All Stories

  1. Crystal structure of the adenylation domain from an ε-poly-l-lysine synthetase provides molecular mechanism for substrate specificity

    Article • Biochemical and Biophysical Research Communications, March 2022, Elsevier

    Professor Kazuya Yamanaka

  2. First enzymological characterization of selenocysteine β-lyase from a lactic acid bacterium, Leuconostoc mesenteroides

    Article • Amino Acids, February 2022, Springer Science + Business Media

    Professor Kazuya Yamanaka

  3. Discovery of a Polyamino Acid Antibiotic Solely Comprising l-β-Lysine by Potential Producer Prioritization-Guided Genome Mining

    Article • ACS Chemical Biology, December 2021, American Chemical Society (ACS)

    Professor Kazuya Yamanaka

  4. Molecular and Mechanistic Characterization of PddB, the First PLP-Independent 2,4-Diaminobutyric Acid Racemase Discovered in an Actinobacterial D-Amino Acid Homopolymer Biosynthesis

    Article • Frontiers in Microbiology, June 2021, Frontiers

    Professor Kazuya Yamanaka

  5. Characterization of an l-α,β-diaminopropionic acid polymer with comb-like structure isolated from a poly(ε-l-lysine)-producing Streptomyces sp.

    Article • Applied Microbiology and Biotechnology, April 2021, Springer Science + Business Media

    Professor Kazuya Yamanaka

  6. The Stereocontrolled Biosynthesis of Mirror-Symmetric 2,4-Diaminobutyric Acid Homopolymers Is Critically Governed by Adenylation Activations

    Article • ACS Chemical Biology, June 2020, American Chemical Society (ACS)

    Professor Kazuya Yamanaka

  7. Enhancement of metabolic flux toward ε-poly-l-lysine biosynthesis by targeted inactivation of concomitant polyene macrolide biosynthesis in Streptomyces albulus

    Article • Journal of Bioscience and Bioengineering, May 2020, Elsevier

    Professor Kazuya Yamanaka

  8. Draft Genome Sequence of the Most Traditional ε-Poly- l -Lysine Producer, Streptomyces albulus NBRC14147

    Article • Microbiology Resource Announcements, January 2019, ASM Journals

    Professor Kazuya Yamanaka

  9. Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination

    Article • January 2019, Elsevier

    Professor Kazuya Yamanaka

  10. Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster

    Article • The Journal of Antibiotics, November 2017, Springer Science + Business Media

    Professor Kazuya Yamanaka

  11. A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis

    Article • Angewandte Chemie International Edition, November 2015, Wiley

    Professor Kazuya Yamanaka

  12. Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis

    Article • Scientific Reports, March 2015, Springer Science + Business Media

    Professor Kazuya Yamanaka

  13. Heterologous Production of Hyaluronic Acid in an ε-Poly-l-Lysine Producer, Streptomyces albulus

    Article • Applied and Environmental Microbiology, March 2015, ASM Journals

    Professor Kazuya Yamanaka

  14. Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

    Article • Nature Chemical Biology, June 2014, Springer Science + Business Media

    Professor Kazuya Yamanaka

  15. ε-Poly-l-Lysine Peptide Chain Length Regulated by the Linkers Connecting the Transmembrane Domains of ε-Poly-l-Lysine Synthetase

    Article • Applied and Environmental Microbiology, June 2014, ASM Journals

    Professor Kazuya Yamanaka

  16. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

    Article • Proceedings of the National Academy of Sciences, January 2014, Proceedings of the National Academy of Sciences

    Professor Kazuya Yamanaka

  17. Mutational analysis of the three tandem domains of ε-poly-l-lysine synthetase catalyzing the l-lysine polymerization reaction

    Article • Journal of Bioscience and Bioengineering, May 2013, Elsevier

    Professor Kazuya Yamanaka

  18. Structures and Comparative Characterization of Biosynthetic Gene Clusters for Cyanosporasides, Enediyne-Derived Natural Products from Marine Actinomycetes

    Article • Journal of the American Chemical Society, March 2013, American Chemical Society (ACS)

    Professor Kazuya Yamanaka

  19. Flavoenzyme-Catalyzed Atropo-Selective N,C -Bipyrrole Homocoupling in Marinopyrrole Biosynthesis

    Article • Journal of the American Chemical Society, August 2012, American Chemical Society (ACS)

    Professor Kazuya Yamanaka

  20. Development of a recombinant ε-poly-L-lysine synthetase expression system to perform mutational analysis

    Article • Journal of Bioscience and Bioengineering, June 2011, Elsevier

    Professor Kazuya Yamanaka

  21. Mechanism of ε-Poly-l-Lysine Production and Accumulation Revealed by Identification and Analysis of an ε-Poly-l-Lysine-Degrading Enzyme

    Article • Applied and Environmental Microbiology, July 2010, ASM Journals

    Professor Kazuya Yamanaka

  22. Biotechnological Production of Poly-Epsilon-l-Lysine for Food and Medical Applications

    Article • January 2010, Springer Science + Business Media

    Professor Kazuya Yamanaka

  23. ε-Poly-L-lysine dispersity is controlled by a highly unusual nonribosomal peptide synthetase

    Article • Nature Chemical Biology, November 2008, Springer Science + Business Media

    Professor Kazuya Yamanaka

  24. Thermostable aldehyde dehydrogenase from psychrophile, Cytophaga sp. KUC-1: enzymological characteristics and functional properties

    Article • Biochemical and Biophysical Research Communications, November 2002, Elsevier

    Professor Kazuya Yamanaka

  25. Psychrophilic valine dehydrogenase of the antarctic psychrophile, 
Cytophaga sp. KUC-1

    Article • European Journal of Biochemistry, August 2001, Wiley

    Professor Kazuya Yamanaka