All Stories

  1. lncRNA MANCR isoforms selectively mediate multiple levels of epigenomic and P53-responsive transcriptional control in triple negative breast cancer

    Article • April 2026, openRxiv

    Dr Karen C Glass

  2. Cryo-EM Structure of Human ATAD2B Reveals a Hexameric Organization Contributes to ATPase Activity and Substrate Coordination

    Article • April 2026, openRxiv

    Dr Karen C Glass

  3. Unraveling the complexity of the histone code: implications for gene regulation and disease

    Article • Genome Biology, March 2026, Springer Science + Business Media

    Dr Karen C Glass

  4. Practical guide for moving from X‑ray crystallography to cryo‑EM for structural biology

    Article • Acta Crystallographica Section D Structural Biology, February 2026, International Union of Crystallography

    Dr Karen C Glass, Karen C. Glass

  5. Breaking Barriers: Transitioning from X-ray Crystallography to Cryo-EM for Structural Studies of ATAD2B

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Dr Karen C Glass

  6. A needed nomenclature for nucleosomes

    Article • Molecular Cell, October 2025, Elsevier

    Dr Karen C Glass

  7. Mitotic bookmarking provides epigenetic persistence or plasticity for biological control and cancer

    Article • Biochemistry and Cell Biology, January 2025, Canadian Science Publishing

    Dr Karen C Glass

  8. Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer

    Article • January 2025, Springer Science + Business Media

    Dr Karen C Glass

  9. The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands

    Article • December 2024, Cold Spring Harbor Laboratory Press

    Dr Karen C Glass

  10. Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan

    Article • Journal of Inorganic Biochemistry, September 2024, Elsevier

    Dr Karen C Glass

  11. Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains

    Article • Journal of Medicinal Chemistry, May 2024, American Chemical Society (ACS)

    Dr Karen C Glass

  12. peaksat: an R package for ChIP-seq peak saturation analysis

    Article • BMC Genomics, January 2023, Springer Science + Business Media

    Dr Karen C Glass

  13. Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparum

    Article • International Journal of Biological Macromolecules, December 2022, Elsevier

    Dr Karen C Glass

  14. Functional networks of the human bromodomain-containing proteins

    Article • Frontiers in Bioinformatics, August 2022, Frontiers

    Dr Karen C Glass

  15. Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype

    Article • January 2022, Springer Science + Business Media

    Dr Karen C Glass, Dr. Andre J van Wijnen

  16. Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle

    Article • January 2022, Springer Science + Business Media

    Dr Karen C Glass, Dr. Andre J van Wijnen

  17. Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison

    Article • International Journal of Molecular Sciences, September 2021, MDPI AG

    Dr Karen C Glass

  18. Coordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Dr Karen C Glass

  19. Functional Roles of Bromodomain Proteins in Cancer

    Article • Cancers, July 2021, MDPI AG

    Dr Karen C Glass

  20. Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism

    Article • Molecular Pharmacology, November 2020, Elsevier

    Dr Karen C Glass

  21. Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain

    Article • Journal of Medicinal Chemistry, October 2020, American Chemical Society (ACS)

    Dr Karen C Glass

  22. The BRPF1 bromodomain is a molecular reader of di-acetyllysine

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Dr Karen C Glass

  23. The BRPF1 bromodomain is a molecular reader of di-acetyllysine

    Article • Current Research in Structural Biology, January 2020, Elsevier

    Dr Karen C Glass

  24. Cover Image, Volume 87, Issue 2

    Article • Proteins Structure Function and Bioinformatics, January 2019, Wiley

    Dr Karen C Glass

  25. Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain

    Article • Proteins Structure Function and Bioinformatics, December 2018, Wiley

    Dr Karen C Glass

  26. Student-directed interactive animation for learning cytochrome P450-mediated drug metabolism

    Article • Currents in Pharmacy Teaching and Learning, December 2018, Elsevier

    Dr Karen C Glass

  27. Structural insights into the recognition of mono- and di-acetyllysine by the ATAD2B bromodomain

    Article • February 2018, Cold Spring Harbor Laboratory Press

    Dr Karen C Glass

  28. Biological function and histone recognition of family IV bromodomain-containing proteins

    Article • Journal of Cellular Physiology, June 2017, Wiley

    Dr Karen C Glass

  29. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect

    Article • Epigenetics, October 2016, Taylor & Francis

    Dr Karen C Glass

  30. Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3

    Article • Journal of Biological Chemistry, June 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Karen C Glass

