All Stories

  1. Ultradeformable liposomal delivery of vismodegib modulates its biological activity in melanoma cells

    Article • Frontiers in Medical Technology, June 2026, Frontiers

    Jaroslav Truksa

  2. Modular Design of Mitochondrion-Targeted Iron Chelators Allows Highly Selective Antiparasitic Activity against Trypanosomes and Apicomplexan Parasites

    Article • ACS Infectious Diseases, December 2025, American Chemical Society (ACS)

    Jaroslav Truksa

  3. Mitochondrial Transfer Rescues Respiration to Support De Novo Pyrimidine Biosynthesis and Tumor Progression

    Article • Cancer Research, November 2025, American Association for Cancer Research (AACR)

    Jaroslav Truksa

  4. Functional mitochondrial respiration is essential for glioblastoma tumour growth

    Article • Oncogene, May 2025, Springer Science + Business Media

    Jaroslav Truksa

  5. Effect of substituents at the C3´, C3´N, C10 and C2-meta-benzoate positions of taxane derivatives on their activity against resistant cancer cells

    Article • Toxicology and Applied Pharmacology, August 2024, Elsevier

    Jaroslav Truksa

  6. NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation

    Article • Frontiers in Pharmacology, June 2024, Frontiers

    Jaroslav Truksa

  7. Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma

    Article • iScience, February 2024, Elsevier

    Jaroslav Truksa

  8. Chelation of Mitochondrial Iron as an Antiparasitic Strategy

    Article • ACS Infectious Diseases, January 2024, American Chemical Society (ACS)

    Jaroslav Truksa

  9. Mitochondrially targeted deferasirox kills cancer cellsviasimultaneous iron deprivation and ferroptosis induction

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Jaroslav Truksa

  10. Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial

    Article • Therapeutic Advances in Medical Oncology, January 2023, SAGE Publications

    Jaroslav Truksa

  11. Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model

    Article • Frontiers in Pharmacology, November 2022, Frontiers

    Jaroslav Truksa

  12. Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene

    Article • Scientific Reports, October 2022, Springer Science + Business Media

    Jaroslav Truksa

  13. Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy

    Article • Cancer Research, March 2021, American Association for Cancer Research (AACR)

    Jaroslav Truksa

  14. Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice

    Article • International Journal of Molecular Sciences, March 2021, MDPI AG

    Jaroslav Truksa

  15. Mitochondrially targeted gentisic acid synergizes with doxycycline in killing breast cancer cells

    Article • Cells, February 2020, MDPI AG

    Jaroslav Truksa

  16. The role of mitochondria in tamoxifen resistance in breast cancer cells

    Article • Free Radical Biology and Medicine, November 2019, Elsevier

    Jaroslav Truksa

  17. Effect of stimulated erythropoiesis on SMAD signaling in iron-overloaded and iron-deficient mice

    Article • PLOS One, April 2019, PLOS

    Jaroslav Truksa

  18. Dihydroorotate Dehydrogenase is critical for tumor initiation of respiration-deficient cancer cells

    Article • Cell Metabolism, February 2019, Elsevier

    Jaroslav Truksa

  19. Liver HFE protein content is posttranscriptionally decreased in iron-deficient mice and rats

    Article • AJP Gastrointestinal and Liver Physiology, October 2018, American Physiological Society

    Jaroslav Truksa

  20. Mitochondrial iron chelation as a novel anti-cancer strategy

    Article • Free Radical Biology and Medicine, May 2018, Elsevier

    Jaroslav Truksa

  21. Estrogen receptor regulation by microRNA

    Article • Cellular Physiology and Biochemistry, January 2018, Karger Publishers

    Jaroslav Truksa

  22. Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice

    Article • PLOS One, October 2017, PLOS

    Jaroslav Truksa

  23. Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats

    Article • Blood Cells Molecules and Diseases, May 2017, Elsevier

    Jaroslav Truksa

  24. Glycol porphyrin derivatives and temoporfin elicit resistance to photodynamic therapy by different mechanisms

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Jaroslav Truksa

  25. Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

    Article • eLife, February 2017, eLife

    Professor Alfred King Lam, Jaroslav Truksa, Dr Bijay Ranjan Pattnaik

  26. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer

    Article • Antioxidants & Redox Signaling, January 2017, Mary Ann Liebert Inc

    Jaroslav Truksa

  27. Tumor-initiating cells exhibit profound deregulation of iron metabolism

    Article • Oncotarget, December 2016, Impact Journals, LLC

    Jaroslav Truksa

  28. MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma

    Article • Oncotarget, April 2016, Impact Journals, LLC

    Jaroslav Truksa

  29. Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats

    Article • PLOS One, February 2016, PLOS

    Jaroslav Truksa

  30. Mitochondrially Targeted Vitamin E Succinate Modulates Expression of Mitochondrial DNA Transcripts and Mitochondrial Biogenesis

