Professor Jeffrey N. Johnston

All Stories

1. 
   Selective RyR2 inhibition reduces arrhythmia susceptibility in human cardiac slices

   Article • The Journal of Physiology, January 2026, Wiley

   Professor Jeffrey N. Johnston

2. 
   Performance-enhancing asymmetric catalysis unlocks tuning without rebuilding

   Article • Chem Catalysis, November 2025, Elsevier

   Professor Jeffrey N. Johnston

3. 
   Introduction of a Single Carboxylic Acid Converts the Cyclic Oligomeric Depsipeptide ent-Verticilide from an RyR2 Inhibitor to RyR2 Activator

   Article • Molecular Pharmacology, October 2025, Elsevier

   Professor Jeffrey N. Johnston

4. 
   Performance-Enhancing Asymmetric Catalysis Driven by Achiral Counterion Design

   Article • Journal of the American Chemical Society, May 2025, American Chemical Society (ACS)

   Professor Jeffrey N. Johnston

5. 
   End-to-End Backbone Cyclization Enhances Passive Permeability of bRo5 Oligomeric Depsipeptides with Nonlinear Size Dependence

   Article • ACS Medicinal Chemistry Letters, March 2025, American Chemical Society (ACS)

   Professor Jeffrey N. Johnston

6. 
   Elucidating Fluorine Steering Effects in Diels‐Alder Reactions Interfaced with Charge‐Enhanced Reactivity

   Article • European Journal of Organic Chemistry, January 2025, Wiley

   Professor Jeffrey N. Johnston

7. 
   Backbone-Determined Antiarrhythmic Structure–Activity Relationships for a Mirror Image, Oligomeric Depsipeptide Natural Product

   Article • Journal of Medicinal Chemistry, July 2024, American Chemical Society (ACS)

   Professor Jeffrey N. Johnston

8. 
   ent-Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in Casq2−/− Mice

   Article • Molecular Pharmacology, March 2024, Elsevier

   Professor Jeffrey N. Johnston

9. 
   Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction

   Article • Journal of the American Chemical Society, January 2024, American Chemical Society (ACS)

   Professor Jeffrey N. Johnston

10. 
    The backbone constitution drives passive permeability independent of side chains in depsipeptide and peptide macrocycles inspired by ent-verticilide

    Article • Chemical Science, January 2024, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

11. 
    ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Professor Jeffrey N. Johnston

12. 
    The selective RyR2 inhibitor ent-verticilide suppresses atrial fibrillation susceptibility caused by Pitx2 deficiency

    Article • Journal of Molecular and Cellular Cardiology, July 2023, Elsevier

    Professor Jeffrey N. Johnston

13. 
    RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

    Article • June 2023, Cold Spring Harbor Laboratory Press

    Professor Jeffrey N. Johnston

14. 
    In Vivo Pharmacokinetic and Pharmacodynamic Properties of the Antiarrhythmic Molecule ent-Verticilide

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2023, Elsevier

    Professor Jeffrey N. Johnston

15. 
    Secondary Orbital Effect Involving Fluorine is Responsible for Substrate‐Controlled Diastereodivergence in the Catalyzed syn‐aza‐Henry Reaction of α‐Fluoronitroalkanes

    Article • Chemistry - A European Journal, March 2023, Wiley

    Professor Jeffrey N. Johnston

16. 
    Enantioselective Synthesis of cis- and trans-Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis

    Article • Organic Letters, February 2023, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

17. 
    Structure–Activity Relationships for the N-Me- Versus N-H-Amide Modification to Macrocyclic ent-Verticilide Antiarrhythmics

    Article • ACS Medicinal Chemistry Letters, October 2022, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

18. 
    Preparation of N-Aryl Amides by Epimerization-Free Umpolung Amide Synthesis

    Article • Journal of the American Chemical Society, September 2022, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

19. 
    Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts

    Article • Circulation, May 2022, Wolters Kluwer Health

    Professor Jeffrey N. Johnston

20. 
    Resolving Bromonitromethane Sourcing by Synthesis: Preparation at the Decagram Scale

    Article • The Journal of Organic Chemistry, April 2022, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

21. 
    Enantioselective iodolactonization to prepare ε-lactone rings using hypervalent iodine

    Article • Chemical Science, January 2022, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

22. 
    Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn-aza-Henry reaction

    Article • Chemical Science, January 2022, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

23. 
    Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity

    Article • ACS Medicinal Chemistry Letters, November 2021, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

