All Stories

  1. Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

    Article • Andrology, April 2025, Wiley

    Professor Jacques J. Tremblay

  2. A New Leydig Cell–Exclusive Cre Line Allows Lineage Tracing of Fetal and Adult Leydig Cell Populations in the Mouse

    Article • Endocrinology, January 2025, Endocrine Society

    Professor Jacques J. Tremblay

  3. Transcription Factors in Leydig Cells

    Article • January 2025, Springer Science + Business Media

    Professor Jacques J. Tremblay

  4. A STAR for the ages: a 30-year historical perspective of the role of transcription factors in the regulation of steroidogenic acute regulatory gene expression

    Article • Journal of Endocrinology, August 2024, Bioscientifica

    Professor Jacques J. Tremblay

  5. Ethylene dimethanesulfonate effects on gene promoter activities related to the endocrine function of immortalized Leydig cell lines R2C and MA-10

    Article • Current Research in Toxicology, January 2024, Elsevier

    Professor Jacques J. Tremblay

  6. ERK5 Cooperates With MEF2C to Regulate Nr4a1 Transcription in MA-10 and MLTC-1 Leydig Cells

    Article • Endocrinology, August 2023, Endocrine Society

    Professor Jacques J. Tremblay

  7. Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis

    Article • Endocrines, August 2023, MDPI AG

    Professor Jacques J. Tremblay

  8. A 35-bp Conserved Region Is Crucial for Insl3 Promoter Activity in Mouse MA-10 Leydig Cells

    Article • International Journal of Molecular Sciences, December 2022, MDPI AG

    Professor Jacques J. Tremblay

  9. Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Professor Jacques J. Tremblay

  10. Comprehensive and Quantitative Analysis of the Changes in Proteomic and Phosphoproteomic Profiles during Stimulation and Repression of Steroidogenesis in MA-10 Leydig Cells

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Professor Jacques J. Tremblay

  11. A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis

    Article • International Journal of Molecular Sciences, October 2022, MDPI AG

    Professor Jacques J. Tremblay

  12. Chicken ovalbumin upstream promoter transcription factor type II interacts and functionally cooperates with GATA4 to regulate anti‐Müllerian hormone receptor type 2 transcription in mouse MA‐10 Leydig cells

    Article • Andrology, August 2022, Wiley

    Professor Jacques J. Tremblay

  13. The Urokinase-Type Plasminogen Activator Contributes to cAMP-Induced Steroidogenesis in MA-10 Leydig Cells

    Article • Endocrines, July 2022, MDPI AG

    Professor Jacques J. Tremblay

  14. The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells

    Article • Reproduction, June 2022, Bioscientifica

    Professor Jacques J. Tremblay

  15. Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression

    Article • Frontiers in Endocrinology, May 2022, Frontiers

    Professor Jacques J. Tremblay

  16. Transcription Factors in the Regulation of Leydig Cell Gene Expression and Function

    Article • Frontiers in Endocrinology, April 2022, Frontiers

    Professor Jacques J. Tremblay

  17. Mechanism of Action of an Environmentally Relevant Organochlorine Mixture in Repressing Steroid Hormone Biosynthesis in Leydig Cells

    Article • International Journal of Molecular Sciences, April 2022, MDPI AG

    Professor Jacques J. Tremblay

  18. Dynamic Expression of the Homeobox Factor PBX1 during Mouse Testis Development

    Article • Endocrines, January 2022, MDPI AG

    Professor Jacques J. Tremblay

  19. Growth hormone-induced STAT5B regulates Star gene expression through a cooperation with cJUN in mouse MA-10 Leydig cells

    Article • Endocrinology, December 2021, Endocrine Society

    Professor Jacques J. Tremblay

  20. Mechanisms of MEHP Inhibitory Action and Analysis of Potential Replacement Plasticizers on Leydig Cell Steroidogenesis

    Article • International Journal of Molecular Sciences, October 2021, MDPI AG

    Professor Jacques J. Tremblay

  21. Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells

    Article • Biology of Reproduction, July 2021, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  22. The Nuclear Receptor COUP-TFII Regulates Amhr2 Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells

