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  1. Intestinal edema induced by LPS-induced endotoxemia is associated with an inflammasome adaptor ASC
  2. IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans’ islets, directly initiates NLRP3 inflammasome activation
  3. Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system
  4. IL-1 as a target in inflammation