All Stories

  1. Biocrystallization: Harnessing natural scaffolds for stable protein crystal formulations

    Article • New Biotechnology, December 2025, Elsevier

    Dr Huaiyu Yang

  2. Nucleation of high-resolution protein crystals on tailored hydrogel membranes: Secondary conformation transition

    Article • Chemical Engineering Journal, December 2025, Elsevier

    Dr Huaiyu Yang

  3. Digital design and optimization of the integrated synthesis and crystallization process using data‐driven approaches

    Article • AIChE Journal, June 2025, Wiley

    Dr Huaiyu Yang

  4. A temperature-driven DNA discrimination strategy to distinguish E. coli DNA and phage 5hmC-modified DNA

    Article • Nucleic Acids Research, June 2025, Oxford University Press (OUP)

    Dr Huaiyu Yang

  5. Different thermal and solubility properties with an identical crystal structure – case of lenalidomide hydrate

    Article • CrystEngComm, January 2025, Royal Society of Chemistry

    Dr Huaiyu Yang

  6. Efficient and sustainable preparation of fine particles by a bubble-assisted freeze-dissolving method

    Article • Nanoscale, January 2025, Royal Society of Chemistry

    Dr Huaiyu Yang

  7. Recyclable near-body temperature eutectic system with double positive temperature coefficient effect for personalised thermal regulation

    Article • Materials Horizons, January 2025, Royal Society of Chemistry

    Dr Huaiyu Yang

  8. The interactions of protein-calcium oxalate in crystallization process

    Article • Chemical Engineering Science, December 2024, Elsevier

    Dr Huaiyu Yang

  9. Supramolecular self-assembly strategy for the enhanced solubility/dissolution rate and anti-cancer efficacy of osimertinib: Insights from multi-component crystals to drug chemistry

    Article • Chemical Engineering Science, November 2024, Elsevier

    Dr Huaiyu Yang

  10. Digital Design of Cooling Crystallization Processes Using a Machine Learning-Based Strategy

    Article • Industrial & Engineering Chemistry Research, October 2024, American Chemical Society (ACS)

    Dr Huaiyu Yang

  11. Fabrication of micro spherulitic particles of carbamazepine-hesperetin cocrystal via QESD with enhanced manufacturability and dissolution

    Article • Particuology, October 2024, Elsevier

    Dr Huaiyu Yang

  12. Data-Driven Point Adjusted Jouyban-Acree-Artificial Neural Network Hybrid Model for Predicting Solubility of Active Pharmaceutical Ingredients in Binary Solvent Mixtures

    Article • Industrial & Engineering Chemistry Research, September 2024, American Chemical Society (ACS)

    Dr Huaiyu Yang

  13. Synthesis of La1-xSrxCoO3-δ and its catalytic oxidation of NO and its reaction path

    Article • Heliyon, July 2024, Elsevier

    Dr Huaiyu Yang

  14. Production of nano-protein particles in living cells

    Article • Chemical Engineering Research and Design, July 2024, Elsevier

    Dr Huaiyu Yang

  15. Rapid and sustainable production of nano and micro medicine crystals via freeze-dissolving technology

    Article • Powder Technology, July 2024, Elsevier

    Dr Huaiyu Yang

  16. Application of efficient and sustainable freeze-dissolving technology in manufacturing of KHCO3 ultrafine particles

    Article • Green Chemical Engineering, June 2024, Tsinghua University Press

    Dr Huaiyu Yang

  17. PEGDA hydrogel microspheres with encapsulated salt for versatile control of protein crystallization

    Article • Journal of Colloid and Interface Science, April 2024, Elsevier

    Dr Huaiyu Yang

  18. Efficient cocrystal coformer screening based on a Machine learning Strategy: A case study for the preparation of imatinib cocrystal with enhanced physicochemical properties

    Article • European Journal of Pharmaceutics and Biopharmaceutics, March 2024, Elsevier

