All Stories

  1. Transformation of Primary Small Intestinal Follicular Lymphoma to CD20-Negative Diffuse Large B-Cell Lymphoma following Rituximab Treatment: A Case Report

    Article • Case Reports in Gastroenterology, November 2025, Karger Publishers

    Hirotsugu Sakamoto

  2. Timing and Predictors for Vonoprazan Dose Escalation in Refractory Gastroesophageal Reflux Disease: A Long-Term Observational Study

    Article • Digestion, June 2025, Karger Publishers

    Hirotsugu Sakamoto

  3. Ischemic treatment of the duodenal windsock web using the ultra-thin endoscope, with modified detachable snares

    Article • Endoscopy, May 2025, Thieme Publishing Group

    Hirotsugu Sakamoto

  4. Complete mucosal healing prevents stricture progression after endoscopic balloon dilation in Crohn's disease

    Article • DEN Open, April 2025, Wiley

    Hirotsugu Sakamoto

  5. Esophageal and Ileal Ulcers Caused by Hydroxycarbamide: A Case Report and Literature Review

    Article • Internal Medicine, March 2025, Japanese Society of Internal Medicine

    Hirotsugu Sakamoto

  6. Biologic therapy for ulcerative colitis associated with immune thrombocytopenia

    Article • Clinical Journal of Gastroenterology, July 2024, Springer Science + Business Media

    Hirotsugu Sakamoto

  7. Endoscopic findings and outcomes of gastric mucosal changes relating to potassium‐competitive acid blocker and proton pump inhibitor therapy

    Article • DEN Open, June 2024, Wiley

    Hirotsugu Sakamoto

  8. The presence of hiatal hernia is a significant predictor for symptomatic recurrence after cessation of vonoprazan therapy for gastroesophageal reflux disease: a long-term observational study

    Article • Scandinavian Journal of Gastroenterology, May 2024, Taylor & Francis

    Hirotsugu Sakamoto

  9. Clip-and-pull method: re-strangulation of a sizable small-bowel polyp for endoscopic ischemic polypectomy

    Article • Endoscopy, May 2024, Thieme Publishing Group

    Hirotsugu Sakamoto

  10. Novel endoscopic strictureplasty with longitudinal incisions and hot biopsy forceps removal for a rectal refractory stricture in Crohn’s disease

    Article • Endoscopy International Open, January 2024, Thieme Publishing Group

    Hirotsugu Sakamoto

  11. Repeat bidirectional double-balloon enteroscopy 1 year later may be proper in Peutz-Jeghers patients with difficult-to-reach polyps

    Article • Endoscopy International Open, September 2023, Thieme Publishing Group

    Hirotsugu Sakamoto

  12. Comparison of blue laser imaging and light‐emitting diode‐blue light imaging for the characterization of colorectal polyps using the Japan narrow‐band imaging expert team classification: The LASEREO and ELUXEO COLonoscopic study

    Article • DEN Open, May 2023, Wiley

    Yoriaki Komeda, Hirotsugu Sakamoto

  13. Maintenance of complete mucosal healing is associated with avoiding restenosis after endoscopic balloon dilation of Crohn's disease‐related small intestinal strictures

    Article • DEN Open, April 2023, Wiley

    Hirotsugu Sakamoto

  14. Vonoprazan Therapy is as Effective for Functional Dyspepsia without Heartburn as Acotiamide Therapy

    Article • Journal of Gastrointestinal and Liver Diseases, March 2023, Romanian Society of Gastroenterology and Heptatology

    Hirotsugu Sakamoto

  15. Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults

    Article • Digestion, January 2023, Karger Publishers

    Hirotsugu Sakamoto

  16. Endoscopic treatment of intussusception due to small intestine polyps in patients with Peutz-Jeghers Syndrome

    Article • Endoscopy International Open, September 2022, Thieme Publishing Group

    Hirotsugu Sakamoto

  17. Probiotics suppress nonalcoholic steatohepatitis and carcinogenesis progression in hepatocyte-specific PTEN knockout mice

    Article • Scientific Reports, September 2022, Springer Science + Business Media

    Hirotsugu Sakamoto

  18. Images of laser and light‐emitting diode colonoscopy for comparing large colorectal lesion visibility with linked color imaging and white‐light imaging

