All Stories

  1. Six new diterpenoids from Croton laevigatus

    Article • Journal of Asian Natural Products Research, August 2018, Taylor & Francis

    Professor Jia Li

  2. Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Professor Jia Li

  3. Probing disease-related proteins with fluorogenic composite materials

    Article • Chemical Society Reviews, January 2015, Royal Society of Chemistry

    Professor Jia Li, Tony D James

  4. Selective fluorogenic imaging of hepatocellular H2S by a galactosyl azidonaphthalimide probe

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Jia Li, Tony D James

  5. Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Jia Li, Tony D James

  6. Correction: Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Jia Li, Tony D James

  7. Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors

    Article • Bioorganic & Medicinal Chemistry, November 2014, Elsevier

    Professor Jia Li

  8. Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors

    Article • European Journal of Medicinal Chemistry, October 2014, Elsevier

    Professor Jia Li

  9. Bioactive rearranged limonoids from the Chinese mangrove Xylocarpus granatum Koenig

    Article • Tetrahedron, September 2014, Elsevier

    Professor Jia Li

  10. Guignardins A–F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors

    Article • Tetrahedron, September 2014, Elsevier

    Professor Jia Li

  11. Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, September 2014, Elsevier

    Professor Jia Li

  12. Hepatoma-selective imaging of heavy metal ions using a ‘clicked’ galactosylrhodamine probe

    Article • Chemical Communications, August 2014, Royal Society of Chemistry

    Professor Jia Li, Tony D James

  13. Corrigendum to “4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B” [Bioorg. Med. Chem. 22 (2014) 3670–3683]

    Article • Bioorganic & Medicinal Chemistry, August 2014, Elsevier

    Professor Jia Li

  14. Synthesis and structure–activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles

    Article • European Journal of Medicinal Chemistry, August 2014, Elsevier

    Professor Jia Li

  15. Four Phragmalin Orthoesters from the Chinese Mangrove Xylocarpus granatum

    Article • Planta Medica, July 2014, Thieme Publishing Group

    Professor Jia Li

  16. A ‘Clicked’ Tetrameric Hydroxamic Acid Glycopeptidomimetic Antagonizes Sugar-Lectin Interactions On The Cellular Level

    Article • Scientific Reports, July 2014, Springer Science + Business Media

    Professor Jia Li

  17. Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells

    Article • Carbohydrate Research, July 2014, Elsevier

    Professor Jia Li

  18. Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation

    Article • Biochemical and Biophysical Research Communications, July 2014, Elsevier

    Professor Jia Li

  19. 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B

    Article • Bioorganic & Medicinal Chemistry, July 2014, Elsevier

    Professor Jia Li

  20. Novel grayanane diterpenoids from Rhododendron principis

    Article • Tetrahedron, July 2014, Elsevier

    Professor Jia Li

  21. Azoxystrobin, a mitochondrial complex III Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitro

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2014, Elsevier

    Professor Jia Li

  22. Hainanerectamines A–C, Alkaloids from the Hainan Sponge Hyrtios erecta

    Article • Marine Drugs, June 2014, MDPI AG

    Professor Jia Li

  23. Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of β‐amino Acids

    Article • Chemical Biology & Drug Design, June 2014, Wiley

    Professor Jia Li

  24. Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors

    Article • Bioorganic & Medicinal Chemistry, June 2014, Elsevier

    Professor Jia Li

  25. Curcusone D, a novel ubiquitin–proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, June 2014, Elsevier

    Professor Jia Li

  26. New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata

    Article • Journal of Asian Natural Products Research, May 2014, Taylor & Francis

    Professor Jia Li, Dr Hua Zhang

  27. Target-Specific Imaging of Transmembrane Receptors Using Quinonyl Glycosides Functionalized Quantum Dots

    Article • Analytical Chemistry, May 2014, American Chemical Society (ACS)

    Yitao Long, Professor Jia Li

  28. Discovery, synthesis, and structure–activity relationships of 20(S)-protopanaxadiol (PPD) derivatives as a novel class of AMPKα2β1γ1 activators

    Article • European Journal of Medicinal Chemistry, May 2014, Elsevier

    Professor Jia Li

  29. Regio- and Diastereoselective Construction of α-Hydroxy-δ-amino Ester Derivatives via 1,4-Conjugate Addition of β,γ-Unsaturated N-Sulfonylimines

    Article • The Journal of Organic Chemistry, April 2014, American Chemical Society (ACS)

    Professor Jia Li

  30. Potent and Orally Efficacious Bisthiazole-Based Histone Deacetylase Inhibitors

    Article • ACS Medicinal Chemistry Letters, April 2014, American Chemical Society (ACS)

    Professor Jia Li

  31. Fluorogenic Resveratrol-Confined Graphene Oxide For Economic and Rapid Detection Of Alzheimer’s Disease

    Article • ACS Applied Materials & Interfaces, April 2014, American Chemical Society (ACS)

