All Stories

  1. Exosomes‐transferred LINC00668 Contributes to Thrombosis by Promoting NETs Formation in Inflammatory Bowel Disease

    Article • Advanced Science, August 2023, Wiley

    Jin-kun Wen

  2. circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells

    Article • Cellular and Molecular Life Sciences, July 2023, Springer Science + Business Media

    Jin-kun Wen

  3. SF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm

    Article • Cell Death and Disease, January 2023, Springer Science + Business Media

    Jin-kun Wen

  4. KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

    Article • Communications Biology, December 2022, Springer Science + Business Media

    Jin-kun Wen

  5. Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor‐promoted inflammatory responses and prostate cancer progression

    Article • The FASEB Journal, October 2022, Wiley

    Jin-kun Wen

  6. miR-155 down-regulation protects the heart from hypoxic damage by activating fructose metabolism in cardiac fibroblasts

    Article • Journal of Advanced Research, July 2022, Elsevier

    Jin-kun Wen

  7. 17β-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression

    Article • Frontiers in Cardiovascular Medicine, November 2021, Frontiers

    Jin-kun Wen

  8. circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA

    Article • Aging, April 2021, Impact Journals, LLC

    Jin-kun Wen

  9. Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis

    Article • International Journal of Molecular Medicine, February 2021, Spandidos Publications

    Jin-kun Wen

  10. CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis

    Article • Journal of Experimental & Clinical Cancer Research, January 2021, Springer Science + Business Media

    Jin-kun Wen

  11. Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose

    Article • Journal of Ethnopharmacology, November 2020, Elsevier

    Jin-kun Wen

  12. Salvia miltiorrhiza-Derived Sal-miR-58 Induces Autophagy and Attenuates Inflammation in Vascular Smooth Muscle Cells

    Article • Molecular Therapy — Nucleic Acids, September 2020, Elsevier

    Jin-kun Wen

  13. Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission

    Article • PLoS Biology, August 2020, PLOS

    Jin-kun Wen

  14. Tanshinone ⅡA inhibits VSMC inflammation and proliferation in vivo and in vitro by downregulating miR-712-5p expression

    Article • European Journal of Pharmacology, August 2020, Elsevier

    Jin-kun Wen

  15. NeuroD1 overexpression in spinal neurons accelerates axonal regeneration after sciatic nerve injury

    Article • Experimental Neurology, May 2020, Elsevier

    Jin-kun Wen

  16. Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis

    Article • Theranostics, January 2020, Ivyspring International Publisher

    Jin-kun Wen

  17. CDK13 Upregulation-Induced Formation of the Positive Feedback Loop Among circCDK13, miR-212-5p/miR-449a and E2F5 Contributes to Prostate Carcinogenesis

    Article • SSRN Electronic Journal, January 2020, Elsevier

    Jin-kun Wen

  18. Morin Inhibits Proliferation and Induces Apoptosis by Modulating the miR-188-5p/PTEN/AKT Regulatory Pathway in CML Cells

    Article • Molecular Cancer Therapeutics, December 2019, American Association for Cancer Research (AACR)

    Jin-kun Wen

  19. Salvianolic acid B inhibits Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression

    Article • Phytomedicine, May 2019, Elsevier

    Jin-kun Wen

  20. Ascorbic Acid Facilitates Neural Regeneration After Sciatic Nerve Crush Injury

    Article • Frontiers in Cellular Neuroscience, March 2019, Frontiers

    Jin-kun Wen

  21. Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway

    Article • Oncogene, December 2018, Springer Science + Business Media

    Jin-kun Wen

  22. Inhibition of RhoA-Subfamily GTPases Suppresses Schwann Cell Proliferation Through Regulating AKT Pathway Rather Than ROCK Pathway

    Article • Frontiers in Cellular Neuroscience, November 2018, Frontiers

    Jin-kun Wen

  23. RhoA regulates Schwann cell differentiation through JNK pathway

    Article • Experimental Neurology, October 2018, Elsevier

    Jin-kun Wen

  24. Regulatory crosstalk between KLF5, miR-29a and Fbw7/CDC4 cooperatively promotes atherosclerotic development

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2018, Elsevier

    Jin-kun Wen

  25. Oxidative Stress Induces Neuronal Apoptosis Through Suppressing Transcription Factor EB Phosphorylation at Ser467

    Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

    Jin-kun Wen

  26. Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel

    Article • Journal of Experimental & Clinical Cancer Research, December 2017, Springer Science + Business Media

