doses of hydrogen sulfide against myocardial ischemia-reperfusion injury in obese type 2 diabetic rats

    Article • Life Sciences, September 2020, Elsevier

    Dr Khosrow Kashfi

  69. Roles and Interaction of the MAPK Signaling Cascade in Aβ25–35-Induced Neurotoxicity Using an Isolated Primary Hippocampal Cell Culture System

    Article • Cellular and Molecular Neurobiology, June 2020, Springer Science + Business Media

    Dr Khosrow Kashfi

  70. Impaired cardiovascular function in male rats with hypo- and hyperthyroidism: Involvement of imbalanced nitric oxide synthase levels

    Article • Endocrine Metabolic & Immune Disorders - Drug Targets, May 2020, Bentham Science Publishers

    Dr Khosrow Kashfi, Dr Asghar Ghasemi

  71. The Principles of Biomedical Scientific Writing: Citation

    Article • International Journal of Endocrinology and Metabolism, April 2020, Kowsar Medical Institute

    Dr Khosrow Kashfi

  72. Nitric oxide in cancer and beyond

    Article • Biochemical Pharmacology, April 2020, Elsevier

    Dr Khosrow Kashfi

  73. Chemical stimulation of the lateral hypothalamus induces antiallodynic and anti-thermal hyperalgesic effects in animal model of neuropathic pain: Involvement of orexin receptors in the spinal cord

    Article • Brain Research, April 2020, Elsevier

    Dr Khosrow Kashfi

  74. The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications

    Article • Biochemical Pharmacology, March 2020, Elsevier

    Dr Khosrow Kashfi

  75. Tumor associated macrophages and ‘NO’

    Article • Biochemical Pharmacology, March 2020, Elsevier

    Dr Khosrow Kashfi

  76. Dose-Dependent Effects of Long-Term Administration of Hydrogen Sulfide on Myocardial Ischemia–Reperfusion Injury in Male Wistar Rats: Modulation of RKIP, NF-κB, and Oxidative Stress

    Article • International Journal of Molecular Sciences, February 2020, MDPI AG

    Dr Khosrow Kashfi

  77. NOSH-aspirin (NBS-1120) inhibits pancreatic cancer cell growth in a xenograft mouse model: Modulation of FoxM1, p53, NF-κB, iNOS, caspase-3 and ROS

    Article • Biochemical Pharmacology, February 2020, Elsevier

    Dr Khosrow Kashfi

  78. The Principles of Biomedical Scientific Writing: Abstract and Keywords

    Article • International Journal of Endocrinology and Metabolism, January 2020, Kowsar Medical Institute

    Dr Khosrow Kashfi

  79. Exploring the Potential of Nitric Oxide and Hydrogen Sulfide (NOSH)-Releasing Synthetic Compounds as Novel Priming Agents against Drought Stress in Medicago sativa Plants

    Article • Biomolecules, January 2020, MDPI AG

    Dr Khosrow Kashfi

  80. Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes

    Article • Biochemical Pharmacology, January 2020, Elsevier

    Dr Khosrow Kashfi

  81. Hydrogen sulfide potentiates the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats

    Article • Nitric Oxide, November 2019, Elsevier

    Dr Khosrow Kashfi

  82. The Principles of Biomedical Scientific Writing: Title

    Article • International Journal of Endocrinology and Metabolism, October 2019, Kowsar Medical Institute

    Dr Khosrow Kashfi

  83. Data Extraction from Graphs Using Adobe Photoshop: Applications for Meta-Analyses

    Article • International Journal of Endocrinology and Metabolism, October 2019, Kowsar Medical Institute