    Professor Jia Li

  32. Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2014, Elsevier

    Professor Jia Li

  33. Discovery of a novel inhibitor of NAD(P)+-dependent malic enzyme (ME2) by high-throughput screening

    Article • Acta Pharmacologica Sinica, March 2014, Springer Science + Business Media

    Professor Jia Li

  34. Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

    Article • Nature Communications, March 2014, Springer Science + Business Media

    Professor Jia Li

  35. Substitution Pattern Reverses the Fluorescence Response of Coumarin Glycoligands upon Coordination with Silver (I)

    Article • Scientific Reports, March 2014, Springer Science + Business Media

    Professor Jia Li

  36. Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors

    Article • European Journal of Medicinal Chemistry, March 2014, Elsevier

    Professor Jia Li

  37. Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum

    Article • Fitoterapia, March 2014, Elsevier

    Professor Jia Li

  38. Sarsolenane and Capnosane Diterpenes from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller as PTP1B Inhibitors

    Article • European Journal of Organic Chemistry, January 2014, Wiley

    Professor Jia Li

  39. Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Jia Li

  40. Dysidaminones A–M, cytotoxic and NF-κB inhibitory sesquiterpene aminoquinones from the South China Sea sponge Dysidea fragilis

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Professor Jia Li

  41. Design, synthesis and biological evaluation of 4′-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Professor Jia Li

  42. Three pairs of variecolortide enantiomers from Eurotium sp. with caspase-3 inhibitory activity

    Article • Fitoterapia, January 2014, Elsevier

    Professor Jia Li

  43. 1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors

    Article • Molecules, December 2013, MDPI AG

    Professor Jia Li

  44. Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

    Article • Toxicology and Applied Pharmacology, December 2013, Elsevier

    Professor Jia Li

  45. The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase

    Article • Bioorganic & Medicinal Chemistry, November 2013, Elsevier

    Professor Jia Li

  46. Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy

    Article • European Journal of Medicinal Chemistry, November 2013, Elsevier

    Professor Jia Li

  47. Berberine combined with 2-deoxy-d-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2013, Elsevier

    Professor Jia Li

  48. A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth

    Article • Journal of Molecular Cell Biology, October 2013, Oxford University Press (OUP)

    Professor Jia Li

  49. Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

    Article • European Journal of Medicinal Chemistry, October 2013, Elsevier

    Professor Jia Li

  50. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors

    Article • European Journal of Medicinal Chemistry, October 2013, Elsevier

    Professor Jia Li

  51. The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, September 2013, Elsevier

    Professor Jia Li

  52. Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors

    Article • Bioorganic & Medicinal Chemistry, September 2013, Elsevier

    Professor Jia Li

  53. Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors

    Article • Bioorganic & Medicinal Chemistry, September 2013, Elsevier

    Professor Jia Li

  54. Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice

    Article • PLoS ONE, August 2013, PLOS

    Professor Jia Li

  55. Sensors: Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite (Adv. Mater. 30/2013)

    Article • Advanced Materials, August 2013, Wiley

    Yitao Long, Professor Jia Li

  56. A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obesity by modulating energy expenditure and food intake

    Article • Diabetologia, August 2013, Springer Science + Business Media

    Professor Jia Li

  57. Capturing intercellular sugar-mediated ligand-receptor recognitions via a simple yet highly biospecific interfacial system

    Article • Scientific Reports, July 2013, Springer Science + Business Media

    Yitao Long, Professor Jia Li, Tony D James

  58. ChemInform Abstract: Bioactive Polyhydroxylated Steroids from the Hainan Soft Coral Sinularia depressa Tixier‐Durivault

    Article • ChemInform, June 2013, Wiley

    Professor Jia Li

  59. The Design and Synthesis of a New Class of RTK/HDAC Dual-Targeted Inhibitors

    Article • Molecules, June 2013, MDPI AG

    Professor Jia Li

  60. The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

    Article • Bioorganic & Medicinal Chemistry, June 2013, Elsevier

    Professor Jia Li

  61. Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite

    Article • Advanced Materials, May 2013, Wiley

    Professor Jia Li

  62. Design and Synthesis of 4‐(2,4,5‐Trifluorophenyl)butane‐1,3‐diamines as Dipeptidyl Peptidase IV Inhibitors

    Article • ChemMedChem, May 2013, Wiley

    Professor Jia Li

  63. Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

    Article • Molecules, May 2013, MDPI AG

    Professor Jia Li

  64. Synthesis and in vitro cytotoxic evaluation of novel $$N$$ -(3,4,5-trimethoxyphenyl)pyridin-2( $$1H$$ )-one derivatives