    Jin-kun Wen

  27. iNOS-derived peroxynitrite mediates high glucose-induced inflammatory gene expression in vascular smooth muscle cells through promoting KLF5 expression and nitration

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, November 2017, Elsevier

    Jin-kun Wen

  28. A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis

    Article • Circulation Research, September 2017, Wolters Kluwer Health

    Jin-kun Wen

  29. Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis

    Article • Molecular Therapy, June 2017, Elsevier

    Jin-kun Wen

  30. Tissue engineering with peripheral blood-derived mesenchymal stem cells promotes the regeneration of injured peripheral nerves

    Article • Experimental Neurology, June 2017, Elsevier

    Jin-kun Wen

  31. Inhibition of KLF5–Myo9b–RhoA Pathway–Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm

    Article • Circulation Research, March 2017, Wolters Kluwer Health

    Jin-kun Wen

  32. 1, 25(OH) 2 D 3 -induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation

    Article • Biochemical and Biophysical Research Communications, January 2017, Elsevier

    Jin-kun Wen

  33. miR-29a regulates vascular neointimal hyperplasia by targeting YY1

    Article • Cell Proliferation, December 2016, Wiley

    Jin-kun Wen

  34. SUMOylation of KLF4 acts as a switch in transcriptional programs that control VSMC proliferation

    Article • Experimental Cell Research, March 2016, Elsevier

    Jin-kun Wen

  35. Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells

    Article • Molecular Neurobiology, January 2016, Springer Science + Business Media

    Jin-kun Wen

  36. Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect

    Article • Scientific Reports, November 2015, Springer Science + Business Media

    Jin-kun Wen

  37. KLF4 mediates the link between TGF-β1-induced gene transcription and H3 acetylation in vascular smooth muscle cells

    Article • The FASEB Journal, September 2015, Wiley

    Jin-kun Wen

  38. TMEM16A and Myocardin Form a Positive Feedback Loop That Is Disrupted by KLF5 During Ang II–Induced Vascular Remodeling

    Article • Hypertension, August 2015, Wolters Kluwer Health

    Jin-kun Wen

  39. miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, July 2015, Elsevier

    Jin-kun Wen

  40. Tongxinluo (TXL), a Traditional Chinese Medicinal Compound, Improves Endothelial Function After Chronic Hypoxia Both In Vivo and In Vitro

    Article • Journal of Cardiovascular Pharmacology, June 2015, Wolters Kluwer Health

    Jin-kun Wen

  41. miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation

    Article • Journal of Molecular and Cellular Cardiology, May 2015, Elsevier

    Jin-kun Wen

  42. Chinese medicine Tongxinluo increases tight junction protein levels by inducing KLF5 expression in microvascular endothelial cells

    Article • Cell Biochemistry and Function, April 2015, Wiley

    Jin-kun Wen

  43. A rare self-injurious case of multiple penetrating brain injury by nails in a young patient with depressive disorder

    Article • Acta Neurologica Belgica, March 2015, Springer Science + Business Media

    Jin-kun Wen

  44. Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter

    Article • Bioscience Reports, November 2014, Portland Press Ltd.

    Jin-kun Wen

  45. Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α

    Article • AJP Heart and Circulatory Physiology, August 2014, American Physiological Society

    Jin-kun Wen

  46. A novel artificial nerve graft for repairing long-distance sciatic nerve defects: a self-assembling peptide nanofiber scaffold-containing poly(lactic-co-glycolic acid) conduit

    Article • Neural Regeneration Research, January 2014, Medknow

    Jiasong Guo, Jin-kun Wen

  47. PPAR-γ agonist stabilizes KLF4 protein via activating Akt signaling and reducing KLF4 ubiquitination

    Article • Biochemical and Biophysical Research Communications, January 2014, Elsevier

    Jin-kun Wen

  48. Synthetic retinoid Am80 up-regulates apelin expression by promoting interaction of RARα with KLF5 and Sp1 in vascular smooth muscle cells

    Article • Biochemical Journal, October 2013, Portland Press Ltd.

