All Stories

  1. Influence of cell phenotype and surface modifications on the cytotoxicity of fluorescent nanodiamonds

    Article • Diamond and Related Materials, March 2025, Elsevier

    Dr Keir C Neuman

  2. Highly sensitive mapping of in vitro type II topoisomerase DNA cleavage sites with SHAN-seq

    Article • Nucleic Acids Research, August 2024, Oxford University Press (OUP)

    Dr Keir C Neuman

  3. UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  4. Single molecule analysis of CENP-A chromatin by high-speed atomic force microscopy

    Article • eLife, September 2023, eLife

    Dr Keir C Neuman

  5. Mesoporous Polydopamine-Encapsulated Fluorescent Nanodiamonds: A Versatile Platform for Biomedical Applications

    Article • ACS Applied Materials & Interfaces, June 2023, American Chemical Society (ACS)

    Dr Keir C Neuman

  6. Cholesterol in the cargo membrane amplifies tau inhibition of kinesin-1-based transport

    Article • Proceedings of the National Academy of Sciences, January 2023, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  7. Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β

    Article • Nature Communications, August 2022, Springer Science + Business Media

    Dr Keir C Neuman

  8. Cholesterol in the cargo membrane reduces kinesin-1 binding to microtubules in the presence of tau

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  9. The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops

    Article • Nature Communications, February 2022, Springer Science + Business Media

    Dr Keir C Neuman

  10. Topoisomerase VI is a chirally-selective, preferential DNA decatenase

    Article • eLife, January 2022, eLife

    Dr Keir C Neuman

  11. General Method to Increase Carboxylic Acid Content on Nanodiamonds

    Article • Molecules, January 2022, MDPI AG

    Dr Keir C Neuman

  12. Highly stable cesium lead bromide perovskite nanocrystals for ultra-sensitive and selective latent fingerprint detection

    Article • Analytica Chimica Acta, October 2021, Elsevier

    Dr Keir C Neuman

  13. CTP and parS coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning

    Article • eLife, July 2021, eLife

    Dr Keir C Neuman

  14. Topoisomerase VI is a chirally-selective, preferential DNA decatenase

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  15. CTP andparScoordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  16. Surface Modification of Fluorescent Nanodiamonds for Biological Applications

    Article • Nanomaterials, January 2021, MDPI AG

    Dr Keir C Neuman

  17. Coarse-grained modelling of DNA plectoneme pinning in the presence of base-pair mismatches

    Article • Nucleic Acids Research, October 2020, Oxford University Press (OUP)

    Dr Keir C Neuman

  18. Biocompatible Fluorescent Nanodiamonds as Multifunctional Optical Probes for Latent Fingerprint Detection

    Article • ACS Applied Materials & Interfaces, January 2020, American Chemical Society (ACS)

    Dr Keir C Neuman

  19. Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques

    Article • Genes, January 2020, MDPI AG

    Dr Keir C Neuman

  20. Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV

    Article • Biochemistry, October 2019, American Chemical Society (ACS)

    Dr Keir C Neuman

  21. Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase

    Article • eLife, August 2019, eLife

    Dr Keir C Neuman

  22. Direct observation of topoisomerase IA gate dynamics

    Article • Nature Structural & Molecular Biology, November 2018, Springer Science + Business Media

    Dr Keir C Neuman

  23. Kinetic Pathway of Torsional DNA Buckling

    Article • The Journal of Physical Chemistry B, October 2018, American Chemical Society (ACS)

    Dr Keir C Neuman

  24. Polydopamine Encapsulation of Fluorescent Nanodiamonds for Biomedical Applications

    Article • Advanced Functional Materials, June 2018, Wiley

    Dr Keir C Neuman

  25. A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

    Article • Nucleic Acids Research, May 2018, Oxford University Press (OUP)

    Dr Keir C Neuman

  26. Defect-facilitated buckling in supercoiled double-helix DNA

    Article • February 2018, American Physical Society (APS)

    Dr Keir C Neuman

  27. RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding

    Article • Nucleic Acids Research, October 2017, Oxford University Press (OUP)

