All Stories

  1. Brain metastasis from non-small cell lung cancer: crosstalk between cancer cells and tumor microenvironment components

    Article • Experimental & Molecular Medicine, December 2025, Springer Science + Business Media

    Jun Young Heo

  2. Laparotomy and burst suppression-inducing sevoflurane induce subtle long-term changes in anxiety and social behavior in late postnatal mice

    Article • Korean Journal of Anesthesiology, August 2025, The Korean Society of Anesthesiologists (KAMJE)

    Jun Young Heo

  3. ATF5-Dependent GDF15 Expression Mediates Anesthesia-Induced Neuroprotection Against Stroke

    Article • December 2024, Cold Spring Harbor Laboratory Press

    Jun Young Heo

  4. Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages

    Article • Cellular and Molecular Immunology, October 2024, Springer Science + Business Media

    Jun Young Heo

  5. Transcriptomic characteristics according to tumor size and SUVmax in papillary thyroid cancer patients

    Article • Scientific Reports, May 2024, Springer Science + Business Media

    Jun Young Heo

  6. Mitochondrial dysfunction precedes hippocampal IL-1β transcription and cognitive impairments after low-dose lipopolysaccharide injection in aged mice

    Article • Heliyon, April 2024, Elsevier

    Jun Young Heo

  7. Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses

    Article • Nature Communications, February 2024, Springer Science + Business Media

    Jun Young Heo

  8. Effects of a Combination of Polynucleotide and Hyaluronic Acid for Treating Osteoarthritis

    Article • International Journal of Molecular Sciences, January 2024, MDPI AG

    Jun Young Heo

  9. Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism

    Article • Molecular Psychiatry, August 2023, Springer Science + Business Media

    Jun Young Heo

  10. ATF5 Attenuates the Secretion of Pro-Inflammatory Cytokines in Activated Microglia

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Jun Young Heo

  11. Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling

    Article • Experimental & Molecular Medicine, February 2023, Springer Science + Business Media

    Jun Young Heo

  12. Targeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation

    Article • Journal of Hematology & Oncology, October 2022, Springer Science + Business Media

    Jun Young Heo

  13. A transcriptomic analysis of cerebral microvessels reveals the involvement of Notch1 signaling in endothelial mitochondrial-dysfunction-dependent BBB disruption

    Article • Fluids and Barriers of the CNS, August 2022, Springer Science + Business Media

    Jun Young Heo

  14. Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice

    Article • Communications Biology, July 2022, Springer Science + Business Media

    Jun Young Heo

  15. Fully portable continuous real-time auscultation with a soft wearable stethoscope designed for automated disease diagnosis

    Article • Science Advances, May 2022, American Association for the Advancement of Science

    Jun Young Heo

  16. Reactive microglia and mitochondrial unfolded protein response following ventriculomegaly and behavior defects in kaolin-induced hydrocephalus

    Article • BMB Reports, April 2022, Korean Society for Biochemistry and Molecular Biology - BMB Reports

    Jun Young Heo

  17. General Anesthesia During Neurodevelopment Reduces Autistic Behavior in Adult BTBR Mice, a Murine Model of Autism

    Article • Frontiers in Cellular Neuroscience, November 2021, Frontiers

    Jun Young Heo

  18. KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson's Disease

    Article • Neurotherapeutics, July 2021, Elsevier

    Jun Young Heo

  19. Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice

    Article • Communications Biology, May 2021, Springer Science + Business Media

    Jun Young Heo

  20. The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB

    Article • Experimental Neurobiology, April 2021, The Korean Society for Brain and Neural Science (KAMJE)

    Jun Young Heo

  21. Angiopoietin-Like Growth Factor Involved in Leptin Signaling in the Hypothalamus

    Article • International Journal of Molecular Sciences, March 2021, MDPI AG

    Jun Young Heo

  22. Auraptene Enhances Junction Assembly in Cerebrovascular Endothelial Cells by Promoting Resilience to Mitochondrial Stress through Activation of Antioxidant Enzymes and mtUPR

    Article • Antioxidants, March 2021, MDPI AG

    Jun Young Heo

  23. EGR1/GADD45α Activation by ROS of Non-Thermal Plasma Mediates Cell Death in Thyroid Carcinoma

    Article • Cancers, January 2021, MDPI AG

    Jun Young Heo

  24. General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

    Article • NeuroToxicology, January 2021, Elsevier

    Jun Young Heo

  25. Head and Neck Cancer Cell Death due to Mitochondrial Damage Induced by Reactive Oxygen Species from Nonthermal Plasma‐Activated Media: Based on Transcriptomic Analysis

