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  1. Genome editing of ABCB6 transporter confers resistance to cypermethrin in the major pest of corn, Spodoptera frugiperda

    Article • Insect Biochemistry and Molecular Biology, May 2026, Elsevier

    Dr Isabel Gomez

  2. Engineering Bacillus thuringiensis Cyt1Aa to function as a surrogate receptor of Cry1A lepidopteran insecticidal proteins

    Article • Pesticide Biochemistry and Physiology, April 2026, Elsevier

    Dr Isabel Gomez

  3. Regulatory diversity in Bacillus thuringiensis cry genes reveals flexible evolutionary strategies for in vivo toxin expression

    Article • PLoS Pathogens, March 2026, PLOS

    Dr Isabel Gomez

  4. ABC transporters knockout in Aedes aegypti induces upregulation of paralogous genes, avoiding resistance development to Bacillus thuringiensis Cry toxins

    Article • PLOS One, July 2025, PLOS

    Professor Mario Soberon, Dr Isabel Gomez

  5. Insights into the structural changes that trigger receptor binding upon proteolytic activation of Bacillus thuringiensis Vip3Aa insecticidal protein

    Article • PLoS Pathogens, December 2024, PLOS

    Dr Isabel Gomez

  6. CRISPR-Cas9 knockout of membrane-bound alkaline phosphatase or cadherin does not confer resistance to Cry toxins in Aedes aegypti

    Article • PLoS Neglected Tropical Diseases, June 2024, PLOS

    Dr Isabel Gomez

  7. Performance insights into spray-dryer microencapsulated Bacillus thuringiensis cry pesticidal proteins with gum arabic and maltodextrin for effective pest control

    Article • Applied Microbiology and Biotechnology, January 2024, Springer Science + Business Media

    Dr Isabel Gomez

  8. Structural changes upon membrane insertion of the insecticidal pore-forming toxins produced by Bacillus thuringiensis

    Article • Frontiers in Insect Science, April 2023, Frontiers

    Dr Isabel Gomez

  9. A major conformational change of N‐terminal helices of Bacillus thuringiensis Cry1Ab insecticidal protein is necessary for membrane insertion and toxicity

    Article • FEBS Journal, January 2023, Wiley

    Dr Isabel Gomez

  10. Mode of action of Bacillus thuringiensis Cry pesticidal proteins

    Article • January 2023, Elsevier

    Dr Isabel Gomez

  11. Whole Genome Sequencing Analysis of Bacillus thuringiensis GR007 Reveals Multiple Pesticidal Protein Genes

    Article • Frontiers in Microbiology, November 2021, Frontiers

    Dr Isabel Gomez

  12. Bacillus thuringiensis Cry1Ab Domain III β-16 Is Involved in Binding to Prohibitin, Which Correlates with Toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae)

    Article • Applied and Environmental Microbiology, January 2021, ASM Journals

    Dr Isabel Gomez

  13. Bacillus thuringiensis Cry1Ab Domain III β-22 Mutants with Enhanced Toxicity to Spodoptera frugiperda (J. E. Smith)

    Article • Applied and Environmental Microbiology, October 2020, ASM Journals

    Professor Mario Soberon, Dr Isabel Gomez

  14. Rearrangement of N-Terminal α-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity

    Article • Toxins, October 2020, MDPI AG

    Professor Mario Soberon, Dr Isabel Gomez

  15. An α‐amylase‐like protein interacts with PirB toxin from Vibrio parahaemolyticus in digestive tract tissue of white shrimp Litopenaeus vannamei

    Article • Aquaculture Research, June 2020, Wiley

    Dr Isabel Gomez

  16. The Cadherin Protein Is Not Involved in Susceptibility to Bacillus thuringiensis Cry1Ab or Cry1Fa Toxins in Spodoptera frugiperda

    Article • Toxins, June 2020, MDPI AG

    Professor Mario Soberon, Dr Isabel Gomez

  17. Identification of midgut membrane proteins from different instars of Helicoverpa armigera (Lepidoptera: Noctuidae) that bind to Cry1Ac toxin