    Dr Khosrow Kashfi

  84. Altered gene expression of hydrogen sulfide‐producing enzymes in the liver and muscles tissues of hyperthyroid rats

    Article • Journal of Cellular Physiology, March 2019, Wiley

    Dr Khosrow Kashfi

  85. Effects of Hydrogen Sulfide on Carbohydrate Metabolism in Obese Type 2 Diabetic Rats

    Article • Molecules, January 2019, MDPI AG

    Dr Khosrow Kashfi

  86. Obesity, Type-2 Diabetes and Cancer: Mechanistic Insights

    Article • Critical Reviews™ in Oncogenesis, January 2019, Begell House

    Dr Khosrow Kashfi

  87. Type 2 Diabetes and Cancer: The Nitric Oxide Connection

    Article • Critical Reviews™ in Oncogenesis, January 2019, Begell House

    Dr Khosrow Kashfi

  88. Development of new generation of vaccines for Brucella abortus

    Article • Heliyon, December 2018, Elsevier

    Dr Khosrow Kashfi

  89. Effects of long-term oral nitrate administration on adiposity in normal adult female rats

    Article • Life Sciences, October 2018, Elsevier

    Dr Khosrow Kashfi

  90. The role of hydrogen sulfide in health and disease

    Article • Biochemical Pharmacology, March 2018, Elsevier

    Dr Khosrow Kashfi

  91. The dichotomous role of H2S in cancer cell biology? Déjà vu all over again

    Article • Biochemical Pharmacology, March 2018, Elsevier

    Dr Khosrow Kashfi

  92. Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension

    Article • Biochemical Pharmacology, March 2018, Elsevier

    Dr Khosrow Kashfi

  93. A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin

    Article • Biomedicine & Pharmacotherapy, November 2017, Elsevier

    Dr Khosrow Kashfi

  94. NO-H 2 S-Releasing Chimeras as a Multifaceted Approach to Cancer Therapy

    Article • January 2017, Elsevier

    Dr Khosrow Kashfi

  95. Nitric Oxide Donors and Therapeutic Applications in Cancer

    Article • January 2017, Elsevier

    Dr Khosrow Kashfi

  96. Gastrointestinal safety, chemotherapeutic potential, and classic pharmacological profile of NOSH ‐naproxen ( AVT ‐219) a dual NO‐ and H 2 S‐releasing hybrid

    Article • Pharmacology Research & Perspectives, March 2016, Wiley

    Dr Khosrow Kashfi

  97. The dual role of iNOS in cancer

    Article • Redox Biology, December 2015, Elsevier

    Dr Khosrow Kashfi

  98. NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid has enhanced chemo-preventive properties compared to aspirin, is gastrointestinal safe with all the classic therapeutic indications

    Article • Biochemical Pharmacology, December 2015, Elsevier

    Dr Khosrow Kashfi

  99. Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling

    Article • Redox Biology, December 2015, Elsevier

    Dr Khosrow Kashfi

  100. NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties

    Article • Redox Biology, December 2015, Elsevier

    Dr Khosrow Kashfi

  101. Synthesis and anti-cancer potential of the positional isomers of NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybrid

    Article • Bioorganic & Medicinal Chemistry Letters, October 2015, Elsevier

    Dr Khosrow Kashfi

  102. HS-Naproxen

    Article • Drug Design Development and Therapy, August 2015, Dove Medical Press

    Dr Khosrow Kashfi, Dr Ravinder Kodela

  103. Utility Of Nitric Oxide And Hydrogen Sulfide-Releasing Chimeras As Anticancer Agents

    Article • Redox Biology, August 2015, Elsevier

    Dr Khosrow Kashfi

  104. NOSH-Aspirin Inhibits Colon Cancer Cell Growth: Effects Of Positional Isomerism

    Article • Redox Biology, August 2015, Elsevier

    Dr Khosrow Kashfi

  105. Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast Cancer Cells in Vitro and in Vivo

    Article • Molecules, July 2015, MDPI AG

    Dr Khosrow Kashfi

  106. NOSH-aspirin (NBS-1120), a dual nitric oxide and hydrogen sulfide-releasing hybrid, reduces inflammatory pain

    Article • Pharmacology Research & Perspectives, May 2015, Wiley

    Dr Khosrow Kashfi

  107. P77

    Article • Nitric Oxide, May 2014, Elsevier

    Dr Khosrow Kashfi

  108. 287 Targeting NF-κB, FoxM1, and p53 in Pancreatic Cancer With NOSH-Aspirin

    Article • Gastroenterology, May 2014, Elsevier

    Dr Khosrow Kashfi

  109. Anti-Cancer Activity of New Designer Hydrogen Sulfide-Donating Hybrids

    Article • Antioxidants & Redox Signaling, February 2014, Mary Ann Liebert Inc

    Dr Khosrow Kashfi

  110. Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expression

    Article • Leukemia Research, October 2013, Elsevier

    Dr Khosrow Kashfi

  111. P09 Therapeutic potential of NOSH-aspirin, a dual nitric oxide- and hydrogen sulfide-donating hybrid in colon cancer

    Article • Nitric Oxide, September 2013, Elsevier

    Dr Khosrow Kashfi

  112. NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders

    Article • Glia, August 2013, Wiley

    Dr Khosrow Kashfi

  113. Flurbiprofen benzyl nitrate (NBS-242) inhibits the growth of A-431 human epidermoid carcinoma cells and targets ß-catenin

    Article • Drug Design Development and Therapy, May 2013, Taylor & Francis

    Dr Khosrow Kashfi

  114. Abstract 4793: NOSH-aspirin inhibits breast cancer cell growth: an effect modulated through reactive oxygen species and independent of the ER status.

