All Stories

  1. Myocardial Function, Heart Failure and Arrhythmia in Marfan Syndrome: A Systematic Literature Review

    Article • Diagnostics, September 2020, MDPI AG

    Dr Julie De Backer

  2. Spontaneous Right Ventricular Pseudoaneurysms and Increased Arrhythmogenicity in a Mouse Model of Marfan Syndrome

    Article • International Journal of Molecular Sciences, September 2020, MDPI AG

    Dr Julie De Backer

  3. Ambulatory Electrocardiographic Monitoring and Ectopic Beat Detection in Conscious Mice

    Article • Sensors, July 2020, MDPI AG

    Dr Julie De Backer

  4. Case-matched Comparison of Cardiovascular Outcome in Loeys-Dietz Syndrome versus Marfan Syndrome

    Article • Journal of Clinical Medicine, November 2019, MDPI AG

    Dr Julie De Backer

  5. Sleep apnea and the impact on cardiovascular risk in patients with Marfan syndrome

    Article • Molecular Genetics & Genomic Medicine, June 2019, Wiley

    Dr Julie De Backer

  6. Genetic counselling and testing in adults with congenital heart disease: A consensus document of the ESC Working Group of Grown-Up Congenital Heart Disease, the ESC Working Group on Aorta and Peripheral Vascular Disease and the European Society of Huma...

    Article • European Journal of Preventive Cardiology, June 2019, SAGE Publications

    Dr Julie De Backer

  7. Real-world healthcare utilization in adult congenital heart disease: a systematic review of trends and ratios

    Article • Cardiology in the Young, May 2019, Cambridge University Press

    Dr Julie De Backer

  8. Disproportion and dysmorphism in an adult Belgian population with Turner syndrome: risk factors for chronic diseases?

    Article • Acta Clinica Belgica, April 2019, Taylor & Francis

    Dr Julie De Backer, Professor Bert Callewaert, Charlotte Lievens

  9. Staffing, activities, and infrastructure in 96 specialised adult congenital heart disease clinics in Europe

    Article • International Journal of Cardiology, April 2019, Elsevier

    Dr Julie De Backer

  10. Vascular Ehlers-Danlos Syndrome Management

    Article • Journal of the American College of Cardiology, April 2019, Elsevier

    Dr Julie De Backer

  11. SMAD4 rare variants in individuals and families with thoracic aortic aneurysms and dissections

    Article • European Journal of Human Genetics, February 2019, Springer Science + Business Media

    Dr Julie De Backer

  12. Body mass index in adults with congenital heart disease

    Article • Congenital Heart Disease, January 2019, Wiley

    Dr Julie De Backer

  13. SMAD3 pathogenic variants: risk for thoracic aortic disease and associated complications from the Montalcino Aortic Consortium

    Article • Journal of Medical Genetics, January 2019, BMJ

    Dr Julie De Backer

  14. OUP accepted manuscript

    Article • European Heart Journal, January 2019, Oxford University Press (OUP)

    Professor Jolien W Roos-Hesselink, Dr Julie De Backer

  15. Cardiovascular Health in Turner Syndrome: A Scientific Statement From the American Heart Association

    Article • Circulation Genomic and Precision Medicine, October 2018, Wolters Kluwer Health

    Dr Julie De Backer

  16. Cardiovascular imaging in Turner syndrome: state-of-the-art practice across the lifespan

    Article • Heart, September 2018, BMJ

    Dr Anthonie L Duijnhouwer, Dr Julie De Backer

  17. Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection

    Article • Journal of the American College of Cardiology, August 2018, Elsevier

    Dr Julie De Backer

  18. Heart failure and sudden cardiac death in heritable thoracic aortic disease caused by pathogenic variants in the SMAD3 gene

    Article • Molecular Genetics & Genomic Medicine, May 2018, Wiley

    Dr Julie De Backer

  19. Organisation of care for pregnancy in patients with congenital heart disease

    Article • Heart, July 2017, BMJ

    Dr Julie De Backer

  20. Sex, pregnancy and aortic disease in Marfan syndrome

    Article • PLoS ONE, July 2017, PLOS

    Dr Julie De Backer

  21. The spectrum of spontaneous coronary artery dissection: illustrated review of the literature

    Article • Acta Cardiologica, June 2017, Taylor & Francis

    Dr Julie De Backer

  22. Efficacy of losartan as add-on therapy to prevent aortic growth and ventricular dysfunction in patients with Marfan syndrome: a randomized, double-blind clinical trial