    Article • Oxidative Medicine and Cellular Longevity, January 2021, Wiley

    Jun Young Heo

  26. Interval-dependent neurotoxicity after multiple ketamine injections in late postnatal mice

    Article • Journal of Anesthesia, November 2020, Springer Science + Business Media

    Jun Young Heo

  27. Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis

    Article • Virulence, September 2020, Taylor & Francis

    Jun Young Heo

  28. Romo1 Inhibition Induces TRAIL-Mediated Apoptosis in Colorectal Cancer

    Article • Cancers, August 2020, MDPI AG

    Jun Young Heo

  29. Increasing the interval between repeated anesthetic exposures reduces long‐lasting synaptic changes in late post‐natal mice

    Article • Journal of Neurochemistry, July 2020, Wiley

    Jun Young Heo

  30. <p>p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis</p>

    Article • International Journal of Nanomedicine, April 2020, Taylor & Francis

    Jun Young Heo

  31. Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

    Article • Nutrients, March 2020, MDPI AG

    Jun Young Heo

  32. The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice

    Article • Frontiers in Cellular Neuroscience, January 2020, Frontiers

    Jun Young Heo

  33. Endothelial-specific Crif1 deletion induces BBB maturation and disruption via the alteration of actin dynamics by impaired mitochondrial respiration

    Article • Journal of Cerebral Blood Flow & Metabolism, January 2020, SAGE Publications

    Jun Young Heo

  34. Altered Mitochondrial Functions and Morphologies in Epithelial Cells Are Associated With Pathogenesis of Chronic Rhinosinusitis With Nasal Polyps

    Article • Allergy Asthma and Immunology Research, January 2020, XMLink

    Jun Young Heo

  35. Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson’s Disease

    Article • Current Biology, January 2020, Elsevier

    Jun Young Heo

  36. Abstract A021: Genipin enhanced apoptosis of gastric cancer by mitochondrial dysfunction and downregulation of Stat3/JAK2/Mcl-1 signaling pathway

    Article • Molecular Cancer Therapeutics, December 2019, American Association for Cancer Research (AACR)

    Jun Young Heo

  37. LIN 28A loss of function is associated with Parkinson's disease pathogenesis

    Article • The EMBO Journal, November 2019, Springer Science + Business Media

    Jun Young Heo

  38. Synergistic Neuroprotective Effect of Schisandra chinensis and Ribes fasciculatum on Neuronal Cell Death and Scopolamine-Induced Cognitive Impairment in Rats

    Article • International Journal of Molecular Sciences, September 2019, MDPI AG

    Jun Young Heo

  39. PTEN/AKT signaling mediates chemoresistance in refractory acute myeloid leukemia through enhanced glycolysis

    Article • Oncology Reports, September 2019, Spandidos Publications

    Jun Young Heo

  40. Non-cell autonomous modulation of tyrosine hydroxylase by HMGB1 released from astrocytes in an acute MPTP-induced mouse model

    Article • IBRO Reports, September 2019, Elsevier

    Jun Young Heo

  41. Non-cell autonomous modulation of tyrosine hydroxylase by HMGB1 released from astrocytes in an acute MPTP-induced Parkinsonian mouse model

    Article • Laboratory Investigation, September 2019, Elsevier

    Jun Young Heo

  42. Chloramphenicol Mitigates Oxidative Stress by Inhibiting Translation of Mitochondrial Complex I in Dopaminergic Neurons of Toxin-Induced Parkinson’s Disease Model

    Article • Oxidative Medicine and Cellular Longevity, August 2019, Hindawi Publishing Corporation

    Jun Young Heo, minho shong

  43. Auraptene Mitigates Parkinson’s Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species

    Article • International Journal of Molecular Sciences, July 2019, MDPI AG

    Jun Young Heo

  44. Anesthesia affects excitatory/inhibitory synapses during the critical synaptogenic period in the hippocampus of young mice: Importance of sex as a biological variable

    Article • NeuroToxicology, January 2019, Elsevier

    Jun Young Heo

  45. L‑Deprenyl exerts cytotoxicity towards acute myeloid leukemia through inhibition of mitochondrial respiration

    Article • Oncology Reports, October 2018, Spandidos Publications

    Jun Young Heo

  46. Histidine Suppresses IgE-Mediated Allergic Responses

    Article • Journal of the Korean Society of Food Science and Nutrition, July 2018, The Korean Society of Food Science and Nutrition

    Jun Young Heo

  47. Abstract 2324: Docosahexaenoic acid-induced Nrf2 may be correlated with cell death by amplification of oxidative stress via induction of klf9 in cervical cancer cells

    Article • Cancer Research, July 2018, American Association for Cancer Research (AACR)

