All Stories

  1. Role of Oxidative Stress and Reactive Metabolites in Cytotoxicity & Mitotoxicity of Clozapine, Diclofenac and Nifedipine in CHO-K1 Cells In Vitro

    Article • Endocrine Metabolic & Immune Disorders - Drug Targets, April 2023, Bentham Science Publishers

    Professor Hilmi Orhan

  2. Mitochondrial Biotransformation of Drugs and other Xenobiotics

    Article • Current Drug Metabolism, July 2021, Bentham Science Publishers

    Professor Hilmi Orhan

  3. Biotransformation of Drugs and other Xenobiotics as Key Modulator of Toxicity

    Article • Current Drug Metabolism, July 2021, Bentham Science Publishers

    Professor Hilmi Orhan

  4. Bioactivation of clozapine by mitochondria of the murine heart: Possible cause of cardiotoxicity

    Article • Toxicology, January 2021, Elsevier

    Professor Hilmi Orhan

  5. 4-methylpyrazole protects against acetaminophen-induced acute kidney injury

    Article • Toxicology and Applied Pharmacology, December 2020, Elsevier

    Professor Hilmi Orhan

  6. Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study

    Article • Medicinal Chemistry Research, November 2019, Springer Science + Business Media

    Professor Hilmi Orhan

  7. Inter-individual and inter-organ variability in the bioactivation of paracetamol by human liver and kidney tissues

    Article • Environmental Toxicology and Pharmacology, July 2018, Elsevier

    Professor Hilmi Orhan

  8. Measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in urine by an improved ELISA

    Article • Toxicology Letters, October 2017, Elsevier

    Professor Hilmi Orhan

  9. Oxidative DNA damage in cancer patients: Associations between persistent organic pollutants and biomarkers of cellular targets

    Article • Toxicology Letters, October 2017, Elsevier

    Professor Hilmi Orhan

  10. Total estrogenic activity of adipose tissue as biomarker of exposure to persistent organic pollutants in humans

    Article • Toxicology Letters, October 2017, Elsevier

    Professor Hilmi Orhan

  11. Biotransformation of clozapine by microsomal and mitochondrial fractions of mouse liver and heart: Organ-specific bioactivation as a possible cause of cardiotoxicity

    Article • Toxicology Letters, September 2016, Elsevier

    Professor Hilmi Orhan

  12. Contribution of reactive metabolites to cytotoxicity of various drugs in vitro: The role of CYP enzymes and metal contamination

    Article • Toxicology Letters, September 2016, Elsevier

    Professor Hilmi Orhan

  13. Involvement of mitochondria in drug-induced toxicities

    Article • Toxicology Letters, September 2016, Elsevier

    Professor Hilmi Orhan

  14. Toxicology as an academic discipline in European Universities

    Article • Toxicology Letters, July 2016, Elsevier

    Professor Hilmi Orhan

  15. Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine analysis by an improved ELISA: An inter-laboratory comparison study

    Article • Free Radical Biology and Medicine, June 2016, Elsevier

    Professor Hilmi Orhan

  16. Metal pollution in biotic and abiotic samples of the Büyük Menderes River, Turkey

    Article • Environmental Science and Pollution Research, March 2016, Springer Science + Business Media

    Professor Hilmi Orhan

  17. Rosiglitazone biotransformation in vitro: Enzyme from different sources and rat organs, and the effect of various glutathione S-transferases in electrophilic intermediate conjugation

    Article • Toxicology Letters, October 2015, Elsevier

    Professor Hilmi Orhan

  18. Periodic monitoring of persistent organic pollutants and molecular damage in Cyprinus carpio from Büyük Menderes River

    Article • Environmental Science and Pollution Research, June 2015, Springer Science + Business Media

    Professor Hilmi Orhan

  19. Extrahepatic Targets and Cellular Reactivity of Drug Metabolites

    Article • Current Medicinal Chemistry, December 2014, Bentham Science Publishers

    Professor Hilmi Orhan

  20. Editorial (Thematic Issue: Bioactivation of Drugs: Enzymes, Reactive Metabolites and Adverse Reactions)

    Article • Current Medicinal Chemistry, December 2014, Bentham Science Publishers

    Professor Hilmi Orhan

  21. Cofactor metals and antioxidant enzymes in cisplatin-treated rats: effect of antioxidant intervention

    Article • Drug and Chemical Toxicology, October 2014, Taylor & Francis

    Professor Hilmi Orhan

  22. Environmental and biological monitoring of persistent organic pollutants in waterbirds by non-invasive versus invasive sampling

