All Stories

  1. SMART 2.0 Statistical Metabolomics Analysis: An R Tool 2.0

    Article • Analytical Chemistry, October 2025, American Chemical Society (ACS)

    Dr. Hsin-Chou Yang

  2. Population-specific polygenic risk scores for people of Han Chinese ancestry

    Article • Nature, October 2025, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  3. The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

    Article • Nature, October 2025, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  4. Deleterious Variants Contribute Minimal Excess Risk in Large-Scale Testing

    Article • October 2024, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  5. Deleterious Variants Contribute Minimal Excess Risk in Large-Scale Testing

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr. Hsin-Chou Yang

  6. The Taiwan Precision Medicine Initiative: A Cohort for Large-Scale Studies

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr. Hsin-Chou Yang

  7. Population-Specific Polygenic Risk Scores Developed for the Han Chinese

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr. Hsin-Chou Yang

  8. AI-driven Integration of Multimodal Imaging Pixel Data and Genome-wide Genotype Data Enhances Precision Health for Type 2 Diabetes: Insights from a Large-scale Biobank Study

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Dr. Hsin-Chou Yang

  9. Risk Assessment of Type 2 Diabetes Using AI

    Article • Nature Communications, May 2024, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  10. AI-Enhanced Integration of Genetic and Medical Imaging Data for Risk Assessment of Type 2 Diabetes

    Article • August 2023, Cold Spring Harbor Laboratory Press

    Dr. Hsin-Chou Yang

  11. Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics based on 10 million genomes

    Article • PNAS Nexus, September 2022, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  12. Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics

    Article • April 2022, Cold Spring Harbor Laboratory Press

    Dr. Hsin-Chou Yang

  13. Genetic ancestry plays a central role in population pharmacogenomics

    Article • Communications Biology, February 2021, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  14. Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations

    Article • Proceedings of the National Academy of Sciences, November 2020, Proceedings of the National Academy of Sciences

    James Liao, Dr. Hsin-Chou Yang

  15. Genomic, geographic and temporal distributions of SARS-CoV-2 mutations

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Dr. Hsin-Chou Yang

  16. Genome-wide association study of morbid obesity in Han Chinese

    Article • BMC Genetics, December 2019, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  17. The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components

    Article • International Journal of Obesity, November 2019, Springer Science + Business Media

    Dr Mahantesh Biradar, Dr. Hsin-Chou Yang

  18. Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer

    Article • Journal of Experimental & Clinical Cancer Research, May 2019, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  19. Vegetable Signatures Derived from Human Urinary Metabolomic Data in Controlled Feeding Studies

    Article • Journal of Proteome Research, December 2018, American Chemical Society (ACS)

    Dr. Hsin-Chou Yang

  20. Homozygosity disequilibrium associated with treatment response and its methylation regulation

    Article • BMC Proceedings, September 2018, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  21. Postprandial Metabolomics Response to Various Cooking Oils in Humans

    Article • Journal of Agricultural and Food Chemistry, May 2018, American Chemical Society (ACS)

    Dr. Hsin-Chou Yang

  22. A Two-Stage Whole-Genome Gene Expression Association Study of Young-Onset Hypertension in Han Chinese Population of Taiwan

    Article • Scientific Reports, January 2018, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  23. Interethnic DNA Methylation Difference and its Implications in Pharmacoepigenetics

    Article • Epigenomics, September 2017, Future Medicine

    Dr. Hsin-Chou Yang, Shih-Kai Chu

  24. OPATs: OmnibusP-value association tests

    Article • Briefings in Bioinformatics, July 2017, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  25. Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  26. Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

    Article • PLOS One, March 2017, PLOS

    Dr. Hsin-Chou Yang

  27. Morbid obesity in Taiwan: Prevalence, trends, associated social demographics, and lifestyle factors

    Article • PLOS One, February 2017, PLOS

    Dr. Hsin-Chou Yang

  28. Homozygosity disequilibrium and its gene regulation

    Article • BMC Proceedings, October 2016, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  29. Genetic signatures of heroin addiction

    Article • Medicine, August 2016, Wolters Kluwer Health

    Dr. Hsin-Chou Yang

  30. SMART: Statistical Metabolomics Analysis—An R Tool

    Article • Analytical Chemistry, June 2016, American Chemical Society (ACS)

    Dr. Hsin-Chou Yang

  31. An integrated analysis tool for analyzing hybridization intensities and genotypes using new-generation population-optimized human arrays

    Article • BMC Genomics, March 2016, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  32. Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients

    Article • PLoS Genetics, March 2016, PLOS

    Dr. Hsin-Chou Yang

  33. Machine learning and data mining in complex genomic data—a review on the lessons learned in Genetic Analysis Workshop 19

    Article • BMC Genetics, February 2016, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  34. Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension

    Article • Hypertension Research, November 2014, Nature

    Professor Jaw-Wen Chen, Dr. Hsin-Chou Yang

  35. A Novel SNP Associated with Nighttime Pulse Pressure in Young-Onset Hypertension Patients Could Be a Genetic Prognostic Factor for Cardiovascular Events in a General Cohort in Taiwan

