All Stories

  1. Novel liquid-liquid extraction and self-emulsion methods for simplified isolation of extra-virgin olive oil phenolics with emphasis on (-)-oleocanthal and its oral anti-breast cancer activity

    Article • PLoS ONE, April 2019, PLOS

    Hassan Y. Ebrahim, PhD, Khalid El Sayed

  2. Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review

    Article • Oxidative Medicine and Cellular Longevity, July 2018, Hindawi Publishing Corporation

    MD ANWAR, Khalid El Sayed, Dr Abiola S Babatunde, JEANCHRISTOPHER CHAMCHEU

  3. Discovery and preliminary structure-activity relationship of the marine natural product manzamines as herpes simplex virus type-1 inhibitors

    Article • Zeitschrift für Naturforschung C, July 2016, De Gruyter

    Khalid El Sayed

  4. ChemInform Abstract: Indole Diterpene Alkaloids as Novel Inhibitors of the Wnt/β‐Catenin Pathway in Breast Cancer Cells.

    Article • ChemInform, April 2014, Wiley

    Khalid El Sayed

  5. Laboratory Exercises to Teach Clinically Relevant Chemistry of Antibiotics

    Article • American Journal of Pharmaceutical Education, March 2014, American Journal of Pharmaceutical Education

    Khalid El Sayed

  6. Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors

    Article • European Journal of Medicinal Chemistry, February 2014, Elsevier

    Khalid El Sayed

  7. Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Khalid El Sayed

  8. Indole diterpene alkaloids as novel inhibitors of the Wnt/β-catenin pathway in breast cancer cells

    Article • European Journal of Medicinal Chemistry, December 2013, Elsevier

    Khalid El Sayed

  9. New Alkaloids from Pancratium maritimum

    Article • Planta Medica, August 2013, Thieme Publishing Group

    Khalid El Sayed, Professor Sabrin R. M. Ibrahim, Professor Gamal A. Mohamed

  10. Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: Preliminary structure–activity relationship and pharmacophore modeling

    Article • Bioorganic & Medicinal Chemistry, August 2013, Elsevier

    Khalid El Sayed

  11. Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer

    Article • Bioorganic & Medicinal Chemistry, April 2013, Elsevier

    Khalid El Sayed

  12. Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer’s Disease: In Vitro and in Vivo Studies

    Article • ACS Chemical Neuroscience, February 2013, American Chemical Society (ACS)

    Khalid El Sayed

  13. Optimization of Marine Triterpene Sipholenols as Inhibitors of Breast Cancer Migration and Invasion

    Article • ChemMedChem, February 2013, Wiley

    Khalid El Sayed

  14. The Veratrum alkaloids jervine, veratramine, and their analogues as prostate cancer migration and proliferation inhibitors: biological evaluation and pharmacophore modeling

    Article • Medicinal Chemistry Research, January 2013, Springer Science + Business Media

    Khalid El Sayed

  15. Structure–activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones

    Article • Medicinal Chemistry Research, January 2013, Springer Science + Business Media

    Khalid El Sayed

  16. Bioguided discovery and pharmacophore modeling of the mycotoxic indole diterpene alkaloids penitrems as breast cancer proliferation, migration, and invasion inhibitors

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Khalid El Sayed

  17. Synthesis, microbial transformation, and pharmacological evaluation of 4,5-dihydronaphtho[2,1-b]furan-2-ones and related analogues

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Khalid El Sayed, Dr Albert Michael Crider

  18. Optimization of tocotrienols as antiproliferative and antimigratory leads

    Article • European Journal of Medicinal Chemistry, January 2013, Elsevier

    Khalid El Sayed

  19. Current Status on Marine Products with Reversal Effect on Cancer Multidrug Resistance

    Article • Marine Drugs, October 2012, MDPI AG

    Khalid El Sayed

  20. Mannich- and Lederer–Manasse-based analogues of the natural product S-(+)-curcuphenol as cancer proliferation and migration inhibitors

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Khalid El Sayed

  21. Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products

    Article • Food and Chemical Toxicology, November 2011, Elsevier

    Khalid El Sayed

  22. Effects of Chemically Characterized Fractions from Aerial Parts ofEchinacea purpureaandE. angustifoliaon Myelopoiesis in Rats

    Article • Planta Medica, August 2011, Thieme Publishing Group

    Khalid El Sayed

  23. Optimization of (Phenylmethylidene)‐hydantoins as Prostate Cancer Migration Inhibitors: SAR‐Directed Design, Synthesis, and Pharmacophore Modeling

