All Stories

  1. Enhanced neoangiogenesis and balance of the immune response mediated by the Wilms' tumor suppressor WT1 favor repair after myocardial infarction

    Article • Theranostics, June 2025, Ivyspring International Publisher

    Kay-Dietrich Wagner

  2. Recent Insights into the Role of PPARs in Disease

    Article • Cells, June 2023, MDPI AG

    Kay-Dietrich Wagner

  3. Molecular Mechanisms of Cardiac Development and Disease

    Article • International Journal of Molecular Sciences, May 2023, MDPI AG

    Kay-Dietrich Wagner

  4. Cardiomyocyte-Specific Wt1 Is Involved in Cardiac Metabolism and Response to Damage

    Article • Journal of Cardiovascular Development and Disease, May 2023, MDPI AG

    Kay-Dietrich Wagner

  5. The Senescence Marker p16Ink4a—A Player of Liver Endothelial Cells Physiology

    Article • March 2023, MDPI AG

    Kay-Dietrich Wagner

  6. Controversies and Recent Advances in Senescence and Aging

    Article • Cells, March 2023, MDPI AG

    Kay-Dietrich Wagner

  7. Pharmacological Utility of PPAR Modulation for Angiogenesis in Cardiovascular Disease

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Kay-Dietrich Wagner

  8. Editorial (Preface) “Cells/Cells of the Cardiovascular System—Editorial Highlights 2020–2021: The Book Selection”

    Article • Cells, December 2022, MDPI AG

    Kay-Dietrich Wagner

  9. P16INK4A—More Than a Senescence Marker

    Article • Life, August 2022, MDPI AG

    Kay-Dietrich Wagner

  10. Peroxisome Proliferator-Activated Receptors and the Hallmarks of Cancer

    Article • Cells, August 2022, MDPI AG

    Kay-Dietrich Wagner

  11. The Editor’s Choice Articles—Section “Cells of the Cardiovascular System” 2020–2021

    Article • Cells, July 2022, MDPI AG

    Kay-Dietrich Wagner

  12. The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis

    Article • Cells, June 2022, MDPI AG

    Kay-Dietrich Wagner

  13. Transcriptional Regulation of Cardiac Development and Disease

    Article • International Journal of Molecular Sciences, March 2022, MDPI AG

    Kay-Dietrich Wagner

  14. Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging

    Article • Cells, February 2022, MDPI AG

    Kay-Dietrich Wagner

  15. Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction

    Article • eLife, October 2021, eLife

    Kay-Dietrich Wagner

  16. Every Beat You Take—The Wilms′ Tumor Suppressor WT1 and the Heart

    Article • International Journal of Molecular Sciences, July 2021, MDPI AG

    Kay-Dietrich Wagner

  17. Implications of the Wilms’ Tumor Suppressor Wt1 in Cardiomyocyte Differentiation

    Article • International Journal of Molecular Sciences, April 2021, MDPI AG

    Kay-Dietrich Wagner

  18. Small Activating RNAs: Towards the Development of New Therapeutic Agents and Clinical Treatments

    Article • Cells, March 2021, MDPI AG

    Kay-Dietrich Wagner

  19. PPARs and Myocardial Infarction

    Article • International Journal of Molecular Sciences, December 2020, MDPI AG

    Kay-Dietrich Wagner

  20. Direct activation of RA signaling in cardiomyocytes protects hearts from apoptosis after myocardial infarction in mice

    Article • December 2020, Cold Spring Harbor Laboratory Press

    Kay-Dietrich Wagner

  21. WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, December 2020, Elsevier

    Kay-Dietrich Wagner

  22. The Role of PPARs in Disease

    Article • Cells, October 2020, MDPI AG

    Kay-Dietrich Wagner

  23. The Emerging Role of PPAR Beta/Delta in Tumor Angiogenesis

    Article • PPAR Research, August 2020, Hindawi Publishing Corporation

    Kay-Dietrich Wagner

  24. PPARs and Angiogenesis—Implications in Pathology

    Article • International Journal of Molecular Sciences, August 2020, MDPI AG

    Kay-Dietrich Wagner

  25. Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

    Article • Cell Metabolism, July 2020, Elsevier

    Kay-Dietrich Wagner

  26. Context-dependent regulation of endothelial cell metabolism: differential effects of the PPARβ/δ agonist GW0742 and VEGF-A

