All Stories

  1. Effect of gene cluster relocation to the central chromosomal compartment on its expression in Streptomyces

    Article • March 2026, openRxiv

    Dr Jean-Luc Pernodet

  2. Fluorescence-Based Soil Survival Analysis of the Xenobiotic- and Metal-Detoxifying Streptomyces sp. MC1

    Article • International Journal of Molecular Sciences, December 2025, MDPI AG

    Dr Jean-Luc Pernodet

  3. Genetic Engineering Approaches for the Microbial Production of Vanillin

    Article • Biomolecules, November 2024, MDPI AG

    Dr Jean-Luc Pernodet

  4. Synteruptor : mining genomic islands for non-classical specialized metabolite gene clusters

    Article • NAR Genomics and Bioinformatics, April 2024, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  5. Root-associated Streptomyces produce galbonolides to modulate plant immunity and promote rhizosphere colonization

    Article • The ISME Journal, January 2024, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  6. Ribosomal RNA operons define a central functional compartment in the Streptomyces chromosome

    Article • Nucleic Acids Research, November 2022, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  7. Marker-Free Genome Engineering in Amycolatopsis Using the pSAM2 Site-Specific Recombination System

    Article • Microorganisms, April 2022, MDPI AG

    Dr Jean-Luc Pernodet

  8. Transcriptional Regulation of Congocidine (Netropsin) Biosynthesis and Resistance

    Article • Applied and Environmental Microbiology, November 2021, ASM Journals

    Dr Jean-Luc Pernodet

  9. Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

    Article • Nature Communications, September 2021, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  10. Towards the sustainable discovery and development of new antibiotics

    Article • Nature Reviews Chemistry, August 2021, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  11. Revised Structure of Anthelvencin A and Characterization of the Anthelvencin Biosynthetic Gene Cluster

    Article • ACS Chemical Biology, March 2020, American Chemical Society (ACS)

    Dr Jean-Luc Pernodet

  12. Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  13. Modular and Integrative Vectors for Synthetic Biology Applications in Streptomyces spp

    Article • Applied and Environmental Microbiology, August 2019, ASM Journals

    Dr Jean-Luc Pernodet

  14. Design of a generic CRISPR-Cas9 approach using the same sgRNA to perform gene editing at distinct loci

    Article • BMC Biotechnology, March 2019, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  15. A Comprehensive Overview of the Cyclodipeptide Synthase Family Enriched with the Characterization of 32 New Enzymes

    Article • Frontiers in Microbiology, February 2018, Frontiers

    Dr Jean-Luc Pernodet

  16. Complete Genome Sequence of Streptomyces sp. TN58, a Producer of Acyl Alpha-l-Rhamnopyranosides

    Article • Genome Announcements, August 2017, ASM Journals

    Dr Jean-Luc Pernodet, soumaya najah

  17. Draft Genome Sequence of Streptomyces sp. M1013, a Close Relative of Streptomyces ambofaciens and Streptomyces coelicolor

    Article • Genome Announcements, July 2017, ASM Journals

    Dr Jean-Luc Pernodet

  18. Characterization of Sviceucin fromStreptomycesProvides Insight into Enzyme Exchangeability and Disulfide Bond Formation in Lasso Peptides

    Article • ACS Chemical Biology, November 2015, American Chemical Society (ACS)

    Dr Jean-Luc Pernodet

  19. Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the spiramycin producer

    Article • Journal of Biotechnology, November 2015, Elsevier

    Dr Jean-Luc Pernodet

  20. Minimum Information about a Biosynthetic Gene cluster

    Article • Nature Chemical Biology, August 2015, Nature

    Dr Jean-Luc Pernodet, Dr Leonilde M Moreira, Kapil Tahlan, Professor Rainer Borriss, Dr Nikos C Kyrpides

  21. The Absence of Pupylation (Prokaryotic Ubiquitin-Like Protein Modification) Affects Morphological and Physiological Differentiation in Streptomyces coelicolor

    Article • Journal of Bacteriology, August 2015, ASM Journals

    Dr Jean-Luc Pernodet

  22. Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity

    Article • Nature Chemical Biology, August 2015, Nature

    Dr Jean-Luc Pernodet

  23. Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis

    Article • ACS Chemical Biology, February 2015, American Chemical Society (ACS)

    Dr Jean-Luc Pernodet

  24. Genome mining of Streptomyces ambofaciens

    Article • Journal of Industrial Microbiology & Biotechnology, November 2013, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  25. Post-PKS Tailoring Steps of the Spiramycin Macrolactone Ring in Streptomyces ambofaciens

    Article • Antimicrobial Agents and Chemotherapy, May 2013, ASM Journals

    Dr Sylvie Lautru, Dr Jean-Luc Pernodet

  26. The Genome Sequence of Streptomyces lividans 66 Reveals a Novel tRNA-Dependent Peptide Biosynthetic System within a Metal-Related Genomic Island

    Article • Genome Biology and Evolution, May 2013, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  27. A Sweet Origin for the Key Congocidine Precursor 4-Acetamidopyrrole-2-carboxylate