    Jin-kun Wen

  49. Localization and function of KLF4 in cytoplasm of vascular smooth muscle cell

    Article • Biochemical and Biophysical Research Communications, June 2013, Elsevier

    Jin-kun Wen

  50. Novel insight into Y‐box binding protein 1 in the regulation of vascular smooth muscle cell proliferation through targeting GC box‐dependent genes

    Article • FEBS Letters, March 2013, Wiley

    Jin-kun Wen

  51. KLF5 and hhLIM cooperatively promote proliferation of vascular smooth muscle cells

    Article • Molecular and Cellular Biochemistry, May 2012, Springer Science + Business Media

    Jin-kun Wen

  52. TGF-β1 Downregulates AT1 Receptor Expression via PKC-δ-Mediated Sp1 Dissociation From KLF4 and Smad-Mediated PPAR-γ Association With KLF4

    Article • Arteriosclerosis Thrombosis and Vascular Biology, April 2012, Wolters Kluwer Health

    Jin-kun Wen

  53. Retinoic Acid Receptor α Mediates All-trans-retinoic Acid-induced Klf4 Gene Expression by Regulating Klf4 Promoter Activity in Vascular Smooth Muscle Cells

    Article • Journal of Biological Chemistry, March 2012, Elsevier

    Jin-kun Wen

  54. Erratum: Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms

    Article • Cell Death and Disease, September 2011, Springer Science + Business Media

    Jin-kun Wen

  55. Acetylbritannilactone suppresses growth via upregulation of kr�ppel-like transcription factor 4 expression in HT-29 colorectal cancer cells

    Article • Oncology Reports, August 2011, Spandidos Publications

    Jin-kun Wen

  56. Erratum: Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia

    Article • BDJ, August 2011, Springer Science + Business Media

    Jin-kun Wen

  57. Celecoxib and acetylbritannilactone interact synergistically to suppress breast cancer cell growth via COX-2-dependent and -independent mechanisms

    Article • Cell Death and Disease, July 2011, Springer Science + Business Media

    Jin-kun Wen

  58. Acetylbritannilactone induces G1 arrest and apoptosis in vascular smooth muscle cells

    Article • International Journal of Cardiology, May 2011, Elsevier

    Jin-kun Wen

  59. Flavonoids fromInula britannicareduces oxidative stress through inhibiting expression and phosphorylation of p47phoxin VSMCs

    Article • Pharmaceutical Biology, April 2011, Taylor & Francis

    Jin-kun Wen

  60. HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs

    Article • BDJ, March 2011, Springer Science + Business Media

    Jin-kun Wen

  61. ATRA activates and PDGF-BB represses the SM22α promoter through KLF4 binding to, or dissociating from, its cis-DNA elements

    Article • Cardiovascular Research, January 2011, European Society of Cardiology

    Jin-kun Wen

  62. miR‐146a and Krüppel‐like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation

    Article • EMBO Reports, November 2010, EMBO

    Jin-kun Wen

  63. Krüppel-like factor 4 interacts with p300 to activate mitofusin 2 gene expression induced by all-trans retinoic acid in VSMCs

    Article • Acta Pharmacologica Sinica, August 2010, Springer Science + Business Media

    Jin-kun Wen

  64. Baicalin inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation through suppressing PDGFRβ-ERK signaling and increase in p27 accumulation and prevents injury-induced neointimal hyperplasia

    Article • BDJ, July 2010, Springer Science + Business Media

    Jin-kun Wen

  65. Krüppel-like Factor 4 Promotes Differentiation by Transforming Growth Factor-β Receptor-mediated Smad and p38 MAPK Signaling in Vascular Smooth Muscle Cells

    Article • Journal of Biological Chemistry, June 2010, Elsevier

    Jin-kun Wen

  66. Blockade of the Ras–Extracellular Signal–Regulated Kinase 1/2 Pathway Is Involved in Smooth Muscle 22α–Mediated Suppression of Vascular Smooth Muscle Cell Proliferation and Neointima Hyperplasia

