All Stories

  1. Water bend–libration as a cellular Raman imaging probe of hydration

    Article • Proceedings of the National Academy of Sciences, October 2023, Proceedings of the National Academy of Sciences

    Jennifer Lee

  2. The N terminus of α-synuclein dictates fibril formation

    Article • Proceedings of the National Academy of Sciences, August 2021, Proceedings of the National Academy of Sciences

    Jennifer Lee

  3. Defining an amyloid link Between Parkinson’s disease and melanoma

    Article • Proceedings of the National Academy of Sciences, August 2020, Proceedings of the National Academy of Sciences

    Jennifer Lee

  4. Unroofing site-specific α-synuclein–lipid interactions at the plasma membrane

    Article • Proceedings of the National Academy of Sciences, July 2020, Proceedings of the National Academy of Sciences

    Jennifer Lee

  5. Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17

    Article • Journal of Biological Chemistry, April 2020, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jennifer Lee

  6. Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells

    Article • ChemBioChem, February 2020, Wiley

    Jennifer Lee

  7. pH-Dependent fibril maturation of a Pmel17 repeat domain isoform revealed by tryptophan fluorescence

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, October 2019, Elsevier

    Jennifer Lee

  8. Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

    Article • Journal of Molecular Biology, September 2019, Elsevier

    Jennifer Lee

  9. N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism

    Article • Biochemistry, August 2019, American Chemical Society (ACS)

    Jennifer Lee

  10. C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease

    Article • Journal of Biological Chemistry, May 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jennifer Lee

  11. Interplay between α-synuclein amyloid formation and membrane structure

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, May 2019, Elsevier

    Jennifer Lee

  12. Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, May 2019, Elsevier

    Jennifer Lee

  13. Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern

    Article • Scientific Reports, March 2019, Springer Science + Business Media

    Jennifer Lee

  14. Segmental 13 C-Labeling and Raman Microspectroscopy of α-Synuclein Amyloid Formation

    Article • Angewandte Chemie, November 2018, Wiley

    Jennifer Lee

  15. Segmental 13 C-Labeling and Raman Microspectroscopy of α-Synuclein Amyloid Formation

    Article • Angewandte Chemie, November 2018, Wiley

    Jennifer Lee

  16. Why Study Functional Amyloids? Lessons from the Repeat Domain of Pmel17

    Article • Journal of Molecular Biology, October 2018, Elsevier

    Jennifer Lee

  17. Stimulation of α-synuclein amyloid formation by phosphatidylglycerol micellar tubules

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 2018, Elsevier

    Jennifer Lee

  18. Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein

    Article • Journal of Biological Chemistry, May 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jennifer Lee

  19. Raman fingerprints of amyloid structures

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Jennifer Lee

  20. Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy

    Article • Journal of Biological Chemistry, November 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jennifer Lee

  21. Taking a Bite Out of Amyloid: Mechanistic Insights into α-Synuclein Degradation by Cathepsin L

    Article • Biochemistry, June 2017, American Chemical Society (ACS)

    Jennifer Lee

  22. Physical Chemistry in Biomedical Research: From Cuvettes toward Cellular Insights

    Article • The Journal of Physical Chemistry Letters, May 2017, American Chemical Society (ACS)

    Jennifer Lee

  23. Reversing the Amyloid Trend: Mechanism of Fibril Assembly and Dissolution of the Repeat Domain from a Human Functional Amyloid

    Article • Israel Journal of Chemistry, January 2017, Wiley

    Jennifer Lee

  24. Segmental Deuteration of α-Synuclein for Neutron Reflectometry on Tethered Bilayers

    Article • The Journal of Physical Chemistry Letters, December 2016, American Chemical Society (ACS)

    Jennifer Lee

  25. Apolipoprotein C-III Nanodiscs Studied by Site-Specific Tryptophan Fluorescence

    Article • Biochemistry, August 2016, American Chemical Society (ACS)

    Jennifer Lee

  26. Single-Particle Tracking of Human Lipoproteins

    Article • Analytical Chemistry, December 2015, American Chemical Society (ACS)

    Jennifer Lee

  27. Tryptophan probes reveal residue-specific phospholipid interactions of apolipoprotein C-III

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, November 2015, Elsevier

    Jennifer Lee

  28. Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

    Article • Proceedings of the National Academy of Sciences, July 2015, Proceedings of the National Academy of Sciences

