All Stories

  1. A solution NMR methodology enabling the elucidation of small molecule phospholipid membrane adhesion and passive permeation parameters

    Article • Chemical Communications, January 2024, Royal Society of Chemistry

    Jose Luis Ortega-Roldan

  2. Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides

    Article • ACS Catalysis, March 2023, American Chemical Society (ACS)

    Jose Luis Ortega-Roldan

  3. Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate

    Article • Molecular Biology and Evolution, February 2023, Oxford University Press (OUP)

    Jose Luis Ortega-Roldan

  4. Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

    Article • Chemical Communications, January 2023, Royal Society of Chemistry

    Jose Luis Ortega-Roldan

  5. Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 protein

    Article • Computational and Structural Biotechnology Journal, January 2023, American Association for the Advancement of Science

    Jose Luis Ortega-Roldan

  6. A Zn2+-triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels

    Article • Journal of Cell Science, August 2022, The Company of Biologists

    Jose Luis Ortega-Roldan

  7. Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ‘druggable’ supramolecular self-associating antimicrobial amphiphiles

    Article • Chemical Science, January 2022, Royal Society of Chemistry

    Jose Luis Ortega-Roldan

  8. Mutually Beneficial Combination of Molecular Dynamics Computer Simulations and Scattering Experiments

    Article • Membranes, July 2021, MDPI AG

    Henrich Frielinghaus, Jose Luis Ortega-Roldan

  9. Establishing a Metabolite Extraction Method to Study the Metabolome of Blastocystis Using NMR

    Article • Molecules, May 2021, MDPI AG

    Anastasios D. Tsaousis, Jose Luis Ortega-Roldan

  10. The elucidation of phospholipid bilayer–small molecule interactions using a combination of phospholipid nanodiscs and solution state NMR techniques

    Article • Chemical Communications, January 2020, Royal Society of Chemistry

    Jose Luis Ortega-Roldan

  11. A quantitative assay to study the lipid selectivity of membrane-associated systems using solution NMR

    Article • Chemical Communications, January 2020, Royal Society of Chemistry

    Jose Luis Ortega-Roldan

  12. Membrane insertion of soluble CLIC1 into active chloride channels is triggered by specific divalent cations

    Article • May 2019, Cold Spring Harbor Laboratory Press

    Jose Luis Ortega-Roldan

  13. Characterizing Protein-Protein Interactions Using Solution NMR Spectroscopy

    Article • January 2018, Springer Science + Business Media

    Jose Luis Ortega-Roldan

  14. Solution NMR studies reveal the location of the second transmembrane domain of the human sigma-1 receptor

    Article • FEBS Letters, January 2015, Wiley

    Jose Luis Ortega-Roldan

  15. Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications

    Article • PLOS One, September 2013, PLOS

    Jose Luis Ortega-Roldan

  16. Characterization of the Human Sigma-1 Receptor Chaperone Domain Structure and Binding Immunoglobulin Protein (BiP) Interactions

    Article • Journal of Biological Chemistry, June 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jose Luis Ortega-Roldan

  17. Multimeric and differential binding of CIN85/CD2AP with two atypical proline‐rich sequences from CD2 and Cbl‐b*

    Article • FEBS Journal, June 2013, Wiley

    Jose Luis Ortega-Roldan

  18. Mapping the Population of Protein Conformational Energy Sub-States from NMR Dipolar Couplings

    Article • Angewandte Chemie, February 2013, Wiley

    Jose Luis Ortega-Roldan

  19. Multi-Timescale Conformational Dynamics of the SH3 Domain of CD2-Associated Protein using NMR Spectroscopy and Accelerated Molecular Dynamics

    Article • Angewandte Chemie, May 2012, Wiley

    Jose Luis Ortega-Roldan

  20. Characterizing weak protein–protein complexes by NMR residual dipolar couplings

    Article • European Biophysics Journal, June 2011, Springer Science + Business Media

    Jose Luis Ortega-Roldan

  21. Solution structure, dynamics and thermodynamics of the three SH3 domains of CD2AP

    Article • Journal of Biomolecular NMR, April 2011, Springer Science + Business Media

    Jose Luis Ortega-Roldan

  22. Structure, Dynamics, and Kinetics of Weak Protein-Protein Complexes from NMR Spin Relaxation Measurements of Titrated Solutions

    Article • Angewandte Chemie, March 2011, Wiley

    Jose Luis Ortega-Roldan

  23. Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings: application to the CD2AP SH3-C:ubiquitin complex

    Article • Nucleic Acids Research, April 2009, Oxford University Press (OUP)

    Jose Luis Ortega-Roldan

  24. The high resolution NMR structure of the third SH3 domain of CD2AP

    Article • Journal of Biomolecular NMR, October 2007, Springer Science + Business Media

    Jose Luis Ortega-Roldan