    Article • April 2013, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  115. Dysfunctional cell signaling dynamics in oncology: Diagnostic, prognostic and treatment opportunities

    Article • Biochemical Pharmacology, March 2013, Elsevier

    Dr Khosrow Kashfi

  116. Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

    Article • Biochemical Pharmacology, March 2013, Elsevier

    Dr Khosrow Kashfi

  117. Positional Isomers of Aspirin Are Equally Potent in Inhibiting Colon Cancer Cell Growth: Differences in Mode of Cyclooxygenase Inhibition

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Khosrow Kashfi

  118. Synthesis and biological activity of NOSH-naproxen (AVT-219) and NOSH-sulindac (AVT-18A) as potent anti-inflammatory agents with chemotherapeutic potential

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Dr Khosrow Kashfi

  119. Abstract B34: NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybrid for treatment of cancer

    Article • Cancer Prevention Research, November 2012, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  120. Abstract 3898: NOSH-aspirin: A novel nitric oxide- and hydrogen sulfide-releasing hybrid for treatment of colon cancer

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  121. Abstract 3899: NOSH compounds: Nitric oxide- and hydrogen sulfide-releasing hybrids, a new class of anti-inflammatory pharmaceuticals

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  122. Abstract 3891: NOSH-aspirin, a novel nitric oxide- and hydrogen sulfide-releasing hybrid, is a potent inhibitor of colon cancer cell growth

    Article • April 2012, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  123. NOSH-Aspirin: A Novel Nitric Oxide–Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals

    Article • ACS Medicinal Chemistry Letters, March 2012, American Chemical Society (ACS)

    Dr Khosrow Kashfi

  124. Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo

    Article • Biochemical Pharmacology, March 2012, Elsevier

    Dr Khosrow Kashfi

  125. NOSH–aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model

    Article • Biochemical and Biophysical Research Communications, March 2012, Elsevier

    Dr Khosrow Kashfi

  126. Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo

    Article • Biochemical Pharmacology, March 2012, Elsevier

    Dr Khosrow Kashfi

  127. Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect

    Article • Biochemical Pharmacology, March 2012, Elsevier

    Dr Khosrow Kashfi

  128. Nitric Oxide Release Is Not Required to Decrease the Ulcerogenic Profile of Nonsteroidal Anti-inflammatory Drugs

    Article • Journal of Medicinal Chemistry, January 2012, American Chemical Society (ACS)

    Dr Khosrow Kashfi

  129. Cell Signaling & Molecular Targets in Cancer

    Article • January 2012, Springer Science + Business Media

    Dr Khosrow Kashfi

  130. Nitric Oxide−Releasing Hybrid Drugs Target Cellular Processes Through S-Nitrosylation

    Article • Forum on Immunopathological Diseases and Therapeutics, January 2012, Begell House

    Dr Khosrow Kashfi

  131. Synthesis and biological activity of acetyl-protected hydroxybenzyl diethyl phosphates (EHBP) as potential chemotherapeutic agents

    Article • Bioorganic & Medicinal Chemistry Letters, December 2011, Elsevier

    Dr Khosrow Kashfi

  132. Membrane microenvironment regulation of carnitine palmitoyltranferases I and II

    Article • Biochemical Society Transactions, May 2011, Portland Press Ltd.

    Dr Khosrow Kashfi

  133. Abstract 807: Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  134. NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation

    Article • Cancer Letters, December 2010, Elsevier

    Dr Khosrow Kashfi

  135. JS-K; a nitric oxide-releasing prodrug, modulates β-catenin/TCF signaling in leukemic Jurkat cells: Evidence of an S-nitrosylated mechanism

    Article • Biochemical Pharmacology, December 2010, Elsevier

    Dr Khosrow Kashfi

  136. Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, Analgesic, Antipyretic, Antioxidant Prodrugs

    Article • Journal of Pharmacology and Experimental Therapeutics, August 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Khosrow Kashfi

  137. Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells

    Article • Biochemical Pharmacology, June 2010, Elsevier

    Dr Khosrow Kashfi

  138. Abstract 1487: Nitric oxide-releasing NSAIDs suppress NF-κB signaling and increase caspase-3 enzyme activityin vitroandin vivothrough S-nitrosylation

    Article • April 2010, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  139. Abstract A42: Comparison between NO-ASA and NONO-ASA as safe anti-inflammatory, analgesic, antipyretic, antioxidant chemopreventive prodrugs

