All Stories

  1. Quantifying Hepatic Enzyme Kinetics of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC, through In Vitro Modeling

    Article • Drug Metabolism and Disposition, May 2019, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat

  2. A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation

    Article • Drug Metabolism and Disposition, January 2019, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat, Yurong Lai

  3. Hepatic Enzymes Relevant to the Disposition of (−)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC

    Article • Drug Metabolism and Disposition, December 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat

  4. When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions

    Article • Drug Metabolism and Disposition, August 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat

  5. The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance

    Article • Drug Metabolism and Disposition, August 2018, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat

  6. Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics

    Article • Drug Metabolism and Disposition, October 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat

  7. Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

    Article • Drug Metabolism and Disposition, June 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat

  8. CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids

    Article • Drug Metabolism and Disposition, March 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Jashvant Unadkat