    Article • Digestive Endoscopy, July 2022, Wiley

    Yoriaki Komeda, Hirotsugu Sakamoto

  19. Long-term changes in serum gastrin levels during standard dose vonoprazan therapy

    Article • Scandinavian Journal of Gastroenterology, July 2022, Taylor & Francis

    Hirotsugu Sakamoto

  20. A pilot study of micro-CT-based whole tissue imaging (WTI) on endoscopic submucosal dissection (ESD) specimens

    Article • Scientific Reports, June 2022, Springer Science + Business Media

    Hirotsugu Sakamoto

  21. Multicenter epidemiological survey of pneumatosis intestinalis in Japan

    Article • BMC Gastroenterology, May 2022, Springer Science + Business Media

    Hirotsugu Sakamoto

  22. The effect of proton pump inhibitors and vonoprazan on the development of ‘gastric mucosal redness’

    Article • Biomedical Reports, May 2022, Spandidos Publications

    Hirotsugu Sakamoto

  23. Changes in gastric morphology during long-term use of vonoprazan compared to proton pump inhibitors

    Article • Singapore Medical Journal, May 2022, Medknow

    Hirotsugu Sakamoto

  24. Underwater Endoscopic Mucosal Resection of Small Rectal Neuroendocrine Tumors

    Article • Frontiers in Medicine, April 2022, Frontiers

    Hirotsugu Sakamoto

  25. Pathological Evaluation of Rectal Cancer Specimens Using Micro-Computed Tomography

    Article • Diagnostics, April 2022, MDPI AG

    Hirotsugu Sakamoto

  26. Clinicopathological characteristics of colorectal serrated polyposis syndrome (SPS): results of a multicenter study by the SPS Study Group in Japan

    Article • Journal of Gastroenterology, February 2022, Springer Science + Business Media

    Hirotsugu Sakamoto

  27. Sequential endoscopic balloon dilations using a calibrated small-caliber-tip transparent hood for a patient with 10 ileal strictures secondary to Crohn’s disease

    Article • Endoscopy, February 2022, Thieme Publishing Group

    Hirotsugu Sakamoto

  28. Multicenter Epidemiological Survey of Pneumatosis Intestinalis in Japan

    Article • October 2021, Research Square

    Hirotsugu Sakamoto

  29. Gel immersion endoscopy: Innovation in securing the visual field – Clinical experience with 265 consecutive procedures

    Article • Endoscopy International Open, June 2021, Thieme Publishing Group

    Hirotsugu Sakamoto

  30. The pocket-creation method facilitates endoscopic submucosal dissection of gastric neoplasms involving the pyloric ring

    Article • Endoscopy International Open, June 2021, Thieme Publishing Group

    Hirotsugu Sakamoto

  31. Pathological evaluation of a rectal endoscopic submucosal dissection specimen using micro-computed tomography

    Article • Endoscopy, June 2021, Thieme Publishing Group

    Hirotsugu Sakamoto

  32. Endoscopic ischemic polypectomy for small-bowel polyps in patients with Peutz–Jeghers syndrome

    Article • Endoscopy, October 2020, Thieme Publishing Group

    Hirotsugu Sakamoto

  33. Prospective randomized trial comparing the pocket-creation method and conventional method of colorectal endoscopic submucosal dissection

    Article • Gastrointestinal Endoscopy, August 2020, Elsevier

    Hirotsugu Sakamoto

  34. The pocket-creation method may facilitate endoscopic submucosal dissection of large colorectal sessile tumors

    Article • Endoscopy International Open, July 2020, Thieme Publishing Group

    Hirotsugu Sakamoto

  35. TH1 cell-inducing Escherichia coli strain identified from the small intestinal mucosa of patients with Crohn’s disease

    Article • Gut Microbes, July 2020, Taylor & Francis

    Hirotsugu Sakamoto

  36. Double-balloon endoscopy facilitates efficient endoscopic resection of duodenal and jejunal polyps in patients with familial adenomatous polyposis