    Article • PLOS One, December 2018, PLOS

    Dr Isabel Gomez

  18. The C-terminal protoxin region of Bacillus thuringiensis Cry1Ab toxin has a functional role in binding to GPI-anchored receptors in the insect midgut

    Article • Journal of Biological Chemistry, December 2018, Elsevier

    Dr Isabel Gomez

  19. Enhancement of Bacillus thuringiensis Cry1Ab and Cry1Fa Toxicity to Spodoptera frugiperda by Domain III Mutations Indicates There Are Two Limiting Steps in Toxicity as Defined by Receptor Binding and Protein Stability

    Article • Applied and Environmental Microbiology, August 2018, ASM Journals

    Professor Mario Soberon, Dr Isabel Gomez

  20. Helix α-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Dr Isabel Gomez

  21. Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis)

    Article • Journal of Biological Chemistry, July 2018, Elsevier

    Dr Isabel Gomez

  22. Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin

    Article • Applied and Environmental Microbiology, June 2018, ASM Journals

    Dr Isabel Gomez

  23. Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity

    Article • Scientific Reports, March 2018, Springer Science + Business Media

    Dr Isabel Gomez

  24. Cell lines as models for the study of Cry toxins from Bacillus thuringiensis

    Article • Insect Biochemistry and Molecular Biology, February 2018, Elsevier

    Professor Mario Soberon, Dr Isabel Gomez

  25. Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda

    Article • Peptides, December 2017, Elsevier

    Dr Isabel Gomez

  26. Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sexta

    Article • Peptides, December 2017, Elsevier

    Dr Isabel Gomez

  27. An Intramolecular Salt Bridge in Bacillus thuringiensis Cry4Ba Toxin Is Involved in the Stability of Helix α-3, Which Is Needed for Oligomerization and Insecticidal Activity

    Article • Applied and Environmental Microbiology, October 2017, ASM Journals

    Dr Isabel Gomez

  28. ABCC2 is associated with Bacillus thuringiensis Cry1Ac toxin oligomerization and membrane insertion in diamondback moth

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Dr Isabel Gomez

  29. Insecticidal Proteins from Bacillus thuringiensis and Their Mechanism of Action

    Article • January 2017, Springer Science + Business Media

    Dr Isabel Gomez

  30. Early expression of the receptor for advanced glycation end products in a toxic model produced by 6-hydroxydopamine in the rat striatum

    Article • Chemico-Biological Interactions, April 2016, Elsevier

    Dr Isabel Gomez

  31. Binding and Oligomerization of Modified and Native Bt Toxins in Resistant and Susceptible Pink Bollworm

    Article • PLOS One, December 2015, PLOS

    Dr Isabel Gomez

  32. Bacillus thuringiensis Cry1AbMod toxin counters tolerance associated with low cadherin expression but not that associated with low alkaline phosphatase expression in Manduca sexta

    Article • Peptides, June 2015, Elsevier

    Dr Isabel Gomez

  33. Identification of Bacillus thuringiensis Cry3Aa toxin domain II loop 1 as the binding site of Tenebrio molitor cadherin repeat CR12

    Article • Insect Biochemistry and Molecular Biology, April 2015, Elsevier

    Dr Isabel Gomez

  34. Identification and Characterization of Receptors for Insecticidal Toxins from Bacillus thuringiensis

    Article • January 2015, Springer Science + Business Media

    Dr Isabel Gomez

  35. Mechanism of action of Bacillus thuringiensis insecticidal toxins and their use in the control of insect pests

    Article • January 2015, Elsevier

    Dr Isabel Gomez

  36. Bacillus thuringiensis Cry1A toxins are versatile proteins with multiple modes of action: two distinct pre-pores are involved in toxicity

    Article • Biochemical Journal, April 2014, Portland Press Ltd.