24. 
    DFT-Based Stereochemical Rationales for the Bifunctional Brønsted Acid/Base-Catalyzed Diastereodivergent and Enantioselective aza-Henry Reactions of α-Nitro Esters

    Article • The Journal of Organic Chemistry, October 2021, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

25. 
    The Formation of Impossible Rings in Macrocyclooligomerizations for Cyclodepsipeptide Synthesis: The 18-from-12 Paradox

    Article • The Journal of Organic Chemistry, June 2021, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

26. 
    Correction to “Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides”

    Article • Journal of the American Chemical Society, April 2021, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

27. 
    RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT

    Article • Circulation Research, February 2021, Wolters Kluwer Health

    Professor Jeffrey N. Johnston

28. 
    Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator

    Article • Organic Letters, October 2020, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

29. 
    Direct Observation and Analysis of the Halo-Amino-Nitro Alkane Functional Group

    Article • Chem, May 2019, Elsevier

    Professor Jeffrey N. Johnston

30. 
    Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

    Article • Proceedings of the National Academy of Sciences, February 2019, Proceedings of the National Academy of Sciences

    Professor Jeffrey N. Johnston

31. 
    The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis

    Article • Chemical Science, January 2019, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

32. 
    Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism

    Article • Journal of the American Chemical Society, December 2018, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

33. 
    Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

    Article • ACS Central Science, December 2018, American Chemical Society (ACS)

    Wei Shi, Professor Jeffrey N. Johnston

34. 
    Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas

    Article • ACS Catalysis, November 2018, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

35. 
    Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space

    Article • October 2018, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

36. 
    Continuous Platform To Generate Nitroalkanes On-Demand (in Situ) Using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

    Article • Organic Process Research & Development, July 2018, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

37. 
    Preparation of Benzyl(( R )‐2‐(4‐(benzyloxy)phenyl)‐2‐(( tert ‐Butoxycarbonyl)Amino)Acetyl)‐D‐Phenylalaninate Using Umpolung Amide Synthesis

    Article • June 2018, Wiley

    Professor Jeffrey N. Johnston

38. 
    Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides

    Article • Journal of the American Chemical Society, March 2018, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

39. 
    Cluster Preface: Alkene Halofunctionalization

    Article • Synlett, February 2018, Thieme Publishing Group

    Professor Jeffrey N. Johnston

40. 
    Biomimetic Desymmetrization of a Carboxylic Acid

    Article • Journal of the American Chemical Society, February 2018, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

41. 
    Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution

    Article • Chemical Science, January 2018, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

42. 
    MDM2 Antagonists Counteract Drug-Induced DNA Damage

    Article • EBioMedicine, October 2017, Elsevier

    Professor Jeffrey N. Johnston

43. 
    1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis­ Using Diverted Umpolung Amide Synthesis

    Article • Synthesis, August 2017, Thieme Publishing Group

    Professor Jeffrey N. Johnston

44. 
    A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions

    Article • Chemical Science, January 2017, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

45. 
    Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control

    Article • Proceedings of the National Academy of Sciences, December 2016, Proceedings of the National Academy of Sciences

    Professor Jeffrey N. Johnston

46. 
    Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy

    Article • Journal of the American Chemical Society, October 2016, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

47. 
    On-Demand Complex Peptide Synthesis: An Aspirational (and Elusive?) Goal for Peptide Synthesis

    Article • Journal of the American Chemical Society, October 2016, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

48. 
    Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid–Base Catalyst with Recycle

    Article • Organic Process Research & Development, February 2016, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

49. 
    A one-pot amidation of primary nitroalkanes

    Article • Chemical Communications, January 2016, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

50. 
    Enantioselective Synthesis of α-Bromonitroalkanes for Umpolung Amide Synthesis: Preparation of tert-Butyl ((1R)-1-(4-(benzyloxy)phenyl)-2-bromo-2-nitroethyl)carbamate

    Article • Organic Syntheses, January 2016, Organic Syntheses

    Professor Jeffrey N. Johnston

51. 
    Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst

    Article • ACS Catalysis, October 2015, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

52. 
    ChemInform Abstract: Oxidative Inter-/Intermolecular Alkene Diamination of Hydroxy Styrenes with Electron-Rich Amines.