    Article • Scientific Reports, May 2020, Springer Science + Business Media

    Kay-Dietrich Wagner

  27. PPAR Beta/Delta and the Hallmarks of Cancer

    Article • Cells, May 2020, MDPI AG

    Kay-Dietrich Wagner

  28. Vascular PPARβ/δ Promotes Tumor Angiogenesis and Progression

    Article • Cells, December 2019, MDPI AG

    Kay-Dietrich Wagner

  29. Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1

    Article • Cells, January 2019, MDPI AG

    Kay-Dietrich Wagner

  30. Erratum to “Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor Beta/Delta Leads to Rapid Cardiac Hypertrophy”

    Article • PPAR Research, October 2018, Hindawi Publishing Corporation

    Kay-Dietrich Wagner

  31. Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4

    Article • Developmental Biology, September 2018, Elsevier

    Kay-Dietrich Wagner

  32. Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

    Article • Journal of Visualized Experiments, October 2017, MyJove Corporation

    Kay-Dietrich Wagner

  33. Andersen’s syndrome mutants produce a knockdown of inwardly rectifying K+ channel in mouse skeletal muscle in vivo

    Article • Cell and Tissue Research, October 2017, Springer Science + Business Media

    Kay-Dietrich Wagner

  34. Coronary Artery Formation Is Driven by Localized Expression of R-spondin3

    Article • Cell Reports, August 2017, Elsevier

    Kay-Dietrich Wagner

  35. CDK9 Regulates Apoptosis of Myoblast Cells by Modulation of microRNA-1 Expression

    Article • Journal of Cellular Biochemistry, July 2017, Wiley

    Dr Hossein GHANBARIAN, Kay-Dietrich Wagner

  36. The differential spatiotemporal expression pattern of shelterin genes throughout lifespan

    Article • Aging, April 2017, Impact Journals, LLC

    Kay-Dietrich Wagner

  37. Small RNA-directed epigenetic programming of embryonic stem cell cardiac differentiation

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Kay-Dietrich Wagner

  38. Dnmt2 in Cardiac Growth: RNA Polymerase II and tRNA Methylation

    Article • PLOS One, June 2016, PLOS

    Kay-Dietrich Wagner

  39. RNA Activation of the Vascular Endothelial Growth Factor Gene ( VEGF ) Promoter by Double-Stranded RNA and Hypoxia: Role of Noncoding VEGF Promoter Transcripts

    Article • Molecular and Cellular Biology, May 2016, ASM Journals

    Kay-Dietrich Wagner

  40. Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio–venous connections

    Article • Proceedings of the National Academy of Sciences, January 2016, Proceedings of the National Academy of Sciences

    Kay-Dietrich Wagner

  41. Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor Beta/Delta Leads to Rapid Cardiac Hypertrophy

    Article • PPAR Research, January 2016, Hindawi Publishing Corporation

    Kay-Dietrich Wagner

  42. TRF2 acts as a transcriptional regulator in tumor angiogenesis

    Article • Molecular & Cellular Oncology, January 2015, Taylor & Francis

    Kay-Dietrich Wagner

  43. The Wilms’ tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression

    Article • Nature Communications, December 2014, Springer Science + Business Media

    Kay-Dietrich Wagner

  44. The Telomeric Protein TRF2 Regulates Angiogenesis by Binding and Activating the PDGFRβ Promoter

    Article • Cell Reports, November 2014, Elsevier

    Kay-Dietrich Wagner

  45. Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14α-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome

    Article • Journal of Biological Chemistry, August 2011, Elsevier

    Kay-Dietrich Wagner

  46. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is highly expressed in liposarcoma and promotes migration and proliferation

    Article • The Journal of Pathology, May 2011, Wiley

    Kay-Dietrich Wagner

  47. The podocyte protein nephrin is required for cardiac vessel formation

    Article • Human Molecular Genetics, March 2011, Oxford University Press (OUP)