    Article • Molecular Diversity, April 2013, Springer Science + Business Media

    Professor Jia Li

  65. Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms

    Article • Acta Pharmacologica Sinica, April 2013, Springer Science + Business Media

    Professor Jia Li

  66. Design, Synthesis, and Evaluation of 3‐Aryl‐4‐pyrrolyl‐maleimides as Glycogen Synthase Kinase‐3β Inhibitors

    Article • Archiv der Pharmazie, April 2013, Wiley

    Professor Jia Li

  67. Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

    Article • ACS Medicinal Chemistry Letters, March 2013, American Chemical Society (ACS)

    Professor Jia Li

  68. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity

    Article • Acta Pharmacologica Sinica, March 2013, Springer Science + Business Media

    Professor Jia Li

  69. Design, Synthesis and Evaluation of 3-(2-Aminoheterocycle)-4-benzyloxyphenylbenzamide Derivatives as BACE-1 Inhibitors

    Article • Molecules, March 2013, MDPI AG

    Professor Jia Li

  70. Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

    Article • Diabetes, March 2013, American Diabetes Association

    Professor Jia Li

  71. New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells

    Article • Marine Drugs, March 2013, MDPI AG

    Professor Jia Li

  72. Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault

    Article • Bioorganic & Medicinal Chemistry Letters, March 2013, Elsevier

    Professor Jia Li

  73. Revisit of a dipropargyl rhodamine probe reveals its alternative ion sensitivity in both a solution and live cells

    Article • The Analyst, January 2013, Royal Society of Chemistry

    Professor Jia Li

  74. Microwave-Assisted Synthesis and Biological Activities of 3,6-Disubstituted-1,2,4-triazine Derivatives

    Article • Chinese Journal of Organic Chemistry, January 2013, Shanghai Institute of Organic Chemistry

    Professor Jia Li

  75. Synthesis and PTP1B Inhibitory Activity of ( E )-1-Substitutedphenyl-3-(4-(( E )-(2-(4-phenylthiazol-2-yl)hydrazono)methyl)phenyl)-prop-2-en-1-ones

    Article • Chinese Journal of Organic Chemistry, January 2013, Shanghai Institute of Organic Chemistry

    Professor Jia Li

  76. Unprecedented Diterpenoids as a PTP1B Inhibitor from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller

    Article • Organic Letters, December 2012, American Chemical Society (ACS)

    Professor Jia Li

  77. Fluevirosines A–C: A Biogenesis Inspired Example in the Discovery of New Bioactive Scaffolds from Flueggea virosa

    Article • Organic Letters, December 2012, American Chemical Society (ACS)

    Professor Jia Li

  78. Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

    Article • Bioorganic & Medicinal Chemistry Letters, December 2012, Elsevier

    Professor Jia Li

  79. Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, December 2012, Elsevier

    Professor Jia Li

  80. ChemInform Abstract: A Novel Class of Small‐Molecule Caspase‐3 Inhibitors Prepared by Multicomponent Reactions.

    Article • ChemInform, November 2012, Wiley

    Professor Jia Li

  81. ChemInform Abstract: Synthesis and Biological Evaluation of Novel Indolin‐2‐one Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors.

    Article • ChemInform, November 2012, Wiley

    Professor Jia Li

  82. Design, Synthesis, Structure–Activity Relationships, and Docking Studies of 1‐(γ‐1,2,3‐Triazol Substituted Prolyl)‐(S)‐3,3‐Difluoropyrrolidines as a Novel Series of Potent and Selective Dipeptidyl Peptidase‐4 Inhibitors

    Article • Chemical Biology & Drug Design, November 2012, Wiley

    Professor Jia Li

  83. ChemInform Abstract: Design, Synthesis and Biological Activity Evaluation of 2‐Mercapto‐4(3H)‐quinazolinone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B.

    Article • ChemInform, November 2012, Wiley

    Professor Jia Li

  84. Discovering Novel α‐aminoacyl‐Containing Proline Derivatives with Potent and Selective Inhibitory Activity Against Dipeptidyl Peptidase IV: Design, Synthesis, Biological Evaluation, and Molecular Modeling

    Article • Chemical Biology & Drug Design, October 2012, Wiley

    Professor Jia Li

  85. Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, September 2012, Taylor & Francis

    Professor Jia Li

  86. A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors

    Article • Journal of Biological Chemistry, September 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jia Li