    Article • Angewandte Chemie, June 2012, Wiley

    Dr Jean-Luc Pernodet

  28. A Sweet Origin for the Key Congocidine Precursor 4-Acetamidopyrrole-2-carboxylate

    Article • Angewandte Chemie, June 2012, Wiley

    Dr Jean-Luc Pernodet

  29. The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

    Article • Natural Product Reports, January 2012, Royal Society of Chemistry

    Dr Jean-Luc Pernodet

  30. Nonribosomal Peptide Synthesis in Animals: The Cyclodipeptide Synthase of Nematostella

    Article • Chemistry & Biology, November 2011, Elsevier

    Dr Jean-Luc Pernodet

  31. Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis

    Article • Nucleic Acids Research, February 2011, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  32. Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciens

    Article • Journal of Bacteriology, September 2010, ASM Journals

    Dr Jean-Luc Pernodet

  33. Glycosylation Steps during Spiramycin Biosynthesis in Streptomyces ambofaciens: Involvement of Three Glycosyltransferases and Their Interplay with Two Auxiliary Proteins

    Article • Antimicrobial Agents and Chemotherapy, May 2010, ASM Journals

    Dr Jean-Luc Pernodet

  34. Transcriptional regulation of the novobiocin biosynthetic gene cluster

    Article • Microbiology, September 2009, Society for General Microbiology

    Dr Jean-Luc Pernodet

  35. Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

    Article • Proceedings of the National Academy of Sciences, May 2009, Proceedings of the National Academy of Sciences

    Dr Jean-Luc Pernodet

  36. Cyclodipeptide synthases are a family of tRNA-dependent peptide bond–forming enzymes

    Article • May 2009, Nature

    Dr Jean-Luc Pernodet

  37. An Iterative Nonribosomal Peptide Synthetase Assembles the Pyrrole-Amide Antibiotic Congocidine in Streptomyces ambofaciens

    Article • Chemistry & Biology, April 2009, Elsevier

    Dr Jean-Luc Pernodet

  38. The integrative element pSAM2 from Streptomyces: kinetics and mode of conjugal transfer

    Article • Molecular Microbiology, July 2008, Wiley

    Dr Jean-Luc Pernodet

  39. Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens

    Article • Microbiology, December 2007, Society for General Microbiology

    Dr Jean-Luc Pernodet

  40. MbtH-like protein-mediated cross-talk between non-ribosomal peptide antibiotic and siderophore biosynthetic pathways in Streptomyces coelicolor M145

    Article • Microbiology, May 2007, Society for General Microbiology

    Dr Jean-Luc Pernodet

  41. Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877

    Article • Microbiology, November 2006, Society for General Microbiology

    Dr Jean-Luc Pernodet

  42. Intraspecific Variability of the Terminal Inverted Repeats of the Linear Chromosome of Streptomyces ambofaciens

    Article • Journal of Bacteriology, September 2006, ASM Journals

    Dr Jean-Luc Pernodet

  43. Evolution of the Terminal Regions of the Streptomyces Linear Chromosome

    Article • Molecular Biology and Evolution, August 2006, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  44. Excisable Cassettes: New Tools for Functional Analysis of Streptomyces Genomes

    Article • Applied and Environmental Microbiology, July 2006, ASM Journals

    Dr Jean-Luc Pernodet

  45. Construction and testing of a bacterial luciferase reporter gene system forin Vivo measurement of nonsense suppression inStreptomyces

    Article • Folia Microbiologica, January 2006, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  46. Macrolide Resistance in Mycobacteria

    Article • Medicinal Chemistry Reviews - Online, December 2005, Bentham Science Publishers

    Dr Jean-Luc Pernodet

  47. Methyltransferase Erm(37) Slips on rRNA to Confer Atypical Resistance in Mycobacterium tuberculosis

    Article • Journal of Biological Chemistry, September 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Jean-Luc Pernodet

  48. Functional Angucycline-Like Antibiotic Gene Cluster in the Terminal Inverted Repeats of the Streptomyces ambofaciens Linear Chromosome

    Article • Antimicrobial Agents and Chemotherapy, February 2004, ASM Journals

    Dr Jean-Luc Pernodet

  49. Molecular Basis of Intrinsic Macrolide Resistance in the Mycobacterium tuberculosis Complex

    Article • Antimicrobial Agents and Chemotherapy, January 2004, ASM Journals

    Dr Jean-Luc Pernodet

  50. Conjugal immunity of Streptomyces strains carrying the integrative element pSAM2 is due to the pif gene (pSAM2 immunity factor)

    Article • Molecular Microbiology, February 2003, Wiley

    Dr Jean-Luc Pernodet

  51. Recombinant Environmental Libraries Provide Access to Microbial Diversity for Drug Discovery from Natural Products

    Article • Applied and Environmental Microbiology, January 2003, ASM Journals

    Dr Jean-Luc Pernodet

  52. The Albonoursin Gene Cluster of S. noursei

    Article • Chemistry & Biology, December 2002, Elsevier

    Dr Jean-Luc Pernodet

  53. Natural and Acquired Macrolide Resistance in Mycobacteria

    Article • Current Drug Targets - Infectious Disorders, December 2002, Bentham Science Publishers

