All Stories

  1. Stroke-Like Episodes and Cerebellar Syndrome in Phosphomannomutase Deficiency (PMM2-CDG): Evidence for Hypoglycosylation-Driven Channelopathy

    Article • International Journal of Molecular Sciences, February 2018, MDPI AG

    Dr Jose M Fernandez-Fernandez

  2. Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses

    Article • Proceedings of the National Academy of Sciences, February 2018, Proceedings of the National Academy of Sciences

    Dr Jose M Fernandez-Fernandez

  3. Cannabis Users Show Enhanced Expression of CB1-5HT2A Receptor Heteromers in Olfactory Neuroepithelium Cells

    Article • Molecular Neurobiology, January 2018, Springer Science + Business Media

    Dr Jose M Fernandez-Fernandez

  4. Cross talk between β subunits, intracellular Ca 2+ signaling, and SNAREs in the modulation of Ca V 2.1 channel steady‐state inactivation

    Article • Physiological Reports, January 2018, Wiley

    Dr Jose M Fernandez-Fernandez

  5. Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel

    Article • Scientific Reports, September 2017, Nature

    Dr Jose M Fernandez-Fernandez

  6. Missense mutations of CACNA1A are a frequent cause of autosomal dominant nonprogressive congenital ataxia

    Article • European Journal of Paediatric Neurology, November 2016, Elsevier

    Dr Jose M Fernandez-Fernandez, Prof Massimiliano Valeriani

  7. Vascular Reactivity Profile of Novel KCa3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed

    Article • Basic & Clinical Pharmacology & Toxicology, February 2016, Wiley

    Dr Jose M Fernandez-Fernandez, Professor Ulf Simonsen

  8. A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx

    Article • PLoS ONE, December 2015, PLOS

    Dr Jose M Fernandez-Fernandez

  9. Tungstate-Targeting of BKαβ1 Channels Tunes ERK Phosphorylation and Cell Proliferation in Human Vascular Smooth Muscle

    Article • PLoS ONE, February 2015, PLOS

    Dr Jose M Fernandez-Fernandez

  10. RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein

    Article • Oncotarget, November 2014, Impact Journals, LLC

    Dr Jose M Fernandez-Fernandez

  11. DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors

    Article • Frontiers in Cellular Neuroscience, October 2014, Frontiers

    Dr Jose M Fernandez-Fernandez

  12. A loss-of-function CACNA1A mutation causing benign paroxysmal torticollis of infancy

    Article • European Journal of Paediatric Neurology, May 2014, Elsevier

    Dr Jose M Fernandez-Fernandez

  13. BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating

    Article • Pflügers Archiv - European Journal of Physiology, October 2013, Springer Science + Business Media

    Dr Jose M Fernandez-Fernandez

  14. Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies

    Article • Molecular Genetics & Genomic Medicine, July 2013, Wiley

    Dr Jose M Fernandez-Fernandez, Daniel Grinberg

  15. TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

    Article • eLife, May 2013, eLife

    Gerard Cantero Recasens, Dr Frederic A Bard, Dr Jose M Fernandez-Fernandez

  16. Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation

    Article • Cardiovascular Research, April 2012, European Society of Cardiology

    Dr Jose M Fernandez-Fernandez

  17. SNP variants within the vanilloidTRPV1andTRPV3receptor genes are associated with migraine in the Spanish population

    Article • American Journal of Medical Genetics Part B Neuropsychiatric Genetics, December 2011, Wiley

    Dr Jose M Fernandez-Fernandez

  18. A Cav3.2/Syntaxin-1A Signaling Complex Controls T-type Channel Activity and Low-threshold Exocytosis

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jose M Fernandez-Fernandez, Lubica Lacinova

  19. A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis

    Article • Proceedings of the National Academy of Sciences, January 2010, Proceedings of the National Academy of Sciences

    Dr Jose M Fernandez-Fernandez, Artur Llobet

  20. KCNE4 suppresses Kv1.3 currents by modulating trafficking, surface expression and channel gating

    Article • Journal of Cell Science, September 2009, The Company of Biologists

    Dr Jose M Fernandez-Fernandez

  21. A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

    Article • Proceedings of the National Academy of Sciences, August 2009, Proceedings of the National Academy of Sciences