    Dr Huaiyu Yang

  19. Different Thermal and Dissolution Properties with Identical Crystal Structure - Case of Lenalidomide

    Article • January 2024, Elsevier

    Dr Huaiyu Yang

  20. Key Parameters Affecting the Phase Transition During Crystallization For Cold Energy Storage – a Review of Experimental Study

    Article • January 2024, Elsevier

    Dr Huaiyu Yang

  21. Modification of solid form of drug in oil-in-water emulsion: Effect of self-assembly of the emulsifier glycyrrhizic acid

    Article • Colloids and Surfaces A Physicochemical and Engineering Aspects, January 2024, Elsevier

    Dr Huaiyu Yang

  22. Practical techniques for protein crystallization: additive assistance and external field intensification

    Article • CrystEngComm, January 2024, Royal Society of Chemistry

    Dr Huaiyu Yang

  23. Enhancement and Regulation of Peptide Crystallization with the Application of Taylor Vortex: A Case Study of Vancomycin

    Article • Industrial & Engineering Chemistry Research, December 2023, American Chemical Society (ACS)

    Dr Huaiyu Yang

  24. Positive and negative effects of graphite flake and monolayer graphene oxide templates on protein crystallization

    Article • Particuology, August 2023, Elsevier

    Dr Huaiyu Yang

  25. Protein Nucleation and Crystallization Process with Process Analytical Technologies in a Batch Crystallizer

    Article • Crystal Growth & Design, June 2023, American Chemical Society (ACS)

    Dr Huaiyu Yang

  26. Prediction of co-amorphous formation using non-bonded interaction energy: Molecular dynamic simulation and experimental validation

    Article • Chemical Engineering Science, May 2023, Elsevier

    Dr Huaiyu Yang

  27. Co-Former Screening Method for Multicomponent Crystals Based on Partial Least Squares Regression: A Case Study of Ciprofloxacin

    Article • Crystal Growth & Design, March 2023, American Chemical Society (ACS)

    Dr Huaiyu Yang

  28. Functional System Based on Glycyrrhizic Acid Supramolecular Hydrogel: Toward Polymorph Control, Stabilization, and Controlled Release

    Article • ACS Applied Materials & Interfaces, February 2023, American Chemical Society (ACS)

    Dr Huaiyu Yang

  29. Application of Efficient and Sustainable Freeze- Dissolving Technology in Manufacturing of Khco3 Ultrafine Particles

    Article • January 2023, Elsevier

    Dr Huaiyu Yang

  30. Fast and simple preparation of microparticles of KHCO3 by a freeze-dissolving method with single solvent or additional antisolvent

    Article • RSC Sustainability, January 2023, Royal Society of Chemistry

    Dr Huaiyu Yang

  31. Protein crystallisation with gas microbubbles as soft template in a microfluidic device

    Article • Molecular Systems Design & Engineering, January 2023, Royal Society of Chemistry

    Dr Huaiyu Yang

  32. Solubility correlation by model with partial molar volume

    Article • The Canadian Journal of Chemical Engineering, November 2022, Wiley

    Dr Huaiyu Yang

  33. Prediction and design of cyclodextrin inclusion complexes formation via machine learning-based strategies

    Article • Chemical Engineering Science, November 2022, Elsevier

    Dr Huaiyu Yang

  34. Phase-Field Model for Drug Release of Water-Swellable Filaments for Fused Filament Fabrication

    Article • Molecular Pharmaceutics, July 2022, American Chemical Society (ACS)

    Dr Huaiyu Yang

  35. Freeze-Dissolving Method: A Fast Green Technology for Producing Nanoparticles and Ultrafine Powder

    Article • ACS Sustainable Chemistry & Engineering, June 2022, American Chemical Society (ACS)

    Dr Huaiyu Yang

  36. Minoxidil Multi-Component Crystals with Aromatic Carboxylic Acids: Theoretical Calculation and Structural Analysis

    Article • Crystal Growth & Design, April 2022, American Chemical Society (ACS)

