All Stories

  1. Replacement, reduction, refinement: 3 days for 3Rs

    Article • ALTEX, January 2022, ALTEX Edition

    Dr Johnny Vincent Roughan

  2. Welfare Assessment, End-Point Refinement and the Effects of Non-Aversive Handling in C57BL/6 Mice with Lewis Lung Cancer

    Article • Animals, December 2021, MDPI AG

    Dr Johnny Vincent Roughan

  3. Neuroinflammation, body temperature and behavioural changes in CD1 male mice undergoing acute restraint stress: An exploratory study

    Article • PLOS One, November 2021, PLOS

    Dr Johnny Vincent Roughan

  4. Benefits of tunnel handling persist after repeated restraint, injection and anaesthesia

    Article • Scientific Reports, September 2020, Springer Science + Business Media

    Dr Johnny Vincent Roughan

  5. Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey

    Article • PLOS One, April 2020, PLOS

    Dr Johnny Vincent Roughan

  6. A refinement approach in a mouse model of rehabilitation research. Analgesia strategy, reduction approach and infrared thermography in spinal cord injury

    Article • PLOS One, October 2019, PLOS

    Silvia Mazzola, Dr Johnny Vincent Roughan

  7. Welfare and Scientific Considerations of Tattooing and Ear Tagging for Mouse Identification

    Article • Journal of the American Association for Laboratory Animal Science, March 2019, American Association for Laboratory Animal Science

    Dr Johnny Vincent Roughan

  8. Analgesics are helpful to cancer research validity

    Article • Laboratory Animals, December 2017, SAGE Publications

    Dr Johnny Vincent Roughan

  9. Efficacy of Intrathecal Morphine in a Model of Surgical Pain in Rats

    Article • PLOS One, October 2016, PLOS

    Dr Johnny Vincent Roughan

  10. Welfare Assessment following Heterotopic or Orthotopic Inoculation of Bladder Cancer in C57BL/6 Mice

    Article • PLOS One, July 2016, PLOS

    Dr Johnny Vincent Roughan

  11. Authors' reply to the comment by Ruan

    Article • European Journal of Pain, July 2016, Wiley

    Dr Johnny Vincent Roughan

  12. Meloxicam prevents COX‐2‐mediated post‐surgical inflammation but not pain following laparotomy in mice

    Article • European Journal of Pain, April 2015, Wiley

    Dr Johnny Vincent Roughan

  13. The Conditioned Place Preference Test for Assessing Welfare Consequences and Potential Refinements in a Mouse Bladder Cancer Model

    Article • PLOS One, August 2014, PLOS

    Dr Johnny Vincent Roughan

  14. Rat Experimental Model of Myocardial Ischemia/Reperfusion Injury: An Ethical Approach to Set up the Analgesic Management of Acute Post-Surgical Pain

    Article • PLOS One, April 2014, PLOS

    Dr Johnny Vincent Roughan

  15. Comparative Effects of Vasectomy Surgery and Buprenorphine Treatment on Faecal Corticosterone Concentrations and Behaviour Assessed by Manual and Automated Analysis Methods in C57 and C3H Mice

    Article • PLOS One, September 2013, PLOS

    Dr Johnny Vincent Roughan

  16. ANTINOCICEPTIVE ACTIVITIES OF HYPTIS CRENATA POHL

    Article • Acta Horticulturae, January 2013, International Society for Horticultural Science (ISHS)

    Dr Johnny Vincent Roughan

  17. A comparison of abdominal and scrotal approach methods of vasectomy and the influence of analgesic treatment in laboratory mice

    Article • Laboratory Animals, October 2012, SAGE Publications

    Dr Johnny Vincent Roughan

  18. A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice

    Article • Applied Animal Behaviour Science, May 2011, Elsevier

    Dr Johnny Vincent Roughan

  19. A guide to defining and implementing protocols for the welfare assessment of laboratory animals: eleventh report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement

    Article • Laboratory Animals, January 2011, SAGE Publications

    Dr Johnny Vincent Roughan

  20. Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine

    Article • Veterinary Anaesthesia and Analgesia, May 2010, Elsevier

    Dr Johnny Vincent Roughan

  21. A preliminary investigation into the practicality of use and duration of action of slow-release preparations of morphine and hydromorphone in laboratory rats

    Article • Laboratory Animals, January 2010, SAGE Publications

    Dr Johnny Vincent Roughan

  22. Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits

    Article • Research in Veterinary Science, October 2009, Elsevier

    Dr Johnny Vincent Roughan

  23. Automated analysis of postoperative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice

    Article • Laboratory Animals, January 2009, SAGE Publications

    Dr Johnny Vincent Roughan

  24. Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse

    Article • Pain, July 2007, Wolters Kluwer Health

    Dr Johnny Vincent Roughan

  25. Training in behaviour-based post-operative pain scoring in rats—An evaluation based on improved recognition of analgesic requirements

    Article • Applied Animal Behaviour Science, February 2006, Elsevier

    Dr Johnny Vincent Roughan

  26. Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit

    Article • Veterinary Anaesthesia and Analgesia, September 2005, Elsevier

    Dr Johnny Vincent Roughan

  27. Excitatory effects of fentanyl upon the rat electroencephalogram and auditory-evoked potential responses during anaesthesia