    Article • Acta Cardiologica, June 2017, Taylor & Francis

    Dr Julie De Backer

  23. The 2017 international classification of the Ehlers-Danlos syndromes

    Article • American Journal of Medical Genetics Part C Seminars in Medical Genetics, March 2017, Wiley

    Dr Julie De Backer, Rodney Grahame

  24. Diagnosis, natural history, and management in vascular Ehlers-Danlos syndrome

    Article • American Journal of Medical Genetics Part C Seminars in Medical Genetics, March 2017, Wiley

    Dr Julie De Backer

  25. Pregnancy in Women With SMAD3 Mutation

    Article • Journal of the American College of Cardiology, March 2017, Elsevier

    Dr Julie De Backer

  26. Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

    Article • Nature Reports Stem Cells, January 2017, Springer Science + Business Media

    Dr Julie De Backer

  27. International Registry of Patients Carrying TGFBR1 or TGFBR2 Mutations

    Article • Circulation Cardiovascular Genetics, December 2016, Wolters Kluwer Health

    Dr Julie De Backer

  28. FBN1 : The disease-causing gene for Marfan syndrome and other genetic disorders

    Article • Gene, October 2016, Elsevier

    Dr Julie De Backer

  29. Long-Term Outcome of Patients with Perimembranous Ventricular Septal Defect: Results from the Belgian Registry on Adult Congenital Heart Disease

    Article • Cardiology, September 2016, Karger Publishers

    Dr Julie De Backer

  30. Mitral valve prolapse syndrome and MASS phenotype: Stability of aortic dilatation but progression of mitral valve prolapse

    Article • IJC Heart & Vasculature, March 2016, Elsevier

    Dr Julie De Backer

  31. Marfan Syndrome and Related Heritable Thoracic Aortic Aneurysms and Dissections

    Article • Current Pharmaceutical Design, September 2015, Bentham Science Publishers

    Dr Julie De Backer

  32. 2015 ESC Guidelines for the management of infective endocarditis

    Article • European Heart Journal, August 2015, European Society of Cardiology

    Prof HECTOR BUENO, Konstantinos Dimopoulos, Dr Julie De Backer

  33. Intrinsic cardiomyopathy in Marfan syndrome: results from in-vivo and ex-vivo studies of the Fbn1C1039G/+ model and longitudinal findings in humans

    Article • Pediatric Research, June 2015, Nature

    Dr Julie De Backer, Dr Bram Trachet

  34. ClinGen — The Clinical Genome Resource

    Article • New England Journal of Medicine, June 2015, New England Journal of Medicine (NEJM/MMS)

    Dr Julie De Backer

  35. Marfan and Sartans: time to wake up!: Figure 1

    Article • European Heart Journal, June 2015, European Society of Cardiology

    Dr Julie De Backer

  36. Perspectives on the revised Ghent criteria for the diagnosis of Marfan syndrome

    Article • The Application of Clinical Genetics, June 2015, Dove Medical Press

    Dr Julie De Backer

  37. Arterial hypertension in Turner syndrome

    Article • Journal of Hypertension, June 2015, Wolters Kluwer Health

    Dr Julie De Backer

  38. Managing aortic aneurysms and dissections during pregnancy

    Article • Expert Review of Cardiovascular Therapy, May 2015, Taylor & Francis

    Dr Julie De Backer

  39. Design and rationale of a prospective, collaborative meta-analysis of all randomized controlled trials of angiotensin receptor antagonists in Marfan syndrome, based on individual patient data: A report from the Marfan Treatment Trialists' Collaboration

    Article • American Heart Journal, May 2015, Elsevier

    Dr Julie De Backer

  40. Marfan Syndrome and Related Heritable Thoracic Aortic Aneurysms and Dissections

    Article • January 2015, Springer Science + Business Media

    Dr Julie De Backer

  41. Gene panel sequencing in heritable thoracic aortic disorders and related entities – results of comprehensive testing in a cohort of 264 patients

    Article • Orphanet Journal of Rare Diseases, January 2015, Springer Science + Business Media

    Dr Julie De Backer

  42. Marfan Syndrome☆

    Article • January 2015, Elsevier

    Dr Julie De Backer

  43. The main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome

    Article • Orphanet Journal of Rare Diseases, December 2014, Springer Science + Business Media

    Dr Julie De Backer

  44. Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome

    Article • New England Journal of Medicine, November 2014, New England Journal of Medicine (NEJM/MMS)

