All Stories

  1. Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV

    Article • Biochemistry, October 2019, American Chemical Society (ACS)

    Dr Keir C Neuman

  2. Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase

    Article • eLife, August 2019, eLife

    Dr Keir C Neuman

  3. Direct observation of topoisomerase IA gate dynamics

    Article • Nature Structural & Molecular Biology, November 2018, Springer Science + Business Media

    Dr Keir C Neuman

  4. Kinetic Pathway of Torsional DNA Buckling

    Article • The Journal of Physical Chemistry B, October 2018, American Chemical Society (ACS)

    Dr Keir C Neuman

  5. Polydopamine Encapsulation of Fluorescent Nanodiamonds for Biomedical Applications

    Article • Advanced Functional Materials, June 2018, Wiley

    Dr Keir C Neuman

  6. A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

    Article • Nucleic Acids Research, May 2018, Oxford University Press (OUP)

    Dr Keir C Neuman

  7. Defect-facilitated buckling in supercoiled double-helix DNA

    Article • February 2018, American Physical Society (APS)

    Dr Keir C Neuman

  8. RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding

    Article • Nucleic Acids Research, October 2017, Oxford University Press (OUP)

    Dr Keir C Neuman

  9. Supercoiling DNA Locates Mismatches

    Article • Physical Review Letters, October 2017, American Physical Society (APS)

    Dr Keir C Neuman

  10. Combined Magnetic Tweezers and Micro-mirror Total Internal Reflection Fluorescence Microscope for Single-Molecule Manipulation and Visualization

    Article • September 2017, Springer Science + Business Media

    Dr Keir C Neuman

  11. Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

    Article • Scientific Reports, August 2017, Nature

    Dr Keir C Neuman

  12. Robust fluorescent labelling of micropipettes for use in fluorescence microscopy: application to the observation of a mosquito borne parasite infection

    Article • Journal of Microscopy, August 2017, Wiley

    Dr Keir C Neuman

  13. Activities of gyrase and topoisomerase IV on positively supercoiled DNA

    Article • Nucleic Acids Research, July 2017, Oxford University Press (OUP)

    Dr Keir C Neuman

  14. Brownian ratchet mechanisms of ParA-mediated partitioning

    Article • Plasmid, July 2017, Elsevier

    Dr Keir C Neuman

  15. Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM

    Article • Journal of Visualized Experiments, June 2017, MyJove Corporation

    Dr Keir C Neuman

  16. Supercoiling DNA locates mismatches

    Article • April 2017, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  17. Brownian Ratchet Mechanism for Faithful Segregation of Low-Copy-Number Plasmids

    Article • Biophysical Journal, April 2017, Elsevier

    Dr Keir C Neuman

  18. Developing Fluorescent Nanodiamonds for In Vitro and In Vivo Biological Imaging

    Article • Biophysical Journal, February 2017, Elsevier

    Dr Keir C Neuman

  19. Energetic Contributions of Plectoneme Tips and Tails

    Article • Biophysical Journal, February 2017, Elsevier

    Dr Keir C Neuman

  20. madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy

    Article • Molecular Biology of the Cell, October 2016, American Society for Cell Biology (ASCB)

    Dr Keir C Neuman

  21. Single molecule measurements of DNA helicase activity with magnetic tweezers and t- test based step-finding analysis

    Article • Methods, August 2016, Elsevier

    Dr Keir C Neuman

  22. The dynamic interplay between DNA topoisomerases and DNA topology

    Article • Biophysical Reviews, July 2016, Springer Science + Business Media

    Dr Keir C Neuman

  23. Fluorescent Nanodiamonds as Fiducial Markers or Nanodiamonds Are Forever.

    Article • Microscopy and Microanalysis, July 2016, Cambridge University Press

    Dr Keir C Neuman

  24. Membrane-bound MinDE complex acts as a toggle switch that drives Min oscillation coupled to cytoplasmic depletion of MinD

    Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  25. Single Molecule Measurements of DNA Decatenation by the Topoisomerase III-RecQ Helicase Complex

    Article • Biophysical Journal, February 2016, Elsevier

    Dr Keir C Neuman

  26. Transportation of an Artifical Cargo by a Par-Min Hybrid System

    Article • Biophysical Journal, February 2016, Elsevier

    Dr Keir C Neuman

  27. A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting

    Article • RNA, December 2015, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  28. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  29. The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling

