All Stories

  1. ALK5 kinase inhibitors in drug discovery: Structural insights and therapeutic applications

    Article • European Journal of Medicinal Chemistry, December 2025, Elsevier

    Professor Jin Cheng-Hua

  2. Design and Synthesis of Betulinic Acid Derivatives as Antifibrotic Agents for Liver Fibrosis

    Article • Journal of Natural Products, November 2025, American Chemical Society (ACS)

    Professor Jin Cheng-Hua

  3. 2′,4′-dihydroxychalcone induces ferroptosis through ERO1A/GPX4 regulatory axis in cholangiocarcinoma

    Article • Phytomedicine, November 2025, Elsevier

    Professor Jin Cheng-Hua

  4. Reactive oxygen species-responsive micelles targeting activated hepatic stellate cells for treating liver fibrosis

    Article • Journal of Controlled Release, September 2025, Elsevier

    Professor Jin Cheng-Hua

  5. Synthesis and Antimicrobial Activity Evaluation of Amide and Sulfonamide Derivatives Containing Imidazo[2,1‐b][1,3,4]Thiadiazole Moiety

    Article • Asian Journal of Organic Chemistry, April 2025, Wiley

    Professor Jin Cheng-Hua

  6. Imidazole-Based ALK5 Inhibitor Attenuates TGF-β/Smad-Mediated Hepatic Stellate Cell Activation and Hepatic Fibrogenesis

    Article • Chemical Research in Toxicology, April 2025, American Chemical Society (ACS)

    Professor Jin Cheng-Hua

  7. Thiazole isomers as potential ALK5 inhibitors alleviate P2X7R-mediated inflammation during liver fibrosis

    Article • International Immunopharmacology, April 2025, Elsevier

    Professor Jin Cheng-Hua

  8. Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing imidazothiadiazole moiety

    Article • Future Medicinal Chemistry, December 2024, Taylor & Francis

    Professor Jin Cheng-Hua

  9. Dual-targeting galactose-functionalized hyaluronic acid modified lipid nanoparticles delivering silybin for alleviating alcoholic liver injury

    Article • International Journal of Pharmaceutics, December 2024, Elsevier

    Professor Jin Cheng-Hua

  10. Synthesis and Antimicrobial Activity of 3-Alkylidene-2-Indolone Derivatives

    Article • Molecules, November 2024, MDPI AG

    Professor Jin Cheng-Hua

  11. Application of Compounds with Anti‐Cardiac Fibrosis Activity: A Review

    Article • Chemistry & Biodiversity, October 2024, Wiley

    Professor Jin Cheng-Hua

  12. Synthesis and biological evaluation of panaxadiol ester derivatives possessing pyrazole and pyrrole moiety as HIF-1α inibitors

    Article • Fitoterapia, September 2024, Elsevier

    Professor Jin Cheng-Hua

  13. Synthesis and biological evaluation of sulfonamide derivatives containing imidazole moiety as ALK5 inhibitors

    Article • Molecular Diversity, August 2024, Springer Science + Business Media

    Professor Jin Cheng-Hua

  14. Recent Advances in Research on Active Compounds Against Hepatic Fibrosis

    Article • Current Medicinal Chemistry, June 2024, Bentham Science Publishers

    Professor Jin Cheng-Hua

  15. Application of 18β-glycyrrhetinic acid in the structural modification of natural products: a review

    Article • Molecular Diversity, April 2024, Springer Science + Business Media

    Professor Jin Cheng-Hua

  16. Synthesis of amide derivatives containing the imidazole moiety and evaluation of their anti‐cardiac fibrosis activity

    Article • Archiv der Pharmazie, April 2024, Wiley

    Professor Jin Cheng-Hua

  17. Synthesis and anti-liver fibrosis activity of imidazole and thiazole compounds containing amino acids

    Article • European Journal of Medicinal Chemistry, April 2024, Elsevier

    Professor Jin Cheng-Hua

  18. Synthesis and Antimicrobial Activity Evaluation of Pyridine Derivatives Containing Imidazo[2,1‐b][1,3,4]Thiadiazole Moiety

    Article • Chemistry & Biodiversity, March 2024, Wiley

    Professor Jin Cheng-Hua

  19. Brazilin-7-acetate, a novel potential drug of Parkinson's disease, hinders the formation of α-synuclein fibril, mitigates cytotoxicity, and decreases oxidative stress

    Article • European Journal of Medicinal Chemistry, January 2024, Elsevier

    Professor Jin Cheng-Hua

  20. Synthesis and Evaluation of Imidazole Derivatives Bearing Imidazo[2,1-b] [1,3,4]thiadiazole Moiety as Antibacterial Agents