    Dr Jose M Fernandez-Fernandez

  22. Late-onset episodic ataxia type 2 associated with a novel loss-of-function mutation in the CACNA1A gene

    Article • Journal of the Neurological Sciences, May 2009, Elsevier

    Dr Jose M Fernandez-Fernandez

  23. Contribution of syntaxin 1A to the genetic susceptibility to migraine: A case–control association study in the Spanish population

    Article • Neuroscience Letters, May 2009, Elsevier

    Dr Jose M Fernandez-Fernandez

  24. The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition

    Article • Pflügers Archiv - European Journal of Physiology, February 2009, Springer Science + Business Media

    Dr Jose M Fernandez-Fernandez

  25. Genetic variation in the KCNMA1 potassium channel α subunit as risk factor for severe essential hypertension and myocardial infarction

    Article • Journal of Hypertension, November 2008, Wolters Kluwer Health

    Dr Jose M Fernandez-Fernandez

  26. Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines

    Article • Pflügers Archiv - European Journal of Physiology, May 2008, Springer Science + Business Media

    Dr Jose M Fernandez-Fernandez

  27. IP 3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5′-6′-epoxyeicosatrienoic acid

    Article • The Journal of Cell Biology, March 2008, Rockefeller University Press

    Dr Jose M Fernandez-Fernandez

  28. Red cardiovascular HERACLES

    Article • Revista Española de Cardiología, January 2008, Elsevier

    Dr Jose M Fernandez-Fernandez

  29. Protective Effect of the KCNMB1 E65K Genetic Polymorphism Against Diastolic Hypertension in Aging Women and Its Relevance to Cardiovascular Risk

    Article • Circulation Research, December 2005, Wolters Kluwer Health

    Dr Jose M Fernandez-Fernandez

  30. Human TRPV4 Channel Splice Variants Revealed a Key Role of Ankyrin Domains in Multimerization and Trafficking

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jose M Fernandez-Fernandez

  31. TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity

    Article • The Journal of Cell Biology, March 2005, Rockefeller University Press

    Dr Jose M Fernandez-Fernandez

  32. Swelling-activated Ca2+ Entry via TRPV4 Channel Is Defective in Cystic Fibrosis Airway Epithelia

    Article • Journal of Biological Chemistry, October 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jose M Fernandez-Fernandez

  33. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension

    Article • Journal of Clinical Investigation, April 2004, American Society for Clinical Investigation

    Dr Jose M Fernandez-Fernandez

  34. Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension

    Article • Journal of Clinical Investigation, April 2004, American Society for Clinical Investigation

    Dr Jose M Fernandez-Fernandez

  35. Plasma Membrane Voltage-dependent Anion Channel Mediates Antiestrogen-activated Maxi Cl- Currents in C1300 Neuroblastoma Cells

    Article • Journal of Biological Chemistry, June 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jose M Fernandez-Fernandez

  36. Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line

    Article • AJP Cell Physiology, August 2002, American Physiological Society

    Dr Jose M Fernandez-Fernandez

  37. Constitutive Activation of G-proteins by Polycystin-1 Is Antagonized by Polycystin-2

    Article • Journal of Biological Chemistry, January 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jose M Fernandez-Fernandez

  38. Multiple pertussis toxin-sensitive G-proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native Gi-proteins do soin situ

    Article • European Journal of Neuroscience, July 2001, Wiley

    Dr Jose M Fernandez-Fernandez

  39. Selective activation of heterologously expressed G protein-gated K+channels by M2muscarinic receptors in rat sympathetic neurones

    Article • The Journal of Physiology, March 1999, Wiley

    Dr Jose M Fernandez-Fernandez

  40. Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells

    Article • FEBS Letters, November 1997, Wiley

    Dr Jose M Fernandez-Fernandez

  41. ω-Conotoxin GVIA blocks nicotine-induced catecholamine secretion by blocking the nicotinic receptor-activated inward currents in bovine chromaffin cells

    Article • Neuroscience Letters, May 1995, Elsevier

    Dr Jose M Fernandez-Fernandez

  42. ω-agatoxin IVA blocks nicotinic receptor channels in bovine chromaffin cells

    Article • FEBS Letters, March 1995, Wiley

    Dr Jose M Fernandez-Fernandez