  87. BMS309403 Stimulates Glucose Uptake in Myotubes through Activation of AMP-Activated Protein Kinase

    Article • PLoS ONE, August 2012, PLOS

    Professor Jia Li

  88. ChemInform Abstract: Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B.

    Article • ChemInform, August 2012, Wiley

    Professor Jia Li

  89. New Azaphilones and Chlorinated Phenolic Glycosides from Chaetomium elatum with Caspase-3 Inhibitory Activity

    Article • Planta Medica, August 2012, Thieme Publishing Group

    Professor Jia Li

  90. A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions

    Article • European Journal of Medicinal Chemistry, August 2012, Elsevier

    Professor Jia Li

  91. Synthesis and Biological Evaluation of 2,4,6‐Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors

    Article • Chemical Biology & Drug Design, July 2012, Wiley

    Professor Jia Li

  92. CCLab—a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design

    Article • Bioorganic & Medicinal Chemistry Letters, July 2012, Elsevier

    Professor Jia Li

  93. Absolute configurations of integracins A, B, and 15′‐dehydroxy‐integracin B

    Article • Chirality, April 2012, Wiley

    Professor Jia Li

  94. CuAAC Click Chemistry Accelerates the Discovery of Novel Chemical Scaffolds as Promising Protein Tyrosine Phosphatases Inhibitors

    Article • Current Medicinal Chemistry, April 2012, Bentham Science Publishers

    Professor Jia Li

  95. Discovery and Optimization of 2,4-Diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors

    Article • Journal of Medicinal Chemistry, March 2012, American Chemical Society (ACS)

    Professor Jia Li

  96. The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone

    Article • Bioorganic & Medicinal Chemistry Letters, March 2012, Elsevier

    Professor Jia Li

  97. Discovery and Structural Modification of 1-Phenyl-3-(1-phenylethyl)urea Derivatives as Inhibitors of Complement

    Article • ACS Medicinal Chemistry Letters, February 2012, American Chemical Society (ACS)

    Professor Jia Li

  98. Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G2-M arrest and apoptosis in HeLa cells

    Article • Acta Pharmacologica Sinica, January 2012, Springer Science + Business Media

    Professor Jia Li

  99. Quantitative Proteomic Analysis of Membrane Proteins Involved in Astroglial Differentiation of Neural Stem Cells by SILAC Labeling Coupled with LC–MS/MS

    Article • Journal of Proteome Research, January 2012, American Chemical Society (ACS)

    Professor Jia Li

  100. ChemInform Abstract: Click to a Focused Library of Benzyl 6‐Triazolo(hydroxy)benzoic Glucosides: Novel Construction of PTP1B Inhibitors on a Sugar Scaffold.

    Article • ChemInform, January 2012, Wiley

    Professor Jia Li

  101. Synthesis and Biological Evaluation of Oleanolic Acid Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

    Article • Heterocycles, January 2012, Japan Institute of Heterocyclic Chemistry

    Professor Jia Li

  102. Design, Synthesis and Biological Activity Evaluation of 2-Mercapto-4(3H)-quinazolinone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B

    Article • Heterocycles, January 2012, Japan Institute of Heterocyclic Chemistry

    Professor Jia Li

  103. Design, Synthesis and Biological Activity Evaluation of 2,5-Diphenyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Fructose-1,6-bisphosphatase

    Article • Heterocycles, January 2012, Japan Institute of Heterocyclic Chemistry

    Professor Jia Li

  104. Synthesis and Anti-tumor Activity Evaluation of Alkyl Heterocyclyl Disulfides

    Article • Chinese Journal of Organic Chemistry, January 2012, Shanghai Institute of Organic Chemistry

    Professor Jia Li

  105. Dysidavarones A–D, New Sesquiterpene Quinones from the Marine Sponge Dysidea avara

    Article • Organic Letters, December 2011, American Chemical Society (ACS)

    Professor Jia Li

  106. 5′-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells

    Article • Biochemical and Biophysical Research Communications, December 2011, Elsevier

    Professor Jia Li

  107. Searching for the Multi-Target-Directed Ligands against Alzheimer’s disease: Discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities

    Article • Bioorganic & Medicinal Chemistry, December 2011, Elsevier

    Professor Jia Li

  108. Synthesis of (Glycopyranosyl‐triazolyl)‐purines and Their Inhibitory Activities against Protein Tyrosine Phosphatase 1B (PTP1B)

    Article • Chemistry & Biodiversity, November 2011, Wiley

    Professor Jia Li

  109. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma

    Article • Acta Biochimica et Biophysica Sinica, October 2011, Oxford University Press (OUP)

    Professor Jia Li

  110. ChemInform Abstract: Synthesis of Triazole‐Linked Amino Acid‐Aryl C‐Glycoside Hybrids via Click Chemistry as Novel PTP1B Inhibitors.