    Dr Huaiyu Yang

  37. Enhancement of protein crystallization with the application of Taylor vortex and Poly(ionic liquid)s

    Article • Chemical Engineering Science, April 2022, Elsevier

    Dr Huaiyu Yang

  38. Macromolecular protein crystallisation with biotemplate of live cells

    Article • Scientific Reports, February 2022, Springer Science + Business Media

    Dr Huaiyu Yang

  39. Prediction of metastable zone widths of ammonium sulphate: modification of the nucleation potential model in an electrolyte system

    Article • CrystEngComm, January 2022, Royal Society of Chemistry

    Dr Huaiyu Yang

  40. Wet Milling, Seeding, and Ultrasound in the Optimization of the Oiling-Out Crystallization Process

    Article • Industrial & Engineering Chemistry Research, December 2021, American Chemical Society (ACS)

    Dr Huaiyu Yang

  41. Effects of Chemical and Geometric Microstructures on the Crystallization of Surface Droplets during Solvent Exchange

    Article • Langmuir, April 2021, American Chemical Society (ACS)

    Dr Huaiyu Yang

  42. Systemic Expression, Purification, and Initial Structural Characterization of Bacteriophage T4 Proteins Without Known Structure Homologs

    Article • Frontiers in Microbiology, April 2021, Frontiers

    Dr Huaiyu Yang

  43. Investigation of Agglomeration in the Presence of Oiling Out in the Antisolvent Crystallization Process

    Article • Industrial & Engineering Chemistry Research, March 2021, American Chemical Society (ACS)

    Dr Huaiyu Yang

  44. Use of additives to regulate solute aggregation and direct conformational polymorph nucleation of pimelic acid

    Article • IUCrJ, February 2021, International Union of Crystallography

    Dr Huaiyu Yang

  45. Cocrystallization of urea and succinic acid in “Nano-Crystallizer”

    Article • Chemical Engineering Science, January 2021, Elsevier

    Dr Huaiyu Yang

  46. Protein crystallisation with air bubble templates: case of gas–liquid–solid interfaces

    Article • CrystEngComm, January 2021, Royal Society of Chemistry

    Dr Huaiyu Yang

  47. Protein purification with nanoparticle-enhanced crystallisation

    Article • Separation and Purification Technology, January 2021, Elsevier

    Dr Huaiyu Yang

  48. Interaction of Metastable Zone Width and Induction Time Based on Nucleation Potential

    Article • Industrial & Engineering Chemistry Research, December 2020, American Chemical Society (ACS)

    Dr Huaiyu Yang

  49. Oiling‐Out Crystallization of Beta‐Alanine on Solid Surfaces Controlled by Solvent Exchange

    Article • Advanced Materials Interfaces, October 2020, Wiley

    Dr Huaiyu Yang

  50. Solubility and thermodynamics of d-glucosamine 2-sulfate sodium salt in water and binary solvent mixtures with methanol, ethanol and n-propanol

    Article • Journal of Molecular Liquids, February 2020, Elsevier

    Dr Huaiyu Yang

  51. Protein crystal occurrence domains in selective protein crystallisation for bio-separation

    Article • CrystEngComm, January 2020, Royal Society of Chemistry

    Dr Huaiyu Yang

  52. Solubility and thermodynamics of l-hydroxyproline in water and (methanol, ethanol, n-propanol) binary solvent mixtures

    Article • Journal of Molecular Liquids, January 2020, Elsevier

    Dr Huaiyu Yang

  53. High Protein-Loading Silica Template for Heterogeneous Protein Crystallization

    Article • Crystal Growth & Design, December 2019, American Chemical Society (ACS)

    Dr Huaiyu Yang

  54. Polymers and Solvent-Induced Polymorphic Selection and Preferential Orientation of Pyrazinamide Crystal

    Article • Crystal Growth & Design, December 2019, American Chemical Society (ACS)

    Dr Huaiyu Yang

  55. Gravity on Crystallization of Lysozyme: Slower or Faster?

    Article • Crystal Growth & Design, November 2019, American Chemical Society (ACS)