    Dr Julie De Backer

  45. A different view on predictors of pulmonary hypertension in secundum atrial septal defect

    Article • International Journal of Cardiology, October 2014, Elsevier

    Dr Julie De Backer

  46. Reference Values for Echocardiographic Assessment of the Diameter of the Aortic Root and Ascending Aorta Spanning All Age Categories

    Article • The American Journal of Cardiology, September 2014, Elsevier

    Dr Julie De Backer

  47. Loeys–Dietz syndrome is a specific phenotype and not a concomitant of any mutation in a gene involved in TGF-β signaling

    Article • Genetics in Medicine, August 2014, Nature

    Dr Julie De Backer

  48. Treatment of pre-existing cardiomyopathy during pregnancy

    Article • Acta Cardiologica, April 2014, Taylor & Francis

    Dr Julie De Backer

  49. Absence of Cardiovascular Manifestations in a Haploinsufficient Tgfbr1 Mouse Model

    Article • PLoS ONE, February 2014, PLOS

    Dr Julie De Backer, Dr Bram Trachet

  50. Relation between genotype and left-ventricular dilatation in patients with Marfan syndrome

    Article • Gene, January 2014, Elsevier

    Dr Julie De Backer

  51. Heart failure in pregnant women with cardiac disease: data from the ROPAC

    Article • Heart, November 2013, BMJ

    Professor Jolien W Roos-Hesselink, Dr Julie De Backer

  52. Functional analysis of the anatomical right ventricular components: should assessment of right ventricular function after repair of tetralogy of Fallot be refined?

    Article • European Journal of Cardio-Thoracic Surgery, November 2013, Oxford University Press (OUP)

    Dr Julie De Backer

  53. Characterization of Cardiovascular Involvement in Pseudoxanthoma Elasticum Families

    Article • Arteriosclerosis Thrombosis and Vascular Biology, November 2013, Wolters Kluwer Health

    Dr Julie De Backer

  54. Worsening in oxygen saturation and exercise capacity predict adverse outcome in patients with Eisenmenger syndrome

    Article • International Journal of Cardiology, September 2013, Elsevier

    Professor Werner Budts, Dr Julie De Backer

  55. Prevalence of Fabry disease in a predominantly hypertensive population with left ventricular hypertrophy

    Article • International Journal of Cardiology, September 2013, Elsevier

    Dr Julie De Backer

  56. Genes in Thoracic Aortic Aneurysms and Dissections - Do they Matter?: Translation and Integration of Research and Modern Genetic Techniques into Daily Clinical Practice

    Article • Aorta, July 2013, Science International Corporation

    Dr Julie De Backer

  57. Echocardiographic Methods, Quality Review, and Measurement Accuracy in a Randomized Multicenter Clinical Trial of Marfan Syndrome

    Article • Journal of the American Society of Echocardiography, June 2013, Elsevier

    Dr Julie De Backer

  58. Characteristics of children and young adults with Marfan syndrome and aortic root dilation in a randomized trial comparing atenolol and losartan therapy

    Article • American Heart Journal, May 2013, Elsevier

    Dr Julie De Backer

  59. Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD

    Article • International Journal of Cardiology, May 2013, Elsevier

    Dr Julie De Backer

  60. Thoracic aortic-aneurysm and dissection in association with significant mitral valve disease caused by mutations in TGFB2

    Article • International Journal of Cardiology, May 2013, Elsevier

    Dr Julie De Backer

  61. Predictive model for late atrial arrhythmia after closure of an atrial septal defect

    Article • International Journal of Cardiology, April 2013, Elsevier

    Dr Julie De Backer

  62. Aneurysm-osteoarthritis syndrome with visceral and iliac artery aneurysms

    Article • Journal of Vascular Surgery, January 2013, Elsevier

    Professor Jolien W Roos-Hesselink, Dr Julie De Backer

  63. Multiple Aneurysms in a Patient With Aneurysms-Osteoarthritis Syndrome

    Article • The Annals of Thoracic Surgery, January 2013, Elsevier

    Dr Julie De Backer

  64. Twenty patients including 7 probands with autosomal dominant cutis laxa confirm clinical and molecular homogeneity

    Article • Orphanet Journal of Rare Diseases, January 2013, Springer Science + Business Media