    Article • Scientific Reports, June 2015, Nature

    Dr Keir C Neuman

  30. Tethered-bead, immune sandwich assay

    Article • Biosensors and Bioelectronics, January 2015, Elsevier

    Dr Keir C Neuman

  31. Untwisting and Unzipping: Magnetic Tweezers Based Measurements of DNA Processing Enzymes

    Article • January 2015, Optical Society of America (OSA)

    Dr Keir C Neuman

  32. Functional Implications of the RecQ Helicase - Topoisomerase III - SSB Complex: Insights from Single Molecule Measurements

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Keir C Neuman

  33. Super-Resolution Mapping of the Dynamics of Periodic Structural Defects in Collagen Fibrils

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Keir C Neuman

  34. Spatial Regulators for Bacterial Cell Division Self-Organize into an Oscillator on a Flat Bilayer

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Keir C Neuman

  35. A robust assay to measure DNA topology-dependent protein binding affinity

    Article • Nucleic Acids Research, December 2014, Oxford University Press (OUP)

    Dr Keir C Neuman

  36. Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

    Article • Biochemistry, September 2014, American Chemical Society (ACS)

    Dr Keir C Neuman

  37. Poisoning of Mitochondrial Topoisomerase I by Lamellarin D

    Article • Molecular Pharmacology, June 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Keir C Neuman

  38. A moving ParA gradient on the nucleoid directs subcellular cargo transport via a chemophoresis force

    Article • BioArchitecture, May 2014, Taylor & Francis

    Dr Keir C Neuman

  39. Wide-field in vivo background free imaging by selective magnetic modulation of nanodiamond fluorescence

    Article • Biomedical Optics Express, March 2014, Optical Society of America (OSA)

    Dr Keir C Neuman

  40. A propagating ATPase gradient drives transport of surface-confined cellular cargo

    Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  41. ATP Binding Induced Conformational Change in RecQ Helicase

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Keir C Neuman

  42. Wide-Field Background Free Imaging by Magnetic Modulation of Nanodiamond Fluorescence

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Keir C Neuman

  43. Domain Architecture of RecQ Helicase Defines Mechanochemical Linkage via Multipartite Interactions with DNA Substrate during Unwinding Activity

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Keir C Neuman

  44. The Tail That Wags the Dog: Topoisomerase IV ParC C-Terminal Domain Controls Strand Passage Activity through Multipartite Topology-Dependent Interactions with DNA

    Article • Journal of Molecular Biology, September 2013, Elsevier

    Dr Keir C Neuman

  45. SnapShot: Single-Molecule Fluorescence

    Article • Cell, June 2013, Elsevier

    Dr Keir C Neuman

  46. Silica Encapsulation of Fluorescent Nanodiamonds for Colloidal Stability and Facile Surface Functionalization

    Article • Journal of the American Chemical Society, May 2013, American Chemical Society (ACS)

    Dr Keir C Neuman

  47. SnapShot: Force Spectroscopy and Single-Molecule Manipulation

    Article • Cell, May 2013, Elsevier

    Dr Keir C Neuman

  48. Chiral Discrimination and Writhe-dependent Relaxation Mechanism of Human Topoisomerase IIα

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Keir C Neuman

  49. Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification

    Article • Nucleic Acids Research, March 2013, Oxford University Press (OUP)

    Dr Keir C Neuman

  50. Matrix Metallopeptidase 9/Gelatinase B

    Article • January 2013, Elsevier

    Dr Keir C Neuman

  51. Sequence Specific pausing of RecQ Helicase

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Keir C Neuman

  52. Below-Equilibrium DNA Topology Simplification by Type II Topoisomerases can be Explained by DNA Linking Number-Dependent Binding Affinity

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Keir C Neuman

  53. A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity

    Article • Proceedings of the National Academy of Sciences, September 2012, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  54. Single-Molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism

    Article • Current Biology, June 2012, Elsevier

    Dr Keir C Neuman

  55. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis

    Article • Nucleic Acids Research, March 2012, Oxford University Press (OUP)