    Article • Medicinal Chemistry, January 2024, Bentham Science Publishers

    Professor Jin Cheng-Hua

  21. Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation

    Article • Bioorganic Chemistry, October 2023, Elsevier

    Professor Jin Cheng-Hua

  22. Synthesis and antimicrobial activity evaluation of pyrazole derivatives containing the imidazo[2,1‐b][1,3,4]thiadiazole moiety

    Article • Archiv der Pharmazie, June 2023, Wiley

    Professor Jin Cheng-Hua

  23. Synthesis and Antibacterial Activity Evaluation of Imidazole Derivatives Containing 6‐Methylpyridine Moiety

    Article • Chemistry & Biodiversity, April 2023, Wiley

    Professor Jin Cheng-Hua

  24. SAR Analysis of Heterocyclic Compounds with Monocyclic and Bicyclic Structures as Antifungal Agents

    Article • ChemMedChem, May 2022, Wiley

    Professor Jin Cheng-Hua

  25. Synthesis and Evaluation of Chiral Rhodanine Derivatives Bearing Quinoxalinyl Imidazole Moiety as ALK5 Inhibitors

    Article • Medicinal Chemistry, May 2022, Bentham Science Publishers

    Hu-Ri Piao, Professor Jin Cheng-Hua

  26. The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis

    Article • Bioorganic Chemistry, May 2022, Elsevier

    Professor Jin Cheng-Hua

  27. Tolcapone Derivative (Tol-D) Inhibits Aβ42 Fibrillogenesis and Ameliorates Aβ42-Induced Cytotoxicity and Cognitive Impairment

    Article • ACS Chemical Neuroscience, February 2022, American Chemical Society (ACS)

    Professor Jin Cheng-Hua

  28. Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation

    Article • The Journal of Nutritional Biochemistry, February 2022, Elsevier

    Professor Jin Cheng-Hua

  29. Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway

    Article • Journal of Ginseng Research, January 2022, Elsevier

    Professor Jin Cheng-Hua

  30. Resveratrol modulates Toxoplasma gondii infection induced liver injury by intervening in the HMGB1/TLR4/NF-κB signaling pathway

    Article • European Journal of Pharmacology, November 2021, Elsevier

    Professor Jin Cheng-Hua

  31. New role of sertraline against Toxoplasma gondii‐induced depression‐like behaviours in mice

    Article • Parasite Immunology, October 2021, Wiley

    Professor Jin Cheng-Hua

  32. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity

    Article • Journal of Ethnopharmacology, June 2021, Elsevier

    Professor Jin Cheng-Hua

  33. Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways

    Article • Journal of Ethnopharmacology, June 2021, Elsevier

    Professor Jin Cheng-Hua

  34. Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD‐L1 expression and enhancing T‐lymphocyte tumor‐killing activity

    Article • Phytotherapy Research, May 2021, Wiley

    Professor Jin Cheng-Hua

  35. Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐b][1,3,4]thiadiazole Analogues

    Article • ChemMedChem, April 2021, Wiley

    Professor Jin Cheng-Hua

  36. Synthesis and evaluation of the epithelial-to- mesenchymal inhibitory activity of indazole-derived imidazoles as dual ALK5/p38α MAP inhibitors

    Article • European Journal of Medicinal Chemistry, April 2021, Elsevier

    Professor Jin Cheng-Hua

  37. Synthesis, Antibacterial and Antifungal Evaluation of Rhodanine Derivatives Bearing Quinoxalinyl Imidazole Moiety as ALK5 Inhibitors

    Article • Chinese Journal of Organic Chemistry, January 2021, Shanghai Institute of Organic Chemistry

    Professor Jin Cheng-Hua

  38. Britannin stabilizes T cell activity and inhibits proliferation and angiogenesis by targeting PD-L1 via abrogation of the crosstalk between Myc and HIF-1α in cancer

    Article • Phytomedicine, January 2021, Elsevier

    Professor Jin Cheng-Hua

  39. Inhibitory Effects of Twenty-Nine Compounds From Potentilla longifolia on Lipid Accumulation and Their Mechanisms in 3T3-L1 Cells

    Article • Frontiers in Pharmacology, November 2020, Frontiers

    Professor Jin Cheng-Hua

  40. Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway

    Article • Journal of Ginseng Research, September 2020, Elsevier

    Professor Jin Cheng-Hua

  41. Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1α and STAT3 (T705) signaling pathways in hepatic cancer

    Article • Journal of Ethnopharmacology, July 2020, Elsevier

    Professor Jin Cheng-Hua

  42. Arctigenin ameliorates depression-like behaviors in Toxoplasma gondii-infected intermediate hosts via the TLR4/NF-κB and TNFR1/NF-κB signaling pathways