    Article • Cancer Prevention Research, January 2010, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  140. Abstract B86: JS‐K, a nitric oxide‐donating prodrug, modulates β‐catenin/TCF signaling in leukemic Jurkat cells through S‐nitrosylation

    Article • January 2010, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  141. Nitro-aspirin inhibits MCF-7 breast cancer cell growth: Effects on COX-2 expression and Wnt/β-catenin/TCF-4 signaling

    Article • Biochemical Pharmacology, November 2009, Elsevier

    Dr Khosrow Kashfi

  142. Anti-Inflammatory Agents as Cancer Therapeutics

    Article • January 2009, Elsevier

    Dr Khosrow Kashfi

  143. Abstract B109: Bioactivated chemotherapeutic agents based on ester-protected hydroxybenzyl phosphates (EHBP) for reversible alkylation of cellular nucleophiles

    Article • Cancer Prevention Research, November 2008, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  144. Abstract A23: Expression profile of genes altered by ester-protected hydroxybenzyl phosphates (EHBP) in T-leukemia cells

    Article • Cancer Prevention Research, November 2008, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  145. Abstract A64: Ester-protected hydroxybenzyl phosphates (EHBP) inhibit the growth of various cultured human cancer cells: Evidence of a tissue type-independent effect

    Article • November 2008, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  146. Abstract A35: JS-K, a nitric oxide-donating prodrug, inhibits the growth of leukemic jurkat cells and modulates β-catenin/TCF signaling

    Article • November 2008, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  147. The mechanism of action of nitric oxide-donating aspirin

    Article • Biochemical and Biophysical Research Communications, July 2007, Elsevier

    Dr Khosrow Kashfi

  148. Nitric Oxide–Donating Aspirin Prevents Pancreatic Cancer in a Hamster Tumor Model

    Article • Cancer Research, April 2006, American Association for Cancer Research (AACR)

    Dr Khosrow Kashfi

  149. NO-donating aspirin induces phase II enzymes in vitro and in vivo

    Article • Carcinogenesis, November 2005, Oxford University Press (OUP)

    Dr Khosrow Kashfi

  150. Non-COX-2 targets and cancer: Expanding the molecular target repertoire of chemoprevention

    Article • Biochemical Pharmacology, October 2005, Elsevier

    Dr Khosrow Kashfi

  151. NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells

    Article • Biochemical Pharmacology, October 2005, Elsevier

    Dr Khosrow Kashfi

  152. Comparison of (+)- and (-)-Hemipalmitoylcarnitinium as Inhibitors of Hepatic Mitochondrial Carnitine Palmitoyltransferases in Diabetic Rats

    Article • Medicinal Chemistry, September 2005, Bentham Science Publishers

    Dr Khosrow Kashfi

  153. Is COX-2 a ‘collateral’ target in cancer prevention?

    Article • Biochemical Society Transactions, August 2005, Portland Press Ltd.

    Dr Khosrow Kashfi

  154. Molecular targets of nitric-oxide-donating aspirin in cancer

    Article • Biochemical Society Transactions, August 2005, Portland Press Ltd.

    Dr Khosrow Kashfi

  155. Cancer Prevention: A New Era beyond Cyclooxygenase-2

    Article • Journal of Pharmacology and Experimental Therapeutics, April 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Khosrow Kashfi

  156. NO-donating aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expression

    Article • Biochemical and Biophysical Research Communications, December 2004, Elsevier

    Dr Khosrow Kashfi

  157. Positional Isomerism Markedly Affects the Growth Inhibition of Colon Cancer Cells by Nitric Oxide-Donating Aspirin in Vitro and in Vivo

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Khosrow Kashfi

  158. In Vitro Metabolism of Nitric Oxide-Donating Aspirin: The Effect of Positional Isomerism

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Khosrow Kashfi

  159. Nitric-oxide-donating NSAIDs as agents for cancer prevention

    Article • Trends in Molecular Medicine, July 2004, Elsevier

    Dr Khosrow Kashfi

  160. NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property?

    Article • Biochemical Pharmacology, June 2004, Elsevier

    Dr Khosrow Kashfi

  161. NO-donating aspirin inhibits intestinal carcinogenesis in Min (APCMin/+) mice

    Article • Biochemical and Biophysical Research Communications, January 2004, Elsevier

    Dr Khosrow Kashfi

  162. Nitric oxide-donating aspirin inhibits β-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear β-catenin–TCF association

    Article • Proceedings of the National Academy of Sciences, October 2003, Proceedings of the National Academy of Sciences