    Article • ChemInform, September 2015, Wiley

    Professor Jeffrey N. Johnston

53. 
    A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines

    Article • Organic Letters, July 2015, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

54. 
    Abstract B12: Synergistic anticancer activity of Aurora A kinase and MDM2 antagonists in melanoma

    Article • Cancer Research, July 2015, American Association for Cancer Research (AACR)

    Professor Jeffrey N. Johnston

55. 
    ChemInform Abstract: Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes.

    Article • ChemInform, July 2015, Wiley

    Professor Jeffrey N. Johnston

56. 
    Enantioselective Small Molecule Synthesis by Carbon Dioxide Fixation using a Dual Brønsted Acid/Base Organocatalyst

    Article • Journal of the American Chemical Society, June 2015, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

57. 
    Oxidative Inter-/Intermolecular Alkene Diamination of Hydroxy Styrenes with Electron-Rich Amines

    Article • Organic Letters, May 2015, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

58. 
    ChemInform Abstract: Broensted Acid Catalyzed Phosphoramidic Acid Additions to Alkenes: Diastereo- and Enantioselective Halogenative Cyclizations for the synthesis of C- and P-Chiral Phosphoramidates.

    Article • ChemInform, April 2015, Wiley

    Professor Jeffrey N. Johnston

59. 
    ChemInform Abstract: Umpolung Amide Synthesis Using Substoichiometric N-Iodosuccinimide (NIS) and Oxygen as a Terminal Oxidant.

    Article • ChemInform, February 2015, Wiley

    Professor Jeffrey N. Johnston

60. 
    Adaptation of a Small-Molecule Hydrogen-Bond Donor Catalyst to an Enantioselective Hetero-Diels–Alder Reaction Hypothesized for Brevianamide Biosynthesis

    Article • Organic Letters, January 2015, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

61. 
    ChemInform Abstract: Organocatalytic, Diastereo‐ and Enantioselective Synthesis of Nonsymmetric cis‐Stilbene Diamines: A Platform for the Preparation of Single‐Enantiomer cis‐Imidazolines for Protein—Protein Inhibition.

    Article • ChemInform, January 2015, Wiley

    Professor Jeffrey N. Johnston

62. 
    Enantioselective synthesis of d-α-amino amides from aliphatic aldehydes

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

63. 
    Mdm2 and Aurora Kinase A Inhibitors Synergize to Block Melanoma Growth by Driving Apoptosis and Immune Clearance of Tumor Cells

    Article • Cancer Research, January 2015, American Association for Cancer Research (AACR)

    Professor Jeffrey N. Johnston

64. 
    ChemInform Abstract: Alkene Diamination Using Electron-Rich Amines: Hypervalent Iodine-Promoted Inter-/Intramolecular C-N Bond Formation.

    Article • ChemInform, December 2014, Wiley

    Professor Jeffrey N. Johnston

65. 
    ChemInform Abstract: Silyl Imine Electrophiles in Enantioselective Catalysis: A Rosetta Stone for Peptide Homologation, Enabling Diverse N-Protected Aryl Glycines from Aldehydes in Three Steps.

    Article • ChemInform, November 2014, Wiley

    Professor Jeffrey N. Johnston

66. 
    Brønsted Acid Catalyzed Phosphoramidic Acid Additions to Alkenes: Diastereo- and Enantioselective Halogenative Cyclizations for the Synthesis ofC- andP-Chiral Phosphoramidates

    Article • Journal of the American Chemical Society, October 2014, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

67. 
    Umpolung Amide Synthesis Using Substoichiometric N-Iodosuccinimide (NIS) and Oxygen as a Terminal Oxidant

    Article • Organic Letters, September 2014, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

68. 
    Alkene Diamination Using Electron-Rich Amines: Hypervalent Iodine-Promoted Inter-/Intramolecular C–N Bond Formation

    Article • Organic Letters, July 2014, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

69. 
    Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

    Article • The Journal of Organic Chemistry, July 2014, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

70. 
    2,6-Bis[(4S)-4-isopropyloxazolin-2-yl]pyridine

    Article • May 2014, Wiley

    Professor Jeffrey N. Johnston

71. 
    Silyl Imine Electrophiles in Enantioselective Catalysis: A Rosetta Stone for Peptide Homologation, Enabling Diverse N-Protected Aryl Glycines from Aldehydes in Three Steps

    Article • Organic Letters, May 2014, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

72. 
    ChemInform Abstract: Preparation of (-)-Nutlin-3 Using Enantioselective Organocatalysis at Decagram Scale.

    Article • ChemInform, March 2014, Wiley

    Professor Jeffrey N. Johnston

73. 
    Preparation of H,4PyrrolidineQuin-BAM (PBAM)

    Article • February 2014, Wiley

    Professor Jeffrey N. Johnston

74. 
    Preparation of (−)-Nutlin-3 Using Enantioselective Organocatalysis at Decagram Scale

    Article • The Journal of Organic Chemistry, November 2013, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