    Dr Isabel Gomez

  37. Differential Role of Manduca sexta Aminopeptidase-N and Alkaline Phosphatase in the Mode of Action of Cry1Aa, Cry1Ab, and Cry1Ac Toxins from Bacillus thuringiensis

    Article • Applied and Environmental Microbiology, May 2013, ASM Journals

    Dr Isabel Gomez

  38. Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non-toxic to Manduca sexta larvae.

    Article • Journal of Biological Chemistry, March 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  39. A Tenebrio molitor GPI-anchored alkaline phosphatase is involved in binding of Bacillus thuringiensis Cry3Aa to brush border membrane vesicles

    Article • Peptides, March 2013, Elsevier

    Dr Isabel Gomez

  40. Oligomerization of Cry11Aa from Bacillus thuringiensis Has an Important Role in Toxicity against Aedes aegypti

    Article • Applied and Environmental Microbiology, February 2013, ASM Journals

    Dr Isabel Gomez

  41. Domains II and III of Bacillus thuringiensis Cry1Ab toxin remain exposed to the solvent after insertion of part of domain I into the membrane.: FIGURE S1.

    Article • Journal of Biological Chemistry, October 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  42. 125. Cadherin Binding Is Not a Limiting Step for Bacillus thuringiensis subs. israelensis Cry4Ba Toxicity to Aedes aegypti Larvae

    Article • Toxicon, August 2012, Elsevier

    Dr Isabel Gomez

  43. Cadherin binding is not a limiting step for Bacillus thuringiensis subsp. israelensis Cry4Ba toxicity to Aedes aegypti larvae

    Article • Biochemical Journal, May 2012, Portland Press Ltd.

    Dr Isabel Gomez

  44. Evolution ofBacillus thuringiensisCry toxins insecticidal activity

    Article • Microbial Biotechnology, March 2012, Wiley

    Dr Isabel Gomez

  45. Role of GPI-Anchored Membrane Receptors in the Mode of Action of Bacillus thuringiensis Cry Toxins

    Article • February 2012, IntechOpen

    Dr Isabel Gomez

  46. Domains II and III of Bacillus thuringiensis Cry1Ab Toxin Remain Exposed to the Solvent after Insertion of Part of Domain I into the Membrane

    Article • Journal of Biological Chemistry, April 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  47. RNA interference in Lepidoptera: An overview of successful and unsuccessful studies and implications for experimental design

    Article • Journal of Insect Physiology, February 2011, Elsevier

    Dr Ioannis Eleftherianos, Professor Kostas Iatrou, Dr Alexie Papanicolaou, Dr Isabel Gomez

  48. New Insights into the Mode of Action of Cry1Ab Toxin used in Transgenic Insect-Resistant Crops

    Article • Southwestern Entomologist, October 2010, Society of Southwestern Entomologists

    Dr Isabel Gomez

  49. Role of Alkaline Phosphatase from Manduca sexta in the Mechanism of Action of Bacillus thuringiensis Cry1Ab Toxin

    Article • Journal of Biological Chemistry, February 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  50. Oligomerization of Cry11Aa from Bacillus thuringiensis Has an Important Role in Toxicity against Aedes aegypti

    Article • Applied and Environmental Microbiology, October 2009, ASM Journals

    Dr Isabel Gomez

  51. Domain II Loop 3 of Bacillus thuringiensis Cry1Ab Toxin Is Involved in a "Ping Pong" Binding Mechanism with Manduca sexta Aminopeptidase-N and Cadherin Receptors

    Article • Journal of Biological Chemistry, October 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  52. Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 2009, Elsevier

    Dr Isabel Gomez

  53. Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation

    Article • Peptides, March 2009, Elsevier

    Dr Isabel Gomez

  54. Employing phage display to study the mode of action of Bacillus thuringiensis Cry toxins

    Article • Peptides, February 2008, Elsevier

    Dr Isabel Gomez

  55. The pre-pore from Bacillus thuringiensis Cry1Ab toxin is necessary to induce insect death in Manduca sexta

    Article • Peptides, February 2008, Elsevier

    Dr Isabel Gomez

  56. Engineering Modified Bt Toxins to Counter Insect Resistance

    Article • Science, December 2007, American Association for the Advancement of Science