    Article • International Immunopharmacology, May 2020, Elsevier

    Professor Jin Cheng-Hua

  43. Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells

    Article • Pharmacological Research, May 2020, Elsevier

    Professor Jin Cheng-Hua

  44. Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer

    Article • Phytomedicine, March 2020, Elsevier

    Professor Jin Cheng-Hua

  45. P2X7 receptor‐targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: A new strategy towards macrophage–hepatocyte crosstalk

    Article • British Journal of Pharmacology, February 2020, Wiley

    Professor Jin Cheng-Hua

  46. Synthesis and evaluation of the HIF-1α inhibitory activity of 3(5)-substituted-4-(quinolin-4-yl)- and 4-(2-phenylpyridin-4-yl)pyrazoles as inhibitors of ALK5

    Article • Bioorganic & Medicinal Chemistry Letters, January 2020, Elsevier

    Professor Jin Cheng-Hua

  47. Design, synthesis, and antifibrosis evaluation of 4-(benzo-[c][1,2,5]thiadiazol-5-yl)-3(5)-(6-methyl- pyridin-2-yl)pyrazole and 3(5)-(6-methylpyridin- 2-yl)-4-(thieno-[3,2,-c]pyridin-2-yl)pyrazole derivatives

    Article • European Journal of Medicinal Chemistry, October 2019, Elsevier

    Professor Jin Cheng-Hua

  48. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ

    Article • Pharmacological Research, September 2019, Elsevier

    Professor Jin Cheng-Hua

  49. Synthesis and biological evaluation of novel benzo[c][1,2,5]thiadiazol-5-yl and thieno[3,2-c]- pyridin-2-yl imidazole derivatives as ALK5 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, August 2019, Elsevier

    Professor Jin Cheng-Hua

  50. Synthesis and Evaluation of 3-Substituted-4-(quinoxalin-6-yl) Pyrazoles as TGF-β Type I Receptor Kinase Inhibitors

    Article • Molecules, December 2018, MDPI AG

    Professor Jin Cheng-Hua

  51. Novel oral transforming growth factor‐β signaling inhibitor EW ‐7197 eradicates CML ‐initiating cells

    Article • Cancer Science, January 2016, Wiley

    Professor Jin Cheng-Hua

  52. Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type I receptor kinase

    Article • Bioorganic & Medicinal Chemistry Letters, November 2015, Elsevier

    Professor Jin Cheng-Hua

  53. Human nails metabolite analysis: A rapid and simple method for quantification of uric acid in human fingernail by high-performance liquid chromatography with UV-detection

    Article • Journal of Chromatography B, October 2015, Elsevier

    Professor Jin Cheng-Hua

  54. Discovery of N-((4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF-β Type I Receptor Kinase as C...

    Article • Journal of Medicinal Chemistry, May 2014, American Chemical Society (ACS)

    Professor Jin Cheng-Hua

  55. 4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type I receptor kinase

    Article • Bioorganic & Medicinal Chemistry, May 2014, Elsevier

    Professor Jin Cheng-Hua

  56. Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

    Article • European Journal of Medicinal Chemistry, November 2012, Elsevier

    Professor Jin Cheng-Hua

  57. EW-7195, a novel inhibitor of ALK5 kinase inhibits EMT and breast cancer metastasis to lung

    Article • European Journal of Cancer, November 2011, Elsevier

    Professor Jin Cheng-Hua

  58. Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, October 2011, Elsevier

    Professor Jin Cheng-Hua

  59. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

    Article • European Journal of Medicinal Chemistry, September 2011, Elsevier

    Professor Jin Cheng-Hua

  60. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

    Article • Bioorganic & Medicinal Chemistry, April 2011, Elsevier

    Professor Jin Cheng-Hua

  61. ChemInform Abstract: Direct Etherification of Alkyl Halides by Sodium Hydride in the Presence of N,N‐Dimethylformamide.

    Article • ChemInform, February 2008, Wiley

    Professor Jin Cheng-Hua

  62. Direct Etherification of Alkyl Halides by Sodium Hydride in the Presence of N,N-Dimethylformamide

    Article • Synlett, September 2007, Thieme Publishing Group

    Professor Jin Cheng-Hua

  63. Regioselective and Diastereoselective Amination with Use of Chlorosulfonyl Isocyanate:  A Short and Efficient Synthesis of (−)-Cytoxazone

    Article • Organic Letters, August 2005, American Chemical Society (ACS)

    Professor Jin Cheng-Hua

  64. Diastereoselective synthesis of unsaturated 1,2-amino alcohols from α-hydroxy allyl ethers using chlorosulfonyl isocyanate

    Article • Tetrahedron Letters, February 2005, Elsevier

    Professor Jin Cheng-Hua