All Stories

  1. Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets

    Article • Thrombosis Research, September 2018, Elsevier

    Dr Joerg Geiger

  2. Standard PREanalytical Code Version 3.0

    Article • Biopreservation and Biobanking, February 2018, Mary Ann Liebert Inc

    Dr Joerg Geiger

  3. Hospital-integrated Biobanking as a Service – The Interdisciplinary Bank of Biomaterials and Data Wuerzburg (ibdw)

    Article • Open Journal of Bioresources, January 2018, Ubiquity Press, Ltd.

    Dr Joerg Geiger

  4. Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

    Article • Blood, November 2016, American Society of Hematology

    Dr Joerg Geiger

  5. The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable

    Article • Interface Focus, February 2016, Royal Society Publishing

    Dr Joerg Geiger, David P Nickerson

  6. Reciprocal regulation of human platelet function by endogenous prostanoids and through multiple prostanoid receptors

    Article • European Journal of Pharmacology, October 2014, Elsevier

    Dr Marcel Mischnik, Dr Joerg Geiger

  7. A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling

    Article • Molecular BioSystems, May 2014, Royal Society of Chemistry

    Dr Marcel Mischnik, Dr Joerg Geiger

  8. Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways

    Article • Blood, December 2013, American Society of Hematology

    Dr Joerg Geiger, Lennart Martens

  9. Response: platelet transcriptome and proteome--relation rather than correlation

    Article • Blood, June 2013, American Society of Hematology

    Dr Joerg Geiger

  10. Deciphering of ADP-induced, phosphotyrosine-dependent signaling networks in human platelets by Src-homology 2 region (SH2)-profiling

    Article • PROTEOMICS, February 2013, Wiley

    Dr Joerg Geiger

  11. Dynamical modelling of prostaglandin signalling in platelets reveals individual receptor contributions and feedback properties

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Dr Marcel Mischnik, Dr Joerg Geiger

  12. A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Dr Marcel Mischnik, Dr Joerg Geiger

  13. Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay

    Article • Transfusion Medicine and Hemotherapy, January 2013, Karger Publishers

    Dr Joerg Geiger

  14. Damit Blut nicht verklumpt

    Article • Chemie in unserer Zeit, December 2012, Wiley

    Dr Joerg Geiger

  15. The oligopeptide DT-2 is a specific PKG I inhibitor onlyin vitro, not in living cells

    Article • British Journal of Pharmacology, September 2012, Wiley

    Dr Joerg Geiger

  16. The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

    Article • Blood, August 2012, American Society of Hematology

    Dr Joerg Geiger, Lennart Martens

  17. Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors

    Article • Clinical Chemistry and Laboratory Medicine (CCLM), January 2012, De Gruyter

    Dr Joerg Geiger

  18. Robust Workflow for iTRAQ-Based Peptide and Protein Quantification

    Article • January 2012, Springer Science + Business Media

    Dr Joerg Geiger

  19. Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, June 2011, Springer Science + Business Media

    Dr Joerg Geiger

  20. The good, the bad, the ugly: Validating the mass spectrometric analysis of modified peptides

    Article • PROTEOMICS, February 2011, Wiley

    Dr Joerg Geiger

  21. Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

    Article • BMC Systems Biology, January 2011, Springer Science + Business Media

    Dr Joerg Geiger

  22. Specific PKG inhibitors: do they really exist?

    Article • BMC Pharmacology, January 2011, Springer Science + Business Media

    Dr Joerg Geiger

  23. Quantification of cAMP and cGMP analogs in intact cells: pitfals in enzyme immunoassays for cyclic nucleotides

    Article • BMC Pharmacology, January 2011, Springer Science + Business Media

    Dr Joerg Geiger

  24. A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways

    Article • Analytical Biochemistry, December 2010, Elsevier

    Dr Joerg Geiger

  25. Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of PKA from an NF-κB-IκB complex

    Article • Journal of Biological Chemistry, March 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Joerg Geiger

  26. Phosphatidylserine surface expression and integrin αIIbβ3 activity on thrombin/convulxin stimulated platelets/particles of different sizes

    Article • British Journal of Haematology, February 2009, Wiley

    Dr Joerg Geiger

  27. Insulin inhibition of platelet-endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets: reply to a rebuttal

    Article • Journal of Thrombosis and Haemostasis, February 2009, Wiley

    Dr Joerg Geiger

  28. Insulin inhibition of platelet-endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets

    Article • Journal of Thrombosis and Haemostasis, February 2008, Wiley

    Dr Joerg Geiger

  29. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

    Article • Nature, July 2007, Nature

    Dr Joerg Geiger

  30. Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase

    Article • Blood, January 2007, American Society of Hematology

    Dr Joerg Geiger

  31. Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS

    Article • Blood Cells Molecules and Diseases, March 2006, Elsevier

    Dr Joerg Geiger

  32. Platelet NAD(P)H-oxidase-generated ROS production regulates  IIb 3-integrin activation independent of the NO/cGMP pathway

    Article • Blood, October 2005, American Society of Hematology

    Dr Joerg Geiger

  33. Monitoring of Clopidogrel Action: Comparison of Methods

    Article • Clinical Chemistry, April 2005, AACC

    Dr Joerg Geiger

  34. Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase

    Article • Blood, April 2004, American Society of Hematology

    Dr Joerg Geiger

  35. Dipyridamole Enhances NO/cGMP-Mediated Vasodilator-Stimulated Phosphoprotein Phosphorylation and Signaling in Human Platelets: In Vitro and In Vivo/Ex Vivo Studies

    Article • Stroke, January 2003, Wolters Kluwer Health

    Dr Joerg Geiger

  36. Inhibition of platelet P2Y12 and α2A receptor signaling by cGMP-dependent protein kinase

    Article • Biochemical Pharmacology, August 2002, Elsevier

    Dr Joerg Geiger

  37. Inhibitors of platelet signal transduction as anti-aggregatory drugs

    Article • Expert Opinion on Investigational Drugs, May 2001, Informa Healthcare

    Dr Joerg Geiger

  38. Anti-aggregatory drugs: I. Platelet receptor antagonists

    Article • Expert Opinion on Therapeutic Patents, October 1999, Informa Healthcare

    Dr Joerg Geiger

  39. Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice

    Article • Proceedings of the National Academy of Sciences, July 1999, Proceedings of the National Academy of Sciences

    Dr Margarita Glazova, Dr Joerg Geiger

  40. Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors

    Article • European Journal of Pharmacology, June 1998, Elsevier

    Dr Joerg Geiger

  41. The cGMP-dependent protein kinase-gene, protein, and function

    Article • Neurochemical Research, January 1993, Springer Science + Business Media

    Dr Joerg Geiger

  42. Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

    Article • Proceedings of the National Academy of Sciences, February 1992, Proceedings of the National Academy of Sciences

    Dr Joerg Geiger