    Article • Chemistry & Biodiversity, August 2011, Wiley

    Khalid El Sayed

  24. Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors

    Article • Bioorganic & Medicinal Chemistry, August 2011, Elsevier

    Khalid El Sayed

  25. Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors

    Article • European Journal of Medicinal Chemistry, April 2011, Elsevier

    Khalid El Sayed

  26. (−)-Oleocanthal as a c-Met Inhibitor for the Control of Metastatic Breast and Prostate Cancers

    Article • Planta Medica, February 2011, Thieme Publishing Group

    Khalid El Sayed

  27. Methods for Evaluation of Structural and Biological Properties of Antiinvasive Natural Products

    Article • January 2011, Springer Science + Business Media

    Khalid El Sayed

  28. Discovery of Novel GSK-3β Inhibitors with Potent in Vitro and in Vivo Activities and Excellent Brain Permeability Using Combined Ligand- and Structure-Based Virtual Screening

    Article • Journal of Medicinal Chemistry, November 2010, American Chemical Society (ACS)

    Khalid El Sayed

  29. Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors

    Article • Bioorganic & Medicinal Chemistry, November 2010, Elsevier

    Khalid El Sayed

  30. Bioactive Natural, Biocatalytic, and Semisynthetic Tobacco Cembranoids

    Article • Planta Medica, November 2010, Thieme Publishing Group

    Khalid El Sayed

  31. Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis

    Article • European Journal of Medicinal Chemistry, November 2010, Elsevier

    Khalid El Sayed

  32. Design, synthesis, and biological evaluation of dibromotyrosine analogues inspired by marine natural products as inhibitors of human prostate cancer proliferation, invasion, and migration

    Article • Bioorganic & Medicinal Chemistry, November 2010, Elsevier

    Khalid El Sayed

  33. Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells

    Article • Biochemical Pharmacology, November 2010, Elsevier

    Khalid El Sayed

  34. 3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches

    Article • European Journal of Medicinal Chemistry, September 2010, Elsevier

    Khalid El Sayed

  35. Manzamine A as a Novel Inhibitor of Herpes Simplex Virus Type-1 Replication in Cultured Corneal Cells

    Article • Planta Medica, July 2010, Thieme Publishing Group

    Khalid El Sayed

  36. Molecular interaction and localization of tocotrienol-rich fraction (TRF) within the matrices of lipid nanoparticles: Evidence studies by Differential Scanning Calorimetry (DSC) and Proton Nuclear Magnetic Resonance spectroscopy (1H NMR)

    Article • Colloids and Surfaces B Biointerfaces, June 2010, Elsevier

    Khalid El Sayed

  37. The Value of Tocotrienols in the Prevention and Treatment of Cancer

    Article • Journal of the American College of Nutrition, June 2010, Taylor & Francis

    Khalid El Sayed

  38. Pachycladins A−E, Prostate Cancer Invasion and Migration Inhibitory Eunicellin-Based Diterpenoids from the Red Sea Soft Coral Cladiella pachyclados

    Article • Journal of Natural Products, April 2010, American Chemical Society (ACS)

    Khalid El Sayed

  39. Semisynthetic Latrunculin Derivatives as Inhibitors of Metastatic Breast Cancer: Biological Evaluations, Preliminary Structure–Activity Relationship and Molecular Modeling Studies

    Article • ChemMedChem, January 2010, Wiley

    Khalid El Sayed

  40. Design and preliminary structure–activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion

    Article • Bioorganic & Medicinal Chemistry, January 2010, Elsevier

    Khalid El Sayed

  41. Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors

    Article • Bioorganic & Medicinal Chemistry, January 2010, Elsevier

    Khalid El Sayed

  42. Rational Design and Semisynthesis of Betulinic Acid Analogues as Potent Topoisomerase Inhibitors

    Article • Journal of Natural Products, August 2009, American Chemical Society (ACS)

    Khalid El Sayed

  43. The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling

    Article • Bioorganic & Medicinal Chemistry, August 2009, Elsevier

    Khalid El Sayed

  44. Sipholane Triterpenoids: Chemistry, Reversal of ABCB1/P-Glycoprotein-Mediated Multidrug Resistance, and Pharmacophore Modeling

    Article • Journal of Natural Products, June 2009, American Chemical Society (ACS)