    Kay-Dietrich Wagner

  48. Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

    Article • Pharmacology & Therapeutics, March 2010, Elsevier

    Kay-Dietrich Wagner

  49. The miR-124-Sox9 paramutation: RNA-mediated epigenetic control of embryonic and adult growth

    Article • Development, November 2009, The Company of Biologists

    Valerie Grandjean, Kay-Dietrich Wagner

  50. Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin

    Article • Cardiovascular Research, April 2009, European Society of Cardiology

    Kay-Dietrich Wagner

  51. Role of the Wilms’ tumour transcription factor, Wt1, in blood vessel formation

    Article • Pflügers Archiv - European Journal of Physiology, December 2008, Springer Science + Business Media

    Kay-Dietrich Wagner

  52. A novel Wilms’ tumor 1 gene mutation in a child with severe renal dysfunction and persistent renal blastema

    Article • Pediatric Nephrology, September 2008, Springer Science + Business Media

    Kay-Dietrich Wagner

  53. RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

    Article • Developmental Cell, June 2008, Elsevier

    Dr Hossein GHANBARIAN, Valerie Grandjean, Kay-Dietrich Wagner

  54. The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivo

    Article • Oncogene, January 2008, Springer Science + Business Media

    Kay-Dietrich Wagner

  55. The Wilms’ tumor suppressor WT1 is associated with melanoma proliferation

    Article • Pflügers Archiv - European Journal of Physiology, October 2007, Springer Science + Business Media

    Kay-Dietrich Wagner

  56. Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1

    Article • AJP Regulatory Integrative and Comparative Physiology, September 2006, American Physiological Society

    Kay-Dietrich Wagner

  57. The Wilms Tumor Suppressor Wt1 Promotes Cell Adhesion through Transcriptional Activation of the α4integrinGene

    Article • Journal of Biological Chemistry, August 2006, Elsevier

    Kay-Dietrich Wagner

  58. An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis

    Article • Current Biology, April 2006, Elsevier

    Kay-Dietrich Wagner

  59. Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1

    Article • Genes & Development, November 2005, Cold Spring Harbor Laboratory Press

    Kay-Dietrich Wagner

  60. A splice variant of the Wilms' tumour suppressorWt1is required for normal development of the olfactory system

    Article • Development, March 2005, The Company of Biologists

    Kay-Dietrich Wagner

  61. The Major Podocyte Protein Nephrin Is Transcriptionally Activated by the Wilms’ Tumor Suppressor WT1

    Article • Journal of the American Society of Nephrology, December 2004, Wolters Kluwer Health

    Kay-Dietrich Wagner

  62. 1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax

    Article • Experimental Eye Research, July 2003, Elsevier

    Kay-Dietrich Wagner

  63. The long-lasting impact of postnatal neuropeptide Y

    Article • AJP Regulatory Integrative and Comparative Physiology, June 2003, American Physiological Society

    Kay-Dietrich Wagner

  64. Characterization of stretch-activated ion currents in isolated atrial myocytes from human hearts

    Article • Pflügers Archiv - European Journal of Physiology, June 2003, Springer Science + Business Media

    Kay-Dietrich Wagner

  65. Oxygen‐regulated expression of the Wilms’ tumor suppressorWt1involves hypoxia‐inducible factor‐1 (HIF‐1)

    Article • The FASEB Journal, May 2003, Wiley

    Kay-Dietrich Wagner

  66. Cardiac fibroblasts and the mechano-electric feedback mechanism in healthy and diseased hearts

    Article • Progress in Biophysics and Molecular Biology, May 2003, Elsevier

    Kay-Dietrich Wagner

  67. The complex life of WT1

    Article • Journal of Cell Science, May 2003, The Company of Biologists

    Kay-Dietrich Wagner

  68. Mechanically induced potentials in atrial fibroblasts from rat hearts are sensitive to hypoxia/reoxygenation

    Article • Pflügers Archiv - European Journal of Physiology, March 2003, Springer Science + Business Media

    Kay-Dietrich Wagner

  69. The Wilms’ tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b)

    Article • Gene, February 2003, Elsevier

    Kay-Dietrich Wagner

  70. Transgenic overexpression of the sarcoplasmic reticulum Ca 2+ ATPase improves reticular Ca 2+ handling in normal and diabetic rat hearts