    Article • Endoscopy, May 2020, Thieme Publishing Group

    Hirotsugu Sakamoto

  37. Significance of Conducting 2 Types of Fecal Tests in Patients With Ulcerative Colitis

    Article • Clinical Gastroenterology and Hepatology, May 2020, Elsevier

    Hirotsugu Sakamoto, Taku Kobayashi

  38. Colon polyp detection using linked color imaging compared to white light imaging: Systematic review and meta‐analysis

    Article • Digestive Endoscopy, January 2020, Wiley

    Hirotsugu Sakamoto

  39. Double-Balloon Endoscopy-Assisted Balloon Dilation of Strictures Secondary to Small-Intestinal Lymphoma

    Article • Clinical Endoscopy, January 2020, The Korean Society of Gastrointestinal Endoscopy (KAMJE)

    Hirotsugu Sakamoto

  40. Effectiveness and Safety of Vonoprazan versus Proton Pump Inhibitors for Second-Line Helicobacter pylori Eradication Therapy: Systematic Review and Meta-Analysis

    Article • Digestion, January 2020, Karger Publishers

    Hirotsugu Sakamoto

  41. Double‐balloon endoscopy using an overtube with a vent

    Article • Digestive Endoscopy, October 2019, Wiley

    Hirotsugu Sakamoto

  42. Timing and Predictors of Recurrence of Dyspepsia Symptoms after Cessation of Acotiamide Therapy for Functional Dyspepsia: A Long-Term Observational Study

    Article • Digestion, May 2019, Karger Publishers

    Hirotsugu Sakamoto

  43. The pocket-creation method facilitates colonic endoscopic submucosal dissection (with video)

    Article • Gastrointestinal Endoscopy, May 2019, Elsevier

    Hirotsugu Sakamoto

  44. Curative endoscopic treatment of intussusception due to a giant colonic lipoma using a wedged balloon and ligation with detachable snares

    Article • Clinical Journal of Gastroenterology, February 2019, Springer Science + Business Media

    Hirotsugu Sakamoto

  45. Gel immersion endoscopy simplifies hemostasis during endoscopic submucosal dissection using the pocket-creation method

    Article • Endoscopy, August 2018, Thieme Publishing Group

    Hirotsugu Sakamoto

  46. Pre-treatment with proton pump inhibitors decreases the success of primary Helicobacter pylori eradication using a vonoprazan-based regimen

    Article • The Kaohsiung Journal of Medical Sciences, August 2018, Wiley

    Hirotsugu Sakamoto

  47. Long-term outcomes of patients with symptomatic gastroesophageal reflux disease treated with vonoprazan

    Article • Scandinavian Journal of Gastroenterology, July 2018, Taylor & Francis

    Hirotsugu Sakamoto

  48. Jejunal endoscopic submucosal dissection is feasible using the pocket-creation method and balloon-assisted endoscopy

    Article • Endoscopy, June 2018, Thieme Publishing Group

    Hirotsugu Sakamoto

  49. Efficacy and safety of cold versus hot snare polypectomy for resecting small colorectal polyps: Systematic review and meta-analysis

    Article • Digestive Endoscopy, May 2018, Wiley

    Hironori Yamamoto, Hirotsugu Sakamoto

  50. Balloon-assisted endoscopy facilitates endoscopic submucosal dissection of difficult superficial proximal colon tumors

    Article • Endoscopy, February 2018, Thieme Publishing Group

    Hirotsugu Sakamoto

  51. Adherence to an Acotiamide Therapeutic Regimen Improves Long-Term Outcomes in Patients with Functional Dyspepsia

    Article • Journal of Gastrointestinal and Liver Diseases, December 2017, Romanian Society of Gastroenterology and Heptatology

    Hirotsugu Sakamoto

  52. Vonoprazan treatment improves gastrointestinal symptoms in patients with gastroesophageal reflux disease

    Article • The Kaohsiung Journal of Medical Sciences, December 2017, Wiley

    Hirotsugu Sakamoto

  53. E-Poster Presentations - A4) Lower GI

    Article • Journal of Gastroenterology and Hepatology, September 2017, Wiley

    Dr Tsutomu Nishida, Hirotsugu Sakamoto

  54. E-Poster Presentations - C) Endoscopy

    Article • Journal of Gastroenterology and Hepatology, September 2017, Wiley

    Hirotsugu Sakamoto

  55. Esophageal endoscopic submucosal dissection using sodium hyaluronate is safe and effective

    Article • Minimally Invasive Therapy & Allied Technologies, July 2017, Taylor & Francis