75. 
    ChemInform Abstract: Enantioselective Synthesis of α-Oxy Amides via Umpolung Amide Synthesis.

    Article • ChemInform, February 2013, Wiley

    Professor Jeffrey N. Johnston

76. 
    VNI Cures Acute and Chronic Experimental Chagas Disease

    Article • The Journal of Infectious Diseases, January 2013, Oxford University Press (OUP)

    Professor Jeffrey N. Johnston

77. 
    Total Synthesis of the Lycopodium Alkaloid Serratezomine A Using Free Radical-Mediated Vinyl Amination to Prepare a β-Stannyl Enamine Linchpin

    Article • The Journal of Organic Chemistry, December 2012, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

78. 
    Organocatalytic, Enantioselective Synthesis of VNI: A Robust Therapeutic Development Platform for Chagas, a Neglected Tropical Disease

    Article • Organic Letters, December 2012, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

79. 
    Enantioselective Synthesis of α-Oxy Amides via Umpolung Amide Synthesis

    Article • Journal of the American Chemical Society, September 2012, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

80. 
    ChemInform Abstract: Chiral Proton Catalysis of Secondary Nitroalkane Additions to Azomethine: Synthesis of a Potent GlyT1 Inhibitor.

    Article • ChemInform, August 2012, Wiley

    Professor Jeffrey N. Johnston

81. 
    ChemInform Abstract: Achiral Counterion Control of Enantioselectivity in a Broensted Acid-Catalyzed Iodolactonization.

    Article • ChemInform, August 2012, Wiley

    Professor Jeffrey N. Johnston

82. 
    Achiral Counterion Control of Enantioselectivity in a Brønsted Acid-Catalyzed Iodolactonization

    Article • Journal of the American Chemical Society, April 2012, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

83. 
    Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

84. 
    Serratezomine A

    Article • January 2012, Springer Science + Business Media

    Professor Jeffrey N. Johnston

85. 
    Preparation of H,4 PyrrolidineQuin-BAM (PBAM)

    Article • Organic Syntheses, January 2012, Organic Syntheses

    Professor Jeffrey N. Johnston

86. 
    Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18 O-labeling

    Article • Proceedings of the National Academy of Sciences, December 2011, Proceedings of the National Academy of Sciences

    Professor Jeffrey N. Johnston

87. 
    Preparation of Isopropyl 2-Diazoacetyl(Phenyl)Carbamate

    Article • November 2011, Wiley

    Professor Jeffrey N. Johnston

88. 
    Total Synthesis of the Chlorine-Containing Hapalindoles K, A, and G

    Article • Angewandte Chemie, July 2011, Wiley

    Professor Jeffrey N. Johnston

89. 
    Total Synthesis of the Chlorine-Containing Hapalindoles K, A, and G

    Article • Angewandte Chemie, July 2011, Wiley

    Professor Jeffrey N. Johnston

90. 
    ChemInform Abstract: Stereoselective Synthesis of Complex Polycyclic Aziridines (XI): Use of the Broensted Acid‐Catalyzed Aza‐Darzens Reaction to Prepare an Orthogonally Protected Mitomycin C Intermediate with Maximal Convergency.

    Article • ChemInform, June 2011, Wiley

    Professor Jeffrey N. Johnston

91. 
    ChemInform Abstract: A Chiral N-Phosphinyl Phosphoramide: Another Offspring for the Sage Phosphoric Acid Progenitor.

    Article • ChemInform, June 2011, Wiley

    Professor Jeffrey N. Johnston

92. 
    Origins of Selectivity in Brønsted Acid-Promoted Diazoalkane−Azomethine Reactions (The Aza-Darzens Aziridine Synthesis)

    Article • Organic Letters, April 2011, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

93. 
    Ein chirales N-Phosphinylphosphoramid: ein weiterer Abkömmling der Phosphorsäure

    Article • Angewandte Chemie, February 2011, Wiley

    Professor Jeffrey N. Johnston

94. 
    A Chiral N-Phosphinyl Phosphoramide: Another Offspring for the Sage Phosphoric Acid Progenitor

    Article • Angewandte Chemie, February 2011, Wiley

    Professor Jeffrey N. Johnston

95. 
    Review of Recent Developments in Asymmetric Organocatalysis

    Article • Journal of the American Chemical Society, January 2011, American Chemical Society (ACS)