    Article • Arteriosclerosis Thrombosis and Vascular Biology, April 2010, Wolters Kluwer Health

    Jin-kun Wen

  67. ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation

    Article • January 2010, Springer Science + Business Media

    Jin-kun Wen

  68. Role of Krüppel-like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells

    Article • IUBMB Life, January 2010, Wiley

    Jin-kun Wen

  69. Krüppel-like factor (KLF) 5 mediates cyclin D1 expression and cell proliferation via interaction with c-Jun in Ang II-induced VSMCs

    Article • Acta Pharmacologica Sinica, December 2009, Springer Science + Business Media

    Jin-kun Wen

  70. Polymorphisms of the ICAM-1 exon 6 (E469K) are associated with differentiation of colorectal cancer

    Article • Journal of Experimental & Clinical Cancer Research, October 2009, Springer Science + Business Media

    Jin-kun Wen

  71. Flavonoids from Inula britannica L. inhibit injury-induced neointimal formation by suppressing oxidative-stress generation

    Article • Journal of Ethnopharmacology, October 2009, Elsevier

    Jin-kun Wen

  72. All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells

    Article • Biochemical and Biophysical Research Communications, September 2009, Elsevier

    Jin-kun Wen

  73. Krüppel-like Factor 4 Inhibits Proliferation by Platelet-derived Growth Factor Receptor β-mediated, Not by Retinoic Acid Receptor α-mediated, Phosphatidylinositol 3-Kinase and ERK Signaling in Vascular Smooth Muscle Cells

    Article • Journal of Biological Chemistry, August 2009, Elsevier

    Jin-kun Wen

  74. Angiotensin II Stimulates KLF5 Phosphorylation and its Interaction with c-Jun Leading to Suppression of p21 Expression in Vascular Smooth Muscle Cells

    Article • The Journal of Biochemistry, July 2009, Oxford University Press (OUP)

    Jin-kun Wen

  75. Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression

    Article • FEBS Journal, May 2009, Wiley

    Jin-kun Wen

  76. Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα through inducing KLF5 dephosphorylation mediated by the PI3K/Akt signaling in vascular smooth muscle cells

    Article • FEBS Letters, March 2009, Wiley

    Jin-kun Wen

  77. 1,6-O,O-diacetylbritannilactones inhibits IκB kinase β-dependent NF-κB activation

    Article • Phytomedicine, March 2009, Elsevier

    Jin-kun Wen

  78. Smooth muscle 22 alpha maintains the differentiated phenotype of vascular smooth muscle cells by inducing filamentous actin bundling

    Article • Life Sciences, March 2009, Elsevier

    Jin-kun Wen

  79. Synergistic co-operation of signal transducer and activator of transcription 5B with activator protein 1 in angiotensin II-induced angiotensinogen gene activation in vascular smooth muscle cells

    Article • FEBS Journal, February 2009, Wiley

    Jin-kun Wen

  80. Kruppel-like Factor 4 is Required for the Expression of Vascular Smooth Muscle Cell Differentiation Marker Genes Induced by All-Trans Retinoic Acid

    Article • The Journal of Biochemistry, May 2008, Oxford University Press (OUP)

    Jin-kun Wen

  81. hhLIM is a novel F‐actin binding protein involved in actin cytoskeleton remodeling

    Article • FEBS Journal, March 2008, Wiley

    Jin-kun Wen

  82. Human heart LIM protein activates atrial-natriuretic-factor gene expression by interacting with the cardiac-restricted transcription factor Nkx2.5

    Article • Biochemical Journal, January 2008, Portland Press Ltd.

