All Stories

  1. Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Justus Cohen

  2. Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes

    Article • Molecular Therapy — Methods & Clinical Development, June 2020, Elsevier

    Justus Cohen

  3. Point Mutations in Retargeted gD Eliminate the Sensitivity of EGFR/EGFRvIII-Targeted HSV to Key Neutralizing Antibodies

    Article • Molecular Therapy — Methods & Clinical Development, March 2020, Elsevier

    Justus Cohen

  4. Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System

    Article • Diseases, August 2018, MDPI AG

    Justus Cohen

  5. Cellular Antisilencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate Early Gene Expression

    Article • Journal of Virology, June 2018, ASM Journals

    Justus Cohen

  6. A Novel Oncolytic Herpes Simplex Virus Design based on the Common Overexpression of microRNA-21 in Tumors

    Article • Journal of Gene Therapy, January 2018, Avens Publishing Group

    Justus Cohen

  7. Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes

    Article • Molecular Therapy — Methods & Clinical Development, September 2017, Elsevier

    Justus Cohen

  8. Engineered HSV vector achieves safe long-term transgene expression in the central nervous system

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Justus Cohen

  9. Syncytial Mutations Do Not Impair the Specificity of Entry and Spread of a Glycoprotein D Receptor-Retargeted Herpes Simplex Virus

    Article • Journal of Virology, October 2016, ASM Journals

    Justus Cohen

  10. Constitutive Expression of GATA4 Dramatically Increases the Cardiogenic Potential of D3 Mouse Embryonic Stem Cells

    Article • The Open Biotechnology Journal, June 2016, Bentham Science Publishers

    Justus Cohen

  11. Development of an oncolytic HSV vector fully retargeted specifically to cellular EpCAM for virus entry and cell-to-cell spread

    Article • Gene Therapy, February 2016, Springer Science + Business Media

    Justus Cohen

  12. An HSV-based library screen identifies PP1α as a negative TRPV1 regulator with analgesic activity in models of pain

    Article • Molecular Therapy — Methods & Clinical Development, January 2016, Elsevier

    Justus Cohen

  13. Moving toward a gene therapy for Huntington’s disease

    Article • Gene Therapy, December 2015, Springer Science + Business Media

    Justus Cohen

  14. CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells

    Article • Scientific Reports, July 2015, Springer Science + Business Media

    Justus Cohen

  15. Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity

    Article • Proceedings of the National Academy of Sciences, March 2015, Proceedings of the National Academy of Sciences

    Justus Cohen

  16. Use of miRNA Response Sequences to Block Off-target Replication and Increase the Safety of an Unattenuated, Glioblastoma-targeted Oncolytic HSV

    Article • Molecular Therapy, January 2015, Elsevier

    Justus Cohen

  17. Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity

    Article • Molecular Therapy — Oncolytics, January 2014, Elsevier

    Justus Cohen

  18. Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus

    Article • Molecular Therapy, March 2013, Elsevier

    Justus Cohen

  19. Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV

    Article • Gene Therapy, December 2012, Springer Science + Business Media

    Justus Cohen

  20. Novel Mutations in gB and gH Circumvent the Requirement for Known gD Receptors in Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread

    Article • Journal of Virology, November 2012, ASM Journals

    Justus Cohen

  21. Gene therapy for the treatment of chronic peripheral nervous system pain

    Article • Neurobiology of Disease, November 2012, Elsevier

    Justus Cohen

  22. Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus

    Article • Advances in Virology, January 2012, Hindawi Publishing Corporation

    Justus Cohen

  23. Mechanism of HSV infection through soluble adapter-mediated virus bridging to the EGF receptor

    Article • Virology, April 2011, Elsevier

    Justus Cohen

  24. Bispecific Adapter-Mediated Retargeting of a Receptor-Restricted HSV-1 Vector to CEA-Bearing Tumor Cells

    Article • Molecular Therapy, March 2011, Elsevier

    Justus Cohen

  25. A Double Mutation in Glycoprotein gB Compensates for Ineffective gD-Dependent Initiation of Herpes Simplex Virus Type 1 Infection

    Article • Journal of Virology, September 2010, ASM Journals

    Justus Cohen

  26. Ectopic matrix metalloproteinase-9 expression in human brain tumor cells enhances oncolytic HSV vector infection

    Article • Gene Therapy, May 2010, Springer Science + Business Media

    Justus Cohen

  27. A Herpes Simplex Virus Vector System for Expression of Complex Cellular cDNA Libraries

    Article • Journal of Virology, May 2010, ASM Journals

    Justus Cohen

  28. Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells

    Article • Veterinary Microbiology, February 2010, Elsevier

    Justus Cohen

  29. Design and application of oncolytic HSV vectors for glioblastoma therapy

    Article • Expert Review of Neurotherapeutics, April 2009, Taylor & Francis

    Justus Cohen

  30. Generation of Herpesvirus Entry Mediator (HVEM)-Restricted Herpes Simplex Virus Type 1 Mutant Viruses: Resistance of HVEM-Expressing Cells and Identification of Mutations That Rescue Nectin-1 Recognition

    Article • Journal of Virology, January 2009, ASM Journals

    Justus Cohen

  31. Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth

    Article • Virology, May 2008, Elsevier

    Justus Cohen

  32. Equine Herpesvirus 1 Enters Cells by Two Different Pathways, and Infection Requires the Activation of the Cellular Kinase ROCK1

