All Stories

  1. Platelet aging and desialylation increase apoptotic priming and BCL-XL dependence

    Article • Cell Death and Disease, January 2026, Springer Science + Business Media

    Dr Johan Spetz

  2. Data from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • November 2025, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  3. Supplementary Figure S1 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • November 2025, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  4. Supplementary Figure S2 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • November 2025, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  5. Supplementary Figure S3 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • November 2025, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  6. Supplementary Figure S4 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • November 2025, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  7. Supplementary Figure S5 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • November 2025, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  8. Supplementary Figure S6 from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • November 2025, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  9. Late apoptotic effects after treatment with 177 Lu-octreotate in small-intestine neuroendocrine GOT1 tumor model

    Article • International Journal of Radiation Biology, August 2025, Taylor & Francis

    Dr Johan Spetz

  10. Data from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  11. Supplementary Figure S1 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  12. Supplementary Figure S1 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  13. Supplementary Figure S2 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  14. Supplementary Figure S2 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  15. Supplementary Figure S3 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  16. Supplementary Figure S3 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  17. Supplementary Figure S4 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  18. Supplementary Figure S4 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  19. Supplementary Figure S5 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  20. Supplementary Figure S5 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  21. Supplementary Figure S6 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  22. Supplementary Figure S6 from Radiation therapy-induced neurocognitive impairment is driven by heightened apoptotic priming in early life and prevented by blocking BAX

    Article • September 2024, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  23. Synergistic Antitumor Effects of 177Lu-Octreotide Combined with an ALK Inhibitor in a High-Risk Neuroblastoma Xenograft Model

    Article • Therapeutics, August 2024, MDPI AG

    Dr Johan Spetz

  24. Late Age- and Dose-Related Effects on the Proteome of Thyroid Tissue in Rats after 131I Exposure

    Article • Radiation, May 2024, MDPI AG

    Dr Johan Spetz

  25. Comparison of 177Lu-octreotate and 177Lu-octreotide for treatment in human neuroblastoma-bearing mice

    Article • Heliyon, May 2024, Elsevier

    Dr Johan Spetz

  26. Late Age- and Dose-Related Effects on the Proteome of Thyroid Tissue in Rats after <sup>131</sup>I Exposure

    Article • March 2024, MDPI AG

    Dr Johan Spetz

  27. Synergistic Antitumor Effects of 177Lu-Octreotide Combined with an ALK Inhibitor in a High-Risk Neuroblastoma Xenograft Model

    Article • March 2024, MDPI AG

    Dr Johan Spetz

  28. Data from Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • October 2023, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  29. Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX

    Article • Cancer Research, July 2023, American Association for Cancer Research (AACR)

    Dr Johan Spetz

  30. Targeting TBK1 to overcome resistance to cancer immunotherapy

    Article • Nature, January 2023, Springer Science + Business Media

    Dr Johan Spetz

  31. Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities

    Article • Science Advances, November 2022, American Association for the Advancement of Science

    Dr Johan Spetz

  32. Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

    Article • Nature Communications, October 2022, Springer Science + Business Media

    Dr Johan Spetz

  33. Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment

    Article • Scientific Reports, April 2022, Springer Science + Business Media

    Dr Johan Spetz

  34. Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I

    Article • Scientific Reports, February 2022, Springer Science + Business Media

    Dr Johan Spetz

  35. Age and Sex Effects across the Blood Proteome after Lonizing Radiation Exposure: Consequences for Biomarker Screening and Risk Assessment

    Article • November 2021, Research Square

    Dr Johan Spetz

  36. Correction: Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure

    Article • PLOS One, October 2021, PLOS

    Dr Johan Spetz

  37. Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate

    Article • BMC Cancer, August 2021, Springer Science + Business Media

    Dr Johan Spetz

  38. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity

    Article • Science Advances, August 2021, American Association for the Advancement of Science

    Dr Johan Spetz

  39. Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics

    Article • Science Signaling, June 2021, American Association for the Advancement of Science

    Dr Johan Spetz

  40. Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure

    Article • PLOS One, December 2020, PLOS

    Dr Johan Spetz

  41. Biodistribution of 131I in mice is influenced by circadian variations

    Article • Scientific Reports, September 2020, Springer Science + Business Media

    Dr Johan Spetz

  42. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr Johan Spetz

  43. Increased therapeutic effect on medullary thyroid cancer using a combination of radiation and tyrosine kinase inhibitors