    Dr Keir C Neuman

  28. Supercoiling DNA Locates Mismatches

    Article • Physical Review Letters, October 2017, American Physical Society (APS)

    Dr Keir C Neuman

  29. Combined Magnetic Tweezers and Micro-mirror Total Internal Reflection Fluorescence Microscope for Single-Molecule Manipulation and Visualization

    Article • September 2017, Springer Science + Business Media

    Dr Keir C Neuman

  30. Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

    Article • Scientific Reports, August 2017, Nature

    Dr Keir C Neuman

  31. Robust fluorescent labelling of micropipettes for use in fluorescence microscopy: application to the observation of a mosquito borne parasite infection

    Article • Journal of Microscopy, August 2017, Wiley

    Dr Keir C Neuman

  32. Activities of gyrase and topoisomerase IV on positively supercoiled DNA

    Article • Nucleic Acids Research, July 2017, Oxford University Press (OUP)

    Dr Keir C Neuman

  33. Brownian ratchet mechanisms of ParA-mediated partitioning

    Article • Plasmid, July 2017, Elsevier

    Dr Keir C Neuman

  34. Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM

    Article • Journal of Visualized Experiments, June 2017, MyJove Corporation

    Dr Keir C Neuman

  35. Supercoiling DNA locates mismatches

    Article • April 2017, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  36. Brownian Ratchet Mechanism for Faithful Segregation of Low-Copy-Number Plasmids

    Article • Biophysical Journal, April 2017, Elsevier

    Dr Keir C Neuman

  37. Developing Fluorescent Nanodiamonds for In Vitro and In Vivo Biological Imaging

    Article • Biophysical Journal, February 2017, Elsevier

    Dr Keir C Neuman

  38. Energetic Contributions of Plectoneme Tips and Tails

    Article • Biophysical Journal, February 2017, Elsevier

    Dr Keir C Neuman

  39. madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy

    Article • Molecular Biology of the Cell, October 2016, American Society for Cell Biology (ASCB)

    Dr Keir C Neuman

  40. Single molecule measurements of DNA helicase activity with magnetic tweezers and t- test based step-finding analysis

    Article • Methods, August 2016, Elsevier

    Dr Keir C Neuman

  41. The dynamic interplay between DNA topoisomerases and DNA topology

    Article • Biophysical Reviews, July 2016, Springer Science + Business Media

    Dr Keir C Neuman

  42. Fluorescent Nanodiamonds as Fiducial Markers or Nanodiamonds Are Forever.

    Article • Microscopy and Microanalysis, July 2016, Cambridge University Press

    Dr Keir C Neuman

  43. Membrane-bound MinDE complex acts as a toggle switch that drives Min oscillation coupled to cytoplasmic depletion of MinD

    Article • Proceedings of the National Academy of Sciences, February 2016, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  44. Single Molecule Measurements of DNA Decatenation by the Topoisomerase III-RecQ Helicase Complex

    Article • Biophysical Journal, February 2016, Elsevier

    Dr Keir C Neuman

  45. Transportation of an Artifical Cargo by a Par-Min Hybrid System

    Article • Biophysical Journal, February 2016, Elsevier

    Dr Keir C Neuman

  46. A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting

    Article • RNA, December 2015, Cold Spring Harbor Laboratory Press

    Dr Keir C Neuman

  47. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system

    Article • Proceedings of the National Academy of Sciences, December 2015, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  48. The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling

    Article • Scientific Reports, June 2015, Nature

    Dr Keir C Neuman

  49. Tethered-bead, immune sandwich assay

    Article • Biosensors and Bioelectronics, January 2015, Elsevier

    Dr Keir C Neuman

  50. Untwisting and Unzipping: Magnetic Tweezers Based Measurements of DNA Processing Enzymes

    Article • January 2015, Optical Society of America (OSA)

    Dr Keir C Neuman

  51. Functional Implications of the RecQ Helicase - Topoisomerase III - SSB Complex: Insights from Single Molecule Measurements