    Article • Antioxidants & Redox Signaling, April 2015, Mary Ann Liebert Inc

    Jaroslav Truksa

  31. Cancer cells can take mitochondria from surrounding cells, and it can help them grow

    Article • Cell Metabolism, January 2015, Elsevier

    Dr David A Eccles, Jaroslav Truksa

  32. The Effect of Mitochondrially Targeted Anticancer Agents on Mitochondrial (Super)Complexes

    Article • January 2015, Springer Science + Business Media

    Jaroslav Truksa

  33. MicroRNA-126 Suppresses Mesothelioma Malignancy by Targeting IRS1 and Interfering with the Mitochondrial Function

    Article • Antioxidants & Redox Signaling, November 2014, Mary Ann Liebert Inc

    Jaroslav Truksa

  34. Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

    Article • Free Radical Biology and Medicine, February 2014, Elsevier

    Jaroslav Truksa

  35. Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

    Article • Free Radical Biology and Medicine, December 2013, Elsevier

    Jaroslav Truksa

  36. Mitochondrial targeting of α-tocopheryl succinate enhances its anti-mesothelioma efficacy

    Article • Redox Report, November 2013, Taylor & Francis

    Jaroslav Truksa

  37. Classification of mitocans, anti-cancer drugs acting on mitochondria

    Article • Mitochondrion, May 2013, Elsevier

    Jaroslav Truksa

  38. Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

    Article • Free Radical Biology and Medicine, June 2011, Elsevier

    Associate Professor Mark J Coster, Jaroslav Truksa

  39. Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

    Article • Journal of Biological Chemistry, February 2011, Elsevier

    Associate Professor Mark J Coster, Jaroslav Truksa, Professor Rafael Moreno-Sanchez

  40. Hippo/Mst1 Stimulates Transcription of the Proapoptotic Mediator NOXA in a FoxO1-Dependent Manner

    Article • Cancer Research, January 2011, American Association for Cancer Research (AACR)

    Jaroslav Truksa

  41. EPO-mediated reduction in Hamp expression in vivo corrects iron deficiency anaemia in TMPRSS6 deficiency

    Article • British Journal of Haematology, July 2010, Wiley

    Jaroslav Truksa

  42. Polymorphisms and mutations of human TMPRSS6 in iron deficiency anemia

    Article • Blood Cells Molecules and Diseases, January 2010, Elsevier

    Jaroslav Truksa

  43. Suppression of the hepcidin-encoding geneHamppermits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

    Article • British Journal of Haematology, November 2009, Wiley

    Jaroslav Truksa

  44. Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

    Article • Blood, November 2008, American Society of Hematology

    Jaroslav Truksa

  45. The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

    Article • Science, May 2008, American Association for the Advancement of Science

    Jaroslav Truksa

  46. The distal location of the iron responsive region of the hepcidin promoter

    Article • Blood, November 2007, American Society of Hematology

    Jaroslav Truksa

  47. The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: Lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters

    Article • Blood Cells Molecules and Diseases, November 2007, Elsevier

    Jaroslav Truksa

  48. Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9

    Article • British Journal of Haematology, October 2007, Wiley

    Jaroslav Truksa

  49. In vivo imaging of hepcidin promoter stimulation by iron and inflammation

    Article • Blood Cells Molecules and Diseases, May 2007, Elsevier

    Jaroslav Truksa

  50. Stimulation of non-transferrin iron uptake by iron deprivation in K562 cells

    Article • Blood Cells Molecules and Diseases, September 2006, Elsevier

    Jaroslav Truksa

  51. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

    Article • Proceedings of the National Academy of Sciences, July 2006, Proceedings of the National Academy of Sciences

    Jaroslav Truksa

  52. Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, July 2005, Springer Science + Business Media

    Jaroslav Truksa

  53. Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation

    Article • APOPTOSIS, March 2005, Springer Science + Business Media

    Jaroslav Truksa

  54. Heat Shock Protein 90 Recognized as an Iron-Binding Protein Associated with the Plasma Membrane of HeLa Cells

    Article • Cellular Physiology and Biochemistry, January 2004, Cell Physiol Biochem Press GmbH and Co KG

    Jaroslav Truksa

  55. Iron deprivation induces apoptosis independently of p53 in human and murine tumour cells

    Article • Cell Proliferation, August 2003, Wiley

    Jaroslav Truksa