    Article • The FASEB Journal, August 2002, Wiley

    Kay-Dietrich Wagner

  71. Decreased susceptibility of cardiac function to hypoxia-reoxygenation in renin-angiotensinogen transgenic rats

    Article • AJP Regulatory Integrative and Comparative Physiology, July 2002, American Physiological Society

    Kay-Dietrich Wagner

  72. The Wilms' tumor suppressorWt1is expressed in the coronary vasculature after myocardial infarction

    Article • The FASEB Journal, May 2002, Wiley

    Kay-Dietrich Wagner

  73. The Wilms' tumor geneWt1is required for normal development of the retina

    Article • The EMBO Journal, March 2002, Wiley

    Kay-Dietrich Wagner

  74. A possible role for atrial fibroblasts in postinfarction bradycardia

    Article • AJP Heart and Circulatory Physiology, March 2002, American Physiological Society

    Kay-Dietrich Wagner

  75. Article • Molecular and Cellular Biochemistry, January 2002, Springer Science + Business Media

    Kay-Dietrich Wagner

  76. Myocardial adrenergic dysfunction in rats with transgenic, human renin-dependent hypertension

    Article • Journal of Hypertension, August 2001, Wolters Kluwer Health

    Kay-Dietrich Wagner

  77. Mechanically induced potentials in rat atrial fibroblasts depend on actin and tubulin polymerisation

    Article • Pflügers Archiv - European Journal of Physiology, July 2001, Springer Science + Business Media

    Kay-Dietrich Wagner

  78. Activation of Vitamin D Receptor by the Wilms' Tumor GeneProduct Mediates Apoptosis of Renal Cells

    Article • Journal of the American Society of Nephrology, June 2001, Wolters Kluwer Health

    Kay-Dietrich Wagner

  79. Article • Molecular and Cellular Biochemistry, January 2001, Springer Science + Business Media

    Kay-Dietrich Wagner

  80. Tie2 Receptor Expression Is Stimulated by Hypoxia and Proinflammatory Cytokines in Human Endothelial Cells

    Article • Circulation Research, September 2000, Wolters Kluwer Health

    Kay-Dietrich Wagner

  81. Oxygen Radical System in Chronic Infarcted Rat Heart: The Effect of Combined Beta Blockade and ACE Inhibition

    Article • Journal of Cardiovascular Pharmacology, May 2000, Wolters Kluwer Health

    Kay-Dietrich Wagner

  82. Mechano-Electric Feedback in Right Atrium After Left Ventricular Infarction in Rats

    Article • Journal of Molecular and Cellular Cardiology, March 2000, Elsevier

    Kay-Dietrich Wagner

  83. Mechanoelectric feedback after left ventricular infarction in rats

    Article • Cardiovascular Research, January 2000, European Society of Cardiology

    Kay-Dietrich Wagner

  84. Article • Cardiovascular Drugs and Therapy, January 2000, Springer Science + Business Media

    Kay-Dietrich Wagner

  85. Mechanically Induced Potentials in Fibroblasts from Human Right Atrium

    Article • Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, March 1999, Wiley

    Kay-Dietrich Wagner

  86. Mechanically induced potentials in fibroblasts from human right atrium

    Article • Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, March 1999, Wiley

    Kay-Dietrich Wagner

  87. Decreased Susceptibility of Contractile Function to Hypoxia/Reoxygenation in Chronic Infarcted Rat Hearts

    Article • Journal of Molecular and Cellular Cardiology, November 1998, Elsevier

    Kay-Dietrich Wagner

  88. Electrophysiological Properties of Mechanosensitive Atrial Fibroblasts From Chronic Infarcted Rat Heart

    Article • Journal of Molecular and Cellular Cardiology, June 1998, Elsevier

    Kay-Dietrich Wagner

  89. Contractile Function of Papillary Muscle From Rats With Different Infarct Size Afterβ-Adrenergic Blockade and ACE-inhibition

    Article • Journal of Molecular and Cellular Cardiology, November 1997, Elsevier

    Kay-Dietrich Wagner

  90. Effects of hypoxia, simulated ischemia and reoxygenation on the contractile function of human atrial trabeculae

    Article • Molecular and Cellular Biochemistry, January 1996, Springer Science + Business Media

    Kay-Dietrich Wagner