All Stories

  1. Analysis of discrepancy in SNEDDS performance for a “brick dust” mebendazole between in-vitro and in-vivo estimation

    Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2026, Elsevier

    Kazutaka Higaki

  2. EGF-induced P-gp expression in tumor vasculature contributes to therapeutic resistance to doxorubicin-PEG-liposomes in mice bearing doxorubicin-resistant B16-BL6 tumors

    Article • Journal of Drug Delivery Science and Technology, April 2025, Elsevier

    Kazutaka Higaki

  3. Repeated sequential administration of pegylated emulsion of SU5416 and liposomal paclitaxel enhances anti-tumor effect in 4T1 breast cancer-bearing mice

    Article • European Journal of Pharmaceutics and Biopharmaceutics, April 2025, Elsevier

    Kazutaka Higaki

  4. Dynamic changes in the distribution equilibrium of drugs in microemulsions associated with drug absorption facilitate the absorption improvement for drugs with low water-solubility by self-microemulsifying drug delivery system (SMEDDS)

    Article • International Journal of Pharmaceutics, April 2025, Elsevier

    Kazutaka Higaki

  5. In vivo systemic evaluation of nasal drug absorption from powder formulations in rats

    Article • European Journal of Pharmaceutics and Biopharmaceutics, February 2025, Elsevier

    Kazutaka Higaki

  6. Specific intermolecular interaction with sodium glycocholate generates the co-amorphous system showing higher physical stability and aqueous solubility of Y5 receptor antagonist of neuropeptide Y, a brick dust molecule

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2024, Elsevier

    Kazutaka Higaki

  7. Vascular normalization with pegylated emulsion of SU5416 enhances anti-tumor effect of liposomal paclitaxel in 4T1 breast cancer-bearing mice: Analysis of intratumoral vessels and microenvironment

    Article • Journal of Drug Delivery Science and Technology, June 2024, Elsevier

    Kazutaka Higaki

  8. Combination of co-amorphization with SNEDDS outperforms Ofev® in the oral absorption of nintedanib

    Article • International Journal of Pharmaceutics, May 2024, Elsevier

    Kazutaka Higaki

  9. Development of Sustained Release System Based on High Water-Absorbable Gel Formation Using Croscarmellose Sodium, Alkaline Excipients and HPMC (ACSH SR System); Novel Application of Croscarmellose Sodium as a Gel Former

    Article • Pharmaceutical Research, November 2023, Springer Science + Business Media

    Kazutaka Higaki

  10. Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers

    Article • Journal of Pharmaceutical Sciences, November 2023, Elsevier

    Kazutaka Higaki

  11. Improvement and characterization of oral absorption behavior of clofazimine by SNEDDS: Quantitative evaluation of extensive lymphatic transport

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2023, Elsevier

    Kazutaka Higaki

  12. Characterization and Interconversion of Two Crystal Forms of NEt-3IB, a Retinoid X Receptor Agonist

    Article • Chemical and Pharmaceutical Bulletin, April 2023, Pharmaceutical Society of Japan

    Kazutaka Higaki

  13. Establishment of a novel in vitro co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs

    Article • International Journal of Pharmaceutics, February 2023, Elsevier

    Kazutaka Higaki

  14. In vivo distribution characteristics and anti-tumor effects of doxorubicin encapsulated in PEG-modified niosomes in solid tumor-bearing mice

    Article • Journal of Drug Delivery Science and Technology, February 2023, Elsevier

    Kazutaka Higaki

  15. Formation of a Stable Co-Amorphous System for a Brick Dust Molecule by Utilizing Sodium Taurocholate with High Glass Transition Temperature

    Article • Pharmaceutics, December 2022, MDPI AG

    Kazutaka Higaki

  16. Analysis of absorption-enhancing mechanisms for combinatorial use of spermine with sodium taurocholate in Caco-2 cells

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2022, Elsevier

    Kazutaka Higaki

  17. Efficient Evaluation of In Vivo Performance in Human for Generic Formulation by Novel Dissolution-Absorption Prediction (DAP) Workflow

    Article • Pharmaceutical Research, July 2022, Springer Science + Business Media

    Kazutaka Higaki

  18. Effect of Excessive Serotonin on Pharmacokinetics of Cephalexin after Oral Administration: Studies with Serotonin-Excessive Model Rats

    Article • Pharmaceutical Research, July 2022, Springer Science + Business Media

    Kazutaka Higaki

  19. Effects of particle size and release property of paclitaxel-loaded nanoparticles on their peritoneal retention and therapeutic efficacy against mouse malignant ascites

