All Stories

  1. Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope

    Article • Proceedings of the National Academy of Sciences, January 2024, Proceedings of the National Academy of Sciences

    ira pastan

  2. Anti-mesothelin immunotoxin induces mesothelioma eradication, anti-tumor immunity, and the development of tertiary lymphoid structures

    Article • Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences

    ira pastan

  3. Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin

    Article • Proceedings of the National Academy of Sciences, May 2022, Proceedings of the National Academy of Sciences

    ira pastan

  4. Immunotherapy-based targeting of MSLN + activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis

    Article • Proceedings of the National Academy of Sciences, July 2021, Proceedings of the National Academy of Sciences

    ira pastan

  5. Elevated Serum Megakaryocyte Potentiating Factor as a Predictor of Poor Survival in Patients with Mesothelioma and Primary Lung Cancer

    Article • The Journal of Applied Laboratory Medicine, January 2018, AACC

    ira pastan, Anish Thomas