    Article • ChemInform, October 2011, Wiley

    Professor Jia Li

  111. Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault

    Article • Journal of Natural Products, September 2011, American Chemical Society (ACS)

    Professor Jia Li

  112. PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism

    Article • Proceedings of the National Academy of Sciences, September 2011, Proceedings of the National Academy of Sciences

    Professor Jia Li

  113. Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors

    Article • Glycoconjugate Journal, September 2011, Springer Science + Business Media

    Professor Jia Li

  114. Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors

    Article • European Journal of Medicinal Chemistry, September 2011, Elsevier

    Professor Jia Li

  115. Synthesis and Biological Evaluation of Novel Indolin-2-One Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors

    Article • Letters in Organic Chemistry, September 2011, Bentham Science Publishers

    Professor Jia Li

  116. Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold

    Article • European Journal of Medicinal Chemistry, September 2011, Elsevier

    Professor Jia Li

  117. Paracaseolide A, First α-Alkylbutenolide Dimer with an Unusual Tetraquinane Oxa-Cage Bislactone Skeleton from Chinese Mangrove Sonneratia paracaseolaris

    Article • Organic Letters, August 2011, American Chemical Society (ACS)

    Professor Jia Li

  118. ChemInform Abstract: Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp. (No. 061316) and Their Inhibiting Caspase‐3 Catalytic Activity in vitro

    Article • ChemInform, August 2011, Wiley

    Professor Jia Li

  119. A new staurosporine analog from ActinomycetesStreptomycessp. (172614)

    Article • Journal of Asian Natural Products Research, August 2011, Taylor & Francis

    Professor Jia Li

  120. Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, August 2011, Elsevier

    Professor Jia Li

  121. ChemInform Abstract: Monosaccharide as a Central Scaffold Toward the Construction of Salicylate‐Based Bidentate PTP1B Inhibitors via Click Chemistry.

    Article • ChemInform, July 2011, Wiley

    Professor Jia Li

  122. Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on ‘clicked’ serine/threonine–monosaccharide hybrids

    Article • Bioorganic & Medicinal Chemistry, July 2011, Elsevier

    Professor Jia Li

  123. Design, Synthesis, and Biological Evaluation of Ring‐Opened Bengamide Analogues

    Article • ChemMedChem, June 2011, Wiley

    Professor Jia Li

  124. Synthesis of novel 6-triazologlycolipids via click chemistry and their preliminary cytotoxicity assessments

    Article • Molecular Diversity, June 2011, Springer Science + Business Media

    Professor Jia Li

  125. ChemInform Abstract: A Unique and Rapid Approach Toward the Efficient Development of Novel Protein Tyrosine Phosphatase (PTP) Inhibitors Based on “Clicked” Pseudo‐Glycopeptides.

    Article • ChemInform, June 2011, Wiley

    Professor Jia Li

  126. Synthesis of Triazole-Linked Amino Acid-Aryl C -Glycoside Hybrids via Click Chemistry as Novel PTP1B Inhibitors

    Article • Chinese Journal of Chemistry, June 2011, Wiley

    Professor Jia Li

  127. Structural and stereochemical studies of five new pregnane steroids from the stem bark of Toona ciliata var. pubescens

    Article • Steroids, May 2011, Elsevier

    Professor Jia Li

  128. Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula

    Article • Chinese Journal of Oceanology and Limnology, May 2011, Springer Science + Business Media

    Professor Jia Li

  129. ChemInform Abstract: Triazole‐Linked Benzylated Glucosyl, Galactosyl, and Mannosyl Monomers and Dimers as Novel Sugar Scaffold‐Based PTP1B Inhibitors.

    Article • ChemInform, April 2011, Wiley

    Professor Jia Li

  130. ChemInform Abstract: Microwave‐Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole‐Linked Salicylic β‐D‐O‐Glycosides with PTP1B Inhibitory Activity.

    Article • ChemInform, March 2011, Wiley

    Professor Jia Li

  131. Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

    Article • Diabetes, February 2011, American Diabetes Association

    Professor Jia Li

  132. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees

    Article • EMBO Reports, February 2011, EMBO

    Professor Jia Li

  133. A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on ‘clicked’ pseudo-glycopeptides

    Article • Bioorganic & Medicinal Chemistry Letters, February 2011, Elsevier

    Professor Jia Li

  134. ‘Click’ to bidentate bis-triazolyl sugar derivatives with promising biological and optical features

    Article • Tetrahedron Letters, February 2011, Elsevier

    Professor Jia Li

  135. Discovery and structural modification of novel inhibitors of PTP1B inspired by the ACT fragment of scleritodermin A

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Professor Jia Li

  136. Protolimonoids and norlimonoids from the stem bark of Toona ciliata var. pubescens

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Professor Jia Li

  137. Microwave-assisted construction of triazole-linked amino acid–glucoside conjugates as novel PTP1B inhibitors

    Article • New Journal of Chemistry, January 2011, Royal Society of Chemistry

    Professor Jia Li

  138. Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp. (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in Vitro

    Article • Chemical and Pharmaceutical Bulletin, January 2011, Pharmaceutical Society of Japan