    Article • Journal of the Endocrine Society, October 2019, Endocrine Society

    Professor Jacques J. Tremblay

  23. Phosphorylation of GATA 4 serine 105 but not serine 261 is required for testosterone production in the male mouse

    Article • Andrology, February 2019, Wiley

    Professor Jacques J. Tremblay

  24. FOXA3 Is Expressed in Multiple Cell Lineages in the Mouse Testis and Regulates Pdgfra Expression in Leydig Cells

    Article • Endocrinology, April 2017, Endocrine Society

    Professor Jacques J. Tremblay

  25. KLF6 cooperates with NUR77 and SF1 to activate the humanINSL3promoter in mouse MA-10 leydig cells

    Article • Journal of Molecular Endocrinology, February 2016, Bioscientifica

    Professor Jacques J. Tremblay

  26. MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells

    Article • Andrology, January 2016, Wiley

    Professor Jacques J. Tremblay

  27. Calcium-dependentNr4a1expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements

    Article • Journal of Molecular Endocrinology, December 2015, Bioscientifica

    Professor Jacques J. Tremblay

  28. The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells

    Article • Endocrinology, December 2015, Endocrine Society

    Professor Jacques J. Tremblay

  29. Correction for Duchez et al., Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A 2 -IIA

    Article • Proceedings of the National Academy of Sciences, November 2015, Proceedings of the National Academy of Sciences

    Professor Jacques J. Tremblay

  30. Molecular regulation of steroidogenesis in endocrine Leydig cells

    Article • Steroids, November 2015, Elsevier

    Professor Jacques J. Tremblay

  31. Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells1

    Article • Biology of Reproduction, July 2015, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  32. MEF2 Cooperates With Forskolin/cAMP and GATA4 to RegulateStarGene Expression in Mouse MA-10 Leydig Cells

    Article • Endocrinology, July 2015, Endocrine Society

    Professor Jacques J. Tremblay

  33. Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A 2 -IIA

    Article • Proceedings of the National Academy of Sciences, June 2015, Proceedings of the National Academy of Sciences

    Professor Jacques J. Tremblay

  34. GATA4 serine 105 phosphorylation is required for testicular steroidogenesis in the mouse

    Article • Reproduction Abstracts, September 2014, Bioscientifica

    Professor Jacques J. Tremblay

  35. A Cell-Autonomous Molecular Cascade Initiated by AMP-Activated Protein Kinase Represses Steroidogenesis

    Article • Molecular and Cellular Biology, September 2014, ASM Journals

    Professor Jacques J. Tremblay

  36. The Nuclear Receptor NR2F2 Activates Star Expression and Steroidogenesis in Mouse MA-10 and MLTC-1 Leydig Cells1

    Article • Biology of Reproduction, July 2014, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  37. In Vitro Exposure of Leydig Cells to an Environmentally Relevant Mixture of Organochlorines Represses Early Steps of Steroidogenesis1

    Article • Biology of Reproduction, June 2014, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  38. MEF2 Is Restricted to the Male Gonad and Regulates Expression of the Orphan Nuclear Receptor NR4A1

    Article • Molecular Endocrinology, June 2014, Endocrine Society

    Professor Jacques J. Tremblay

  39. The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells

    Article • April 2014, Bioscientifica

    Professor Jacques J. Tremblay

  40. The Calcium Signaling Pathway Regulates Leydig Cell Steroidogenesis through a Transcriptional Cascade Involving the Nuclear Receptor NR4A1 and the Steroidogenic Acute Regulatory Protein

    Article • Endocrinology, January 2013, Endocrine Society

    Professor Jacques J. Tremblay

  41. Activation of AMPK Actively Represses Steroid Hormone Synthesis in MA-10 Leydig Cells.

    Article • Biology of Reproduction, August 2012, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  42. FOXA3 Is Expressed in Postnatal Leydig Cells and Regulates Pdgfra Gene Transcription.

    Article • Biology of Reproduction, July 2011, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  43. Functional Cooperation Between GATA Factors and cJUN on the Star Promoter in MA-10 Leydig Cells

    Article • Journal of Andrology, February 2011, Wiley

    Professor Jacques J. Tremblay

  44. Transcription of platelet-derived growth factor receptor   in Leydig cells involves specificity protein 1 and 3

    Article • Journal of Molecular Endocrinology, February 2011, Bioscientifica

    Professor Jacques J. Tremblay

  45. What Signals Testis Descent?

    Article • Biology of Reproduction, November 2010, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  46. Expression of ladybird-like homeobox 2 (LBX2) during ovarian development and folliculogenesis in the mouse

    Article • Journal of Molecular Histology, September 2010, Springer Science + Business Media

    Professor Jacques J. Tremblay

  47. Nuclear Receptors in Leydig Cell Gene Expression and Function1

    Article • Biology of Reproduction, July 2010, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  48. Estradiol represses Insulin-like 3 expression and promoter activity in MA-10 Leydig cells

    Article • Toxicology, April 2009, Elsevier

    Professor Jacques J. Tremblay

  49. Nuclear Receptors, Testosterone, and Posttranslational Modifications in Human INSL3 Promoter Activity in Testicular Leydig Cells

    Article • Annals of the New York Academy of Sciences, April 2009, Wiley

    Professor Jacques J. Tremblay

  50. The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors

    Article • Cancer Letters, March 2009, Elsevier

    Professor Jacques J. Tremblay

  51. Transcriptional cooperation between NF-κB p50 and CCAAT/enhancer binding protein β regulates Nur77 transcription in Leydig cells