    Article • European Journal of Anaesthesiology, July 2005, Wolters Kluwer Health

    Dr Johnny Vincent Roughan

  28. Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats

    Article • Behavioural Pharmacology, November 2004, Wolters Kluwer Health

    Dr Johnny Vincent Roughan

  29. Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam

    Article • Laboratory Animals, July 2004, SAGE Publications

    Dr Johnny Vincent Roughan

  30. Evaluation of a short duration behaviour-based post-operative pain scoring system in rats

    Article • European Journal of Pain, October 2003, Wiley

    Dr Johnny Vincent Roughan

  31. Effects of different propofol infusion rates on EEG activity and AEP responses in rats

    Article • Journal of Veterinary Pharmacology and Therapeutics, October 2003, Wiley

    Dr Johnny Vincent Roughan

  32. Pain assessment and control in laboratory animals

    Article • Laboratory Animals, April 2003, SAGE Publications

    Dr Johnny Vincent Roughan

  33. Comparison of electroencephalogram activity and auditory evoked responses during isoflurane and halothane anaesthesia in the rat

    Article • Veterinary Anaesthesia and Analgesia, January 2003, Elsevier

    Dr Johnny Vincent Roughan

  34. Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative pain in animals

    Article • Laboratory Animals, July 2002, SAGE Publications

    Dr Johnny Vincent Roughan

  35. Anaesthesia with ketamine/medetomidine in the rabbit: influence of route of administration and the effect of combination with butorphanol

    Article • Veterinary Anaesthesia and Analgesia, January 2002, Elsevier

    Dr Johnny Vincent Roughan

  36. Evaluation of auditory evoked potentials to predict depth of anaesthesia during fentanyl/fluanisone−midazolam anaesthesia in rats

    Article • Veterinary Anaesthesia and Analgesia, October 2001, Elsevier

    Dr Johnny Vincent Roughan

  37. Induction of anaesthesia with desflurane and isoflurane in the rabbit

    Article • Laboratory Animals, April 2001, SAGE Publications

    Dr Johnny Vincent Roughan

  38. Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats

    Article • Pain, February 2001, Wolters Kluwer Health

    Dr Johnny Vincent Roughan

  39. Assessment of ketamine/medetomidine anaesthesia in the New Zealand White rabbit

    Article • Veterinary Anaesthesia and Analgesia, January 2001, Elsevier

    Dr Johnny Vincent Roughan

  40. Effects of surgery and analgesic administration on spontaneous behaviour in singly housed rats

    Article • Research in Veterinary Science, December 2000, Elsevier

    Dr Johnny Vincent Roughan

  41. Sufentanil and medetomidine anaesthesia in the rat and its reversal with atipamezole and butorphanol

    Article • Laboratory Animals, July 2000, SAGE Publications

    Dr Johnny Vincent Roughan

  42. Effects of repeated anaesthesia with ketamine/medetomidine and of pre-anaesthetic administration of buprenorphine in rats

    Article • Laboratory Animals, April 2000, SAGE Publications

    Dr Johnny Vincent Roughan

  43. The influence of pre-anaesthetic administration of buprenorphine on the anaesthetic effects of ketamine/medetomidine and pentobarbitone in rats and the consequences of repeated anaesthesia

    Article • Laboratory Animals, July 1999, SAGE Publications

    Dr Johnny Vincent Roughan

  44. A new porcine model of reperfusion injury after lung transplantation

    Article • Laboratory Animals, April 1999, SAGE Publications

    Stephen clark, Dr Johnny Vincent Roughan

  45. Use of oral buprenorphine ('buprenorphine jello') for postoperative analgesia in rats-a clinical trial

    Article • Laboratory Animals, April 1999, SAGE Publications

    Dr Johnny Vincent Roughan

  46. Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1

    Article • Journal of Thoracic and Cardiovascular Surgery, March 1999, Elsevier

    Stephen clark, Dr Johnny Vincent Roughan

  47. Induction of anaesthesia with sevoflurane and isoflurane in the rabbit

    Article • Laboratory Animals, January 1999, SAGE Publications

    Dr Johnny Vincent Roughan

  48. Epicortical slow potential shifts and sensory-evoked potentials are related to seizure propensity in gerbils

    Article • Journal of Comparative Physiology A, May 1998, Springer Science + Business Media

    Dr Johnny Vincent Roughan

  49. Large slow potential shifts occur during halothane anaesthesia in gerbils

    Article • Journal of Comparative Physiology A, May 1998, Springer Science + Business Media

    Dr Johnny Vincent Roughan

  50. Influence of oral buprenorphine, oral naltrexone or morphine on the effects of laparotomy in the rat

    Article • Laboratory Animals, April 1998, SAGE Publications

    Dr Johnny Vincent Roughan

  51. Sustained potential shifts in the toad tectum reflect prey-catching and avoidance behavior.

    Article • Behavioral Neuroscience, February 1995, American Psychological Association (APA)

    Dr Johnny Vincent Roughan