    Dr Keir C Neuman

  56. Non-Equilibrium Topology Simplification by Type II Topoisomerases: A Test of Kinetic Proofreading

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Keir C Neuman

  57. Quantitative Characterization of Dyes Embedded in Nanoparticles by Single-Molecule Fluorescence

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Keir C Neuman

  58. Distinct Uncoiling Mechanisms of Human Nuclear and Mitochondrial Type IB Topoisomerases

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Keir C Neuman

  59. Quantitative characterization of fluorophores in multi-component nanoprobes by single-molecule fluorescence

    Article • Biomedical Optics Express, September 2011, Optical Society of America (OSA)

    Dr Keir C Neuman

  60. Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification

    Article • Nucleic Acids Research, March 2011, Oxford University Press (OUP)

    Dr Keir C Neuman

  61. Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV

    Article • Nucleic Acids Research, February 2011, Oxford University Press (OUP)

    Dr Keir C Neuman

  62. Magnetic Tweezers for Single-Molecule Manipulation

    Article • January 2011, Springer Science + Business Media

    Dr Keir C Neuman

  63. Single-Molecule Measurements of Topoisomerase Activity with Magnetic Tweezers

    Article • January 2011, Springer Science + Business Media

    Dr Keir C Neuman

  64. Evolutionary twist on topoisomerases: Conversion of gyrase to topoisomerase IV

    Article • Proceedings of the National Academy of Sciences, December 2010, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  65. Single-molecule Measurements of DNA Topology and Topoisomerases

    Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Keir C Neuman

  66. Single-Molecule Study of Human Topoisomerase II

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Keir C Neuman

  67. Determining the Role DNA of Bending in Topology Simplification by Type II Topoisomerases

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Keir C Neuman

  68. Single Molecule Study of the Motion of Matrix Metalloprotease MMP1 on Type I Collagen Fiber Shows Proteolysis Driven Hindered Biased Diffusion

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Keir C Neuman

  69. Mechanisms of chiral discrimination by topoisomerase IV

    Article • Proceedings of the National Academy of Sciences, April 2009, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  70. Mutational Analysis of the Helicase-like Domain ofThermotoga maritimaReverse Gyrase

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Keir C Neuman

  71. Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

    Article • Nature Methods, May 2008, Springer Science + Business Media

    Dr Keir C Neuman

  72. Single-Molecule Micromanipulation Techniques

    Article • Annual Review of Materials Research, August 2007, Annual Reviews

    Dr Keir C Neuman

  73. Pulling on the Nascent RNA during Transcription Does Not Alter Kinetics of Elongation or Ubiquitous Pausing

    Article • Molecular Cell, July 2006, Elsevier

    Dr Keir C Neuman

  74. Sequence-Resolved Detection of Pausing by Single RNA Polymerase Molecules

    Article • Cell, June 2006, Elsevier

    Dr Keir C Neuman

  75. Statistical determination of the step size of molecular motors

    Article • Journal of Physics Condensed Matter, November 2005, Institute of Physics Publishing

    Dr Keir C Neuman

  76. Shedding light on life

    Article • Physics World, October 2005, Institute of Physics Publishing

    Dr Keir C Neuman

  77. Measurement of the effective focal shift in an optical trap

    Article • Optics Letters, June 2005, Optical Society of America (OSA)

    Dr Keir C Neuman

  78. Simultaneous, coincident optical trapping and single-molecule fluorescence

    Article • Nature Methods, October 2004, Springer Science + Business Media

    Dr Keir C Neuman

  79. Optical trapping

    Article • Review of Scientific Instruments, September 2004, American Institute of Physics

    Dr Keir C Neuman

  80. Ubiquitous Transcriptional Pausing Is Independent of RNA Polymerase Backtracking

    Article • Cell, November 2003, Elsevier

    Dr Keir C Neuman

  81. Characterization of Photodamage to Escherichia coli in Optical Traps

    Article • Biophysical Journal, November 1999, Elsevier

    Dr Keir C Neuman

  82. Nonlamellar Phases Induced by the Interaction of Gramicidin S with Lipid Bilayers. A Possible Relationship to Membrane-Disrupting Activity†

    Article • Biochemistry, June 1997, American Chemical Society (ACS)

    Dr Keir C Neuman

  83. Studies of DNA-Protein Interactions at the Single Molecule Level with Magnetic Tweezers

    Article • Springer Science + Business Media

    Dr Keir C Neuman