    Jin-kun Wen

  83. Roscovitine inhibits ERK1/2 activation induced by angiotensin II in vascular smooth muscle cells

    Article • FEBS Letters, December 2007, Wiley

    Jin-kun Wen

  84. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response

    Article • European Journal of Pharmacology, December 2007, Elsevier

    Jin-kun Wen

  85. Acetylbritannilactone Inhibits Neointimal Hyperplasia after Balloon Injury of Rat Artery by Suppressing Nuclear Factor-κB Activation

    Article • Journal of Pharmacology and Experimental Therapeutics, October 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jin-kun Wen

  86. Blockade of integrin β3–FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury

    Article • Cardiovascular Pathology, September 2007, Elsevier

    Jin-kun Wen

  87. Livin/ML-IAP as a new target for cancer treatment

    Article • Cancer Letters, June 2007, Elsevier

    Jin-kun Wen

  88. Osteopontin stimulates vascular smooth muscle cell migration by inducing FAK phosphorylation and ILK dephosphorylation

    Article • Biochemical and Biophysical Research Communications, April 2007, Elsevier

    Jin-kun Wen

  89. Intermedin1–53 protects the heart against isoproterenol-induced ischemic injury in rats

    Article • European Journal of Pharmacology, November 2006, Elsevier

    Jin-kun Wen

  90. Hyperplasia suppressor gene associates with smooth muscle α-actin and is involved in the redifferentiation of vascular smooth muscle cells

    Article • Heart and Vessels, September 2006, Springer Science + Business Media

    Jin-kun Wen

  91. Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells

    Article • AJP Cell Physiology, July 2006, American Physiological Society

    Jin-kun Wen

  92. hhLIM is involved in cardiomyogenesis of embryonic stem cells

    Article • Biochemistry (Moscow), January 2006, Pleiades Publishing Ltd

    Jin-kun Wen

  93. Expression of HSG is essential for mouse blastocyst formation

    Article • Biochemical and Biophysical Research Communications, September 2005, Elsevier

    Jin-kun Wen

  94. Matrix metalloproteinase-2 and tissue inhibitor of metallo-proteinase-2 in colorectal carcinoma invasion and metastasis

    Article • World Journal of Gastroenterology, January 2005, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Jin-kun Wen

  95. Application of genomics and proteomics in study of traditional Chinese medicine

    Article • Journal of Chinese Integrative Medicine, September 2004, Journal of Chinese Integrative Medicine Press

    Jin-kun Wen

  96. hhLIM protein is involved in cardiac hypertrophy

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, September 2004, Elsevier

    Jin-kun Wen

  97. Acetylbritannilatone suppresses NO and PGE2 synthesis in RAW 264.7 macrophages through the inhibition of iNOS and COX-2 gene expression

    Article • Life Sciences, June 2004, Elsevier

    Jin-kun Wen

  98. Triterpenoids fromSchisandra henryi with cytotoxic effect on leukemia and hela cellsin vitro

    Article • Archives of Pharmacal Research, November 2003, Springer Science + Business Media

    Jin-kun Wen

  99. Supplementing Qi and activating blood circulation in gene regulation of vascular smooth muscle cells

    Article • Journal of Chinese Integrative Medicine, May 2003, Journal of Chinese Integrative Medicine Press

    Jin-kun Wen

  100. Article • Biochemistry (Moscow), January 2003, Springer Science + Business Media

    Jin-kun Wen

  101. Erratum to “Comparison of gene expression patterns and migration capability at quiescent and proliferating vascular smooth muscle cells stimulated by cytokines”

    Article • Life Sciences, June 2002, Elsevier

    Jin-kun Wen

  102. Comparison of gene expression patterns and migration capability at quiescent and proliferating vascular smooth muscle cells stimulated by cytokines

    Article • Life Sciences, January 2002, Elsevier

    Jin-kun Wen

  103. 10.1007/s10541-008-3018-1

    Article • January 2000, CrossRef Test Account

    Jin-kun Wen

  104. Article • Biochemistry (Moscow), January 2000, Springer Science + Business Media

    Jin-kun Wen

  105. Mitochondrial DNA variation in cattle of South China: origin and introgression

    Article • Animal Genetics, August 1999, Wiley

    Jin-kun Wen

  106. Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

    Article • Biochemical and Biophysical Research Communications, March 1991, Elsevier

    Jin-kun Wen

  107. Molecular analysis of human acatalasemia

    Article • Journal of Molecular Biology, January 1990, Elsevier

    Jin-kun Wen