All Stories

  1. Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

    Article • Science Signaling, April 2026, American Association for the Advancement of Science

    Dr James N Sleigh

  2. TBK1 activity regulates the directionality of axonal transport of signalling endosomes

    Article • Life Science Alliance, February 2026, Life Science Alliance, LLC

    Dr James N Sleigh

  3. Disruption of BDNF signalling in neuropathologies

    Article • Biochemical Society Transactions, February 2026, Portland Press Ltd.

    Dr James N Sleigh

  4. CNTF specifically slows down the axonal transport of signalling endosomes

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  5. TBK1 activity regulates the directionality of axonal transport of signalling endosomes

    Article • September 2025, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  6. Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age

    Article • Neurobiology of Aging, September 2025, Elsevier

    Dr James N Sleigh

  7. Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in aged mice

    Article • January 2025, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  8. Shared mechanisms and pathological phenotypes underlying aminoacyl-tRNA synthetase-related neuropathies

    Article • Neural Regeneration Research, December 2024, Wolters Kluwer Health

    Dr James N Sleigh

  9. Refining gene delivery to skeletal muscle with a dual-strategy approach of muscle-tropic AAV capsids and muscle-specific promoters

    Article • August 2024, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  10. The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex

    Article • The EMBO Journal, July 2024, Springer Science + Business Media

    Dr James N Sleigh

  11. Age‐specific and compartment‐dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

    Article • Aging Cell, June 2024, Wiley

    Dr James N Sleigh

  12. The node of Ranvier influences thein vivoaxonal transport of mitochondria and signalling endosomes

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  13. Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy

    Article • Neurobiology of Disease, June 2024, Elsevier

    Dr James N Sleigh

  14. Targeting muscle to treat Charcot-Marie-Tooth disease

    Article • Neural Regeneration Research, December 2023, Wolters Kluwer Health

    Dr James N Sleigh

  15. Brain-derived neurotrophic factor amplifies neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  16. Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

    Article • September 2023, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  17. Spinal Muscular Atrophy: A Rare but Treatable Disease of the Nervous System

    Article • Frontiers for Young Minds, August 2023, Frontiers

    Dr James N Sleigh

  18. Boosting peripheral BDNF rescues impaired in vivo axonal transport in CMT2D mice

    Article • JCI Insight, May 2023, American Society for Clinical Investigation

    Dr James N Sleigh

  19. Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  20. In vivo imaging of axonal transport in peripheral nerves of rodent forelimbs

    Article • Neuronal Signaling, January 2023, Portland Press Ltd.

    Dr James N Sleigh

  21. Neuroscience highlights in 2022: cytoskeletal transport

    Article • The Lancet Neurology, January 2023, Elsevier

    Dr James N Sleigh

  22. Intraperitoneal Injection of Neonatal Mice

    Article • BIO-PROTOCOL, January 2023, Bio-Protocol, LLC

    Dr James N Sleigh

  23. Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor

    Article • Acta Neuropathologica Communications, December 2022, Springer Science + Business Media

    Dr James N Sleigh

  24. Editorial: Peripheral nerve anatomy in health and disease

    Article • Journal of Anatomy, October 2022, Wiley

    Dr James N Sleigh

  25. BDNF-dependent modulation of axonal transport is selectively impaired in ALS

    Article • Acta Neuropathologica Communications, August 2022, Springer Science + Business Media

    Dr James N Sleigh

  26. Editorial: Pathways and Processes Underpinning Axonal Biology and Pathobiology

    Article • Frontiers in Molecular Neuroscience, March 2022, Frontiers

    Dr James N Sleigh

  27. Coupling axonal mRNA transport and local translation to organelle maintenance and function

    Article • Current Opinion in Cell Biology, February 2022, Elsevier

    Dr James N Sleigh

  28. Expanding the Toolkit for <em>In Vivo</em> Imaging of Axonal Transport

    Article • Journal of Visualized Experiments, December 2021, MyJove Corporation

    Dr James N Sleigh

  29. A longitudinal and cross‐sectional study of plasma neurofilament light chain concentration in Charcot‐Marie‐Tooth disease

    Article • Journal of the Peripheral Nervous System, December 2021, Wiley

    Dr James N Sleigh

  30. BDNF-dependent modulation of axonal transport is selectively impaired in ALS

    Article • December 2021, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  31. Dissection, in vivo imaging and analysis of the mouse epitrochleoanconeus muscle

    Article • Journal of Anatomy, June 2021, Wiley

    Dr James N Sleigh

  32. NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease

    Article • Scientific Reports, June 2021, Springer Science + Business Media

    Dr James N Sleigh

  33. NMJ-Analyser: high-throughput morphological screening of neuromuscular junctions identifies subtle changes in mouse neuromuscular disease models

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  34. Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels

    Article • Frontiers in Cellular Neuroscience, August 2020, Frontiers

    Dr James N Sleigh

  35. Intramuscular Delivery of Gene Therapy for Targeting the Nervous System

    Article • Frontiers in Molecular Neuroscience, July 2020, Frontiers

    Dr James N Sleigh

  36. Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

    Article • Cell Death and Disease, July 2020, Springer Science + Business Media

    Dr James N Sleigh

  37. A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

    Article • BMC Research Notes, June 2020, Springer Science + Business Media

    Dr James N Sleigh

  38. A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

    Article • June 2020, Research Square

    Dr James N Sleigh

  39. Morphological variability is greater at developing than mature mouse neuromuscular junctions

    Article • Journal of Anatomy, June 2020, Wiley

    Dr James N Sleigh

  40. Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  41. A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

    Article • May 2020, Research Square

    Dr James N Sleigh

  42. Altered sensory neuron development in CMT2D mice is site-specific and linked to increased GlyRS levels

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  43. Post-synaptic morphology of mouse neuromuscular junctions is linked to muscle fibre type