    Professor Jeffrey N. Johnston

96. 
    Stereoselective synthesis of complex polycyclic aziridines: use of the Brønsted acid-catalyzed aza-Darzens reaction to prepare an orthogonally protected mitomycin C intermediate with maximal convergency

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

97. 
    Catalytic, enantioselective synthesis of stilbene cis-diamines: A concise preparation of (−)-Nutlin-3, a potent p53/MDM2 inhibitor

    Article • Chemical Science, January 2011, Royal Society of Chemistry

    Professor Jeffrey N. Johnston

98. 
    Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate Reductase

    Article • Journal of Biological Chemistry, January 2011, Elsevier

    Professor Jeffrey N. Johnston

99. 
    PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE

    Article • Organic Syntheses, January 2011, Organic Syntheses

    Professor Jeffrey N. Johnston

100. 
     Brønsted acid-promoted azide–olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A

     Article • Beilstein Journal of Organic Chemistry, December 2010, Beilstein Institut

     Professor Jeffrey N. Johnston

101. 
     Chiral Brønsted Base-Promoted Nitroalkane Alkylation: Enantioselective Synthesis of sec -Alkyl-3-Substituted Indoles

     Article • Organic Letters, December 2010, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

102. 
     Umpolung reactivity in amide and peptide synthesis

     Article • Nature, June 2010, Nature

     Professor Jeffrey N. Johnston

103. 
     ChemInform Abstract: Catalytic Enantioselective Michael Additions to Unsaturated Ester Derivatives Using Chiral Copper(II) Lewis Acid Complexes.

     Article • ChemInform, June 2010, Wiley

     Professor Jeffrey N. Johnston

104. 
     ChemInform Abstract: Stereocontrolled Elaboration of Natural (-)-Polycavernoside A, a Powerfully Toxic Metabolite of the Red Alga Polycavernosa tsudai.

     Article • ChemInform, June 2010, Wiley

     Professor Jeffrey N. Johnston

105. 
     ChemInform Abstract: To Protonate or Alkylate? Stereoselective Broensted Acid Catalysis of C-C Bond Formation Using Diazoalkanes

     Article • ChemInform, June 2010, Wiley

     Professor Jeffrey N. Johnston

106. 
     ChemInform Abstract: Nonconventional Carbon Additions to Azomethines. Aryl Amination/Indoline Synthesis by Direct Aryl Radical Addition to Azomethine Nitrogen.

     Article • ChemInform, May 2010, Wiley

     Professor Jeffrey N. Johnston

107. 
     ChemInform Abstract: Enantioselective and Diastereoselective Mukaiyama-Michael Reactions Catalyzed by Bis(oxazoline) Copper(II) Complexes.

     Article • ChemInform, May 2010, Wiley

     Professor Jeffrey N. Johnston

108. 
     ChemInform Abstract: Use of the Vicinal Element Effect for Regiochemical Control of Quinone Substitutions and Its Implication for Convergent Mitomycin Construction.

     Article • ChemInform, May 2010, Wiley

     Professor Jeffrey N. Johnston

109. 
     ChemInform Abstract: Broensted Acid Activation of α-Diazo Imide: A syn-Selective Glycolate Mannich Reaction.

     Article • ChemInform, March 2010, Wiley

     Professor Jeffrey N. Johnston

110. 
     To Protonate or Alkylate? Stereoselective Brønsted Acid Catalysis of CC Bond Formation Using Diazoalkanes

     Article • Angewandte Chemie, March 2010, Wiley

     Professor Jeffrey N. Johnston

111. 
     Protonierung oder Alkylierung? Stereoselektive Brønsted-Säure-katalysierte C-C-Verknüpfungen mit Diazoalkanen

     Article • Angewandte Chemie, March 2010, Wiley

     Professor Jeffrey N. Johnston

112. 
     Bifunctional Asymmetric Catalysis: Amplification of Brønsted Basicity Can Orthogonally Increase the Reactivity of a Chiral Brønsted Acid

     Article • Journal of the American Chemical Society, February 2010, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

113. 
     ChemInform Abstract: Use of Comparative Triazolinium Triflate Fragmentation Rates as a Tool to Assay Relative Competency of Broensted Bases in N→N Proton Transfer.