    Dr Julie De Backer

  65. In-Frame Mutations in Exon 1 of SKI Cause Dominant Shprintzen-Goldberg Syndrome

    Article • The American Journal of Human Genetics, November 2012, Elsevier

    Dr Julie De Backer

  66. Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria

    Article • Human Mutation, July 2012, Wiley

    Dr Julie De Backer

  67. Aggressive Cardiovascular Phenotype of Aneurysms-Osteoarthritis Syndrome Caused by Pathogenic SMAD3 Variants

    Article • Journal of the American College of Cardiology, July 2012, Elsevier

    Professor Jolien W Roos-Hesselink, Dr Julie De Backer

  68. The Ghent Marfan Trial — A randomized, double-blind placebo controlled trial with losartan in Marfan patients treated with β-blockers

    Article • International Journal of Cardiology, June 2012, Elsevier

    Dr Julie De Backer, Dr Bram Trachet

  69. Right Ventricular Function in Patients With Eisenmenger Syndrome

    Article • The American Journal of Cardiology, April 2012, Elsevier

    Dr Julie De Backer

  70. Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

    Article • Journal of Medical Genetics, December 2011, BMJ

    Professor Jolien W Roos-Hesselink, Dr Julie De Backer

  71. The importance of pulmonary artery pressures on late atrial arrhythmia in transcatheter and surgically closed ASD type secundum

    Article • International Journal of Cardiology, October 2011, Elsevier

    Dr Julie De Backer

  72. Applying massive parallel sequencing to molecular diagnosis of Marfan and Loeys-Dietz syndromes

    Article • Human Mutation, July 2011, Wiley

    Dr Julie De Backer

  73. A Quantitative Comparison Between Baseline Hemodynamics and End-Stage Aneurysm Formation in ApoE −/− Mice

    Article • June 2011, ASME International

    Dr Julie De Backer, Dr Bram Trachet

  74. An Integrated Framework to Quantitatively Link Mouse-Specific Hemodynamics to Aneurysm Formation in Angiotensin II-infused ApoE −/− mice

    Article • Annals of Biomedical Engineering, May 2011, Springer Science + Business Media

    Dr Julie De Backer, Dr Bram Trachet

  75. Iron deficiency is associated with adverse outcome in Eisenmenger patients

    Article • European Heart Journal, May 2011, European Society of Cardiology

    Dr Julie De Backer

  76. PREDICTING THE OCCURRENCE OF ATRIAL ARRHYTHMIA AFTER CLOSURE OF AN ATRIAL SEPTAL DEFECT

    Article • Journal of the American College of Cardiology, April 2011, Elsevier

    Dr Julie De Backer

  77. Resolving in-vivo flow fields in the systemic circulation of the mouse through combined ultrasound imaging and computational fluid dynamics

    Article • October 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Julie De Backer, Dr Bram Trachet

  78. Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial

    Article • The Lancet, October 2010, Elsevier

    Dr Julie De Backer

  79. Cardiovascular manifestations in men and women carrying a FBN1 mutation

    Article • European Heart Journal, August 2010, European Society of Cardiology

    Dr Julie De Backer

  80. Short stature, severe aortic root dilation, skin hyperextensibility, extreme joint laxity and craniofacial dysmorphic features: a probable new syndrome

    Article • Clinical Dysmorphology, July 2010, Wolters Kluwer Health

    Dr Julie De Backer

  81. The revised Ghent nosology for the Marfan syndrome

    Article • Journal of Medical Genetics, June 2010, BMJ

    Dr Julie De Backer

  82. Expanding the phenotype of sudden cardiac death—An unusual presentation of a family with a Lamin A/C mutation

    Article • International Journal of Cardiology, January 2010, Elsevier

    Dr Julie De Backer

  83. The Belgian Eisenmenger syndrome registry: Implications for treatment strategies?

    Article • Acta Cardiologica, August 2009, Peeters Publishers

    Dr Julie De Backer

  84. Circulating Transforming Growth Factor-β in Marfan Syndrome

    Article • Circulation, August 2009, Wolters Kluwer Health

    Dr Julie De Backer

  85. Patient-Specific Modelling of Aortic Arch Wall Shear Stress Patterns in Patients With Marfan Syndrome

    Article • June 2009, ASME International

    Dr Julie De Backer, Dr Bram Trachet

  86. Short-term systolic and diastolic ventricular performance after surgical ventricular restoration for dilated ischemic cardiomyopathy

    Article • European Journal of Cardio-Thoracic Surgery, June 2009, Oxford University Press (OUP)

    Dr Julie De Backer

  87. Marfan and Marfan-like syndromes

    Article • Artery Research, February 2009, Elsevier

    Dr Julie De Backer

  88. Clinical and Molecular Study of 320 Children With Marfan Syndrome and Related Type I Fibrillinopathies in a Series of 1009 Probands With Pathogenic FBN1 Mutations