    Dr Huaiyu Yang

  56. Optimization of Vapor Diffusion Conditions for Anti-CD20 Crystallization and Scale-Up to Meso Batch

    Article • Crystals, April 2019, MDPI AG

    Dr Huaiyu Yang, PhD Dr. Rocco Caliandro

  57. Jumping into Metastable 1:1 Urea–Succinic Acid Cocrystal Zone by Freeze-Drying

    Article • Crystal Growth & Design, January 2019, American Chemical Society (ACS)

    Dr Huaiyu Yang

  58. Development and Workflow of a Continuous Protein Crystallization Process: A Case of Lysozyme

    Article • Crystal Growth & Design, January 2019, American Chemical Society (ACS)

    Dr Huaiyu Yang

  59. Continuous protein crystallisation platform and process: Case of lysozyme

    Article • Chemical Engineering Research and Design, August 2018, Elsevier

    Dr Huaiyu Yang

  60. Review on Life Cycle of Parabens: Synthesis, Degradation, Characterization and Safety Analysis

    Article • Current Organic Chemistry, May 2018, Bentham Science Publishers

    Dr Huaiyu Yang

  61. Relating induction time and metastable zone width

    Article • CrystEngComm, January 2017, Royal Society of Chemistry

    Dr Huaiyu Yang

  62. Selective crystallisation of carbamazepine polymorphs on surfaces with differing properties

    Article • CrystEngComm, January 2017, Royal Society of Chemistry

    Dr Huaiyu Yang

  63. Effect of Oscillatory Flow on Nucleation Kinetics of Butyl Paraben

    Article • Crystal Growth & Design, February 2016, American Chemical Society (ACS)

    Dr Huaiyu Yang

  64. Crystal structure of the co-crystal butylparaben–isonicotinamide (1/1)

    Article • Acta Crystallographica Section E Crystallographic Communications, January 2016, International Union of Crystallography

    Dr Huaiyu Yang

  65. Relation between metastable zone width and induction time of butyl paraben in ethanol

    Article • CrystEngComm, January 2015, Royal Society of Chemistry

    Dr Huaiyu Yang

  66. Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

    Article • Fluid Phase Equilibria, January 2015, Elsevier

    Dr Huaiyu Yang

  67. Reply to the “Comment on ‘Relation between metastable zone width and induction time of butyl paraben in ethanol’” by L.-D. Shiau, CrystEngComm, 2015, 17, DOI: 10.1039/C5CE00101C

    Article • CrystEngComm, January 2015, Royal Society of Chemistry

    Dr Huaiyu Yang

  68. Influence of Solvent and Solid-State Structure on Nucleation of Parabens

    Article • Crystal Growth & Design, August 2014, American Chemical Society (ACS)

    Dr Huaiyu Yang

  69. Ternary phase diagrams of ethyl paraben and propyl paraben in ethanol aqueous solvents

    Article • Fluid Phase Equilibria, August 2014, Elsevier

    Dr Huaiyu Yang

  70. Sandwich crystals of butyl paraben

    Article • CrystEngComm, January 2014, Royal Society of Chemistry

    Dr Huaiyu Yang

  71. Nucleation of Butyl Paraben in Different Solvents

    Article • Crystal Growth & Design, October 2013, American Chemical Society (ACS)

    Dr Huaiyu Yang

  72. Investigation of Batch Cooling Crystallization in a Liquid–Liquid Separating System by PAT

    Article • Organic Process Research & Development, June 2012, American Chemical Society (ACS)

    Dr Huaiyu Yang

  73. Thermodynamics of molecular solids in organic solvents

    Article • The Journal of Chemical Thermodynamics, May 2012, Elsevier

    Dr Huaiyu Yang

  74. Solubility of Butyl Paraben in Methanol, Ethanol, Propanol, Ethyl Acetate, Acetone, and Acetonitrile

    Article • Journal of Chemical & Engineering Data, November 2010, American Chemical Society (ACS)

    Dr Huaiyu Yang

  75. The Effect of Temperature and Solvent Composition on Transformation of β- to α-Glycine As Monitored in Situ by FBRM and PVM

    Article • Organic Process Research & Development, November 2009, American Chemical Society (ACS)

    Dr Huaiyu Yang