     Article • ChemInform, December 2009, Wiley

     Professor Jeffrey N. Johnston

114. 
     Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N→N proton transfer

     Article • Bioorganic & Medicinal Chemistry Letters, September 2009, Elsevier

     Professor Jeffrey N. Johnston

115. 
     ChemInform Abstract: Total Synthesis of the Lycopodium Alkaloid (+)-Serratezomine A.

     Article • ChemInform, July 2009, Wiley

     Professor Jeffrey N. Johnston

116. 
     Total Synthesis of the Lycopodium Alkaloid (+)-Serratezomine A

     Article • Journal of the American Chemical Society, March 2009, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

117. 
     ChemInform Abstract: A Formal Enantioselective Acetate Mannich Reaction: The Nitro Functional Group as a Traceless Agent for Activation and Enantiocontrol in the Synthesis of β-Amino Acids.

     Article • ChemInform, March 2009, Wiley

     Professor Jeffrey N. Johnston

118. 
     ChemInform Abstract: A Diastereo- and Enantioselective Synthesis of α-Substituted anti-α,β-Diaminophosphonic Acid Derivatives.

     Article • ChemInform, January 2009, Wiley

     Professor Jeffrey N. Johnston

119. 
     Brønsted acid activation of α-diazo imide: a syn-selective glycolate Mannich reaction

     Article • Chemical Communications, January 2009, Royal Society of Chemistry

     Professor Jeffrey N. Johnston

120. 
     ChemInform Abstract: A Diastereo- and Enantioselective Synthesis of α-Substituted syn-α,β-Diamino Acids.

     Article • ChemInform, September 2008, Wiley

     Professor Jeffrey N. Johnston

121. 
     A Formal Enantioselective Acetate Mannich Reaction: The Nitro Functional Group as a Traceless Agent for Activation and Enantiocontrol in the Synthesis of β-Amino Acids

     Article • Organic Letters, September 2008, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

122. 
     ChemInform Abstract: Free Radical-Mediated Aryl Amination: Convergent Two- and Three-Component Couplings to Chiral 2,3-Disubstituted Indolines.

     Article • ChemInform, August 2008, Wiley

     Professor Jeffrey N. Johnston

123. 
     A Preparation of Enantiomerically Enriched Axially Chiral β-Diketimines: Synthesis of (−)- and (+)-IAN Amine

     Article • Organic Letters, June 2008, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

124. 
     A Diastereo- and Enantioselective Synthesis of α-Substituted syn -α,β-Diamino Acids

     Article • Journal of the American Chemical Society, May 2008, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

125. 
     ChemInform Abstract: Synthesis of the ABC- (I) and D-Ring Systems (II) of the Indole Alkaloid Ambiguine G (III).

     Article • ChemInform, April 2008, Wiley

     Professor Jeffrey N. Johnston

126. 
     Free Radical-Mediated Aryl Amination:  Convergent Two- and Three-Component Couplings to Chiral 2,3-Disubstituted Indolines

     Article • The Journal of Organic Chemistry, March 2008, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

127. 
     On the Nature of Rate Acceleration in the Synthesis and Fragmentation of Triazolines by Brønsted Acid:  Secondary Catalysis by Water (Hydronium Triflate)

     Article • Journal of the American Chemical Society, January 2008, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

128. 
     A diastereo- and enantioselective synthesis of α-substituted anti-α,β-diaminophosphonic acid derivatives

     Article • Chemical Communications, January 2008, Royal Society of Chemistry

     Professor Jeffrey N. Johnston

129. 
     Synthesis of the ABC- and D-Ring Systems of the Indole Alkaloid Ambiguine G

     Article • Organic Letters, November 2007, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

130. 
     Chiral Proton Catalysis: Enantioselective Broensted Acid Catalyzed Additions of Nitroacetic Acid Derivatives as Glycine Equivalents.

     Article • ChemInform, August 2007, Wiley

     Professor Jeffrey N. Johnston

131. 
     Chiral Proton Catalysis:  Enantioselective Brønsted Acid Catalyzed Additions of Nitroacetic Acid Derivatives as Glycine Equivalents

     Article • Journal of the American Chemical Society, March 2007, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

132. 
     Synthesis of an Advanced Intermediate en Route to the Mitomycin Natural Products

     Article • Organic Letters, December 2006, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

133. 
     Preparation of a protected phosphoramidon precursor via an H-Phosphonate coupling strategy

     Article • Bioorganic & Medicinal Chemistry Letters, November 2006, Elsevier

     Professor Jeffrey N. Johnston

134. 
     A Case Study in Biomimetic Total Synthesis: Polyolefin Carbocyclizations to Terpenes and Steroids

     Article • ChemInform, April 2006, Wiley

     Professor Jeffrey N. Johnston

135. 
     On the use of a Modified Latin Hypercube Sampling (MLHS) method in the estimation of a Mixed Logit Model for vehicle choice