    Jennifer Lee

  29. α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

    Article • Journal of Biological Chemistry, June 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jennifer Lee

  30. Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C

    Article • Biochemical and Biophysical Research Communications, February 2015, Elsevier

    Jennifer Lee

  31. Lysophospholipid-Containing Membranes Modulate the Fibril Formation of the Repeat Domain of a Human Functional Amyloid, Pmel17

    Article • Journal of Molecular Biology, December 2014, Elsevier

    Jennifer Lee

  32. Structural Features of Membrane-bound Glucocerebrosidase and α-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy

    Article • Journal of Biological Chemistry, November 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jennifer Lee

  33. Molecular Origin of pH-Dependent Fibril Formation of a Functional Amyloid

    Article • ChemBioChem, June 2014, Wiley

    Jennifer Lee

  34. Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III

    Article • Biochemistry, May 2014, American Chemical Society (ACS)

    Jennifer Lee

  35. Alpha-Synuclein Lipid-Dependent Membrane Binding and Translocation through the α-Hemolysin Channel

    Article • Biophysical Journal, February 2014, Elsevier

    Jennifer Lee

  36. Mechanism of Assembly of the Non-Covalent Spectrin Tetramerization Domain from Intrinsically Disordered Partners

    Article • Journal of Molecular Biology, January 2014, Elsevier

    Jennifer Lee

  37. Emerging insights into the mechanistic link between α-synuclein and glucocerebrosidase in Parkinson's disease

    Article • Biochemical Society Transactions, November 2013, Portland Press Ltd.

    Jennifer Lee

  38. Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation

    Article • Journal of the American Chemical Society, October 2013, American Chemical Society (ACS)

    Jennifer Lee

  39. Saposin C Protects Glucocerebrosidase against α-Synuclein Inhibition

    Article • Biochemistry, October 2013, American Chemical Society (ACS)

    Jennifer Lee

  40. NMR Structure of Calmodulin Complexed to an N-Terminally Acetylated α-Synuclein Peptide

    Article • Biochemistry, May 2013, American Chemical Society (ACS)

    Jennifer Lee

  41. Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity

    Article • Molecular Genetics and Metabolism, January 2013, Elsevier

    Jennifer Lee

  42. Biophysics of α-synuclein membrane interactions

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, February 2012, Elsevier

    Jennifer Lee

  43. Depth of α-Synuclein in a Bilayer Determined by Fluorescence, Neutron Reflectometry, and Computation

    Article • Biophysical Journal, February 2012, Elsevier

    Jennifer Lee

  44. 5-Fluoro-d,l-Tryptophan as a Dual NMR and Fluorescent Probe of α-Synuclein

    Article • January 2012, Springer Science + Business Media

    Jennifer Lee

  45. Probing Fibril Dissolution of the Repeat Domain of a Functional Amyloid, Pmel17, on the Microscopic and Residue Level

    Article • Biochemistry, December 2011, American Chemical Society (ACS)

    Jennifer Lee

  46. α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases

    Article • Journal of Biological Chemistry, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Jennifer Lee

  47. Residue-Specific Fluorescent Probes of α-Synuclein: Detection of Early Events at the N- and C-Termini during Fibril Assembly

    Article • Biochemistry, March 2011, American Chemical Society (ACS)

    Jennifer Lee

  48. Deuteration of Escherichia coli Enzyme INtr alters its stability

    Article • Archives of Biochemistry and Biophysics, March 2011, Elsevier

    Jennifer Lee

  49. The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17

    Article • Physical Chemistry Chemical Physics, January 2011, Royal Society of Chemistry

    Jennifer Lee

  50. Copper(ii) enhances membrane-bound α-synuclein helix formation

    Article • Metallomics, January 2011, Oxford University Press (OUP)

    Jennifer Lee

  51. Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17

    Article • Proceedings of the National Academy of Sciences, November 2010, Proceedings of the National Academy of Sciences

    Jennifer Lee

  52. Evidence for Copper-dioxygen Reactivity during α-Synuclein Fibril Formation

    Article • Journal of the American Chemical Society, May 2010, American Chemical Society (ACS)

    Jennifer Lee

  53. Tryptophan Probes at the α-Synuclein and Membrane Interface

    Article • The Journal of Physical Chemistry B, April 2010, American Chemical Society (ACS)