    Article • PLOS One, June 2014, PLOS

    Professor Jaw-Wen Chen, Dr. Hsin-Chou Yang

  36. Analysis of homozygosity disequilibrium using whole-genome sequencing data

    Article • BMC Proceedings, June 2014, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  37. A Three-Stage Genome-Wide Association Study Combining Multilocus Test and Gene Expression Analysis for Young-Onset Hypertension in Taiwan Han Chinese

    Article • American Journal of Hypertension, January 2014, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  38. Applying genome-wide gene-based expression quantitative trait locus mapping to study population ancestry and pharmacogenetics

    Article • BMC Genomics, January 2014, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  39. Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

    Article • PLOS One, December 2013, PLOS

    Dr. Hsin-Chou Yang

  40. The DAO Gene Is Associated with Schizophrenia and Interacts with Other Genes in the Taiwan Han Chinese Population

    Article • PLOS One, March 2013, PLOS

    Dr. Hsin-Chou Yang

  41. Fine-Mapping Angiotensin-Converting Enzyme Gene: Separate QTLs Identified for Hypertension and for ACE Activity

    Article • PLOS One, March 2013, PLOS

    Professor Jaw-Wen Chen, Dr. Hsin-Chou Yang

  42. A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

    Article • PLOS One, April 2012, PLOS

    Dr. Hsin-Chou Yang

  43. Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association Study

    Article • PLOS One, March 2012, PLOS

    Professor Jaw-Wen Chen, Dr. Hsin-Chou Yang

  44. Integrative analysis of single nucleotide polymorphisms and gene expression efficiently distinguishes samples from closely related ethnic populations

    Article • BMC Genomics, January 2012, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  45. A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes

    Article • Diabetes, August 2011, American Diabetes Association

    Dr. Hsin-Chou Yang

  46. SAQC: SNP Array Quality Control

    Article • BMC Bioinformatics, April 2011, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  47. LOHAS: loss‐of‐heterozygosity analysis suite

    Article • Genetic Epidemiology, February 2011, Wiley

    Dr. Hsin-Chou Yang

  48. A new analysis tool for individual-level allele frequency for genomic studies

    Article • BMC Genomics, January 2010, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  49. Genome-Wide Association Study of Young-Onset Hypertension in the Han Chinese Population of Taiwan

    Article • PLOS One, May 2009, PLOS

    Professor Jaw-Wen Chen, Dr. Hsin-Chou Yang

  50. Nonparametric estimation of LOH using Affymetrix SNP genotyping arrays for unpaired samples

    Article • Journal of Human Genetics, November 2008, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  51. PoooL: an efficient method for estimating haplotype frequencies from large DNA pools

    Article • Bioinformatics, June 2008, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  52. Kernel-Based Association Test

    Article • Genetics, June 2008, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  53. Using the longest significance run to estimate region-specific p-values in genetic association mapping studies

    Article • BMC Bioinformatics, May 2008, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  54. MPDA: Microarray pooled DNA analyzer

    Article • BMC Bioinformatics, April 2008, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  55. Genome-Wide Scan for Quantitative ACE Activity in Taiwan Young-Onset Hypertension Study

    Article • Human Heredity, September 2007, Karger Publishers

    Professor Jaw-Wen Chen, Dr. Hsin-Chou Yang

  56. A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments

    Article • Nucleic Acids Research, August 2006, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  57. A sliding‐window weighted linkage disequilibrium test

    Article • Genetic Epidemiology, July 2006, Wiley

    Dr. Hsin-Chou Yang

  58. A Comparison of Individual Genotyping and Pooled DNA Analysis for Polymorphism Validation Prior to Large‐Scale Genetic Studies

    Article • Annals of Human Genetics, May 2006, Wiley

    Dr. Hsin-Chou Yang

  59. PDA: Pooled DNA analyzer

    Article • BMC Bioinformatics, April 2006, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  60. A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians

    Article • Journal of Biomedical Science, March 2006, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  61. A genome-wide scanning and fine mapping study of COGA data

    Article • BMC Genetics, December 2005, Springer Science + Business Media

    Dr. Hsin-Chou Yang

  62. Modeling Animals' Behavioral Response by Markov Chain Models for Capture–Recapture Experiments

    Article • Biometrics, December 2005, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  63. Breast cancer risk associated with genotypic polymorphism of the mitosis‐regulating gene Aurora‐A/STK15/BTAK

    Article • International Journal of Cancer, February 2005, Wiley

    Dr. Hsin-Chou Yang

  64. New Adjustment Factors and Sample Size Calculation in a DNA-Pooling Experiment With Preferential Amplification

    Article • Genetics, January 2005, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  65. Receptor mediated effect of serotonergic transmission in patients with bipolar affective disorder

    Article • Journal of Medical Genetics, October 2003, BMJ

    Dr. Hsin-Chou Yang

  66. Estimation of the Size of an Open Population Using Local Estimating Equations II: A Partially Parametric Approach

    Article • Biometrics, June 2003, Oxford University Press (OUP)

    Dr. Hsin-Chou Yang

  67. Population size estimation using local sample coverage for open populations

    Article • Journal of Statistical Planning and Inference, May 2003, Elsevier

    Dr. Hsin-Chou Yang

  68. Association Mapping Using Pooled DNA

    Article • Springer Science + Business Media

    Dr. Hsin-Chou Yang