    Khalid El Sayed

  45. Erratum to “Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products” [Bioorg. Med. Chem. 17 (2009) 1731–1738]

    Article • Bioorganic & Medicinal Chemistry, April 2009, Elsevier

    Khalid El Sayed

  46. Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products

    Article • Bioorganic & Medicinal Chemistry, February 2009, Elsevier

    Khalid El Sayed

  47. Antiproliferative Triterpenes from Melaleuca ericifolia

    Article • Journal of Natural Products, October 2008, American Chemical Society (ACS)

    Khalid El Sayed

  48. Sinulodurins A and B, Antiproliferative and Anti-invasive Diterpenes from the Soft Coral Sinularia dura

    Article • Journal of Natural Products, July 2008, American Chemical Society (ACS)

    Khalid El Sayed

  49. Biocatalytic and semisynthetic optimization of the anti-invasive tobacco (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol

    Article • Bioorganic & Medicinal Chemistry, March 2008, Elsevier

    Khalid El Sayed

  50. Latrunculin A and Its C-17-O-Carbamates Inhibit Prostate Tumor Cell Invasion and HIF-1 Activation in Breast Tumor Cells

    Article • Journal of Natural Products, February 2008, American Chemical Society (ACS)

    Khalid El Sayed

  51. Semisynthetic Studies on the Manzamine Alkaloids

    Article • Journal of Natural Products, January 2008, American Chemical Society (ACS)

    Khalid El Sayed

  52. Semisynthetic and Biotransformation Studies of (1S,2E,4S,6R,7E,11E)-2,7,11-Cembratriene-4,6-diol

    Article • Journal of Natural Products, January 2008, American Chemical Society (ACS)

    Khalid El Sayed

  53. Sipholenol A, a marine‐derived sipholane triterpene, potently reverses P‐glycoprotein (ABCB1)‐mediated multidrug resistance in cancer cells

    Article • Cancer Science, July 2007, Wiley

    Khalid El Sayed

  54. Biocatalysis of the Anticancer Sipholane Triterpenoids

    Article • Planta Medica, June 2007, Thieme Publishing Group

    Khalid El Sayed

  55. Biocatalytic and semisynthetic studies of the anticancer tobacco cembranoids

    Article • Expert Opinion on Investigational Drugs, May 2007, Informa Healthcare

    Khalid El Sayed

  56. Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Sipholane Triterpenoids

    Article • Journal of Natural Products, May 2007, American Chemical Society (ACS)

    Khalid El Sayed

  57. Anticancer and Antiinflammatory Sulfur‐Containing Semisynthetic Derivatives of Sarcophine.

    Article • ChemInform, January 2007, Wiley

    Khalid El Sayed

  58. Antiproliferative potential of sarcophine and its semisynthetic sulfur-containing derivatives against human mammary carcinoma cell lines

    Article • Journal of Natural Medicines, December 2006, Springer Science + Business Media

    Khalid El Sayed

  59. Biocatalytic and Antimetastatic Studies of the Marine Cembranoids Sarcophine and 2-epi-16-Deoxysarcophine

    Article • Journal of Natural Products, June 2006, American Chemical Society (ACS)

    Khalid El Sayed

  60. Bioactive Natural and Semisynthetic Latrunculins

    Article • Journal of Natural Products, January 2006, American Chemical Society (ACS)

    Khalid El Sayed

  61. Anticancer and Anti-inflammatory Sulfur-Containing Semisynthetic Derivatives of Sarcophine

    Article • Chemical and Pharmaceutical Bulletin, January 2006, Pharmaceutical Society of Japan

    Khalid El Sayed

  62. Natural Products as Angiogenesis Modulators

    Article • Mini-Reviews in Medicinal Chemistry, November 2005, Bentham Science Publishers

    Khalid El Sayed

  63. Bioactive Rearranged and Halogenated Semisynthetic Derivatives of the Marine Natural Product Sarcophine

    Article • Journal of Natural Products, November 2004, American Chemical Society (ACS)

    Khalid El Sayed

  64. Trisulcusine: A Novel Spiro Quinazoline Alkaloid from Anisotes trisulcus

    Article • ChemInform, March 2003, Wiley

    Khalid El Sayed

  65. Marine Natural Products as Prototype Agrochemical Agents

    Article • Journal of Agricultural and Food Chemistry, March 2003, American Chemical Society (ACS)