    Article • Journal of Virology, August 2007, ASM Journals

    Justus Cohen

  33. Characterization of soluble glycoprotein D-mediated herpes simplex virus type 1 infection

    Article • Virology, April 2007, Elsevier

    Justus Cohen

  34. Soluble V Domain of Nectin-1/HveC Enables Entry of Herpes Simplex Virus Type 1 (HSV-1) into HSV-Resistant Cells by Binding to Viral Glycoprotein D

    Article • Journal of Virology, January 2006, ASM Journals

    Justus Cohen

  35. Herpes Simplex Virus Targeting to the EGF Receptor by a gD-Specific Soluble Bridging Molecule

    Article • Molecular Therapy, April 2005, Elsevier

    Justus Cohen

  36. Equine Herpesvirus 1 Utilizes a Novel Herpesvirus Entry Receptor

    Article • Journal of Virology, March 2005, ASM Journals

    Justus Cohen

  37. Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IκBα and HSV thymidine kinase

    Article • Cancer Gene Therapy, February 2005, Springer Science + Business Media

    Justus Cohen

  38. Enhanced efficacy of conditionally replicating herpes simplex virus (G207) combined with 5-fluorouracil and surgical resection in peritoneal cancer dissemination models

    Article • The Journal of Gene Medicine, January 2005, Wiley

    Justus Cohen

  39. Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery

    Article • Molecular Therapy, October 2003, Elsevier

    Justus Cohen

  40. Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model

    Article • Gene Therapy, April 2002, Springer Science + Business Media

    Justus Cohen

  41. Herpesvirus-Mediated Systemic Delivery of Nerve Growth Factor

    Article • Molecular Therapy, January 2001, Elsevier

    Justus Cohen

  42. Pseudotyping of Glycoprotein D-Deficient Herpes Simplex Virus Type 1 with Vesicular Stomatitis Virus Glycoprotein G Enables Mutant Virus Attachment and Entry

    Article • Journal of Virology, August 2000, ASM Journals

    Justus Cohen

  43. Effective Treatment of Experimental Glioblastoma by HSV Vector-Mediated TNFα and HSV-tk Gene Transfer in Combination with Radiosurgery and Ganciclovir Administration

    Article • Molecular Therapy, August 2000, Elsevier

    Justus Cohen

  44. Pseudotyping of Glycoprotein D-Deficient Herpes Simplex Virus Type 1 with Vesicular Stomatitis Virus Glycoprotein G Enables Mutant Virus Attachment and Entry

    Article • Journal of Virology, March 2000, ASM Journals

    Justus Cohen

  45. Connexin 43-Enhanced Suicide Gene Therapy Using Herpesviral Vectors

    Article • Molecular Therapy, January 2000, Elsevier

    Justus Cohen

  46. U1 small nuclear RNA-promoted exon selection requires a minimal distance between the position of U1 binding and the 3' splice site across the exon.

    Article • Molecular and Cellular Biology, December 1997, ASM Journals

    Justus Cohen

  47. Phenotypic heterogeneity associated with the splicing mutation in congenital adrenal hyperplasia due to 21-hydroxylase deficiency

    Article • The Journal of Clinical Endocrinology & Metabolism, November 1996, Endocrine Society

    Justus Cohen

  48. U1 snRNA promotes the selection of nearby 5' splice sites by U6 snRNA in mammalian cells.

    Article • Genes & Development, February 1996, Cold Spring Harbor Laboratory Press

    Justus Cohen

  49. Suppression of mammalian 5' splice-site defects by U1 small nuclear RNAs from a distance.

    Article • Proceedings of the National Academy of Sciences, October 1994, Proceedings of the National Academy of Sciences

    Justus Cohen

  50. Expression of the H-ras proto-oncogene is controlled by alternative splicing

    Article • Cell, August 1989, Elsevier

    Justus Cohen

  51. A point mutation in the last intron responsible for increased expression and transforming activity of the c-Ha-ras oncogene

    Article • Nature, July 1988, Springer Science + Business Media

    Justus Cohen

  52. "Retroposon" insertion into the cellular oncogene c-myc in canine transmissible venereal tumor.

    Article • Proceedings of the National Academy of Sciences, February 1985, Proceedings of the National Academy of Sciences

    Justus Cohen

  53. Rearrangement of the oncogene c-mos in mouse myeloma NSI and hybridomas

    Article • Nature, December 1983, Springer Science + Business Media

    Justus Cohen

  54. Organization and evolution of immunoglobulin VH gene subgroups.

    Article • Proceedings of the National Academy of Sciences, July 1982, Proceedings of the National Academy of Sciences

    Justus Cohen

  55. Simple DNA sequences in homologous flanking regions near immunoglobulin VHgenes: a role in gene interaction?

    Article • Nucleic Acids Research, January 1982, Oxford University Press (OUP)

    Justus Cohen

  56. Diversity of germ-line immunoglobulin VH genes

    Article • Nature, July 1981, Springer Science + Business Media

    Justus Cohen

  57. Cloning and sequence of the cDNA corresponding to the variable region of immonoglobin heavy chain MPC11

    Article • Nucleic Acids Research, January 1980, Oxford University Press (OUP)

    Justus Cohen