    Hironori Yamamoto, Hirotsugu Sakamoto

  56. Vonoprazan 10 mg daily is effective for the treatment of patients with proton pump inhibitor-resistant gastroesophageal reflux disease

    Article • Biomedical Reports, July 2017, Spandidos Publications

    Hirotsugu Sakamoto

  57. Mucosal healing of Crohn’s disease in a patient with concurrent systemic lupus erythematosus using infliximab

    Article • Clinical Journal of Gastroenterology, March 2017, Springer Science + Business Media

    Hirotsugu Sakamoto

  58. Reply to Tan et al.

    Article • Endoscopy, March 2017, Thieme Publishing Group

    Hirotsugu Sakamoto

  59. Double-Balloon Colonoscopy Has a Higher Cecal Intubation Rate Than Conventional Colonoscopy Using a Colon Simulator

    Article • Digestive Diseases and Sciences, February 2017, Springer Science + Business Media

    Hirotsugu Sakamoto

  60. Pocket-creation method facilitates endoscopic submucosal dissection of colorectal laterally spreading tumors, non-granular type

    Article • Endoscopy International Open, February 2017, Thieme Publishing Group

    Hirotsugu Sakamoto

  61. Duodenal endoscopic submucosal dissection is feasible using the pocket-creation method

    Article • Endoscopy, November 2016, Thieme Publishing Group

    Hirotsugu Sakamoto

  62. Use of an over-the-scope clipping device for closure of a jejuno-sigmoid fistula: a case report with long-term follow-up

    Article • Clinical Journal of Gastroenterology, September 2016, Springer Science + Business Media

    Hirotsugu Sakamoto

  63. Comparison of vonoprazan and proton pump inhibitors for eradication of Helicobacter pylori

    Article • The Kaohsiung Journal of Medical Sciences, May 2016, Wiley

    Hirotsugu Sakamoto

  64. Gel Immersion Endoscopy With Water Replacement for Endoscopic Hemostasis Using Mono-Polar Hemostatic Forceps

    Article • Gastrointestinal Endoscopy, May 2016, Elsevier

    Hirotsugu Sakamoto

  65. Su1638 Pocket-Creation Method Facilitates Endoscopic Submucosal Dissection of Colorectal Laterally Spreading Tumors Non-Granular Type

    Article • Gastrointestinal Endoscopy, May 2016, Elsevier

    Hirotsugu Sakamoto

  66. Mo2028 The Cast Hood Facilitates Double-Balloon Endoscopy in Patients With Small Intestinal Crohn's Disease

    Article • Gastrointestinal Endoscopy, May 2016, Elsevier

    Hirotsugu Sakamoto

  67. Laterally Spreading Tumor of the Rectum Delineated with Linked Color Imaging Technology

    Article • Clinical Endoscopy, March 2016, The Korean Society of Gastrointestinal Endoscopy (KAMJE)

    Hirotsugu Sakamoto

  68. Long-term Outcomes in Patients with Small Intestinal Strictures Secondary to Crohnʼs Disease After Double-balloon Endoscopy-assisted Balloon Dilation

    Article • Inflammatory Bowel Diseases, February 2016, Oxford University Press (OUP)

    Hirotsugu Sakamoto

  69. The effect of acotiamide on epigastric pain syndrome and postprandial distress syndrome in patients with functional dyspepsia

    Article • The Journal of Medical Investigation, January 2016, University of Tokushima Faculty of Medicine

    Hirotsugu Sakamoto

  70. Long-Term Outcomes in Patients with Overt Obscure Gastrointestinal Bleeding After Negative Double-Balloon Endoscopy

    Article • Digestive Diseases and Sciences, July 2015, Springer Science + Business Media

    Hirotsugu Sakamoto

  71. Advanced rectal carcinoma caused by tumor cell implantation after curative endoscopic submucosal dissection of an intramucosal rectal carcinoma