    Dr Jean-Luc Pernodet

  54. Erratum to “Development of a conditional lethal system for a Streptomyces lividans strain and its use to investigate conjugative transfer in soil”

    Article • FEMS Microbiology Ecology, April 2002, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  55. Erratum to “Development of a conditional lethal system for a Streptomyces lividans strain and its use to investigate conjugative transfer in soil” [FEMS Microbiology Ecology 38 (2001) 115–121]1

    Article • FEMS Microbiology Ecology, April 2002, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  56. Characterization of the attP site of the integrative element pSAM2 from Streptomyces ambofaciens

    Article • Microbiology, January 2002, Society for General Microbiology

    Dr Jean-Luc Pernodet

  57. Development of a conditional lethal system for a Streptomyces lividans strain and its use to investigate conjugative transfer in soil

    Article • FEMS Microbiology Ecology, December 2001, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  58. Development of a conditional lethal system for a Streptomyces lividans strain and its use to investigate conjugative transfer in soil

    Article • FEMS Microbiology Ecology, December 2001, Oxford University Press (OUP)

    Dr Jean-Luc Pernodet

  59. KorSA from the Streptomyces Integrative Element pSAM2 Is a Central Transcriptional Repressor: Target Genes and Binding Sites

    Article • Journal of Bacteriology, March 2000, ASM Journals

    Dr Jean-Luc Pernodet

  60. Dispensable ribosomal resistance to spiramycin conferred by srmA in the spiramycin producer Streptomyces ambofaciens

    Article • Microbiology, September 1999, Society for General Microbiology

    Dr Jean-Luc Pernodet

  61. Characterization of a Glycosyl Transferase Inactivating Macrolides, Encoded by gimA from Streptomyces ambofaciens

    Article • Antimicrobial Agents and Chemotherapy, October 1998, ASM Journals

    Dr Jean-Luc Pernodet

  62. Structure of the chromosomal insertion site for pSAM2: functional analysis in Escherichia coli

    Article • Molecular Microbiology, April 1998, Wiley

    Dr Jean-Luc Pernodet

  63. Antibiotic resistance gene cassettes derived from the π interposon for use in E. coli and Streptomyces

    Article • Gene, May 1997, Elsevier

    Dr Jean-Luc Pernodet

  64. Complete conversion of antibiotic precursor to pristinamycin IIA by overexpression of Streptomyces pristinaespiralis biosynthetic genes

    Article • Nature Biotechnology, April 1997, Nature

    Dr Jean-Luc Pernodet

  65. The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.

    Article • Antimicrobial Agents and Chemotherapy, March 1996, ASM Journals

    Dr Jean-Luc Pernodet

  66. Characterization of pra, a gene for replication control in pSAM2, the integrating element of Streptomyces ambofaciens

    Article • Molecular Microbiology, August 1995, Wiley

    Dr Jean-Luc Pernodet

  67. Identification of a Gene Encoding the Replication Initiator Protein of the Streptomyces Integrating Element, pSAM2

    Article • Plasmid, March 1994, Elsevier

    Dr Jean-Luc Pernodet

  68. Mode and origin of replication of pSAM2, a conjugative integrating element of Streptomyces ambofaciens

    Article • Molecular Microbiology, November 1993, Wiley

    Dr Jean-Luc Pernodet

  69. Resistance to spiramycin in Streptomyces ambofaciens, the producer organism, involves at least two different mechanisms

    Article • Journal of General Microbiology, May 1993, Society for General Microbiology

    Dr Jean-Luc Pernodet

  70. Functional analysis of the Streptomyces ambofaciens element pSAM2

    Article • Plasmid, January 1991, Elsevier

    Dr Jean-Luc Pernodet

  71. Measurement of Translational Accuracy in Streptomyces

    Article • January 1991, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  72. Organization and nucleotide sequence analysis of a ribosomal RNA gene cluster from Streptomyces ambofaciens

    Article • Gene, June 1989, Elsevier

    Dr Jean-Luc Pernodet

  73. The integrated conjugative plasmid pSAM2 of Streptomyces ambofaciens is related to temperate bacteriophages.

    Article • The EMBO Journal, March 1989, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  74. Structural analysis of loci involved in pSAM2 site-specific integration in Streptomyces

    Article • Plasmid, January 1989, Elsevier

    Dr Jean-Luc Pernodet

  75. Site-specific integration of plasmid pSAM2 in Streptomyces lividans and S. ambofaciens

    Article • June 1988, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  76. Excision and integration of a self-transmissible replicon of Streptomyces ambofaciens

    Article • Gene, January 1987, Elsevier

    Dr Jean-Luc Pernodet

  77. Plasmids in different strains of Streptomyces ambofaciens: free and integrated form of plasmid pSAM2

    Article • January 1984, Springer Science + Business Media

    Dr Jean-Luc Pernodet

  78. Isolation and physical characterization of streptomycete plasmids

    Article • January 1981, Springer Science + Business Media

    Dr Jean-Luc Pernodet