     Article • Transportation Research Part B Methodological, February 2006, Elsevier

     Professor Jeffrey N. Johnston

136. 
     Chiral Proton Catalysis: pK a Determination for a BAM-HX Brønsted Acid

     Article • Synlett, January 2006, Thieme Publishing Group

     Professor Jeffrey N. Johnston

137. 
     A Case Study in Biomimetic Total Synthesis:  Polyolefin Carbocyclizations to Terpenes and Steroids

     Article • Chemical Reviews, December 2005, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

138. 
     Broensted Acid-Promoted Olefin Aziridination and Formal anti-Aminohydroxylation.

     Article • ChemInform, June 2005, Wiley

     Professor Jeffrey N. Johnston

139. 
     Brønsted Acid-Promoted Olefin Aziridination and Formal a nti -Aminohydroxylation

     Article • Journal of the American Chemical Society, February 2005, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

140. 
     Free Radical-Mediated Aryl Amination: A Practical Synthesis of ( R )- and ( S )-7-Azaindoline α-Amino Acid

     Article • Synthesis, January 2005, Thieme Publishing Group

     Professor Jeffrey N. Johnston

141. 
     A Remarkably Facile Zirconium(IV) → Aluminum(III) β-Diketiminate Transmetalation That Also Results in a More Active Olefin Polymerization Catalyst upon Activation

     Article • Organometallics, November 2004, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

142. 
     The Broensted Acid Catalyzed Direct Aza-Darzens Synthesis of N-Alkyl cis-Aziridines.

     Article • ChemInform, June 2004, Wiley

     Professor Jeffrey N. Johnston

143. 
     IAN Amines:  Chiral C2-Symmetric Zirconium(IV) Complexes from Readily Modified Axially Chiral C1-Symmetric β-Diketimines

     Article • Organometallics, April 2004, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

144. 
     Free Radical-Mediated Vinyl Amination: A Mild, General Pyrrolidinyl Enamine Synthesis.

     Article • ChemInform, March 2004, Wiley

     Professor Jeffrey N. Johnston

145. 
     Chiral Proton Catalysis:  A Catalytic Enantioselective Direct Aza-Henry Reaction

     Article • Journal of the American Chemical Society, March 2004, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

146. 
     The Brønsted Acid-Catalyzed Direct Aza-Darzens Synthesis of N -Alkyl cis -Aziridines

     Article • Journal of the American Chemical Society, February 2004, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

147. 
     Enantioenriched Axially Chiral b-Diketimines: Determination of the IAN-amine Barrier to Atrop- isomerization

     Article • Heterocycles, January 2004, Japan Institute of Heterocyclic Chemistry

     Professor Jeffrey N. Johnston

148. 
     Free radical-mediated vinyl amination: a mild, general pyrrolidinyl enamine synthesis

     Article • Tetrahedron, November 2003, Elsevier

     Professor Jeffrey N. Johnston

149. 
     The First Azacyclopentenyl Carbinyl Radical Isomerizations (ACCRI): Independent Use of Steric and Electronic (Polarization) Effects as Gating Elements.

     Article • ChemInform, October 2003, Wiley

     Professor Jeffrey N. Johnston

150. 
     Free Radical-Mediated Aryl Amination and Its Use in a Convergent [3 + 2] Strategy for Enantioselective Indoline α-Amino Acid Synthesis.

     Article • ChemInform, June 2003, Wiley

     Professor Jeffrey N. Johnston

151. 
     The First Azacyclopentenyl Carbinyl Radical Isomerizations (ACCRI):  Independent Use of Steric and Electronic (Polarization) Effects as Gating Elements

     Article • Journal of the American Chemical Society, May 2003, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

152. 
     N-Propenoyl Camphor-10,2-sultam

     Article • April 2003, Wiley

     Professor Jeffrey N. Johnston

153. 
     N-Glyoxyloyl-(2R)-bornane-10,2-sultam

     Article • April 2003, Wiley

     Professor Jeffrey N. Johnston

154. 
     Free Radical Mediated Vinyl Amination: Access-to N,N-Dialkyl Enamines and Their β-Stannyl and β-Thio Derivatives.

