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  1. Obesity, sleep apnea, and cancer

    Article • International Journal of Obesity, February 2020, Springer Science + Business Media

    Isaac Almendros

  2. Obstructive sleep apnea intensifies stroke severity following middle cerebral artery occlusion

    Article • Sleep Medicine, January 2020, Elsevier

    Isaac Almendros

  3. Cancer and Sleep Apnea: Cutaneous Melanoma as a Case Study

    Article • American Journal of Respiratory and Critical Care Medicine, December 2019, American Thoracic Society

    Isaac Almendros, David Gozal

  4. Differential effect of intermittent hypoxia and sleep fragmentation on PD-1/PD-L1 upregulation

    Article • SLEEP, November 2019, Oxford University Press (OUP)

    Isaac Almendros

  5. Effects of Sustained and Intermittent Hypoxia on Human Lung Cancer Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, October 2019, American Thoracic Society

    Isaac Almendros

  6. Late Breaking Abstract - Fetal blood hypoxia/reoxygenation swings are reduced by placental oxygen transfer in a model ovine pregnancy with sleep apnea

    Article • September 2019, European Respiratory Society (ERS)

    Isaac Almendros

  7. Lung extracellular matrix hydrogel for 3D bioprinting of lung mesenchymal stem cells

    Article • September 2019, European Respiratory Society (ERS)

    Isaac Almendros

  8. Early Career Members at the Lung Science Conference and the Sleep and Breathing Conference 2019

    Article • Breathe, September 2019, European Respiratory Society (ERS)

    Dr. Sabine Bartel, Isaac Almendros

  9. Aortic remodelling induced by obstructive apneas is normalized with mesenchymal stem cells infusion

    Article • Scientific Reports, August 2019, Springer Science + Business Media

    Isaac Almendros

  10. Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology

    Article • ERJ Open Research, July 2019, European Respiratory Society (ERS)

    Isaac Almendros, Michael Furian

  11. Why ERS Early Career Members should attend the International Congress 2019 in Madrid

    Article • Breathe, June 2019, European Respiratory Society (ERS)

    Isaac Almendros

  12. Preview of Sleep and Breathing Conference 2019 and report on Early Career Member international collaboration

    Article • Breathe, March 2019, European Respiratory Society (ERS)

    Isaac Almendros

  13. Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnoea patients

    Article • European Respiratory Journal, January 2019, European Respiratory Society (ERS)

    MD Francisco Garcia-Rio, Isaac Almendros

  14. Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma

    Article • CHEST Journal, December 2018, Elsevier

    Isaac Almendros

  15. Intermittent Hypoxia Severity in Animal Models of Sleep Apnea

    Article • Frontiers in Physiology, November 2018, Frontiers

    Isaac Almendros

  16. Passive Stiffness of Left Ventricular Myocardial Tissue Is Reduced by Ovariectomy in a Post-menopause Mouse Model

    Article • Frontiers in Physiology, November 2018, Frontiers

    Isaac Almendros

  17. Aging Reduces Intermittent Hypoxia–induced Lung Carcinoma Growth in a Mouse Model of Sleep Apnea

    Article • American Journal of Respiratory and Critical Care Medicine, November 2018, American Thoracic Society

    Isaac Almendros

  18. Overnight Change in Urinary Prostacyclin and Thromboxane in Obstructive Sleep Apnea

    Article • Archivos de Bronconeumología, November 2018, Elsevier

    Isaac Almendros

  19. Intermittent hypoxia and cancer: Undesirable bed partners?

    Article • Respiratory Physiology & Neurobiology, October 2018, Elsevier

    Isaac Almendros

  20. Clinical physiology and sleep: highlights from the European Respiratory Society Congress 2018 presented by early career members

    Article • Journal of Thoracic Disease, September 2018, AME Publishing Company

    Isaac Almendros

  21. Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study

    Article • Frontiers in Physiology, August 2018, Frontiers

    Isaac Almendros

  22. Early Career Members at the ERS Lung Science Conference: cell-matrix interactions in lung disease and regeneration

    Article • Breathe, June 2018, European Respiratory Society (ERS)

    Dr. Sabine Bartel, Isaac Almendros

  23. Zooming in on the ERS fellowships and the International Congress

    Article • Breathe, May 2018, European Respiratory Society (ERS)

    Isaac Almendros, Dr. Sabine Bartel, Dr. Giuseppe Fabio Parisi

  24. Acetylsalicylic Acid Prevents Intermittent Hypoxia-Induced Vascular Remodeling in a Murine Model of Sleep Apnea

    Article • Frontiers in Physiology, May 2018, Frontiers

    Isaac Almendros

  25. Exosomal Cargo Properties, Endothelial Function and Treatment of Obesity Hypoventilation Syndrome: A Proof of Concept Study

    Article • Journal of Clinical Sleep Medicine, May 2018, American Academy of Sleep Medicine (AASM)

    Isaac Almendros

  26. Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients

    Article • Frontiers in Neurology, April 2018, Frontiers

    Isaac Almendros

  27. Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea

    Article • European Respiratory Journal, March 2018, European Respiratory Society (ERS)