    Dr Isabel Gomez

  57. Bacillus thuringiensis Cry1Ab Mutants Affecting Oligomer Formation Are Non-toxic to Manduca sexta Larvae

    Article • Journal of Biological Chemistry, May 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  58. Role of receptor interaction in the mode of action of insecticidal Cry and Cyt toxins produced by Bacillus thuringiensis

    Article • Peptides, January 2007, Elsevier

    Dr Isabel Gomez

  59. Specific Epitopes of Domains II and III ofBacillus thuringiensisCry1Ab Toxin Involved in the Sequential Interaction with Cadherin and Aminopeptidase-N Receptors inManduca sexta

    Article • Journal of Biological Chemistry, September 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  60. Structural Changes of the Cry1Ac Oligomeric Pre-Pore fromBacillus thuringiensisInduced byN-Acetylgalactosamine Facilitates Toxin Membrane Insertion†

    Article • Biochemistry, August 2006, American Chemical Society (ACS)

    Dr Isabel Gomez

  61. Structural and functional analysis of the pre-pore and membrane-inserted pore of Cry1Ab toxin

    Article • Journal of Invertebrate Pathology, July 2006, Elsevier

    Dr Isabel Gomez

  62. Functional display of Bacillus thuringiensis Cry1Ac toxin on T7 phage

    Article • Journal of Invertebrate Pathology, May 2006, Elsevier

    Dr Isabel Gomez

  63. Role of Tryptophan Residues in Toxicity of Cry1Ab Toxin from Bacillus thuringiensis

    Article • Applied and Environmental Microbiology, January 2006, ASM Journals

    Dr Isabel Gomez

  64. Oligomerization triggers binding of a Bacillus thuringiensis Cry1Ab pore-forming toxin to aminopeptidase N receptor leading to insertion into membrane microdomains

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, November 2004, Elsevier

    Dr Isabel Gomez

  65. Tryptophan Spectroscopy Studies and Black Lipid Bilayer Analysis Indicate that the Oligomeric Structure of Cry1Ab Toxin from Bacillus thuringiensis Is the Membrane-Insertion Intermediate †

    Article • Biochemistry, January 2004, American Chemical Society (ACS)

    Dr Isabel Gomez

  66. Molecular Basis for Bacillus thuringiensis Cry1Ab Toxin Specificity:  Two Structural Determinants in the Manduca sexta Bt-R 1 Receptor Interact with Loops α-8 and 2 in Domain II of Cy1Ab Toxin †

    Article • Biochemistry, September 2003, American Chemical Society (ACS)

    Dr Isabel Gomez

  67. Functional studies of helix alpha-5 region from Bacillus thuringiensis Cry1Ab delta-endotoxin

    Article • January 2003, Taylor & Francis

    Dr Isabel Gomez

  68. Hydropathic Complementarity Determines Interaction of Epitope 869HITDTNNK876 in Manduca sexta Bt-R1 Receptor with Loop 2 of Domain II of Bacillus thuringiensis Cry1A Toxins

    Article • Journal of Biological Chemistry, June 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Isabel Gomez

  69. Pore formation activity of Cry1Ab toxin from Bacillus thuringiensis in an improved membrane vesicle preparation from Manduca sexta midgut cell microvilli

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2002, Elsevier

    Dr Isabel Gomez

  70. Cadherin-like receptor binding facilitates proteolytic cleavage of helix α-1 in domain I and oligomer pre-pore formation ofBacillus thuringiensisCry1Ab toxin

    Article • FEBS Letters, February 2002, Wiley

    Dr Isabel Gomez

  71. Evidence for intermolecular interaction as a necessary step for pore-formation activity and toxicity of Bacillus thuringiensis Cry1Ab toxin

    Article • FEMS Microbiology Letters, October 2000, Oxford University Press (OUP)

    Dr Isabel Gomez