All Stories

  1. Absorption, Distribution, Metabolism, and Excretion of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Humans

    Article • Current Drug Metabolism, July 2021, Bentham Science Publishers

    Jasper Dingemanse

  2. Absorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects

    Article • Xenobiotica, August 2019, Taylor & Francis

    Jasper Dingemanse

  3. Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects

    Article • Drug Design Development and Therapy, March 2019, Dove Medical Press

    Jasper Dingemanse

  4. Clinical Pharmacology of the Reversible and Potent P2Y12 Receptor Antagonist ACT-246475 After Single Subcutaneous Administration in Healthy Male Subjects

    Article • The Journal of Clinical Pharmacology, August 2018, Wiley

    Jasper Dingemanse

  5. Assessment of Peripheral Serotonin Synthesis Using Stable Isotope-Labeled Tryptophan

    Article • Clinical Pharmacology & Therapeutics, May 2018, Wiley

    Jasper Dingemanse

  6. Lucerastat, an Iminosugar for Substrate Reduction Therapy: Tolerability, Pharmacodynamics, and Pharmacokinetics in Patients With Fabry Disease on Enzyme Replacement

    Article • Clinical Pharmacology & Therapeutics, August 2017, Wiley

    Jasper Dingemanse

  7. Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects

    Article • British Journal of Clinical Pharmacology, August 2017, Wiley

    Jasper Dingemanse