    Article • Journal of Molecular Endocrinology, November 2008, Bioscientifica

    Professor Jacques J. Tremblay

  52. The nuclear receptors NUR77 and SF1 play additive roles with c-JUN through distinct elements on the mouse Star promoter

    Article • Journal of Molecular Endocrinology, November 2008, Bioscientifica

    Professor Jacques J. Tremblay

  53. Hypoxia-Inducible Factor-1  Is Constitutively Expressed in Murine Leydig Cells and Regulates 3 -Hydroxysteroid Dehydrogenase Type 1 Promoter Activity

    Article • Journal of Andrology, October 2008, Wiley

    Professor Jacques J. Tremblay

  54. cAMP-Induced Expression of the Orphan Nuclear Receptor Nur77 in MA-10 Leydig Cells Involves a CaMKI Pathway

    Article • Journal of Andrology, October 2008, Wiley

    Professor Jacques J. Tremblay

  55. Antagonistic Effects of Testosterone and the Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate onINSL3Transcription in Leydig Cells

    Article • Endocrinology, September 2008, Endocrine Society

    Professor Jacques J. Tremblay

  56. The Orphan Nuclear Receptor NUR77 Regulates Hormone-InducedStARTranscription in Leydig Cells through Cooperation with Ca2+/Calmodulin-Dependent Protein Kinase I

    Article • Molecular Endocrinology, September 2008, Endocrine Society

    Professor Jacques J. Tremblay

  57. Glucocorticoids antagonize cAMP-induced Star transcription in Leydig cells through the orphan nuclear receptor NR4A1

    Article • Journal of Molecular Endocrinology, June 2008, Bioscientifica

    Professor Jacques J. Tremblay

  58. IL-6 downregulates transcription of NTPDase2 via specific promoter elements

    Article • AJP Gastrointestinal and Liver Physiology, March 2008, American Physiological Society

    Professor Jacques J. Tremblay

  59. Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis

    Article • BMC Developmental Biology, January 2008, Springer Science + Business Media

    Professor Jacques J. Tremblay

  60. THE TRANSCRIPTION FACTOR KLF6 IS EXPRESSED IN SOMATIC CELLS AND IN A SUBPOPULATION OF GERM CELLS DURING MOUSE TESTICULAR DEVELOPMENT

    Article • Biology of Reproduction, July 2007, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  61. CHARACTERIZATION OF THE PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGF-Rα) PROMOTER IN MOUSE LEYDIG CELLS

    Article • Biology of Reproduction, July 2007, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  62. EXPRESSION OF THE LADYBIRD-LIKE HOMEOBOX 2 (LBX2) FACTOR DURING OVARIAN DEVELOPMENT IN THE MOUSE

    Article • Biology of Reproduction, July 2007, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  63. The Orphan Nuclear Receptor NR4A1 Regulates Insulin-Like 3 Gene Transcription in Leydig Cells1

    Article • Biology of Reproduction, February 2006, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  64. Role of Nuclear Receptors in INSL3 Gene Transcription in Leydig Cells

    Article • Annals of the New York Academy of Sciences, December 2005, Wiley

    Professor Jacques J. Tremblay

  65. GATA Factors and the Nuclear Receptors, Steroidogenic Factor 1/Liver Receptor Homolog 1, Are Key Mutual Partners in the Regulation of the Human 3β-Hydroxysteroid Dehydrogenase Type 2 Promoter

    Article • Molecular Endocrinology, September 2005, Endocrine Society

    Professor Jacques J. Tremblay

  66. The Human 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4Isomerase Type 2 Promoter Is a Novel Target for the Immediate Early Orphan Nuclear Receptor Nur77 in Steroidogenic Cells

    Article • Endocrinology, February 2005, Endocrine Society

    Professor Jacques J. Tremblay

  67. New Insights into the Regulation of Mammalian Sex Determination and Male Sex Differentiation

    Article • January 2005, Elsevier

    Professor Jacques J. Tremblay

  68. The 25th Volume: Role of the GATA Family of Transcription Factors in Andrology

    Article • Journal of Andrology, July 2004, Wiley

    Professor Jacques J. Tremblay

  69. Pitx1 in vivo Promoter Activity and Mechanisms of Positive Autoregulation

    Article • Neuroendocrinology, October 2003, Karger Publishers

    Professor Jacques J. Tremblay

  70. A Mutated Form of Steroidogenic Factor 1 (SF-1 G35E) That Causes Sex Reversal in Humans Fails to Synergize with Transcription Factor GATA-4