    Dr Khosrow Kashfi

  163. No-donating NSAIDs are more potent than traditional NSAIDs in inhibiting the growth of cultured human colon cancer cells

    Article • Gastroenterology, April 2003, Elsevier

    Dr Khosrow Kashfi

  164. Nitric Oxide-Donating Nonsteroidal Anti-Inflammatory Drugs Inhibit the Growth of Various Cultured Human Cancer Cells: Evidence of a Tissue Type-Independent Effect

    Article • Journal of Pharmacology and Experimental Therapeutics, December 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Khosrow Kashfi

  165. Lipid Metabolism and Membrane Composition Are Altered in the Brains of Type II Diabetic Mice

    Article • Journal of Neurochemistry, November 2002, Wiley

    Dr Khosrow Kashfi

  166. Inhibition of Bacterial Superantigens by Peptides and Antibodies

    Article • Infection and Immunity, October 2002, ASM Journals

    Dr Khosrow Kashfi

  167. Colon cancer prevention with NO-releasing NSAIDs

    Article • Prostaglandins & Other Lipid Mediators, February 2002, Elsevier

    Dr Khosrow Kashfi

  168. The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines

    Article • Cancer Letters, March 2001, Elsevier

    Dr Khosrow Kashfi

  169. Inhibition of Bacterial Superantigens by Peptides and Antibodies

    Article • Infection and Immunity, February 2001, ASM Journals

    Dr Khosrow Kashfi

  170. Fenretinide inhibits phorbol ester-induced cyclooxygenase-2 expression in human colon adenocarcinoma cells

    Article • Biochemical Society Transactions, August 1997, Portland Press Ltd.

    Dr Khosrow Kashfi

  171. The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, May 1996, Elsevier

    Dr Khosrow Kashfi

  172. Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human*

    Article • Clinical Pharmacology & Therapeutics, December 1995, Springer Science + Business Media

    Dr Khosrow Kashfi

  173. Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I

    Article • Biochemical Journal, September 1995, Portland Press Ltd.

    Dr Khosrow Kashfi

  174. Omeprazole Coinduces Multiple Xenobiotic-metabolizing Enzymes in the Rata

    Article • Annals of the New York Academy of Sciences, September 1995, Wiley

    Dr Khosrow Kashfi

  175. Phenolic Antioxidants Induce UDP-glucuronosyltransferase in Rat Livera

    Article • Annals of the New York Academy of Sciences, September 1995, Wiley

    Dr Khosrow Kashfi

  176. Temperature effects on malonyl-CoA inhibition of carnitine palmitoyltransferase I

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, July 1995, Elsevier

    Dr Khosrow Kashfi

  177. Diabetes and proteolysis: Effects on carnitine palmitoyltransferase-I and malonyl-CoA binding

    Article • Lipids, May 1995, Wiley

    Dr Khosrow Kashfi

  178. Differential induction of glutathione S-transferase in rat aorta versus liver

    Article • Biochemical Pharmacology, May 1994, Elsevier

    Dr Khosrow Kashfi

  179. Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, May 1994, Elsevier

    Dr Khosrow Kashfi

  180. Yonetani-Theorell analysis of hepatic carnitine palmitoyltransferase-I inhibition indicates two distinct inhibitory binding sites.

    Article • Journal of Biological Chemistry, March 1994, Elsevier

    Dr Khosrow Kashfi

  181. Inhibition of carnitine palmitoyltransferase of the hepatic mitochondrial outer membrane (CPT-I) by 2-bromopalmitoyl-CoA

    Article • Biochemical Society Transactions, November 1993, Portland Press Ltd.

    Dr Khosrow Kashfi

  182. Proteinase treatment of intact hepatic mitochondria has differential effects on inhibition of carnitine palmitoyltransferase by different inhibitors

    Article • Biochemical Journal, March 1992, Portland Press Ltd.

    Dr Khosrow Kashfi

  183. Malonyl-CoA inhibits proteolysis of carnitine palmitoyltransferase

    Article • Biochemical and Biophysical Research Communications, July 1991, Elsevier

    Dr Khosrow Kashfi

  184. Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA

    Article • Biochemical and Biophysical Research Communications, June 1991, Elsevier

    Dr Khosrow Kashfi

  185. Inhibition of mitochondrial carnitine palmitoyltransferases by adriamycin and adriamycin analogues

    Article • Biochemical Pharmacology, October 1990, Elsevier

    Dr Khosrow Kashfi

  186. Topology of Hepatic Mitochondrial Carnitine Palmitoyltransferase I

    Article • Springer Science + Business Media

    Dr Khosrow Kashfi