    Khalid El Sayed

  66. Microbial and Chemical Transformation Studies of the Bioactive Marine Sesquiterpenes (S)-(+)-Curcuphenol and -Curcudiol Isolated from a Deep Reef Collection of the Jamaican Sponge Didiscus oxeata

    Article • Journal of Natural Products, September 2002, American Chemical Society (ACS)

    Khalid El Sayed

  67. 12,34-Oxamanzamines, novel biocatalytic and natural products from manzamine producing Indo-Pacific sponges

    Article • Tetrahedron, September 2002, Elsevier

    Khalid El Sayed

  68. Toward Computing Relative Configurations:  16-epi-Latrunculin B, a New Stereoisomer of the Actin Polymerization Inhibitor Latrunculin B

    Article • Journal of the American Chemical Society, June 2002, American Chemical Society (ACS)

    Khalid El Sayed

  69. Transformation of lactone to lactam in sarcophine and antimalarial activity of the resulting N-substituted azasarcophines

    Article • Tetrahedron, May 2002, Elsevier

    Khalid El Sayed

  70. Microbial Transformation of Rubijervine

    Article • Chemical and Pharmaceutical Bulletin, January 2002, Pharmaceutical Society of Japan

    Khalid El Sayed

  71. Microbial Transformation of Hypoestenone

    Article • Journal of Natural Products, February 2001, American Chemical Society (ACS)

    Khalid El Sayed

  72. Transformation of jervine by Cunninghamella elegans ATCC 9245

    Article • Phytochemistry, September 2000, Elsevier

    Khalid El Sayed

  73. New Quinoline Alkaloids from Ruta chalepensis

    Article • Journal of Natural Products, June 2000, American Chemical Society (ACS)

    Khalid El Sayed

  74. ChemInform Abstract: Marine Natural Products as Antituberculosis Agents.

    Article • ChemInform, May 2000, Wiley

    Khalid El Sayed

  75. Bioactive 12-Oleanene Triterpene and Secotriterpene Acids from Maytenus undata

    Article • Journal of Natural Products, April 2000, American Chemical Society (ACS)

    Khalid El Sayed

  76. ChemInform Abstract: Marine Natural Products as Leads to Develop New Drugs and Insecticides

    Article • ChemInform, April 2000, Wiley

    Khalid El Sayed

  77. Microbial transformation of papaveraldine

    Article • Phytochemistry, March 2000, Elsevier

    Khalid El Sayed

  78. Marine Natural Products as Antituberculosis Agents

    Article • Tetrahedron, February 2000, Elsevier

    Khalid El Sayed

  79. Natural Products as Antiviral Agents

    Article • January 2000, Elsevier

    Khalid El Sayed

  80. The Biocatalytic Transformation of Furan to Amide in the Bioactive Marine Natural Product Palinurin

    Article • The Journal of Organic Chemistry, November 1999, American Chemical Society (ACS)

    Khalid El Sayed

  81. Marine Natural Products as Leads to Develop New Drugs and Insecticides

    Article • July 1999, Taylor & Francis

    Khalid El Sayed

  82. Koninginin G, a New Metabolite from Trichoderma aureoviride

    Article • Journal of Natural Products, December 1998, American Chemical Society (ACS)

    Khalid El Sayed

  83. Structurally Novel Bioconversion Products of the Marine Natural Product Sarcophine Effectively Inhibit JB6 Cell Transformation

    Article • The Journal of Organic Chemistry, September 1998, American Chemical Society (ACS)

    Khalid El Sayed

  84. New Pyrrole Alkaloids from Solanum sodomaeum

    Article • Journal of Natural Products, May 1998, American Chemical Society (ACS)

    Khalid El Sayed

  85. Microbial Biotransformation of Veratramine

    Article • Journal of Natural Products, January 1998, American Chemical Society (ACS)

    Khalid El Sayed

  86. Phytochemical Analysis ofGeigeria alataandFrancoeuria crispaEssential Oils

    Article • Planta Medica, October 1997, Thieme Publishing Group

    Khalid El Sayed

  87. A Study of Alkaloids in Veratrum viride Aiton

    Article • International Journal of Pharmacognosy, January 1996, Taylor & Francis

    Khalid El Sayed

  88. A New Norcembranoid Dimer from the Red Sea Soft Coral Sinularia gardineri

    Article • Journal of Natural Products, January 1996, American Chemical Society (ACS)

    Khalid El Sayed

  89. Two steroidal alkaloids from veratrum viride

    Article • Phytochemistry, April 1995, Elsevier

    Khalid El Sayed