All Stories

  1. Article
    Glycoblotting-Based Ovo-Sulphoglycomics Reveals Phosphorylated N-Glycans as a Possible Host Factor of AIV Prevalence in Waterfowls
    Hiroshi HINOU
  2. Article
    Sodium-Doped 3-Amino-4-hydroxybenzoic Acid: Rediscovered Matrix for Direct MALDI Glycotyping of O-Linked Glycopeptides and Intact Mucins
    Hiroshi HINOU
  3. Article
    Glycoblotting enables seamless and straightforward workflow for MALDI‐TOF/MS‐based sulphoglycomics of N‐ and O‐glycans
    Hiroshi HINOU
  4. Article
    Cover Feature: Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α‐Dystroglycan O‐Mannosylated Core M1 Glycoconjugates In situ (ChemBioChem 14/2023)
    Hiroshi HINOU
  5. Article
    Altering the Modular Architecture of Galectins Affects its Binding with Synthetic α‐Dystroglycan O‐Mannosylated Core M1 Glycoconjugates In situ
    Hiroshi HINOU
  6. Article
    DHB Matrix with Additives for Direct MALDI Mass Spectrometry of Carbohydrates and Glycoconjugates
    Hiroshi HINOU
  7. Article
    Development of O Antigen Rapid Typing by MALDI-TOF MS
    Hiroshi HINOU
  8. Article
    Generation 6 Polyamidoamine Dendrimer Provides an Ideal Nanoparticular Platform for Enzyme-assisted Synthesis of Glycopeptides Having Bulky and Complex Glycans
    Hiroshi HINOU
  9. Article
    Exploring the In situ pairing of human galectins toward synthetic O-mannosylated core M1 glycopeptides of α-dystroglycan
    Hiroshi HINOU
  10. Article
    Direct MALDI Glycotyping of Glycoproteins toward Practical Subtyping of Biological Samples
    Hiroshi HINOU
  11. Article
    BOA/DHB/Na: An Efficient UV-MALDI Matrix for High-Sensitivity and Auto-Tagging Glycomics
    Hiroshi HINOU
  12. Article
    Cover Feature: Glycan‐Selective MALDI In‐Source Decay Analysis of Intact Glycoproteins (Anal. Sens. 2/2022)
    Hiroshi HINOU
  13. Article
    Selective reaction monitoring approach using structure-defined synthetic glycopeptides for validating glycopeptide biomarkers pre-determined by bottom-up glycoproteomics
    Hiroshi HINOU
  14. Article
    Glycan‐Selective MALDI In‐Source Decay Analysis of Intact Glycoproteins
    Hiroshi HINOU
  15. Article
    Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery
    Hiroshi HINOU
  16. Article
    Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics
    Hiroshi HINOU
  17. Article
    Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes
    Hiroshi HINOU
  18. Article
    A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes
    Hiroshi HINOU
  19. Article
    Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment
    Hiroshi HINOU
  20. Article
    Aniline derivative/DHB/alkali metal matrices for reflectron mode MALDI-TOF and TOF/TOF MS analysis of unmodified sialylated oligosaccharides and glycopeptides
    Hiroshi HINOU
  21. Article
    Glycan-immobilized dual-channel field effect transistor biosensor for the rapid identification of pandemic influenza viral particles
    Hiroshi HINOU
  22. Article
    Synthetic glycopeptides reveal specific binding pattern and conformational change at O-mannosylated position of α-dystroglycan by POMGnT1 catalyzed GlcNAc modification
    Hiroshi HINOU
  23. Article
    Exploring serum and immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women
    Hiroshi HINOU
  24. Article
    Healthy human serum N-glycan profiling reveals the influence of ethnic variation on the identified cancer-relevant glycan biomarkers
    Hiroshi HINOU
  25. Article
    Glycoblotting of Egg White Reveals Diverse N-Glycan Expression in Quail Species
    Hiroshi HINOU
  26. Article
    Synthetic Glycopeptides Allow for the Quantitation of Scarce Nonfucosylated IgG Fc N-Glycans of Therapeutic Antibody
