All Stories

  1. Adrenal lipoma formation via PI(3,4,5)P 3 /AKT-dependent transdifferentiation of adrenocortical cells into adipocytes

    Article • Proceedings of the National Academy of Sciences, September 2025, Proceedings of the National Academy of Sciences

    Associate Professor Hyeon-Cheol Lee-Okada

  2. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice

    Article • Molecular Psychiatry, February 2023, Springer Science + Business Media

    Associate Professor Hyeon-Cheol Lee-Okada

  3. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3

    Article • Nature Communications, December 2022, Springer Science + Business Media

    Associate Professor Hyeon-Cheol Lee-Okada

  4. Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production

    Article • Communications Biology, September 2022, Springer Science + Business Media

    Associate Professor Hyeon-Cheol Lee-Okada

  5. A Western Diet Alters Skin Ceramides and Compromises the Skin Barrier in Ears

    Article • Journal of Investigative Dermatology, July 2022, Elsevier

    Associate Professor Hyeon-Cheol Lee-Okada

  6. FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis

    Article • January 2022, Cold Spring Harbor Laboratory Press

    Associate Professor Hyeon-Cheol Lee-Okada

  7. Dietary intake of n-3 polyunsaturated fatty acids alters the lipid mediator profile of the kidney but does not attenuate renal insufficiency

    Article • Biochemical and Biophysical Research Communications, December 2021, Elsevier

    Associate Professor Hyeon-Cheol Lee-Okada

  8. Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid‐depleted mice

    Article • FEBS Letters, June 2021, Wiley

    Associate Professor Hyeon-Cheol Lee-Okada

  9. Development of a liquid chromatography–electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids

    Article • The Journal of Biochemistry, May 2021, Oxford University Press (OUP)

    Associate Professor Hyeon-Cheol Lee-Okada

  10. Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells

    Article • FEBS Open Bio, October 2020, Wiley

    Associate Professor Hyeon-Cheol Lee-Okada

  11. Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence

    Article • Gastric Cancer, March 2020, Springer Science + Business Media

    Associate Professor Hyeon-Cheol Lee-Okada

  12. Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, March 2020, Elsevier

    Associate Professor Hyeon-Cheol Lee-Okada

  13. Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice

    Article • Journal of Gastroenterology and Hepatology, February 2020, Wiley

    Associate Professor Hyeon-Cheol Lee-Okada

  14. Carboxylesterase 2: A Key Enzyme in Drug and Prodrug Metabolism

    Article • Juntendo Medical Journal, January 2020, The Jutendo Medical Journal

    Associate Professor Hyeon-Cheol Lee-Okada

  15. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

    Article • Life Science Alliance, December 2019, Life Science Alliance, LLC

    Associate Professor Hyeon-Cheol Lee-Okada

  16. Omega-3 fatty acid EPA does not ameliorate itch in murine models of atopic dermatitis and psoriasis

    Article • Journal of Dermatological Science, July 2019, Elsevier

    Associate Professor Hyeon-Cheol Lee-Okada

  17. Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, June 2019, Elsevier

    Associate Professor Hyeon-Cheol Lee-Okada

  18. Autophagy regulates lipid metabolism through selective turnover of NCoR1

    Article • Nature Communications, April 2019, Springer Science + Business Media

    Associate Professor Hyeon-Cheol Lee-Okada

  19. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation

    Article • BPB Reports, January 2019, Pharmaceutical Society of Japan

    Associate Professor Hyeon-Cheol Lee-Okada

  20. Dietary omega-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses

    Article • The FASEB Journal, November 2018, Federation of American Societies For Experimental Biology (FASEB)

    Prof Takehiko Yokomizo, Toshiaki Hirakata, Akira Matsuda, Associate Professor Hyeon-Cheol Lee-Okada

  21. Applications of mass spectrometry-based targeted and non-targeted lipidomics

    Article • Biochemical and Biophysical Research Communications, October 2018, Elsevier

    Associate Professor Hyeon-Cheol Lee-Okada

  22. Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle

    Article • AJP Regulatory Integrative and Comparative Physiology, June 2018, American Physiological Society

    Associate Professor Hyeon-Cheol Lee-Okada

  23. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer

    Article • Disease Markers, January 2018, Hindawi Publishing Corporation

    Hajime Orita, Associate Professor Hyeon-Cheol Lee-Okada

  24. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases

    Article • Chemistry & Biology, July 2015, Elsevier

    Associate Professor Hyeon-Cheol Lee-Okada

  25. ABHD4 Regulates Multiple Classes of N-Acyl Phospholipids in the Mammalian Central Nervous System

    Article • Biochemistry, April 2015, American Chemical Society (ACS)

    Associate Professor Hyeon-Cheol Lee-Okada

  26. Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein

    Article • Genes to Cells, March 2013, Wiley

    Associate Professor Hyeon-Cheol Lee-Okada

  27. LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice

    Article • Molecular Biology of the Cell, December 2012, American Society for Cell Biology (ASCB)

    Associate Professor Hyeon-Cheol Lee-Okada

  28. Depletion ofmboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling inCaenorhabditis elegans

    Article • Genes to Cells, August 2012, Wiley

    Associate Professor Hyeon-Cheol Lee-Okada

  29. Member of the membrane-boundO-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity

    Article • Genes to Cells, August 2008, Wiley

    Associate Professor Hyeon-Cheol Lee-Okada

  30. Caenorhabditis elegans mboa-7, a Member of the MBOAT Family, Is Required for Selective Incorporation of Polyunsaturated Fatty Acids into Phosphatidylinositol

    Article • Molecular Biology of the Cell, March 2008, American Society for Cell Biology (ASCB)

    Associate Professor Hyeon-Cheol Lee-Okada