    Article • Endoscopy, June 2015, Thieme Publishing Group

    Hironori Yamamoto, Hirotsugu Sakamoto

  72. A novel method for endoscopic placement of a capsule endoscope with use of a transparent hood and real-time viewer

    Article • Endoscopy, June 2015, Thieme Publishing Group

    Hirotsugu Sakamoto

  73. Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 (Cdx2) Transgenic Mice

    Article • Intestinal Research, January 2015, Korean Association for the Study of Intestinal Diseases (KAMJE)

    Hirotsugu Sakamoto

  74. Elevated Serum anti-Helicobacter pylori IgG Levels is a Predictor of Successful Eradication Therapy

    Article • Journal of Gastroenterology and Hepatology Research, January 2015, ACT Publishing Group

    Hirotsugu Sakamoto

  75. Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells

    Article • Gut and Liver, September 2014, The Editorial Office of Gut and Liver

    Hirotsugu Sakamoto

  76. A calibrated, small-caliber tip, transparent hood to aid endoscopic balloon dilation of intestinal strictures in Crohn’s disease: successful use of prototype

    Article • Endoscopy, November 2013, Thieme Publishing Group

    Hirotsugu Sakamoto

  77. SOX9 Is Highly Expressed in Nonampullary Duodenal Adenoma and Adenocarcinoma in Humans

    Article • Gut and Liver, September 2013, The Editorial Office of Gut and Liver

    Hirotsugu Sakamoto

  78. Double-balloon endoscopy for hepatolithiasis with multiple stones associated with reflux of intestinal contents into the bile duct in a patient with Roux-en-Y hepaticojejunostomy

    Article • Digestive Endoscopy, October 2012, Wiley

    Hirotsugu Sakamoto

  79. Nonsurgical management of small-bowel polyps in Peutz–Jeghers syndrome with extensive polypectomy by using double-balloon endoscopy

    Article • Gastrointestinal Endoscopy, August 2011, Elsevier

    Hirotsugu Sakamoto

  80. A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes

    Article • Archives of Virology, April 2011, Springer Science + Business Media

    Hirotsugu Sakamoto

  81. Cell lineage dynamics in the process leading to intestinal metaplasia

    Article • Journal of Gastroenterology, March 2011, Springer Science + Business Media

    Hirotsugu Sakamoto

  82. Encyclopedia of Cancer

    Article • January 2011, Springer Science + Business Media

    Hirotsugu Sakamoto

  83. Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach

    Article • Scandinavian Journal of Gastroenterology, July 2010, Taylor & Francis

    Hirotsugu Sakamoto

  84. Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation

    Article • Biochemical Journal, April 2010, Portland Press Ltd.

    Hirotsugu Sakamoto

  85. Intestinal metaplasia in gallbladder correlates with high amylase levels in bile in patients with a morphologically normal pancreaticobiliary duct

    Article • Human Pathology, December 2009, Elsevier

    Hirotsugu Sakamoto

  86. Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach

    Article • European Journal of Biochemistry, September 2009, Wiley

    Hirotsugu Sakamoto

  87. A New Technique for Direct Percutaneous Endoscopic Jejunostomy Using Double Balloon Endoscopy and Magnetic Anchors in a Porcine Model

    Article • Gastrointestinal Endoscopy, April 2008, Elsevier

    Hirotsugu Sakamoto

  88. Successful Endoscopic Balloon Dilation Therapy with Infliximab for Crohn's Strictures

    Article • Gastrointestinal Endoscopy, April 2008, Elsevier

    Hirotsugu Sakamoto

  89. Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-κB

    Article • Journal of Gastroenterology, September 2007, Springer Science + Business Media

    Hirotsugu Sakamoto

  90. A close relationship between intestinal metaplasia and Cdx2 expression in human gallbladders with cholelithiasis

    Article • Human Pathology, January 2007, Elsevier

    Hirotsugu Sakamoto

  91. The intestine-specific homeobox gene Cdx2 induces expression of the basic helix–loop–helix transcription factor Math1

    Article • Differentiation, July 2006, Elsevier

    Hirotsugu Sakamoto

  92. Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan

    Article • Journal of General Virology, December 2005, Society for General Microbiology

    Hirotsugu Sakamoto

  93. Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine

    Article • The International Journal of Developmental Biology, January 2005, UBC Press

    Hirotsugu Sakamoto