    Professor Jia Li

  139. Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy

    Article • Bioorganic & Medicinal Chemistry Letters, January 2011, Elsevier

    Professor Jia Li

  140. Preparation of triazole-linked glycosylated α-ketocarboxylic acid derivatives as new PTP1B inhibitors

    Article • Carbohydrate Research, January 2011, Elsevier

    Professor Jia Li

  141. Cytotoxic Amide Alkaloids from Piper boehmeriaefolium

    Article • Journal of Natural Products, December 2010, American Chemical Society (ACS)

    Professor Jia Li

  142. Expeditious preparation of triazole-linked glycolipids via microwave accelerated click chemistry and their electrochemical and biological assessments

    Article • Tetrahedron, December 2010, Elsevier

    Professor Jia Li

  143. Rubiyunnanins C–H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-κB activation

    Article • Bioorganic & Medicinal Chemistry, December 2010, Elsevier

    Professor Jia Li

  144. Synthesis and antitumor evaluation of methyl spongoate analogs

    Article • Steroids, December 2010, Elsevier

    Professor Jia Li

  145. 1H and 13C assignments of two new macrocyclic lactones isolated from Streptomyces sp. 211726 and revised assignments of Azalomycins F3a, F4aand F5a

    Article • Magnetic Resonance in Chemistry, November 2010, Wiley

    Professor Jia Li

  146. Characterization and Online Detection of Surfactin Isomers Based on HPLC-MSn Analyses and Their Inhibitory Effects on the Overproduction of Nitric Oxide and the Release of TNF-α and IL-6 in LPS-Induced Macrophages

    Article • Marine Drugs, October 2010, MDPI AG

    Professor Jia Li

  147. Azalomycin F4a 2-ethylpentyl ester, a new macrocyclic lactone, from mangrove actinomycete Streptomyces sp. 211726

    Article • Chinese Chemical Letters, August 2010, Elsevier

    Professor Jia Li

  148. Discovery of novel PTP1B inhibitors with antihyperglycemic activity

    Article • Acta Pharmacologica Sinica, August 2010, Springer Science + Business Media

    Professor Jia Li

  149. 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models

    Article • Bioorganic & Medicinal Chemistry, August 2010, Elsevier

    Professor Jia Li

  150. Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer’s disease

    Article • Bioorganic & Medicinal Chemistry, August 2010, Elsevier

    Professor Jia Li

  151. Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B

    Article • Bioorganic & Medicinal Chemistry, June 2010, Elsevier

    Professor Jia Li

  152. Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B

    Article • Bioorganic & Medicinal Chemistry Letters, May 2010, Elsevier

    Professor Jia Li

  153. Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B

    Article • Food Chemistry, April 2010, Elsevier

    Professor Jia Li

  154. AMPK Activators as Novel Therapeutics for Type 2 Diabetes

    Article • Current Topics in Medicinal Chemistry, March 2010, Bentham Science Publishers

    Professor Jia Li

  155. Design and synthesis of a highly selective fluorescent turn-on probe for thiol bioimaging in living cells

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Professor Jia Li

  156. Triazole-linked Benzylated Glucosyl, Galactosyl, and Mannosyl Monomers and Dimers as Novel Sugar Scaffold-based PTP1B Inhibitors

    Article • Chemistry Letters, January 2010, Chemical Society of Japan

    Professor Jia Li

  157. Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B

    Article • Bioorganic & Medicinal Chemistry Letters, December 2009, Elsevier

    Professor Jia Li

  158. Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

    Article • Chinese Chemical Letters, December 2009, Elsevier

    Professor Jia Li

  159. Correction: Hong, K. et al. Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China. Mar. Drugs 2009, 7, 24–44

    Article • Marine Drugs, October 2009, MDPI AG

    Professor Jia Li

  160. High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice

    Article • Diabetes, October 2009, American Diabetes Association

    Professor Jia Li

  161. LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation

    Article • Acta Pharmacologica Sinica, September 2009, Springer Science + Business Media

    Professor Jia Li

  162. Synthesis and Biological Evaluation of C7‐Demethyl Largazole Analogues

    Article • ChemMedChem, July 2009, Wiley

    Professor Jia Li

  163. Diterpenoids from the Hainan Soft Coral Sinularia parva

    Article • Helvetica Chimica Acta, July 2009, Wiley

    Professor Jia Li

  164. Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

    Article • Bioorganic & Medicinal Chemistry, July 2009, Elsevier

    Professor Jia Li

  165. Two New Unprecedented Acetonyl‐Bearing Sesquiterpenes from the Hainan Sponge Dysidea fragilis

    Article • Chemistry & Biodiversity, June 2009, Wiley

    Professor Jia Li

  166. Design and Synthesis of Matrix Metalloprotease Photoaffinity Trimodular Probes

    Article • Chinese Journal of Chemistry, April 2009, Wiley

    Professor Jia Li

  167. High-throughput screening using pseudotyped lentiviral particles: A strategy for the identification of HIV-1 inhibitors in a cell-based assay

