All Stories

  1. Altered Sensory Neuron Development in CMT2D Mice Is Site-Specific and Linked to Increased GlyRS Levels

    Article • Frontiers in Cellular Neuroscience, August 2020, Frontiers

    Dr James N Sleigh

  2. Intramuscular Delivery of Gene Therapy for Targeting the Nervous System

    Article • Frontiers in Molecular Neuroscience, July 2020, Frontiers

    Dr James N Sleigh

  3. Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

    Article • Cell Death and Disease, July 2020, Springer Science + Business Media

    Dr James N Sleigh

  4. A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

    Article • BMC Research Notes, June 2020, Springer Science + Business Media

    Dr James N Sleigh

  5. A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

    Article • June 2020, Research Square

    Dr James N Sleigh

  6. Morphological variability is greater at developing than mature mouse neuromuscular junctions

    Article • Journal of Anatomy, June 2020, Wiley

    Dr James N Sleigh

  7. Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  8. A video protocol for rapid dissection of mouse dorsal root ganglia from defined spinal levels

    Article • May 2020, Research Square

    Dr James N Sleigh

  9. Altered sensory neuron development in CMT2D mice is site-specific and linked to increased GlyRS levels

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  10. Post-synaptic morphology of mouse neuromuscular junctions is linked to muscle fibre type

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  11. Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

    Article • Acta Neuropathologica Communications, March 2020, Springer Science + Business Media

    Dr James N Sleigh

  12. Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes

    Article • Cell Reports, March 2020, Elsevier

    Dr James N Sleigh

  13. Axonal Transport: The Delivery System Keeping Nerve Cells Alive

    Article • Frontiers for Young Minds, February 2020, Frontiers

    Dr James N Sleigh

  14. In Vivo Imaging of Anterograde and Retrograde Axonal Transport in Rodent Peripheral Nerves

    Article • January 2020, Springer Science + Business Media

    Dr James N Sleigh

  15. Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

    Article • November 2019, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  16. The evolution of the axonal transport toolkit

    Article • Traffic, November 2019, Wiley

    Dr James N Sleigh

  17. Axonal transport and neurological disease

    Article • Nature Reviews Neurology, September 2019, Springer Science + Business Media

    Dr James N Sleigh

  18. Neuronal over-expression of OXR1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo

    Article • Human Molecular Genetics, September 2019, Oxford University Press (OUP)

    Dr James N Sleigh

  19. Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

    Article • The Journal of Cell Biology, May 2019, Rockefeller University Press

    Dr James N Sleigh

  20. ALS mice carrying pathological mutant TDP-43, but not mutant FUS, display axonal transport defects in vivo

    Article • October 2018, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  21. UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy

    Article • Brain, September 2018, Oxford University Press (OUP)

    Dr James N Sleigh

  22. Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy

    Article • Frontiers in Molecular Neuroscience, February 2018, Frontiers

    Dr James N Sleigh

  23. Antisense oligonucleotides and other genetic therapies made simple

    Article • Practical Neurology, February 2018, BMJ

    Dr James N Sleigh

  24. Aligned electrospun fibers for neural patterning

    Article • Biotechnology Letters, January 2018, Springer Science + Business Media

    Dr James N Sleigh

  25. Engineered method for directional growth of muscle sheets on electrospun fibers

    Article • Journal of Biomedical Materials Research Part A, December 2017, Wiley

    Dr James N Sleigh

  26. Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis

    Article • Frontiers in Molecular Neuroscience, December 2017, Frontiers

    Dr James N Sleigh

  27. Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis

    Article • Scientific Reports, August 2017, Nature

    Dr James N Sleigh

  28. Sensory neuron fate is altered in human neuropathy caused by Gars mutations

    Article • Proceedings of the National Academy of Sciences, March 2017, Proceedings of the National Academy of Sciences

    Dr James N Sleigh

  29. Methodological advances in imaging intravital axonal transport

    Article • F1000Research, March 2017, Faculty of 1000, Ltd.

    Dr James N Sleigh, Dr Alison E Twelvetrees , Prof Giampietro Schiavo

  30. Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular development and homeostasis

    Article • October 2016, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  31. Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

    Article • Proceedings of the National Academy of Sciences, September 2016, Proceedings of the National Academy of Sciences

    Dr James N Sleigh

  32. Sensory neuron fate is developmentally perturbed by Gars mutations causing human neuropathy

    Article • August 2016, Cold Spring Harbor Laboratory Press

    Dr James N Sleigh

  33. Axonal transport is unnaffected by aging

    Article • Matters, June 2016, Sciencematters

    Dr James N Sleigh

  34. Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d

    Article • Journal of Neuroscience, March 2016, Society for Neuroscience

    Dr James N Sleigh

  35. A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia

    Article • BMC Research Notes, February 2016, Springer Science + Business Media

    Dr James N Sleigh

  36. Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy

    Article • Annals of Neurology, January 2016, Wiley

    Dr James N Sleigh

  37. In vivo imaging of axonal transport in murine motor and sensory neurons

    Article • Journal of Neuroscience Methods, January 2016, Elsevier

    Dr James N Sleigh

  38. The muscle is a major player in neuropathology of a fly model of peripheral neuropathy

    Article • Human Molecular Genetics, May 2015, Oxford University Press (OUP)

    Dr James N Sleigh

  39. Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles

    Article • Journal of Neuroscience Methods, April 2014, Elsevier

    Dr James N Sleigh

  40. Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

    Article • Neurobiology of Aging, April 2014, Elsevier

    Dr James N Sleigh

  41. Delayed motor neuron-muscle synapse development anticipates degeneration in peripheral neuropathy

    Article • Human Molecular Genetics, December 2013, Oxford University Press (OUP)

    Dr James N Sleigh

  42. Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy

    Article • Human Molecular Genetics, September 2013, Oxford University Press (OUP)

    Dr James N Sleigh

  43. Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease

    Article • Disease Models & Mechanisms, March 2013, The Company of Biologists

    Dr James N Sleigh

  44. Spinal muscular atrophy at the crossroads of basic science and therapy

    Article • Neuromuscular Disorders, January 2013, Elsevier

    Dr James N Sleigh

  45. Invertebrate models of spinal muscular atrophy: Insights into mechanisms and potential therapeutics

    Article • BioEssays, October 2011, Wiley

    Dr James N Sleigh

  46. The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy

    Article • Disease Models & Mechanisms, June 2011, The Company of Biologists

    Dr James N Sleigh

  47. Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects

    Article • PLoS Genetics, October 2010, PLOS

    Dr James N Sleigh

  48. A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds

    Article • Human Molecular Genetics, October 2010, Oxford University Press (OUP)

    Dr James N Sleigh

  49. Functional analysis of nematode nicotinic receptors

    Article • Bioscience Horizons The International Journal of Student Research, February 2010, Oxford University Press (OUP)

    Dr James N Sleigh

  50. C. elegans models of neuromuscular diseases expedite translational research

    Article • Translational Neuroscience, January 2010, De Gruyter

    Dr James N Sleigh