    Jennifer Lee

  54. Energy Transfer Ligands of the GluR2 Ligand Binding Core

    Article • Biochemistry, March 2010, American Chemical Society (ACS)

    Jennifer Lee

  55. Effect of dioxygen on copper(II) binding to α-synuclein

    Article • Journal of Inorganic Biochemistry, March 2010, Elsevier

    Jennifer Lee

  56. Identification of the Minimal Copper(II)-Binding α-Synuclein Sequence

    Article • Inorganic Chemistry, October 2009, American Chemical Society (ACS)

    Jennifer Lee

  57. Folding energy landscape of cytochrome cb 562

    Article • Proceedings of the National Academy of Sciences, May 2009, Proceedings of the National Academy of Sciences

    Jennifer Lee

  58. Synchronous vs Asynchronous Chain Motion in α-Synuclein Contact Dynamics

    Article • The Journal of Physical Chemistry B, January 2009, American Chemical Society (ACS)

    Jennifer Lee

  59. Spermine Binding to Parkinson’s Protein α-Synuclein and Its Disease-Related A30P and A53T Mutants

    Article • The Journal of Physical Chemistry B, September 2008, American Chemical Society (ACS)

    Jennifer Lee

  60. Copper(II) Binding to α-Synuclein, the Parkinson’s Protein

    Article • Journal of the American Chemical Society, June 2008, American Chemical Society (ACS)

    Jennifer Lee

  61. α-Synuclein Tertiary Contact Dynamics

    Article • The Journal of Physical Chemistry B, March 2007, American Chemical Society (ACS)

    Jennifer Lee

  62. Site-specific collapse dynamics guide the formation of the cytochrome c′ four-helix bundle

    Article • Proceedings of the National Academy of Sciences, January 2007, Proceedings of the National Academy of Sciences

    Jennifer Lee

  63. Equilibrium unfolding of the poly(glutamic acid)20 helix

    Article • Biopolymers, January 2007, Wiley

    Jennifer Lee

  64. α-Synuclein Structures Probed by 5-Fluorotryptophan Fluorescence and19F NMR Spectroscopy

    Article • The Journal of Physical Chemistry B, April 2006, American Chemical Society (ACS)

    Jennifer Lee

  65. Tertiary Contact Formation in α-Synuclein Probed by Electron Transfer

    Article • Journal of the American Chemical Society, November 2005, American Chemical Society (ACS)

    Jennifer Lee

  66. α-Synuclein structures from fluorescence energy-transfer kinetics: Implications for the role of the protein in Parkinson's disease

    Article • Proceedings of the National Academy of Sciences, November 2004, Proceedings of the National Academy of Sciences

    Jennifer Lee

  67. α-Synuclein: Stable compact and extended monomeric structures and pH dependence of dimer formation

    Article • Journal of the American Society for Mass Spectrometry, October 2004, American Chemical Society (ACS)

    Jennifer Lee

  68. The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH 3 ) 5 (His-33)-Zn-cytochrome c

    Article • Proceedings of the National Academy of Sciences, March 2003, Proceedings of the National Academy of Sciences

    Jennifer Lee

  69. Cloning, heterologous expression, and characterization of recombinant class II cytochromes c from Rhodopseudomonas palustris

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, January 2003, Elsevier

    Jennifer Lee

  70. Structural features of cytochrome c ′ folding intermediates revealed by fluorescence energy-transfer kinetics

    Article • Proceedings of the National Academy of Sciences, October 2002, Proceedings of the National Academy of Sciences

    Jennifer Lee

  71. The Cytochrome c Folding Landscape Revealed by Electron-transfer Kinetics

    Article • Journal of Molecular Biology, July 2002, Elsevier

    Jennifer Lee

  72. Cytochrome c ′ folding triggered by electron transfer: Fast and slow formation of four-helix bundles

    Article • Proceedings of the National Academy of Sciences, July 2001, Proceedings of the National Academy of Sciences

    Jennifer Lee

  73. Cytochrome b 562 folding triggered by electron transfer: Approaching the speed limit for formation of a four-helix-bundle protein

    Article • Proceedings of the National Academy of Sciences, June 1999, Proceedings of the National Academy of Sciences

    Jennifer Lee