    Article • PLOS One, May 2020, PLOS

    Dr Johan Spetz

  44. Preface: Life through death—Key role of cellular suicide for colonial and organismal homeostasis

    Article • January 2020, Elsevier

    Dr Johan Spetz

  45. Preface: Life through death—Key role of cellular suicide for colonial and organismal homeostasis

    Article • January 2020, Elsevier

    Dr Johan Spetz

  46. Preface: Life through death—Key role of cellular suicide for colonial and organismal homeostasis

    Article • January 2020, Elsevier

    Dr Johan Spetz

  47. Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer

    Article • PLOS One, November 2019, PLOS

    Dr Johan Spetz

  48. Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice

    Article • EJNMMI Research, March 2019, Springer Science + Business Media

    Dr Johan Spetz

  49. Multiparametric MR for non-invasive evaluation of tumour tissue histological characteristics after radionuclide therapy

    Article • NMR in Biomedicine, January 2019, Wiley

    Dr Johan Spetz

  50. T Cells and Regulated Cell Death

    Article • January 2019, Elsevier

    Dr Johan Spetz

  51. Deconvolution of expression microarray data reveals 131I-induced responses otherwise undetected in thyroid tissue

    Article • PLOS One, July 2018, PLOS

    Dr Johan Spetz

  52. Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177 Lu[Lu]-octreotate therapy

    Article • Nuclear Medicine and Biology, May 2018, Elsevier

    Dr Johan Spetz

  53. Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor

    Article • Translational Oncology, April 2018, Elsevier

    Dr Johan Spetz

  54. Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment

    Article • Current Treatment Options in Cardiovascular Medicine, March 2018, Springer Science + Business Media

    Dr Johan Spetz

  55. Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice

    Article • BMC Cancer, August 2017, Springer Science + Business Media

    Dr Johan Spetz

  56. Transcriptional response to 131I exposure of rat thyroid gland

    Article • PLOS One, February 2017, PLOS

    Dr Johan Spetz

  57. Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

    Article • EJNMMI Research, January 2017, Springer Science + Business Media

    Dr Johan Spetz

  58. Non-targeted transcriptomic effects upon thyroid irradiation: similarity between in-field and out-of-field responses varies with tissue type

    Article • Scientific Reports, October 2016, Springer Science + Business Media

    Dr Johan Spetz

  59. Gene expression signature in mouse thyroid tissue after 131I and 211At exposure

    Article • EJNMMI Research, October 2015, Springer Science + Business Media

    Dr Johan Spetz

  60. Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after Administration

    Article • PLOS One, July 2015, PLOS

    Dr Johan Spetz

  61. Transcriptional response in normal mouse tissues after i.v. 211At administration - response related to absorbed dose, dose rate, and time

    Article • EJNMMI Research, January 2015, Springer Science + Business Media

    Dr Johan Spetz

  62. Time- and dose rate-related effects of internal 177Lu exposure on gene expression in mouse kidney tissue

    Article • Nuclear Medicine and Biology, November 2014, Elsevier

    Dr Johan Spetz

  63. Biodistribution and Dosimetry of Free 211At, 125I− and 131I− in Rats

    Article • Cancer Biotherapy & Radiopharmaceuticals, November 2013, Mary Ann Liebert Inc

    Dr Johan Spetz

  64. Radionuclide Therapy via SSTR: Future Aspects from Experimental Animal Studies

    Article • Neuroendocrinology, January 2013, Karger Publishers

    Dr Johan Spetz

  65. Specific Binding and Uptake of 131I-MIBG and 111In-Octreotide in Metastatic Paraganglioma - Tools for Choice of Radionuclide Therapy

    Article • Hormone and Metabolic Research, May 2012, Thieme Publishing Group

    Dr Johan Spetz

  66. Biodistribution of 177Lu-octreotate and 111In-minigastrin in female nude mice transplanted with human medullary thyroid carcinoma GOT2

    Article • Oncology Reports, October 2011, Spandidos Publications

    Dr Johan Spetz