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Keir C Neuman

  52. Super-Resolution Mapping of the Dynamics of Periodic Structural Defects in Collagen Fibrils

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Keir C Neuman

  53. Spatial Regulators for Bacterial Cell Division Self-Organize into an Oscillator on a Flat Bilayer

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Keir C Neuman

  54. A robust assay to measure DNA topology-dependent protein binding affinity

    Article • Nucleic Acids Research, December 2014, Oxford University Press (OUP)

    Dr Keir C Neuman

  55. Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

    Article • Biochemistry, September 2014, American Chemical Society (ACS)

    Dr Keir C Neuman

  56. Poisoning of Mitochondrial Topoisomerase I by Lamellarin D

    Article • Molecular Pharmacology, June 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Keir C Neuman

  57. A moving ParA gradient on the nucleoid directs subcellular cargo transport via a chemophoresis force

    Article • BioArchitecture, May 2014, Taylor & Francis

    Dr Keir C Neuman

  58. Wide-field in vivo background free imaging by selective magnetic modulation of nanodiamond fluorescence

    Article • Biomedical Optics Express, March 2014, Optical Society of America (OSA)

    Dr Keir C Neuman

  59. A propagating ATPase gradient drives transport of surface-confined cellular cargo

    Article • Proceedings of the National Academy of Sciences, February 2014, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  60. ATP Binding Induced Conformational Change in RecQ Helicase

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Keir C Neuman

  61. Wide-Field Background Free Imaging by Magnetic Modulation of Nanodiamond Fluorescence

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Keir C Neuman

  62. Domain Architecture of RecQ Helicase Defines Mechanochemical Linkage via Multipartite Interactions with DNA Substrate during Unwinding Activity

    Article • Biophysical Journal, January 2014, Elsevier

    Dr Keir C Neuman

  63. The Tail That Wags the Dog: Topoisomerase IV ParC C-Terminal Domain Controls Strand Passage Activity through Multipartite Topology-Dependent Interactions with DNA

    Article • Journal of Molecular Biology, September 2013, Elsevier

    Dr Keir C Neuman

  64. SnapShot: Single-Molecule Fluorescence

    Article • Cell, June 2013, Elsevier

    Dr Keir C Neuman

  65. Silica Encapsulation of Fluorescent Nanodiamonds for Colloidal Stability and Facile Surface Functionalization

    Article • Journal of the American Chemical Society, May 2013, American Chemical Society (ACS)

    Dr Keir C Neuman

  66. SnapShot: Force Spectroscopy and Single-Molecule Manipulation

    Article • Cell, May 2013, Elsevier

    Dr Keir C Neuman

  67. Chiral Discrimination and Writhe-dependent Relaxation Mechanism of Human Topoisomerase IIα

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Keir C Neuman

  68. Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification

    Article • Nucleic Acids Research, March 2013, Oxford University Press (OUP)

    Dr Keir C Neuman

  69. Matrix Metallopeptidase 9/Gelatinase B

    Article • January 2013, Elsevier

    Dr Keir C Neuman

  70. Sequence Specific pausing of RecQ Helicase

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Keir C Neuman

  71. Below-Equilibrium DNA Topology Simplification by Type II Topoisomerases can be Explained by DNA Linking Number-Dependent Binding Affinity

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Keir C Neuman

  72. A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity

    Article • Proceedings of the National Academy of Sciences, September 2012, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  73. Single-Molecule Tracking of Collagenase on Native Type I Collagen Fibrils Reveals Degradation Mechanism

    Article • Current Biology, June 2012, Elsevier

    Dr Keir C Neuman

  74. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis

    Article • Nucleic Acids Research, March 2012, Oxford University Press (OUP)

    Dr Keir C Neuman

  75. Non-Equilibrium Topology Simplification by Type II Topoisomerases: A Test of Kinetic Proofreading

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Keir C Neuman

  76. Quantitative Characterization of Dyes Embedded in Nanoparticles by Single-Molecule Fluorescence

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Keir C Neuman

  77. Distinct Uncoiling Mechanisms of Human Nuclear and Mitochondrial Type IB Topoisomerases

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Keir C Neuman

  78. Quantitative characterization of fluorophores in multi-component nanoprobes by single-molecule fluorescence

    Article • Biomedical Optics Express, September 2011, Optical Society of America (OSA)