    Article • Antiviral Research, March 2009, Elsevier

    Professor Jia Li

  168. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase

    Article • Bioorganic & Medicinal Chemistry, February 2009, Elsevier

    Professor Jia Li

  169. Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids

    Article • Acta Pharmacologica Sinica, January 2009, Springer Science + Business Media

    Professor Jia Li

  170. AMP-activated Protein Kinase Is Involved in Neural Stem Cell Growth Suppression and Cell Cycle Arrest by 5-Aminoimidazole-4-carboxamide-1- -D-ribofuranoside and Glucose Deprivation by Down-regulating Phospho-retinoblastoma Protein and Cyclin D

    Article • Journal of Biological Chemistry, January 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jia Li

  171. Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China

    Article • Marine Drugs, January 2009, MDPI AG

    Professor Jia Li

  172. Identification of pharmacophore model, synthesis and biological evaluation of N-phenyl-1-arylamide and N-phenylbenzenesulfonamide derivatives as BACE 1 inhibitors

    Article • Bioorganic & Medicinal Chemistry, December 2008, Elsevier

    Professor Jia Li

  173. Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl)propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers

    Article • Tetrahedron, November 2008, Elsevier

    Professor Jia Li

  174. Discovery and characterization of a novel inhibitor of CDC25B, LGH000451

    Article • Acta Pharmacologica Sinica, October 2008, Springer Science + Business Media

    Professor Jia Li

  175. Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species

    Article • Journal of Biological Chemistry, September 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jia Li

  176. Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities

    Article • Bioorganic & Medicinal Chemistry, September 2008, Elsevier

    Professor Jia Li

  177. Illudalic acid as a potential LAR inhibitor: Synthesis, SAR, and preliminary studies on the mechanism of action

    Article • Bioorganic & Medicinal Chemistry, August 2008, Elsevier

    Professor Jia Li

  178. Soluble Polymer-Supported Synthesis of 5-Arylidene Thiazolidinones and Pyrimidinones Using a Novel Traceless Linker Strategy

    Article • Journal of Combinatorial Chemistry, July 2008, American Chemical Society (ACS)

    Professor Jia Li

  179. Sesquiterpenes from the Hainan Sponge Dysidea septosa

    Article • Journal of Natural Products, July 2008, American Chemical Society (ACS)

    Professor Jia Li

  180. Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

    Article • Diabetes, May 2008, American Diabetes Association

    Professor Jia Li

  181. Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation

    Article • European Journal of Pharmacology, April 2008, Elsevier

    Professor Jia Li

  182. Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

    Article • Journal of Biological Chemistry, March 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jia Li

  183. Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening

    Article • Acta Pharmacologica Sinica, February 2008, Springer Science + Business Media

    Professor Jia Li

  184. AICAR Induces Astroglial Differentiation of Neural Stem Cells via Activating the JAK/STAT3 Pathway Independently of AMP-activated Protein Kinase

    Article • Journal of Biological Chemistry, January 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jia Li

  185. Design, Synthesis, and Biological Evaluation of Caprolactam‐Modified Bengamide Analogues

    Article • ChemMedChem, January 2008, Wiley

    Professor Jia Li

  186. Growth inhibition and induction of early apoptosis by arenicolsterol A, a novel cytotoxic enolic sulphated sterol from the marine annelid,Arenicola cristata

    Article • Journal of Asian Natural Products Research, December 2007, Taylor & Francis

    Professor Jia Li

  187. Anti-Helicobacter pyloriand Thrombin Inhibitory Components from Chinese Dragon’s Blood,Dracaena cochinchinensis

    Article • Journal of Natural Products, September 2007, American Chemical Society (ACS)

    Professor Jia Li

  188. Activity‐Based Protein Profiling for Type I Methionine Aminopeptidase by Using Photo‐Affinity Trimodular Probes

    Article • ChemBioChem, August 2007, Wiley

    Professor Jia Li

  189. Benzoquinones from Ardisia japonica with Inhibitory Activity towards Human Protein Tyrosine Phosphatase 1B (PTP1B)

    Article • Chemistry & Biodiversity, May 2007, Wiley

    Professor Jia Li

  190. Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2007, Elsevier

    Professor Jia Li

  191. Two New Coumarins from Fraxinus chinensis Rexb.

    Article • Journal of Integrative Plant Biology, February 2007, Wiley

    Professor Jia Li

  192. Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1β

    Article • Biochemistry and Cell Biology, February 2007, Canadian Science Publishing

    Professor Jia Li

  193. Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

    Article • Molecules, December 2006, MDPI AG

    Professor Jia Li

  194. Vascular development is disrupted by endothelial cell-specific expression of the anti-apoptotic protein Bcl-2

    Article • Angiogenesis, December 2006, Springer Science + Business Media

    Professor Jia Li, Professor Stephen Charnock-Jones

  195. Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to ?-secretase

    Article • Acta Pharmacologica Sinica, December 2006, Springer Science + Business Media

