All Stories

  1. SLAM-seq reveals independent contributions of RNA processing and stability to gene expression in African trypanosomes

    Article • Nucleic Acids Research, December 2024, Oxford University Press (OUP)

    Dr. Jurgen R Haanstra

  2. SLAM-seq reveals independent contributions of RNA processing and stability to gene expression in African trypanosomes

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Dr. Jurgen R Haanstra

  3. The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host

    Article • International Journal for Parasitology, June 2024, Elsevier

    Dr. Jurgen R Haanstra

  4. The fully automated Sysmex XN-31 hematology analyzer can detect bloodstream form Trypanosoma brucei

    Article • Diagnostic Microbiology and Infectious Disease, April 2024, Elsevier

    Dr. Jurgen R Haanstra

  5. How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell

    Article • PLoS Pathogens, July 2023, PLOS

    Dr. Jurgen R Haanstra

  6. Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis

    Article • Proceedings of the National Academy of Sciences, April 2020, Proceedings of the National Academy of Sciences

    Dr. Jurgen R Haanstra

  7. Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

    Article • Scientific Reports, April 2018, Nature

    Dr. Jurgen R Haanstra

  8. Metabolite Depletion Affects Flux Profiling of Cell Lines

    Article • Trends in Biochemical Sciences, April 2018, Elsevier

    Dr. Jurgen R Haanstra

  9. Low affinity membrane transporters can increase net substrate uptake rate by reducing efflux

    Article • November 2017, Cold Spring Harbor Laboratory Press

    Dr. Jurgen R Haanstra

  10. Targeting pathogen metabolism without collateral damage to the host

    Article • Scientific Reports, January 2017, Nature

    Dr. Jurgen R Haanstra

  11. Attacking Blood‐Borne Parasites with Mathematics

    Article • July 2016, Wiley

    Dr. Jurgen R Haanstra

  12. Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, May 2016, Elsevier

    Dr. Jurgen R Haanstra

  13. Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression

    Article • BMC Genomics, April 2016, Springer Science + Business Media

    Dr. Jurgen R Haanstra

  14. Drug target identification through systems biology

    Article • Drug Discovery Today Technologies, August 2015, Elsevier

    Dr. Jurgen R Haanstra

  15. Evolution, dynamics and specialized functions of glycosomes in metabolism and development of trypanosomatids

    Article • Current Opinion in Microbiology, December 2014, Elsevier

    Dr. Jurgen R Haanstra

  16. In or out? On the tightness of glycosomal compartmentalization of metabolites and enzymes in Trypanosoma brucei

    Article • Molecular and Biochemical Parasitology, November 2014, Elsevier

    Dr. Jurgen R Haanstra

  17. Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

    Article • Molecular Microbiology, September 2014, Wiley

    Dr. Jurgen R Haanstra

  18. The Silicon Trypanosome

    Article • January 2014, Elsevier

    mark girolami, Dr. Jurgen R Haanstra

  19. Dissecting the Catalytic Mechanism of Trypanosoma brucei Trypanothione Synthetase by Kinetic Analysis and Computational Modeling

    Article • Journal of Biological Chemistry, June 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Jurgen R Haanstra

  20. Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism

    Article • PLoS Neglected Tropical Diseases, January 2013, PLOS

    Dr. Jurgen R Haanstra

  21. Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes

    Article • International Journal for Parasitology, June 2012, Elsevier

    Dr. Jurgen R Haanstra

  22. EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs

    Article • Blood, May 2012, American Society of Hematology

    Dr. Jurgen R Haanstra

  23. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia

    Article • Blood, February 2012, American Society of Hematology

    Dr. Jurgen R Haanstra

  24. Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors

    Article • Anemia, January 2012, Hindawi Publishing Corporation

    Dr. Jurgen R Haanstra

  25. A domino effect in drug action: from metabolic assault towards parasite differentiation

    Article • Molecular Microbiology, November 2010, Wiley

    Dr. Jurgen R Haanstra

  26. Lineage-instructive function of C/EBP  in multipotent hematopoietic cells and early thymic progenitors

    Article • Blood, August 2010, American Society of Hematology

    Dr. Jurgen R Haanstra

  27. Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

    Article • Proceedings of the National Academy of Sciences, November 2008, Proceedings of the National Academy of Sciences

    Dr. Jurgen R Haanstra

  28. Control and Regulation of Gene Expression: QUANTITATIVE ANALYSIS OF THE EXPRESSION OF PHOSPHOGLYCERATE KINASE IN BLOODSTREAM FORM TRYPANOSOMA BRUCEI

    Article • Journal of Biological Chemistry, November 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Jurgen R Haanstra

  29. Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event

    Article • Journal of Molecular Endocrinology, August 2005, Bioscientifica

    Dr. Jurgen R Haanstra

  30. Experimental andin SilicoAnalyses of Glycolytic Flux Control in Bloodstream FormTrypanosoma brucei

    Article • Journal of Biological Chemistry, June 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Jurgen R Haanstra, Professor Fred R. Opperdoes

  31. Article • Molecular Biology Reports, January 2002, Springer Science + Business Media

    Dr. Jurgen R Haanstra