    Article • International Journal of Pharmaceutics, July 2022, Elsevier

    Kazutaka Higaki

  20. Extensive improvement of oral bioavailability of mebendazole, a brick dust, by polymer-containing SNEDDS preparation: Disruption of high crystallinity by utilizing its counter ion

    Article • European Journal of Pharmaceutics and Biopharmaceutics, March 2022, Elsevier

    Kazutaka Higaki

  21. Effect of Doxorubicin Release Rate From Polyethylene Glycol-Modified Liposome on Anti-tumor Activity in B16-BL6 Tumor-Bearing Mice

    Article • Journal of Pharmaceutical Sciences, February 2022, Elsevier

    Kazutaka Higaki

  22. Possible Regulation of P-glycoprotein Function by Adrenergic Agonists in a Vascular-luminal Perfused Preparation of Small Intestine

    Article • Journal of Pharmaceutical Sciences, December 2021, Elsevier

    Kazutaka Higaki

  23. Sequential administration of PEG-Span 80 niosome enhances anti-tumor effect of doxorubicin-containing PEG liposome

    Article • European Journal of Pharmaceutics and Biopharmaceutics, December 2021, Elsevier

    Kazutaka Higaki

  24. Spermine with Sodium Taurocholate Enhances Pulmonary Absorption of Macromolecules in Rats

    Article • Journal of Pharmaceutical Sciences, October 2021, Elsevier

    Kazutaka Higaki

  25. Improvement of lipid solubility and oral bioavailability of a poorly water- and poorly lipid-soluble drug, rebamipide, by utilizing its counter ion and SNEDDS preparation

    Article • European Journal of Pharmaceutical Sciences, April 2021, Elsevier

    Kazutaka Higaki

  26. Pharmacokinetic analysis of new synthetic antimalarial N-251

    Article • Tropical Medicine and Health, July 2019, Springer Science + Business Media

    Kazutaka Higaki

  27. Quantitative Estimation of the Effect of Nasal Mucociliary Function on in Vivo Absorption of Norfloxacin after Intranasal Administration to Rats

    Article • Molecular Pharmaceutics, August 2018, American Chemical Society (ACS)

    Kazutaka Higaki

  28. The relationship between in vivo nasal drug clearance and in vitro nasal mucociliary clearance: Application to the prediction of nasal drug absorption

    Article • European Journal of Pharmaceutical Sciences, May 2018, Elsevier

    Kazutaka Higaki

  29. Development of extended-release solid dispersion granules of tacrolimus: evaluation of release mechanism and human oral bioavailability

    Article • Journal of Pharmacy and Pharmacology, September 2017, Wiley

    Kazutaka Higaki

  30. Development of Safe and Potent Oil-in-Water Emulsion of Paclitaxel to Treat Peritoneal Dissemination

    Article • Journal of Pharmaceutical Sciences, April 2017, Elsevier

    Kazutaka Higaki

  31. Evaluation of pharmacokinetic/pharmacodynamic indices of topical ophthalmic gatifloxacin against Staphylococcus aureus utilising an in vitro aqueous humour pharmacokinetic model

    Article • International Journal of Antimicrobial Agents, January 2017, Elsevier

    Kazutaka Higaki

  32. Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers

    Article • Biomarkers, November 2016, Taylor & Francis

    Kazutaka Higaki

  33. In-vivo disposition characteristics of PEG niosome and its interaction with serum proteins

    Article • International Journal of Pharmaceutics, October 2016, Elsevier

    Kazutaka Higaki

  34. Preparation of extended release solid dispersion formulations of tacrolimus using ethylcellulose and hydroxypropylmethylcellulose by solvent evaporation method

    Article • Journal of Pharmacy and Pharmacology, January 2016, Oxford University Press (OUP)

    Kazutaka Higaki

  35. Efficient anti-tumor effect of photodynamic treatment with polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer encapsulating hydrophobic porphyrin derivative

    Article • European Journal of Pharmaceutical Sciences, January 2016, Elsevier

    Kazutaka Higaki

  36. Analysis of Intra- and Intersubject Variability in Oral Drug Absorption in Human Bioequivalence Studies of 113 Generic Products

    Article • Molecular Pharmaceutics, November 2015, American Chemical Society (ACS)

    Kazutaka Higaki

  37. Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System

    Article • Pharmaceutical Research, February 2015, Springer Science + Business Media