    Hiroshi HINOU
  27. Article
    Further applications of classical amide coupling reagents: Microwave‐assisted esterification on solid phase
    Hiroshi HINOU
  28. Article
    Synthetic glycopeptides as a designated standard in focused glycoproteomics to discover serum cancer biomarkers
    Hiroshi HINOU
  29. Article
    The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer
    Hiroshi HINOU
  30. Article
    Glycopeptides as Targets for Dendritic Cells: Exploring MUC1 Glycopeptides Binding Profile toward Macrophage Galactose-Type Lectin (MGL) Orthologs
    Hiroshi HINOU
  31. Article
    An Efficient Glycoblotting-Based Analysis of Oxidized Lipids in Liposomes and a Lipoprotein
    Dr Takayuki FurukawaHiroshi HINOU
  32. Article
    Chemical Synthesis Demonstrates That Dynamic O-Glycosylation Regulates the Folding and Functional Conformation of a Pivotal EGF12 Domain of the Human NOTCH1 Receptor
    Hiroshi HINOU
  33. Article
    Synthetic Mucin‐Like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth‐Regulatory Galectins in Arrays
    Hiroshi HINOU
  34. Article
    Glycoblotting method allows for rapid and efficient glycome profiling of human Alzheimer's disease brain, serum and cerebrospinal fluid towards potential biomarker discovery
    Hiroshi HINOU
  35. Article
    Convergent Solid-Phase Synthesis of Macromolecular MUC1 Models Truly Mimicking Serum Glycoprotein Biomarkers of Interstitial Lung Diseases
    Hiroshi HINOU
  36. Article
    Solid-phase synthesis of C-mannosylated glycopeptide on WSXWS motif of human erythropoietin receptor
    Hiroshi HINOU
  37. Article
    Synthetic Human NOTCH1 EGF Modules Unraveled Molecular Mechanisms for the Structural and Functional Roles of Calcium Ions and O-Glycans in the Ligand-Binding Region
    Hiroshi HINOU
  38. Article
    Effects of the multiple O-glycosylation states on antibody recognition of the immunodominant motif in MUC1 extracellular tandem repeats
    Hiroshi HINOU
  39. Article
    Novel β-galactosynthase–β-mannosynthase dual activity of β-galactosidase from Aspergillus oryzae uncovered using monomer sugar substrates
    Hiroshi HINOU
  40. Article
    Large-Scale Glycomics of Livestock: Discovery of Highly Sensitive Serum Biomarkers Indicating an Environmental Stress Affecting Immune Responses and Productivity of Holstein Dairy Cows
    Hiroshi HINOU
  41. Article
    The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR
    Hiroshi HINOU
  42. Article
    A comprehensive glycome profiling of Huntington's disease transgenic mice
    Hiroshi HINOU
  43. Article
    Rapid Endolysosomal Escape and Controlled Intracellular Trafficking of Cell Surface Mimetic Quantum-Dots-Anchored Peptides and Glycopeptides
    Hiroshi HINOU
  44. Article
    Fast Epitope Mapping for the Anti‐MUC1 Monoclonal Antibody by Combining a One‐Bead‐One‐Glycopeptide Library and a Microarray Platform
    Hiroshi HINOU
  45. Article
    A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides
    Hiroshi HINOU
  46. Article
    Synthesis of neoglycosphingolipid from methoxyamino-functionalized ceramide
    Hiroshi HINOU
  47. Article
    Potential Usage for In Vivo Lectin Screening in Live Animals Utilizing Cell Surface Mimetic Glyco-nanoparticles, Phosphorylcholine-Coated Quantum Dots (PC-QDs)
    Hiroshi HINOU
  48. Article
    A New Approach for the Synthesis of Hyperbranched N-Glycan Core Structures from Locust Bean Gum
    Hiroshi HINOU
  49. Article
    Attomolar Detection of Influenza A Virus Hemagglutinin Human H1 and Avian H5 Using Glycan-Blotted Field Effect Transistor Biosensor
    Hiroshi HINOU
  50. Article