     Article • ChemInform, April 2003, Wiley

     Professor Jeffrey N. Johnston

155. 
     Free Radical-Mediated Aryl Amination and Its Use in a Convergent [3 + 2] Strategy for Enantioselective Indoline α-Amino Acid Synthesis

     Article • Journal of the American Chemical Society, December 2002, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

156. 
     Free Radical-Mediated Vinyl Amination:  Access to N,N-Dialkyl Enamines and Their β-Stannyl and β-Thio Derivatives

     Article • Organic Letters, November 2002, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

157. 
     2,6-Bis[(4S)-4-isopropyloxazolin-2-yl]pyridine

     Article • October 2002, Wiley

     Professor Jeffrey N. Johnston

158. 
     IAN-Amines: Direct Entry to a ChiralC2-Symmetric Zirconium(IV)β-Diketimine Complex

     Article • Angewandte Chemie, January 2002, Wiley

     Professor Jeffrey N. Johnston

159. 
     IAN-Amines: Direct Entry to a Chiral C2-Symmetric Zirconium(IV) β-Diketimine Complex Financial support has been provided by a GAANN Fellowship to S.B.C. (2001) and by Indiana University. IAN-amines are amines that are derived from Isoquinoline and 2-Am...

     Article • Angewandte Chemie, January 2002, Wiley

     Professor Jeffrey N. Johnston

160. 
     Use of the V icinal Element Effect for Regiochemical Control of Quinone Substitutions and Its Implication for Convergent Mitomycin Construction

     Article • Organic Letters, November 2001, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

161. 
     Enantioselective and Diastereoselective Mukaiyama−Michael Reactions Catalyzed by Bis(oxazoline) Copper(II) Complexes

     Article • Journal of the American Chemical Society, April 2001, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

162. 
     Lithium Aluminum Hydride-Cerium(III) Chloride

     Article • April 2001, Wiley

     Professor Jeffrey N. Johnston

163. 
     Chromium(VI) Oxide-3,5-Dimethylpyrazole

     Article • April 2001, Wiley

     Professor Jeffrey N. Johnston

164. 
     Lithium Aluminum Hydride-Cobalt(II) Chloride

     Article • April 2001, Wiley

     Professor Jeffrey N. Johnston

165. 
     Diphenylacetylene

     Article • April 2001, Wiley

     Professor Jeffrey N. Johnston

166. 
     Article • Organic Letters, April 2001, CrossRef Test Account

     Professor Jeffrey N. Johnston

167. 
     Nonconventional Carbon Additions to Azomethines. Aryl Amination/Indoline Synthesis by Direct Aryl Radical Addition to Azomethine Nitrogen

     Article • Organic Letters, April 2001, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

168. 
     Stereocontrolled Elaboration of Natural (−)-Polycavernoside A, a Powerfully Toxic Metabolite of the Red Alga Polycavernosa tsudai

     Article • Journal of the American Chemical Society, December 1999, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

169. 
     Catalytic Enantioselective Michael Additions to Unsaturated Ester Derivatives Using Chiral Copper(II) Lewis Acid Complexes

     Article • Organic Letters, September 1999, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

170. 
     Stereochemical Models for the Enantiocontrolled Construction of Fully Functionalized C Rings via Intramolecular Aldolization in Advanced Precursors to Paclitaxel

     Article • The Journal of Organic Chemistry, October 1998, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

171. 
     New Extensions of the Anionic Oxy-Cope/Intramolecular SN' Reaction Cascade

     Article • Synthetic Communications, April 1998, Taylor & Francis

     Professor Jeffrey N. Johnston

172. 
     Application of an S → O Allylic Transposition in the Context of a Bridgehead Olefinic System. New Opportunities for the Structural Modification of Bicyclo[6.2.1]undecanes via Transannular Ring Closure

     Article • The Journal of Organic Chemistry, January 1998, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

173. 
     Single Stereodifferentiation Associated with Carbon Atom Insertion during the Oxonium Ion-Initiated Pinacol Rearrangement of Dihydrofuranyl and Dihydropyranyl Carbinols

     Article • The Journal of Organic Chemistry, March 1997, American Chemical Society (ACS)

     Professor Jeffrey N. Johnston

174. 
     Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

     Article • Bioorganic & Medicinal Chemistry Letters, April 1996, Elsevier

     Professor Jeffrey N. Johnston

175. 
     Studies directed toward the total synthesis of polycavernoside A. Enantioselective synthesis of the disaccharide component

     Article • Tetrahedron Letters, June 1995, Elsevier

     Professor Jeffrey N. Johnston

176. 
     Bromonitromethane

     Article • Wiley

     Professor Jeffrey N. Johnston