    Isaac Almendros

  28. Alzheimer’s Disease Mutant Mice Exhibit Reduced Brain Tissue Stiffness Compared to Wild-type Mice in both Normoxia and following Intermittent Hypoxia Mimicking Sleep Apnea

    Article • Frontiers in Neurology, January 2018, Frontiers

    Isaac Almendros

  29. Temporal trajectories of novel object recognition performance in mice exposed to intermittent hypoxia

    Article • European Respiratory Journal, December 2017, European Respiratory Society (ERS)

    David Gozal, Isaac Almendros

  30. Early Career Members at the ERS International Congress 2017: highlights from the Assemblies

    Article • Breathe, December 2017, European Respiratory Society (ERS)

    Alexander Mathioudakis, Isaac Almendros, Dimitrios Magouliotis, Sara Lundell

  31. A prospective multicenter cohort study of cutaneous melanoma

    Article • Melanoma Research, December 2017, Wolters Kluwer Health

    Isaac Almendros

  32. Early Career Members at the ERS LSC 2017: mechanistic overlap between chronic lung injury and cancer

    Article • Breathe, November 2017, European Respiratory Society (ERS)

    Isaac Almendros, Dr. Sabine Bartel, Darcy Wagner

  33. Exosomes and Metabolic Function in Mice Exposed to Alternating Dark-Light Cycles Mimicking Night Shift Work Schedules

    Article • Frontiers in Physiology, November 2017, Frontiers

    Isaac Almendros

  34. Clinical physiology and sleep: insights from the European Respiratory Society Congress 2017

    Article • Journal of Thoracic Disease, November 2017, AME Publishing Company

    Isaac Almendros

  35. Frequency and magnitude of intermittent hypoxia modulate endothelial wound healing in a cell culture model of sleep apnea

    Article • Journal of Applied Physiology, November 2017, American Physiological Society

    Isaac Almendros

  36. Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea

    Article • European Respiratory Journal, October 2017, European Respiratory Society (ERS)

    Isaac Almendros

  37. Ageing and chronic intermittent hypoxia mimicking sleep apnea do not modify local brain tissue stiffness in healthy mice

    Article • Journal of the Mechanical Behavior of Biomedical Materials, July 2017, Elsevier

    Isaac Almendros

  38. Intermittent hypoxia increases kidney tumor vascularization in a murine model of sleep apnea

    Article • PLoS ONE, June 2017, PLOS

    Isaac Almendros

  39. Apnea del sueño y agresividad tumoral

    Article • Archivos de Bronconeumología, June 2017, Elsevier

    Isaac Almendros

  40. Visceral White Adipose Tissue after Chronic Intermittent and Sustained Hypoxia in Mice

    Article • American Journal of Respiratory Cell and Molecular Biology, April 2017, American Thoracic Society

    David Gozal, Isaac Almendros

  41. Sleep apnoea, insulin resistance and diabetes: the first step is in the fat

    Article • European Respiratory Journal, April 2017, European Respiratory Society (ERS)

    MD Francisco Garcia-Rio, Isaac Almendros

  42. Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Isaac Almendros

  43. Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Isaac Almendros

  44. Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice

    Article • European Respiratory Journal, February 2017, European Respiratory Society (ERS)

    Ana Obeso, Isaac Almendros

  45. Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery

    Article • SLEEP, December 2016, Oxford University Press (OUP)

    Isaac Almendros

  46. Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea

    Article • SLEEP, December 2016, Oxford University Press (OUP)

    Isaac Almendros

  47. Early effects of continuous positive airway pressure in a rodent model of allergic rhinitis

    Article • Sleep Medicine, November 2016, Elsevier

    Isaac Almendros

  48. Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea

    Article • CHEST Journal, November 2016, Elsevier

    Isaac Almendros

  49. Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice

    Article • Scientific Reports, October 2016, Springer Science + Business Media

    Isaac Almendros

  50. Normoxic Recovery Mimicking Treatment of Sleep Apnea Does Not Reverse Intermittent Hypoxia-Induced Bacterial Dysbiosis and Low-Grade Endotoxemia in Mice

    Article • SLEEP, October 2016, Oxford University Press (OUP)

    Isaac Almendros

  51. Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation

    Article • Oncotarget, July 2016, Impact Journals, LLC

    Isaac Almendros

  52. Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung

    Article • Oncotarget, June 2016, Impact Journals, LLC

    Isaac Almendros

  53. Does obstructive sleep apnea confer risk to induce or enhance tumor malignancy?

    Article • Sleep Medicine Reviews, June 2016, Elsevier

    Isaac Almendros

  54. Intermittent Hypoxia-Induced Cardiovascular Remodeling Is Reversed by Normoxia in a Mouse Model of Sleep Apnea

    Article • CHEST Journal, June 2016, Elsevier

    Isaac Almendros

  55. Obstructive sleep apnea and Fuhrman grade in patients with clear cell renal cell carcinoma treated surgically

    Article • World Journal of Urology, April 2016, Springer Science + Business Media