    A novel approach for the parallel synthesis of glycopeptides by combining solid-phase peptide synthesis and dendrimer-supported enzymatic modifications
    Hiroshi HINOU
  51. Article
    Microwave‐Assisted Solid‐Phase Synthesis of Antifreeze Glycopeptides
    Hiroshi HINOU
  52. Article
    Site-Specific Conformational Alteration Induced by Sialylation of MUC1 Tandem Repeating Glycopeptides at an Epitope Region for the Anti-KL-6 Monoclonal Antibody
    Hiroshi HINOU
  53. Article
    Macrocyclic Mechanism‐Based Inhibitor for Neuraminidases
    Hiroshi HINOU
  54. Article
    Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes
    Hiroshi HINOU
  55. Article
    Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation
    Dr Takayuki FurukawaHiroshi HINOU
  56. Article
    Strict Stereocontrol by 2,4-O-Di-tert-butylsilylene Group on β-Glucuronylations
    Dr Takayuki FurukawaHiroshi HINOU
  57. Article
    Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases
    Hiroshi HINOU
  58. Article
    An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation
    Hiroshi HINOU
  59. Article
    H-bonding promotion of peptide solubility and cyclization by fluorinated alcohols
    Hiroshi HINOU
  60. Article
    A potential glucuronate glycosyl donor with 2-O-acyl-6,3-lactone structure: efficient synthesis of glycosaminoglycan disaccharides
    Dr Takayuki FurukawaHiroshi HINOU
  61. Article
    Toward Green and Sustainable Chemical Glycosylation: Enhanced Lewis Acidity of Recyclable Solid Super Acid Catalyst, SO4/ZrO2 by CaCl2 Doping
    Hiroshi HINOU
  62. Article
    Importance of Sialic Acid Residues Illuminated by Live Animal Imaging Using Phosphorylcholine Self-Assembled Monolayer-Coated Quantum Dots
    Hiroshi HINOU
  63. Article
    A Strategy for Neuraminidase Inhibitors Using Mechanism‐Based Labeling Information
    Hiroshi HINOU
  64. Article
    An Efficient Approach for the Characterization of Mucin‐Type Glycopeptides: The Effect of O‐Glycosylation on the Conformation of Synthetic Mucin Peptides
  65. Article
    Glycoblotting-Assisted O-Glycomics: Ammonium Carbamate Allows for Highly Efficient O-Glycan Release from Glycoproteins
    Hiroshi HINOU
  66. Article
    Artificial Golgi Apparatus: Globular Protein-like Dendrimer Facilitates Fully Automated Enzymatic Glycan Synthesis
    Hiroshi HINOU
  67. Article
    Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor
    Hiroshi HINOU
  68. Article
    An Efficient Approach to the Discovery of Potent Inhibitors against Glycosyltransferases
    Hiroshi HINOU
  69. Article
    Unexpected Tolerance of Glycosylation by UDP-GalNAc:Polypeptide α-N-Acetylgalactosaminyltransferase Revealed by Electron Capture Dissociation Mass Spectrometry: Carbohydrate as Potential Protective Groups
  70. Article
    A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence
    Hiroshi HINOU
  71. Article
    Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase
    Hiroshi HINOU
  72. Article
    An Efficient Strategy for the Exploration of Specific Inhibitors of Sialyltransferases
    Hiroshi HINOU
  73. Article
    Microwave Effect for Glycosylation Promoted by Solid Super Acid in Supercritical Carbon Dioxide
    Hiroshi HINOU
  74. Article
    An Essential Epitope of Anti-MUC1 Monoclonal Antibody KL-6 Revealed by Focused Glycopeptide Library
    Hiroshi HINOU
  75. Article
    Functional Neoglycopeptides: Synthesis and Characterization of a New Class of MUC1 Glycoprotein Models Having Core 2-Based O-Glycan and Complex-Type N-Glycan Chains
    Hiroshi HINOU
  76. Article
    One-pot synthesis of cyclic antifreeze glycopeptides
    Dr. Masakazu HachisuHiroshi HINOU
  77. Article