    Article • Journal of Biological Chemistry, October 2003, Elsevier

    Professor Jacques J. Tremblay

  71. Novel roles for GATA transcription factors in the regulation of steroidogenesis

    Article • The Journal of Steroid Biochemistry and Molecular Biology, June 2003, Elsevier

    Professor Jacques J. Tremblay

  72. Transcription Factor GATA-4 Is Activated by Phosphorylation of Serine 261 via the cAMP/Protein Kinase A Signaling Pathway in Gonadal Cells

    Article • Journal of Biological Chemistry, June 2003, Elsevier

    Professor Jacques J. Tremblay

  73. Friend of GATA (FOG)-1 and FOG-2 Differentially Repress the GATA-Dependent Activity of Multiple Gonadal Promoters

    Article • Endocrinology, October 2002, Endocrine Society

    Professor Jacques J. Tremblay

  74. Protein Kinase A-Dependent Cooperation between GATA and CCAAT/Enhancer-Binding Protein Transcription Factors Regulates Steroidogenic Acute Regulatory Protein Promoter Activity

    Article • Endocrinology, October 2002, Endocrine Society

    Professor Jacques J. Tremblay

  75. Modulation of Endogenous GATA-4 Activity Reveals Its Dual Contribution to Mullerian Inhibiting Substance Gene Transcription in Sertoli Cells

    Article • Molecular Endocrinology, September 2001, Endocrine Society

    Professor Jacques J. Tremblay

  76. Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells1

    Article • Biology of Reproduction, April 2001, Oxford University Press (OUP)

    Professor Jacques J. Tremblay

  77. GATA Factors Differentially Activate Multiple Gonadal Promoters through Conserved GATA Regulatory Elements1

    Article • Endocrinology, March 2001, Endocrine Society

    Professor Jacques J. Tremblay

  78. Transcriptional Properties of Ptx1 and Ptx2 Isoforms

    Article • Neuroendocrinology, January 2000, Karger Publishers

    Professor Jacques J. Tremblay

  79. Transcription Factor GATA-4 Enhances Müllerian Inhibiting Substance Gene Transcription through a Direct Interaction with the Nuclear Receptor SF-1

    Article • Molecular Endocrinology, August 1999, Endocrine Society

    Professor Jacques J. Tremblay

  80. Transcription Factor GATA-4 Enhances Mullerian Inhibiting Substance Gene Transcription through a Direct Interaction with the Nuclear Receptor SF-1

    Article • Molecular Endocrinology, August 1999, Endocrine Society

    Professor Jacques J. Tremblay

  81. Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain

    Article • The EMBO Journal, June 1999, Wiley

    Professor Jacques J. Tremblay

  82. Egr-1 Is a Downstream Effector of GnRH and Synergizes by Direct Interaction with Ptx1 and SF-1 To Enhance Luteinizing Hormone β Gene Transcription

    Article • Molecular and Cellular Biology, April 1999, ASM Journals

    Professor Jacques J. Tremblay

  83. The PTX family of homeodomain transcription factors during pituitary developments

    Article • Molecular and Cellular Endocrinology, May 1998, Elsevier

    Professor Jacques J. Tremblay

  84. Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH

    Article • Development, April 1998, The Company of Biologists

    Professor Jacques J. Tremblay

  85. The pan-Pituitary Activator of Transcription, Ptx1 (Pituitary Homeobox 1), Acts in Synergy with SF-1 and Pit1 and Is an Upstream Regulator of the Lim-Homeodomain Gene Lim3/Lhx3

    Article • Molecular Endocrinology, March 1998, Endocrine Society

    Professor Jacques J. Tremblay

  86. The pan-Pituitary Activator of Transcription, Ptx1 (Pituitary Homeobox 1), Acts in Synergy with SF-1 and Pit1 and Is an Upstream Regulator of the Lim-Homeodomain Gene Lim3/Lhx3

    Article • Molecular Endocrinology, March 1998, Endocrine Society

    Professor Jacques J. Tremblay

  87. La famille Ptx des facteurs de transcription à homéodomaine.

    Article • médecine/sciences, January 1998, INIST-CNRS

    Professor Jacques J. Tremblay

  88. A homeodomain gene Ptx 3 has highly restricted brain expression in mesencephalic dopaminergic neurons

    Article • Proceedings of the National Academy of Sciences, November 1997, Proceedings of the National Academy of Sciences

    Professor Jacques J. Tremblay

  89. Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins Syndrome

    Article • Mammalian Genome, November 1997, Springer Science + Business Media

    Professor Jacques J. Tremblay

  90. Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene.

    Article • Genes & Development, May 1996, Cold Spring Harbor Laboratory Press

    Professor Jacques J. Tremblay

  91. Transcription Factors as Regulators of Gene Expression During Leydig Cell Differentiation and Function

    Article • Springer Science + Business Media

    Professor Jacques J. Tremblay