    Isaac Almendros

  56. Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice

    Article • International Journal of Obesity, March 2016, Springer Science + Business Media

    Isaac Almendros

  57. Microarray-based analysis of plasma cirDNA epigenetic modification profiling in xenografted mice exposed to intermittent hypoxia

    Article • Genomics Data, September 2015, Elsevier

    Isaac Almendros

  58. Relación entre apnea del sueño y cáncer

    Article • Archivos de Bronconeumología, September 2015, Elsevier

    Isaac Almendros

  59. Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment

    Article • Cancer Letters, June 2015, Elsevier

    Isaac Almendros

  60. Sex Dimorphism in Late Gestational Sleep Fragmentation and Metabolic Dysfunction in Offspring Mice

    Article • SLEEP, April 2015, Oxford University Press (OUP)

    Isaac Almendros

  61. Resveratrol Attenuates Intermittent Hypoxia-Induced Macrophage Migration to Visceral White Adipose Tissue and Insulin Resistance in Male Mice

    Article • Endocrinology, February 2015, Endocrine Society

    Isaac Almendros

  62. Increased upper airway collapsibility in a mouse model of Marfan syndrome

    Article • Respiratory Physiology & Neurobiology, February 2015, Elsevier

    PhD Renata kelly da Palma, Isaac Almendros

  63. Reduced NADPH oxidase type 2 activity mediates sleep fragmentation-induced effects on TC1 tumors in mice

    Article • OncoImmunology, February 2015, Taylor & Francis

    Isaac Almendros

  64. Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea

    Article • International Journal of Obesity, October 2014, Springer Science + Business Media

    Isaac Almendros

  65. The polymorphic and contradictory aspects of intermittent hypoxia

    Article • AJP Lung Cellular and Molecular Physiology, July 2014, American Physiological Society

    Isaac Almendros

  66. Brain Tissue Hypoxia and Oxidative Stress Induced by Obstructive Apneas is Different in Young and Aged Rats

    Article • SLEEP, July 2014, Oxford University Press (OUP)

    Isaac Almendros

  67. Sleep apnea awakens cancer

    Article • OncoImmunology, March 2014, Taylor & Francis

    Almendros Pedro, Isaac Almendros

  68. Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea

    Article • American Journal of Respiratory and Critical Care Medicine, March 2014, American Thoracic Society

    Isaac Almendros

  69. Fragmented Sleep Accelerates Tumor Growth and Progression through Recruitment of Tumor-Associated Macrophages and TLR4 Signaling

    Article • Cancer Research, January 2014, American Association for Cancer Research (AACR)

    Isaac Almendros

  70. Atrial fibrosis in a chronic murine model of obstructive sleep apnea: mechanisms and prevention by mesenchymal stem cells

    Article • Respiratory Research, January 2014, Springer Science + Business Media

    Isaac Almendros

  71. Oxygen diffusion and consumption in extracellular matrix gels: Implications for designing three-dimensional cultures

    Article • Journal of Biomedical Materials Research Part A, September 2013, Wiley

    Isaac Almendros

  72. Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea

    Article • Respiratory Physiology & Neurobiology, May 2013, Elsevier

    Isaac Almendros

  73. Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea

    Article • Sleep Medicine, December 2012, Elsevier

    Isaac Almendros, maria bonsignore

  74. Potential Role of Adult Stem Cells in Obstructive Sleep Apnea

    Article • Frontiers in Neurology, January 2012, Frontiers

    Isaac Almendros

  75. Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoea

    Article • European Respiratory Journal, December 2011, European Respiratory Society (ERS)

    Isaac Almendros

  76. Early and mid-term effects of obstructive apneas in myocardial injury and inflammation

    Article • Sleep Medicine, December 2011, Elsevier

    Isaac Almendros, maria bonsignore

  77. Tissue Oxygenation in Brain, Muscle, and Fat in a Rat Model of Sleep Apnea: Differential Effect of Obstructive Apneas and Intermittent Hypoxia

    Article • SLEEP, August 2011, Oxford University Press (OUP)

    Isaac Almendros, maria bonsignore

  78. Mesenchymal stem cells reduce inflammation in a rat model of obstructive sleep apnea

    Article • Respiratory Physiology & Neurobiology, July 2010, Elsevier

    Isaac Almendros

  79. Effects of heated humidification on nasal inflammation in a CPAP rat model

    Article • Sleep Medicine, April 2010, Elsevier

    Isaac Almendros

  80. Changes in oxygen partial pressure of brain tissue in an animal model of obstructive apnea

    Article • January 2010, Springer Science + Business Media

    Isaac Almendros

  81. One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung

    Article • Respiratory Physiology & Neurobiology, June 2008, Elsevier

    Isaac Almendros

  82. Upper airway collapse and reopening induce inflammation in a sleep apnoea model

    Article • European Respiratory Journal, March 2008, European Respiratory Society (ERS)

    Isaac Almendros

  83. Rheology of Passive and Adhesion-Activated Neutrophils Probed by Atomic Force Microscopy

    Article • Biophysical Journal, November 2006, Elsevier

    Isaac Almendros