    Article • PEDIATRICS, January 2009, American Academy of Pediatrics (AAP)

    Dr Julie De Backer

  89. Strain Rate Imaging Detects Early Cardiac Effects of Pegylated Liposomal Doxorubicin as Adjuvant Therapy in Elderly Patients with Breast Cancer

    Article • Journal of the American Society of Echocardiography, December 2008, Elsevier

    Dr Julie De Backer

  90. Comprehensive clinical and molecular assessment of 32 probands with congenital contractural arachnodactyly: Report of 14 novel mutations and review of the literature

    Article • Human Mutation, November 2008, Wiley

    Dr Julie De Backer

  91. The expanding cardiovascular phenotype of Marfan syndrome

    Article • European Journal of Echocardiography, August 2008, European Society of Cardiology

    Dr Julie De Backer

  92. Effect of an Abdominal Aortic Aneurysm on Wave Reflection in the Aorta

    Article • IEEE Transactions on Biomedical Engineering, May 2008, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Julie De Backer

  93. Successful alcohol septal ablation for late recurrence of left ventricular outflow tract obstruction after surgical myectomy in hypertrophic obstructive cardiomyopathy

    Article • Acta Cardiologica, April 2008, Peeters Publishers

    Dr Julie De Backer

  94. The Impact of an Abdominal Aortic Aneurysm on Aortic Wave Reflection

    Article • June 2007, ASME International

    Dr Julie De Backer

  95. Marfan Syndrome

    Article • January 2007, Elsevier

    Dr Julie De Backer

  96. Three arginine to cysteine substitutions in the pro-alpha (I)-collagen chain cause Ehlers-Danlos syndrome with a propensity to arterial rupture in early adulthood

    Article • Human Mutation, January 2007, Wiley

    Dr Julie De Backer

  97. Synergistic inhibition of the enzymatic activity of aminopeptidase N by divalent metal ion chelators

    Article • Fundamental and Clinical Pharmacology, December 2006, Wiley

    Dr Julie De Backer

  98. Primary impairment of left ventricular function in Marfan syndrome

    Article • International Journal of Cardiology, October 2006, Elsevier

    Professor Thierry C Gillebert, Dr Julie De Backer

  99. Aneurysm Syndromes Caused by Mutations in the TGF-β Receptor

    Article • New England Journal of Medicine, August 2006, New England Journal of Medicine (NEJM/MMS)

    Dr Julie De Backer

  100. A critical analysis of minor cardiovascular criteria in the diagnostic evaluation of patients with Marfan syndrome

    Article • Genetics in Medicine, July 2006, Nature

    Dr Julie De Backer

  101. Variability of aortic stiffness is not associated with the fibrillin 1 genotype in patients with Marfan's syndrome

    Article • Heart, May 2006, BMJ

    Dr Julie De Backer

  102. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome

    Article • Nature Genetics, March 2006, Nature

    Dr Julie De Backer

  103. Echocardiographically estimated left ventricular end-diastolic and right ventricular systolic pressure in normotensive healthy individuals

    Article • The International Journal of Cardiovascular Imaging, March 2006, Springer Science + Business Media

    Dr Julie De Backer

  104. Effects of age, gender, and left ventricular mass on septal mitral annulus velocity (E′) and the ratio of transmitral early peak velocity to E′ (E/E′)

    Article • The American Journal of Cardiology, April 2005, Elsevier

    Professor Thierry C Gillebert, Dr Julie De Backer

  105. Evaluation of left ventricular dimensions and function in Marfan's syndrome without significant valvular regurgitation

    Article • The American Journal of Cardiology, March 2005, Elsevier

    Dr Julie De Backer

  106. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

    Article • Nature Genetics, January 2005, Nature

    Dr Julie De Backer

  107. Functional analysis of the common carotid artery

    Article • Journal of Hypertension, May 2004, Wolters Kluwer Health

    Professor Thierry C Gillebert, Dr Julie De Backer

  108. DUP25 remains unconfirmed

    Article • American Journal of Medical Genetics, January 2004, Wiley

    Dr Julie De Backer

  109. Diastolic dysfunction, infarct size, and exercise capacity in remote myocardial infarction: a combined approach of mitral E-wave deceleration time and color M-mode flow propagation velocity

    Article • The American Journal of Cardiology, March 2002, Elsevier

    Professor Thierry C Gillebert, Dr Julie De Backer

  110. Connective Tissue Disorders

    Article • Wiley

    Dr Julie De Backer