    Dr Keir C Neuman

  79. Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification

    Article • Nucleic Acids Research, March 2011, Oxford University Press (OUP)

    Dr Keir C Neuman

  80. Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV

    Article • Nucleic Acids Research, February 2011, Oxford University Press (OUP)

    Dr Keir C Neuman

  81. Magnetic Tweezers for Single-Molecule Manipulation

    Article • January 2011, Springer Science + Business Media

    Dr Keir C Neuman

  82. Single-Molecule Measurements of Topoisomerase Activity with Magnetic Tweezers

    Article • January 2011, Springer Science + Business Media

    Dr Keir C Neuman

  83. Evolutionary twist on topoisomerases: Conversion of gyrase to topoisomerase IV

    Article • Proceedings of the National Academy of Sciences, December 2010, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  84. Single-molecule Measurements of DNA Topology and Topoisomerases

    Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Keir C Neuman

  85. Single-Molecule Study of Human Topoisomerase II

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Keir C Neuman

  86. Determining the Role DNA of Bending in Topology Simplification by Type II Topoisomerases

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Keir C Neuman

  87. Single Molecule Study of the Motion of Matrix Metalloprotease MMP1 on Type I Collagen Fiber Shows Proteolysis Driven Hindered Biased Diffusion

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Keir C Neuman

  88. Mechanisms of chiral discrimination by topoisomerase IV

    Article • Proceedings of the National Academy of Sciences, April 2009, Proceedings of the National Academy of Sciences

    Dr Keir C Neuman

  89. Mutational Analysis of the Helicase-like Domain ofThermotoga maritimaReverse Gyrase

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Keir C Neuman

  90. Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

    Article • Nature Chemical Biology, May 2008, Springer Science + Business Media

    Dr Keir C Neuman

  91. Single-Molecule Micromanipulation Techniques

    Article • Annual Review of Materials Science, August 2007, Annual Reviews

    Dr Keir C Neuman

  92. Pulling on the Nascent RNA during Transcription Does Not Alter Kinetics of Elongation or Ubiquitous Pausing

    Article • Molecular Cell, July 2006, Elsevier

    Dr Keir C Neuman

  93. Sequence-Resolved Detection of Pausing by Single RNA Polymerase Molecules

    Article • Cell, June 2006, Elsevier

    Dr Keir C Neuman

  94. Statistical determination of the step size of molecular motors

    Article • Journal of Physics Condensed Matter, November 2005, Institute of Physics Publishing

    Dr Keir C Neuman

  95. Shedding light on life

    Article • Physics World, October 2005, Institute of Physics Publishing

    Dr Keir C Neuman

  96. Measurement of the effective focal shift in an optical trap

    Article • Optics Letters, June 2005, Optical Society of America (OSA)

    Dr Keir C Neuman

  97. Simultaneous, coincident optical trapping and single-molecule fluorescence

    Article • Nature Chemical Biology, October 2004, Springer Science + Business Media

    Dr Keir C Neuman

  98. Optical trapping

    Article • Review of Scientific Instruments, September 2004, American Institute of Physics

    Dr Keir C Neuman

  99. Ubiquitous Transcriptional Pausing Is Independent of RNA Polymerase Backtracking

    Article • Cell, November 2003, Elsevier

    Dr Keir C Neuman

  100. Characterization of Photodamage to Escherichia coli in Optical Traps

    Article • Biophysical Journal, November 1999, Elsevier

    Dr Keir C Neuman

  101. Nonlamellar Phases Induced by the Interaction of Gramicidin S with Lipid Bilayers. A Possible Relationship to Membrane-Disrupting Activity†

    Article • Biochemistry, June 1997, American Chemical Society (ACS)

    Dr Keir C Neuman

  102. Studies of DNA-Protein Interactions at the Single Molecule Level with Magnetic Tweezers

    Article • Springer Science + Business Media

    Dr Keir C Neuman