    Jun Young Heo

  48. Abstract 2872: Mechanism of anti-proliferative and anti-invasive actions of ω3-polyunsaturated fatty acids in human hypopharyngeal carcinoma cells

    Article • Cancer Research, July 2018, American Association for Cancer Research (AACR)

    Jun Young Heo

  49. PO-072 ω3-polyunsaturated fatty acids inhibit cell growth and invasion of human hypopharyngeal carcinoma cells

    Article • June 2018, BMJ

    Jun Young Heo

  50. Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220

    Article • Neurochemistry International, January 2018, Elsevier

    Jun Young Heo

  51. Adenine attenuates lipopolysaccharide-induced inflammatory reactions

    Article • Korean Journal of Physiology and Pharmacology, January 2018, The Korean Physiological Society and The Korean Society of Pharmacology (KAMJE)

    Jun Young Heo

  52. Copine1 regulates neural stem cell functions during brain development

    Article • Biochemical and Biophysical Research Communications, January 2018, Elsevier

    Jun Young Heo

  53. ω3-polyunsaturated fatty acids induce cell death through apoptosis and autophagy in glioblastoma cells: In vitro and in vivo

    Article • Oncology Reports, November 2017, Spandidos Publications

    Jun Young Heo

  54. Activation of the HMGB1-RAGE axis upregulates TH expression in dopaminergic neurons via JNK phosphorylation

    Article • Biochemical and Biophysical Research Communications, November 2017, Elsevier

    Jun Young Heo

  55. Hochu-ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome

    Article • Molecules, June 2017, MDPI AG

    Jun Young Heo

  56. Single and multiple sevoflurane exposures during pregnancy and offspring behavior in mice

    Article • Pediatric Anesthesia, May 2017, Wiley

    Jun Young Heo

  57. Hochu-Ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome

    Article • May 2017, MDPI AG

    Jun Young Heo

  58. Sevoflurane Exposure during the Critical Period Affects Synaptic Transmission and Mitochondrial Respiration but Not Long-term Behavior in Mice

    Article • Anesthesiology, February 2017, Wolters Kluwer Health

    Jun Young Heo

  59. A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities

    Article • Experimental Neurobiology, January 2017, The Korean Society for Brain and Neural Science (KAMJE)

    Jun Young Heo

  60. Docosahexaenoic acid induces ROS-mediated apoptosis through the Nrf2–Klf9–Txnrd2 pathway in HeLa cells

    Article • European Journal of Cancer, July 2016, Elsevier

    Jun Young Heo

  61. Docosahexaenoic acid induces cell death through downregulation of hedgehog signaling via the activation of SIRT6 in human non-small cell lung carcinomas harboring EGFR mutations

    Article • European Journal of Cancer, July 2016, Elsevier

    Jun Young Heo

  62. Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases

    Article • Oncotarget, June 2016, Impact Journals, LLC

    Jun Young Heo

  63. Metabolic characterization of imatinib-resistant BCR-ABL T315I chronic myeloid leukemia cells indicates down-regulation of glycolytic pathway and low ROS production

    Article • Leukemia & Lymphoma, February 2016, Taylor & Francis

    Jun Young Heo

  64. Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation

    Article • Oncotarget, October 2015, Impact Journals, LLC

    Jun Young Heo

  65. 2906 Omega-3 polyunsaturated fatty acids suppress glioblastoma cells invasion and metastasis in vitro and in vivo

    Article • European Journal of Cancer, September 2015, Elsevier

    Jun Young Heo

  66. Abstract 1767: Anti-proliferative and anti-invasive action of omega-3 polyunsaturated fatty acids in stomach cancer cells

    Article • Cancer Research, August 2015, American Association for Cancer Research (AACR)

    Jun Young Heo

  67. Abstract 1901: Endogenous increase of omega-3 polyunsaturated fatty acids through expression of of ω3-desaturase gene inhibits tumorigenicity and metastasis of prostate cancer cells in vitro and in vivo

    Article • Cancer Research, August 2015, American Association for Cancer Research (AACR)

    Jun Young Heo

  68. High-capacity glycolytic and mitochondrial oxidative metabolisms mediate the growth ability of glioblastoma

    Article • International Journal of Oncology, July 2015, Spandidos Publications

    Jun Young Heo

  69. Induction of Angiogenesis by Matrigel Coating of VEGF-Loaded PEG/PCL-Based Hydrogel Scaffolds for hBMSC Transplantation

    Article • Molecules and Cells, July 2015, Korean Society for Molecular and Cellular Biology