    Professor Jia Li

  196. Conserved  -Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase   Subunits

    Article • Journal of Biological Chemistry, November 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jia Li

  197. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, November 2006, Elsevier

    Professor Jia Li

  198. Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2006, Elsevier

    Professor Jia Li

  199. Synthesis of Miltirone Analogues as Inhibitors of Cdc25 Phosphatases.

    Article • ChemInform, July 2006, Wiley

    Professor Jia Li

  200. Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors

    Article • Bioorganic & Medicinal Chemistry, July 2006, Elsevier

    Professor Jia Li

  201. Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin

    Article • Bioorganic & Medicinal Chemistry Letters, June 2006, Elsevier

    Professor Jia Li

  202. PTP1B inhibitors from Saussrurea Lappa

    Article • Journal of Asian Natural Products Research, April 2006, Taylor & Francis

    Professor Jia Li

  203. O-methyl nakafuran-8 lactone, a new sesquiterpenoid from a hainan marine sponge Dysidea sp.

    Article • Journal of Asian Natural Products Research, April 2006, Taylor & Francis

    Professor Jia Li

  204. Design, Synthesis, and Biological Evaluation of Isoquinoline-1,3,4-trione Derivatives as Potent Caspase-3 Inhibitors

    Article • Journal of Medicinal Chemistry, February 2006, American Chemical Society (ACS)

    Professor Jia Li

  205. Daturametelins H, I, and J: Three New Withanolide Glycosides from Datura metel L.

    Article • Chemistry & Biodiversity, February 2006, Wiley

    Professor Jia Li

  206. Identification of Potent Type I MetAP Inhibitors by Simple Bioisosteric Replacement. Part 1. Synthesis and Preliminary SAR Studies of Thiazole‐4‐carboxylic Acid Thiazol‐2‐ylamide Derivatives.

    Article • ChemInform, January 2006, Wiley

    Professor Jia Li

  207. Selective Inhibition of Matrix Metalloproteinase Isozymes and in Vivo Protection against Emphysema by Substituted γ-Keto Carboxylic Acids

    Article • Journal of Medicinal Chemistry, December 2005, American Chemical Society (ACS)

    Professor Jia Li

  208. Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2005, Elsevier

    Professor Jia Li

  209. Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, September 2005, Elsevier

    Professor Jia Li

  210. Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives

    Article • Bioorganic & Medicinal Chemistry Letters, August 2005, Elsevier

    Professor Jia Li

  211. Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo

    Article • Bioorganic & Medicinal Chemistry Letters, March 2005, Elsevier

    Professor Jia Li

  212. PTP1B inhibitors from Ardisia japonica

    Article • Journal of Asian Natural Products Research, February 2005, Taylor & Francis

    Professor Jia Li

  213. Furostanoside from Asparagus filicinus

    Article • Journal of Asian Natural Products Research, February 2005, Taylor & Francis

    Professor Jia Li

  214. Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors

    Article • Tetrahedron, February 2005, Elsevier

    Professor Jia Li

  215. Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent

    Article • Bioorganic & Medicinal Chemistry Letters, February 2005, Elsevier

    Professor Jia Li

  216. Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold

    Article • Bioorganic & Medicinal Chemistry Letters, February 2005, Elsevier

    Professor Jia Li

  217. Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes

    Article • Bioorganic & Medicinal Chemistry, June 2004, Elsevier

    Professor Jia Li

  218. Tetrahydroisoquinoline Based Sulfonamide Hydroxamates as Potent Matrix Metalloproteinase Inhibitors.

    Article • ChemInform, April 2004, Wiley

    Professor Jia Li

  219. Mutations at the S1 Sites of Methionine Aminopeptidases from Escherichia coli and Homo sapiens Reveal the Residues Critical for Substrate Specificity

    Article • Journal of Biological Chemistry, February 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Jia Li

  220. Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, January 2004, Elsevier

    Professor Jia Li

  221. Specificity for inhibitors of metal-substituted methionine aminopeptidase

    Article • Biochemical and Biophysical Research Communications, July 2003, Elsevier

    Professor Jia Li

  222. Discovery and Structural Modification of Inhibitors of Methionine Aminopeptidases from Escherichia coli and Saccharomyces cerevisiae

    Article • Journal of Medicinal Chemistry, May 2003, American Chemical Society (ACS)

    Professor Jia Li, Dr Gerald H Lushington

  223. New Insights into the Function and Regulation of Endothelial Cell Apoptosis

    Article • Angiogenesis, January 2003, Springer Science + Business Media

    Professor Jia Li

  224. Natural PTP1B Inhibitors from broussonetia papyrifera

    Article • Bioorganic & Medicinal Chemistry Letters, December 2002, Elsevier

    Professor Jia Li