  31. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain

    Article • FEBS Letters, September 2014, Wiley

    Dr Karen C Glass

  32. Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands

    Article • Acta Crystallographica Section F Structural Biology Communications, September 2014, International Union of Crystallography

    Dr Karen C Glass

  33. Crystal Structure of the human BRPF1 bromodomain in complex with a histone H2AK5ac peptide

    Article • September 2014, Protein Data Bank, Rutgers University

    Dr Karen C Glass

  34. Crystal Structure of the human BRPF1 bromodomain in complex with a histone H4K12ac peptide

    Article • September 2014, Protein Data Bank, Rutgers University

    Dr Karen C Glass

  35. Curcumin and Dimethoxycurcumin Induced Epigenetic Changes in Leukemia Cells

    Article • Pharmaceutical Research, September 2014, Springer Science + Business Media

    Dr Karen C Glass

  36. The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease

    Article • Journal of Cellular Physiology, July 2014, Wiley

    Dr Karen C Glass

  37. Molecular Insights into the Recognition of N-Terminal Histone Modifications by the BRPF1 Bromodomain

    Article • Journal of Molecular Biology, April 2014, Elsevier

    Dr Karen C Glass

  38. Fast automated protein NMR data collection and assignment by ADAPT-NMR on Bruker spectrometers

    Article • Journal of Magnetic Resonance, November 2013, Elsevier

    Dr Karen C Glass

  39. Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity

    Article • Genes & Development, September 2013, Cold Spring Harbor Laboratory Press

    Dr Karen C Glass

  40. Histone H3R2 Symmetric Dimethylation and Histone H3K4 Trimethylation Are Tightly Correlated in Eukaryotic Genomes

    Article • Cell Reports, February 2012, Elsevier

    Dr Karen C Glass

  41. Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation

    Article • Molecular and Cellular Biology, December 2011, ASM Journals

    Dr Karen C Glass

  42. Molecular Mechanism of MLL PHD3 and RNA Recognition by the Cyp33 RRM Domain

    Article • Journal of Molecular Biology, July 2010, Elsevier

    Dr Karen C Glass

  43. Structural Insight into p53 Recognition by the 53BP1 Tandem Tudor Domain

    Article • Journal of Molecular Biology, May 2010, Elsevier

    Dr Karen C Glass

  44. Structural Insight Into Histone Recognition by the ING PHD Fingers

    Article • Current Drug Targets, May 2009, Bentham Science Publishers

    Dr Karen C Glass

  45. HBO1 HAT Complexes Target Chromatin throughout Gene Coding Regions via Multiple PHD Finger Interactions with Histone H3 Tail

    Article • Molecular Cell, January 2009, Elsevier

    Dr Karen C Glass

  46. ING4 Mediates Crosstalk between Histone H3 K4 Trimethylation and H3 Acetylation to Attenuate Cellular Transformation

    Article • Molecular Cell, January 2009, Elsevier

    Dr Karen C Glass

  47. The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide

    Article • Proteins Structure Function and Bioinformatics, July 2008, Wiley

    Dr Karen C Glass

  48. Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor

    Article • Journal of Molecular Biology, July 2008, Elsevier

    Dr Karen C Glass

  49. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

    Article • Nature, November 2007, Springer Science + Business Media

    Dr Karen C Glass

  50. Substrate Recognition by the Hetero-Octameric ATP Phosphoribosyltransferase from Lactococcus lactis

    Article • Biochemistry, November 2006, American Chemical Society (ACS)

    Dr Karen C Glass

  51. Activation of the Hetero-octameric ATP Phosphoribosyl Transferase through Subunit Interface Rearrangement by a tRNA Synthetase Paralog

    Article • Journal of Biological Chemistry, July 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Karen C Glass

  52. The Quaternary Structure of the HisZ−HisG N-1-(5‘-Phosphoribosyl)-ATP Transferase from Lactococcus lactis

    Article • Biochemistry, August 2002, American Chemical Society (ACS)

    Dr Karen C Glass