All Stories

  1. Targeting the endocannabinoid system to suppress mTORC1 hyperactivation in TSC-associated kidney disease

    Article • AJP Renal Physiology, September 2025, American Physiological Society

    Joseph Tam

  2. Characterization of Neurensin-2 knockout mice: insights into stress-resilience mechanisms

    Article • Translational Psychiatry, July 2025, Springer Science + Business Media

    Joseph Tam

  3. 5′LysTTT tRNA fragments support survival of botulinum-intoxicated neurons by blocking ferroptosis

    Article • Genomic Psychiatry, May 2025, Genomic Press

    Joseph Tam

  4. Metabolic reprogramming driven by Ant2 deficiency augments T Cell function and anti-tumor immunity in mice

    Article • Nature Communications, May 2025, Springer Science + Business Media

    Joseph Tam

  5. Synthesis and Pharmacological Characterization of Novel Peripheral Cannabinoid-1 Receptor Blockers Based on a Tricyclic Scaffold

    Article • Journal of Medicinal Chemistry, April 2025, American Chemical Society (ACS)

    Joseph Tam

  6. 5-Methoxy-2-aminoindane Reverses Diet-Induced Obesity and Improves Metabolic Parameters in Mice: A Potential New Class of Antiobesity Therapeutics

    Article • ACS Pharmacology & Translational Science, July 2024, American Chemical Society (ACS)

    Joseph Tam

  7. The Autophagic Activator GHF-201 Can Alleviate Pathology in a Mouse Model and in Patient Fibroblasts of Type III Glycogenosis

    Article • Biomolecules, July 2024, MDPI AG

    Joseph Tam

  8. The Autophagic Activator GHF-201 can Alleviate Pathology in a Mouse Model and in Patient Fibroblasts of Type III Glycogenosis

    Article • June 2024, MDPI AG

    Joseph Tam

  9. Cover Image

    Article • Journal of the American Society of Nephrology, March 2024, Wolters Kluwer Health

    Joseph Tam

  10. Renal Mitochondrial ATP Transporter Ablation Ameliorates Obesity-Induced Chronic Kidney Disease

    Article • Journal of the American Society of Nephrology, January 2024, Wolters Kluwer Health

    Joseph Tam

  11. Renal Endocannabinoid Dysregulation in Obesity-Induced Chronic Kidney Disease in Humans

    Article • International Journal of Molecular Sciences, September 2023, MDPI AG

    Joseph Tam

  12. Systemic Changes in Endocannabinoids and Endocannabinoid-like Molecules in Response to Partial Nephrectomy-Induced Ischemia in Humans

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Joseph Tam

  13. Kidney Proximal Tubule GLUT2—More than Meets the Eye

    Article • Cells, December 2022, MDPI AG

    Joseph Tam

  14. Salivary Endocannabinoid Profiles in Chronic Orofacial Pain and Headache Disorders: An Observational Study Using a Novel Tool for Diagnosis and Management

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Joseph Tam

  15. Herbal Cannabis Use Is Not Associated with Changes in Levels of Endocannabinoids and Metabolic Profile Alterations among Older Adults

    Article • Life, October 2022, MDPI AG

    Joseph Tam

  16. Blood RNA Sequencing Indicates Upregulated BATF2 and LY6E and Downregulated ISG15 and MT2A Expression in Children with Autism Spectrum Disorder

    Article • International Journal of Molecular Sciences, August 2022, MDPI AG

    Joseph Tam

  17. Reduced Endocannabinoid Tone in Saliva of Chronic Orofacial Pain Patients

    Article • Molecules, July 2022, MDPI AG

    Joseph Tam

  18. Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2

    Article • eLife, May 2022, eLife

    Joseph Tam

  19. The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet- and Genetic-Induced Obesity

    Article • International Journal of Molecular Sciences, May 2022, MDPI AG

    Joseph Tam

  20. Effects of Environmental Heat Load on Endocannabinoid System Components in Adipose Tissue of High Yielding Dairy Cows

    Article • Animals, March 2022, MDPI AG

    Joseph Tam

  21. Placental colonization by Fusobacterium nucleatum is mediated by binding of the Fap2 lectin to placentally displayed Gal-GalNAc

    Article • Cell Reports, March 2022, Elsevier

    Joseph Tam

  22. Fenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential

    Article • Molecules, February 2022, MDPI AG

    Joseph Tam

  23. Do endocannabinoids acting via hepatic CB-1 contribute to NAFLD and hepatic insulin resistance?

    Article • Journal of Clinical Investigation, January 2022, American Society for Clinical Investigation

    Joseph Tam

  24. Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice

    Article • The Journal of Nutritional Biochemistry, December 2021, Elsevier

    Joseph Tam

  25. Pathogenesis of diabesity‐induced kidney disease: role of kidney nutrient sensing

    Article • FEBS Journal, March 2021, Wiley

    Joseph Tam

  26. Renal Proximal Tubule Cell Cannabinoid-1 Receptor Regulates Bone Remodeling and Mass via a Kidney-to-Bone Axis

    Article • Cells, February 2021, MDPI AG

    Joseph Tam

  27. Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Joseph Tam

  28. Dual inhibition of cannabinoid CB 1 receptor and inducible NOS attenuates obesity‐induced chronic kidney disease

    Article • British Journal of Pharmacology, December 2019, Wiley

    Dr Resat Cinar, Joseph Tam

  29. HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity

    Article • Molecules, October 2019, MDPI AG

    Joseph Tam

  30. Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome

    Article • Toxins, May 2019, MDPI AG

    Joseph Tam

  31. WWOX somatic ablation in skeletal muscles alters glucose metabolism

    Article • Molecular Metabolism, April 2019, Elsevier

    Joseph Tam

  32. Cannabinoid‐1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells

    Article • Diabetes Obesity and Metabolism, September 2018, Wiley

    Joseph Tam

  33. Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor

    Article • Bone, March 2018, Elsevier

    Joseph Tam

  34. The therapeutic potential of targeting the peripheral endocannabinoid/CB 1 receptor system

    Article • European Journal of Internal Medicine, March 2018, Elsevier

    Joseph Tam

  35. Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues

    Article • Gastroenterology, November 2017, Elsevier

    Joseph Tam

  36. Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

    Article • Molecular Metabolism, October 2017, Elsevier

    Dr Resat Cinar, Joseph Tam

  37. Metabolic Profiling of CB1 Neutral Antagonists

    Article • January 2017, Elsevier

    Joseph Tam

  38. CB1 cannabinoid receptors mediate endochondral skeletal growth attenuation by Δ9-tetrahydrocannabinol

    Article • Annals of the New York Academy of Sciences, January 2015, Wiley

    Joseph Tam

  39. Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

    Article • Journal of Clinical Investigation, October 2010, American Society for Clinical Investigation

    Joseph Tam

  40. Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

    Article • Journal of Clinical Investigation, August 2010, American Society for Clinical Investigation

    Joseph Tam

  41. The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling

    Article • The FASEB Journal, August 2007, Wiley

    Joseph Tam

  42. Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling

    Article • Molecular Pharmacology, June 2006, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Joseph Tam