    Mechanism-Based Probing, Characterization, and Inhibitor Design of Glycosidases and Glycosyltransferases
    Hiroshi HINOU
  78. Article
    A new glycosylation method part 3: study of microwave effects at low temperatures to control reaction pathways and reduce byproducts
    Hiroshi HINOU
  79. Article
    Highly Efficient and Versatile Synthesis of Proteoglycan Core Structures from 1,6‐Anhydro‐β‐lactose as a Key Starting Material
    Hiroshi HINOU
  80. Article
    Structural analysis of O‐glycopeptides employing negative‐ and positive‐ion multi‐stage mass spectra obtained by collision‐induced and electron‐capture dissociations in linear ion trap time‐of‐flight mass spectrometry
    Hiroshi HINOU
  81. Article
    One‐Pot Solid‐Phase Glycoblotting and Probing by Transoximization for High‐Throughput Glycomics and Glycoproteomics
    Hiroshi HINOU
  82. Article
    Construction and Structural Characterization of Versatile Lactosaminoglycan-Related Compound Library for the Synthesis of Complex Glycopeptides and Glycosphingolipids
    Hiroshi HINOU
  83. Article
    Glycosidation Promoted by a Reusable Solid Superacid in Supercritical Carbon Dioxide
    Hiroshi HINOU
  84. Article
    Construction of Highly Glycosylated Mucin-Type Glycopeptides Based on Microwave-Assisted Solid-Phase Syntheses and Enzymatic Modifications
    Hiroshi HINOU
  85. Article
    Mechanism‐Based Inhibitors to Probe Transitional States of Glycoside Hydrolases
    Hiroshi HINOU
  86. Article
    Characterization of Vibrio cholerae Neuraminidase by a Novel Mechanism-Based Fluorescent Labeling Reagent
    Hiroshi HINOU
  87. Article
    Combinatorial Synthesis of MUC1 Glycopeptides:  Polymer Blotting Facilitates Chemical and Enzymatic Synthesis of Highly Complicated Mucin Glycopeptides
    Hiroshi HINOU
  88. Article
    A novel glycosylation concept; microwave-assisted acetal-exchange type glycosylations from methyl glycosides as donors
    Hiroshi HINOU
  89. Article
    Molecular Transporter Between Polymer Platforms: Highly Efficient Chemoenzymatic Glycopeptide Synthesis by the Combined Use of Solid‐Phase and Water‐Soluble Polymer Supports
    Hiroshi HINOU
  90. Article
    Rapid Microwave-Assisted Solid-Phase Glycopeptide Synthesis
    Hiroshi HINOU
  91. Article
    High‐Throughput Protein Glycomics: Combined Use of Chemoselective Glycoblotting and MALDI‐TOF/TOF Mass Spectrometry
    Hiroshi HINOU
  92. Article
    Efficient strategy for convergent synthesis of trans-fused polycyclic ethers based on an intramolecular SmI2-promoted cyclization of iodo ester
    Hiroshi HINOU
  93. Article
    Systematic Syntheses and Inhibitory Activities of Bisubstrate-Type Inhibitors of Sialyltransferases
    Hiroshi HINOU
  94. Article
    Synthesis of a useful anomeric thioacetate of an N-acetyllactosamine derivative and its application
    Hiroshi HINOU
  95. Article
    Bisubstrate-type inhibitor of sialyltransferases
    Hiroshi HINOU
  96. Article
    Efficient convergent synthesis of a trans-fused 6-6-6-6-membered tetracyclic ether ring system
    Hiroshi HINOU
  97. Article
    Hiroshi HINOU
  98. Article
    Synthesis of Amphiphilic Chitopentaose and Chitoheptaose Derivatives Using a Common Disaccharidic Synthon as the Chain Elongation Unit
    Hiroshi HINOU
  99. Article
    Novel synthesis of l-iduronic acid using trehalose as the disaccharidic starting material
    Hiroshi HINOU
  100. Article
    Efficient Conversion of a 1,6-Anhydro Chitobiose Derivative into the Corresponding Tetradecyl β-Glycoside Derivative by Means of Participation of a Neighboring Tetradecanamide Group
    Hiroshi HINOU
  101. Article
    Synthesis of Amphiphilic Chitoheptaose Derivative
    Hiroshi HINOU