    Jun Young Heo

  70. Sevoflurane exposure during the neonatal period induces long-term memory impairment but not autism-like behaviors

    Article • Pediatric Anesthesia, June 2015, Wiley

    Jun Young Heo

  71. Adenine suppresses IgE-mediated mast cell activation

    Article • Molecular Immunology, June 2015, Elsevier

    Jun Young Heo

  72. Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition

    Article • BioMed Research International, January 2015, Hindawi Publishing Corporation

    Jun Young Heo

  73. Docosahexaenoic acid prevents paraquat-induced reactive oxygen species production in dopaminergic neurons via enhancement of glutathione homeostasis

    Article • Biochemical and Biophysical Research Communications, January 2015, Elsevier

    Jun Young Heo

  74. Docosahexaenoic acid induces the degradation of HPV E6/E7 oncoproteins by activating the ubiquitin–proteasome system

    Article • Cell Death and Disease, November 2014, Springer Science + Business Media

    Jun Young Heo

  75. Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells

    Article • BMC Cancer, July 2014, Springer Science + Business Media

    Jun Young Heo

  76. SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

    Article • Oncogene, March 2014, Springer Science + Business Media

    Jun Young Heo

  77. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1

    Article • Journal of Anesthesia, June 2013, Springer Science + Business Media

    Jun Young Heo

  78. An Indole Derivative Protects Against Acetaminophen-Induced Liver Injury by Directly Binding to N-Acetyl-p-Benzoquinone Imine in Mice

    Article • Antioxidants & Redox Signaling, May 2013, Mary Ann Liebert Inc

    Jun Young Heo

  79. The Omega-3 Polyunsaturated Fatty Acid DHA Induces Simultaneous Apoptosis and Autophagy via Mitochondrial ROS-Mediated Akt-mTOR Signaling in Prostate Cancer Cells Expressing Mutant p53

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Jun Young Heo

  80. 140 Omega-3 Polyunsaturated Fatty Acids Inhibit Brain Cancer Cell Growth by Apoptosis and Autophgy

    Article • European Journal of Cancer, July 2012, Elsevier

    Jun Young Heo

  81. Abstract 4654: Docosahexaenoic acid induces autophagy through reactive oxygen species /mTOR pathway in p53 mutant cancer cells

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Jun Young Heo

  82. Abstract 2071: Docosahexaenoic acid-induced apoptosis is directly linked to mitochondria-mediated reactive oxygen species production in human cervical cancer cells

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Jun Young Heo

  83. Abstract 2274: Docosahexaenoic acid-induced cell death may be related to inhibition of mTOR through AMPK activation and PI3K/Akt inhibition in human non-small cell lung cancer cells

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Jun Young Heo

  84. Abstract 1985: Omega-3 polyunsaturated fatty acids induce cell cytotoxicity through apoptosis and autophgy in brain cancer in vitro and in vivo

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Jun Young Heo

  85. Abstract 4175: Reactive oxygen species-dependent ERK and JNK activation is important to docasahexaenoic acid-induced cell cytotoxicity in human ovarian cancer cells

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Jun Young Heo

  86. DJ-1 Null Dopaminergic Neuronal Cells Exhibit Defects in Mitochondrial Function and Structure: Involvement of Mitochondrial Complex I Assembly

    Article • PLOS One, March 2012, PLOS

    Jun Young Heo

  87. Omega-3-Polyunsaturated Fatty Acids Suppress Pancreatic Cancer Cell Growth in vitro and in vivo via Downregulation of Wnt/Beta-Catenin Signaling

    Article • Pancreatology, December 2011, Elsevier

    Jun Young Heo

  88. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53

    Article • Autophagy, November 2011, Taylor & Francis

    Jun Young Heo

  89. DJ-1 mediates paraquat-induced dopaminergic neuronal cell death

    Article • Toxicology Letters, April 2011, Elsevier

    Jun Young Heo

  90. Abstract 2867: Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling in human cancer cells

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Jun Young Heo

  91. Abstract 1040: Downregulation of PI3K/Akt signaling is related to DHA-induced cytotoxicity in A549 human lung cancer cells

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Jun Young Heo

  92. Abstract 862: Expression of the fat-1 gene retards the growth of cervical cancer cells in vitro and in vivo

    Article • Cancer Research, April 2011, American Association for Cancer Research (AACR)

    Jun Young Heo

  93. Expression regulation and function of Pref-1 during adipogenesis of human mesenchymal stem cells (MSCs)

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, August 2009, Elsevier

    Jun Young Heo

  94. Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem Cells

    Article • Stem Cells, June 2009, Wiley

    Jun Young Heo

  95. The tumorigenic, invasive and metastatic potential of epithelial and round subpopulations of the SW480 human colon cancer cell line

    Article • Molecular Medicine Reports, January 2008, Spandidos Publications

    Jun Young Heo