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  1. George Starkey’s 1658 challenge to Galenists to compare their treatment results with his
  2. Antoine de Lavoisier’s role in designing a single-blind trial to assess whether ‘Animal Magnetism’ exists
  3. Francis Bacons comments on the power of negative observations in his Novum Organum, first published in 1620
  4. Petrarchs letter to Boccaccio 'on the proud and presumptuous behaviour of physicians