    Kazutaka Higaki

  38. Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature

    Article • Journal of Controlled Release, February 2015, Elsevier

    Kazutaka Higaki

  39. A novel approach to overcome multidrug resistance: Utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors

    Article • European Journal of Pharmaceutical Sciences, October 2014, Elsevier

    Kazutaka Higaki

  40. Determinants for In Vivo Antitumor Effect of Angiogenesis Inhibitor SU5416 Formulated in PEGylated Emulsion

    Article • Journal of Pharmaceutical Sciences, August 2014, Elsevier

    Kazutaka Higaki

  41. Assessment of Tacrolimus Absorption From the Human Intestinal Tract: Open-Label, Randomized, 4-Way Crossover Study

    Article • Clinical Therapeutics, May 2014, Elsevier

    Kazutaka Higaki

  42. Pharmacokinetics and Safety of Resveratrol Derivatives in Humans after Oral Administration of Melinjo (Gnetum gnemon L.) Seed Extract Powder

    Article • Journal of Agricultural and Food Chemistry, February 2014, American Chemical Society (ACS)

    Kazutaka Higaki

  43. Development of transdermal therapeutic formulation of CNS5161, a novel NMDA receptor antagonist, by utilizing pressure-sensitive adhesives II: Improved transdermal absorption and evaluation of efficacy and safety

    Article • European Journal of Pharmaceutical Sciences, February 2014, Elsevier

    Kazutaka Higaki

  44. Regulation system of serine protease production in Vibrio vulnificus strain NCIMB 2137, a metalloprotease-gene negative strain isolated from a diseased eel

    Article • Aquaculture, December 2013, Elsevier

    Kazutaka Higaki

  45. Effects of temperature, growth phase and luxO-disruption on regulation systems of toxin production in Vibrio vulnificus strain L-180, a human clinical isolate

    Article • World Journal of Microbiology and Biotechnology, September 2013, Springer Science + Business Media

    Kazutaka Higaki

  46. Aminoalkylmethacrylate copolymer E improves oral bioavailability of YM466 by suppressing drug–bile interaction

    Article • Journal of Pharmaceutical Sciences, September 2013, Elsevier

    Kazutaka Higaki

  47. Establishment of Novel Prediction System of Intestinal Absorption in Humans Using Human Intestinal Tissues

    Article • Journal of Pharmaceutical Sciences, August 2013, Elsevier

    Kazutaka Higaki

  48. <i>In Vitro</i> Evaluation of the Ciliary Beat Frequency of the Rat Nasal Epithelium Using a High-Speed Digital Imaging System

    Article • Biological and Pharmaceutical Bulletin, January 2013, Pharmaceutical Society of Japan

    Kazutaka Higaki

  49. Deeper Penetration into Tumor Tissues and Enhanced in Vivo Antitumor Activity of Liposomal Paclitaxel by Pretreatment with Angiogenesis Inhibitor SU5416

    Article • Molecular Pharmaceutics, November 2012, American Chemical Society (ACS)

    Kazutaka Higaki

  50. Novel Comb-Shaped PEG Modification Enhances the Osteoclastic Inhibitory Effect and Bone Delivery of Osteoprotegerin After Intravenous Administration in Ovariectomized Rats

    Article • Pharmaceutical Research, June 2012, Springer Science + Business Media

    Kazutaka Higaki

  51. Evaluation of Factors Affecting Gastrointestinal Absorption of a Novel Anticoagulant FX-93 for Development of Oral Formulation

    Article • Journal of Pharmaceutical Sciences, June 2012, Elsevier

    Kazutaka Higaki

  52. Formulation and Evaluation of Paclitaxel-Loaded Polymeric Nanoparticles Composed of Polyethylene Glycol and Polylactic Acid Block Copolymer

    Article • Biological and Pharmaceutical Bulletin, January 2012, Pharmaceutical Society of Japan

    Kazutaka Higaki

  53. Development of Transdermal Therapeutic Formulation of CNS5161, a Novel N-Methyl-D-aspartate Receptor Antagonist, by Utilizing Pressure-Sensitive Adhesives I

    Article • Biological and Pharmaceutical Bulletin, January 2012, Pharmaceutical Society of Japan

    Kazutaka Higaki

  54. <i>In Vitro</i> Evaluation of Nasal Mucociliary Clearance Using Excised Rat Nasal Septum

    Article • Biological and Pharmaceutical Bulletin, January 2012, Pharmaceutical Society of Japan