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  44. Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

    Article • Acta Neuropathologica Communications, March 2020, Springer Science + Business Media

    Dr James N Sleigh

  45. Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes

    Article • Cell Reports, March 2020, Elsevier

    Dr James N Sleigh

  46. Axonal Transport: The Delivery System Keeping Nerve Cells Alive

    Article • Frontiers for Young Minds, February 2020, Frontiers

    Dr James N Sleigh

  47. In Vivo Imaging of Anterograde and Retrograde Axonal Transport in Rodent Peripheral Nerves

    Article • January 2020, Springer Science + Business Media

    Dr James N Sleigh

  48. Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

    Article • November 2019, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  49. The evolution of the axonal transport toolkit

    Article • Traffic, November 2019, Wiley

    Dr James N Sleigh

  50. Axonal transport and neurological disease

    Article • Nature Reviews Neurology, September 2019, Springer Science + Business Media

    Dr James N Sleigh

  51. Neuronal over-expression of OXR1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo

    Article • Human Molecular Genetics, September 2019, Oxford University Press (OUP)

    Dr James N Sleigh

  52. Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

    Article • Journal of Cell Biology, May 2019, Rockefeller University Press

    Dr James N Sleigh

  53. ALS mice carrying pathological mutant TDP-43, but not mutant FUS, display axonal transport defects in vivo

    Article • October 2018, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  54. UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy

    Article • Brain, September 2018, Oxford University Press (OUP)

    Dr James N Sleigh

  55. Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy

    Article • Frontiers in Molecular Neuroscience, February 2018, Frontiers

    Dr James N Sleigh

  56. Antisense oligonucleotides and other genetic therapies made simple

    Article • Practical Neurology, February 2018, BMJ

    Dr James N Sleigh

  57. Aligned electrospun fibers for neural patterning

    Article • Biotechnology Letters, January 2018, Springer Science + Business Media

    Dr James N Sleigh

  58. Engineered method for directional growth of muscle sheets on electrospun fibers

    Article • Journal of Biomedical Materials Research Part A, December 2017, Wiley

    Dr James N Sleigh

  59. Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

    Article • Frontiers in Molecular Neuroscience, December 2017, Frontiers

    Dr James N Sleigh

  60. Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis

    Article • Scientific Reports, August 2017, Nature

    Dr James N Sleigh

  61. Sensory neuron fate is altered in human neuropathy caused by Gars mutations

    Article • Proceedings of the National Academy of Sciences, March 2017, Proceedings of the National Academy of Sciences

    Dr James N Sleigh

  62. Methodological advances in imaging intravital axonal transport

    Article • F1000Research, March 2017, Faculty of 1000, Ltd.

    Dr James N Sleigh, Dr Alison E Twelvetrees , Prof Giampietro Schiavo

  63. Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular development and homeostasis

    Article • October 2016, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  64. Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

    Article • Proceedings of the National Academy of Sciences, September 2016, Proceedings of the National Academy of Sciences

    Dr James N Sleigh

  65. Sensory neuron fate is developmentally perturbed by Gars mutations causing human neuropathy

    Article • August 2016, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  66. Axonal transport is unnaffected by aging

    Article • Matters, June 2016, Sciencematters

    Dr James N Sleigh

  67. Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d

    Article • Journal of Neuroscience, March 2016, Society for Neuroscience

    Dr James N Sleigh

  68. A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia

    Article • BMC Research Notes, February 2016, Springer Science + Business Media

    Dr James N Sleigh

  69. Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy

    Article • Annals of Neurology, January 2016, Wiley

    Dr James N Sleigh

  70. In vivo imaging of axonal transport in murine motor and sensory neurons

    Article • Journal of Neuroscience Methods, January 2016, Elsevier

    Dr James N Sleigh

  71. The muscle is a major player in neuropathology of a fly model of peripheral neuropathy

    Article • Human Molecular Genetics, May 2015, Oxford University Press (OUP)

    Dr James N Sleigh

  72. Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles

    Article • Journal of Neuroscience Methods, April 2014, Elsevier

    Dr James N Sleigh

  73. Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

    Article • Neurobiology of Aging, April 2014, Elsevier

    Dr James N Sleigh

  74. Delayed motor neuron-muscle synapse development anticipates degeneration in peripheral neuropathy

    Article • Human Molecular Genetics, December 2013, Oxford University Press (OUP)

    Dr James N Sleigh

  75. Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy

    Article • Human Molecular Genetics, September 2013, Oxford University Press (OUP)

    Dr James N Sleigh

  76. Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease

    Article • Disease Models & Mechanisms, March 2013, The Company of Biologists

    Dr James N Sleigh

  77. Spinal muscular atrophy at the crossroads of basic science and therapy

    Article • Neuromuscular Disorders, January 2013, Elsevier

    Dr James N Sleigh

  78. Invertebrate models of spinal muscular atrophy: Insights into mechanisms and potential therapeutics

    Article • BioEssays, October 2011, Wiley

    Dr James N Sleigh

  79. The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy

    Article • Disease Models & Mechanisms, June 2011, The Company of Biologists

    Dr James N Sleigh

  80. Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects

    Article • PLoS Genetics, October 2010, PLOS

    Dr James N Sleigh

  81. A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

    Article • Human Molecular Genetics, October 2010, Oxford University Press (OUP)

    Dr James N Sleigh

  82. Functional analysis of nematode nicotinic receptors

    Article • Bioscience Horizons The International Journal of Student Research, February 2010, Oxford University Press (OUP)

    Dr James N Sleigh

  83. C. elegans models of neuromuscular diseases expedite translational research

    Article • Translational Neuroscience, January 2010, De Gruyter

    Dr James N Sleigh