    Kazutaka Higaki

  55. Antimalarial activity of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and its carboxylic acid derivatives

    Article • Parasitology International, December 2011, Elsevier

    Kazutaka Higaki

  56. Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol

    Article • Parasitology International, September 2011, Elsevier

    Dr Satoru Kawai, Kazutaka Higaki

  57. Sex differences in pharmacokinetics of cilostazol in rats

    Article • Xenobiotica, July 2011, Taylor & Francis

    Kazutaka Higaki

  58. Design and Evaluation of Emulsion Generation Device Using Ultrasonic Vibration and Microchannel

    Article • Japanese Journal of Applied Physics, July 2011, Institute of Physics Publishing

    Kazutaka Higaki

  59. PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy

    Article • International Journal of Pharmaceutics, June 2011, Elsevier

    Kazutaka Higaki

  60. Emulsion Generating Microchannel Device Oscillated by 2.25 MHz Ultrasonic Vibrator

    Article • Japanese Journal of Applied Physics, July 2010, Institute of Physics Publishing

    Kazutaka Higaki

  61. Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer

    Article • Journal of Pharmaceutical Sciences, December 2009, Elsevier

    Kazutaka Higaki

  62. Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells

    Article • International Journal of Pharmaceutics, February 2009, Elsevier

    Kazutaka Higaki

  63. Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers

    Article • International Journal of Pharmaceutics, February 2009, Elsevier

    Kazutaka Higaki

  64. In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells

    Article • Journal of Controlled Release, January 2009, Elsevier

    Kazutaka Higaki

  65. Quantitative Evaluation of PEPT1 Contribution to Oral Absorption of Cephalexin in Rats

    Article • Pharmaceutical Research, September 2008, Springer Science + Business Media

    Kazutaka Higaki

  66. Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humans

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2008, Elsevier

    Kazutaka Higaki

  67. In vitro–in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol

    Article • Journal of Controlled Release, August 2008, Elsevier

    Kazutaka Higaki

  68. Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers

    Article • International Journal of Pharmaceutics, July 2008, Elsevier

    Kazutaka Higaki

  69. Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: Importance of vascular permeability within tumors

    Article • International Journal of Pharmaceutics, July 2008, Elsevier

    Kazutaka Higaki

  70. Effect of percutaneous endoscopic gastrostomy on gastrointestinal motility: evaluation by gastric-emptying scintigraphy

    Article • Nuclear Medicine Communications, June 2008, Wolters Kluwer Health

    Kazutaka Higaki

  71. Correlation between Cyclosporine Blood Concentration-Dose Ratio and Biochemical Parameters in Living-Donor Lung Transplant Patients

    Article • Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), January 2008, Japanese Society of Pharmaceutical Health Care and Sciences

    Kazutaka Higaki

  72. Safe Improvement of Drug Absorption by Combinatorial Use of Sodium Laurate with Amino Acids: Cytoprotection by Amino Acids and Its Mechanisms

    Article • ChemInform, August 2007, Wiley

    Kazutaka Higaki

  73. Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition

    Article • International Journal of Pharmaceutics, February 2007, Elsevier

    Kazutaka Higaki

  74. Safe Improvement of Drug Absorption by Combinatorial Use of Sodium Laurate with Amino Acids: Cytoprotection by Amino Acids and Its Mechanisms

    Article • YAKUGAKU ZASSHI, January 2007, Pharmaceutical Society of Japan

    Kazutaka Higaki

  75. Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer

    Article • Journal of Pharmaceutical Sciences, October 2006, Elsevier

    Kazutaka Higaki

  76. Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption

    Article • Journal of Controlled Release, October 2006, Elsevier

    Kazutaka Higaki

  77. Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): In vivo evaluation

    Article • Journal of Controlled Release, May 2006, Elsevier

    Kazutaka Higaki

  78. Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine

    Article • Journal of Controlled Release, November 2005, Elsevier

    Kazutaka Higaki

  79. Regulation of Drug Absorption from Small Intestine by Enteric Nervous System I: a Poorly Absorbable Drug Via Passive Diffusion

    Article • Drug Metabolism and Pharmacokinetics, January 2004, Japanese Society for the Study of Xenobiotics

    Kazutaka Higaki

  80. Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium

    Article • Journal of Pharmaceutical Sciences, March 2002, Elsevier

    Kazutaka Higaki

  81. Amino Acids Protect Epithelial Cells From Local Toxicity by Absorption Enhancer, Sodium Laurate

    Article • Journal of Pharmaceutical Sciences, October 2001, Elsevier

    Kazutaka Higaki