    Article • Toxicology Letters, October 2014, Elsevier

    Professor Hilmi Orhan

  23. Organochlorine pesticides and antioxidant enzymes are inversely correlated with liver enzyme gene expression in Cyprinus carpio

    Article • Toxicology Letters, October 2014, Elsevier

    Professor Hilmi Orhan

  24. Interindividual variability in generating acetaminophen reactive metabolite NAPQI by various human liver and kidney microsomes

    Article • Toxicology Letters, August 2013, Elsevier

    Professor Hilmi Orhan

  25. Target organs and cellular reactivity of drug metabolites

    Article • Toxicology Letters, August 2013, Elsevier

    Professor Hilmi Orhan

  26. Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2′-deoxyguanosine

    Article • Antioxidants & Redox Signaling, June 2013, Mary Ann Liebert Inc

    Professor Hilmi Orhan

  27. Interference of Metals and Medications with the Detection of Lipid Peroxidation in Humans by Photometric TBARS Assay

    Article • Current Analytical Chemistry, April 2013, Bentham Science Publishers

    Professor Hilmi Orhan

  28. Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity

    Article • Biomarkers, November 2012, Taylor & Francis

    Professor Hilmi Orhan

  29. Correlation of vitellogenin with halogenated organic pollutants in wild carp liver

    Article • Toxicology Letters, June 2012, Elsevier

    Professor Hilmi Orhan

  30. PBDEs and their effect on protein oxidation in wild carp liver from Büyük Menderes River

    Article • Toxicology Letters, June 2012, Elsevier

    Professor Hilmi Orhan

  31. PCB pollution and macromolecular damage in Cyprinus carpio in Buyuk Menderes River: From ecotoxicology to risk assessment

    Article • Toxicology Letters, August 2011, Elsevier

    Professor Hilmi Orhan

  32. Conventional and Novel Approaches in Generating and Characterization of Reactive Intermediates from Drugs/Drug Candidates

    Article • Current Drug Metabolism, May 2011, Bentham Science Publishers

    Professor Hilmi Orhan

  33. Monitoring of industrial and agricultural pollution by antioxidant enzyme activities and protein oxidation in carp along the River Buyuk Menderes: Preliminary implications

    Article • Toxicology Letters, July 2010, Elsevier

    Professor Hilmi Orhan

  34. Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats

    Article • Experimental and Toxicologic Pathology, January 2009, Elsevier

    Professor Hilmi Orhan

  35. Evaluation of food quality by analysing lipid decomposition products

    Article • Toxicology Letters, October 2008, Elsevier

    Professor Hilmi Orhan

  36. Monitoring of regional aquatic pollution by 8-OHdG and MDA tissue levels in fish

    Article • Toxicology Letters, October 2008, Elsevier

    Professor Hilmi Orhan

  37. Analyses of representative biomarkers of exposure and effect by chromatographic, mass spectrometric, and nuclear magnetic resonance techniques: Method development and application in life sciences

    Article • Journal of Separation Science, February 2007, Wiley

    Professor Hilmi Orhan

  38. Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes

    Article • Toxicology in Vitro, September 2006, Elsevier

    Professor Hilmi Orhan

  39. Preventive effect of aminoguanidine on cisplatin-induced nephrotoxicity in rats—Comparison to Vitamins E and C

    Article • Toxicology Letters, September 2006, Elsevier

    Professor Hilmi Orhan

  40. Screening the Oxidative Potential of Several Mono- and Di-Halogenated Biphenyls and Biphenyl Ethers in Rat Hepatocytes

    Article • Combinatorial Chemistry & High Throughput Screening, July 2006, Bentham Science Publishers

    Professor Hilmi Orhan

  41. Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids

    Article • Biochemical Journal, March 2006, Portland Press Ltd.

    Professor Hilmi Orhan

  42. Synthesis and evaluation ofin vitroantioxidant capacities of some benzimidazole derivatives

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2006, Taylor & Francis

    Professor Hilmi Orhan

  43. Quantification of urinary o,o′-dityrosine, a biomarker for oxidative damage to proteins, by high performance liquid chromatography with triple quadrupole tandem mass spectrometryA comparison with ion-trap tandem mass spectrometry

    Article • Journal of Chromatography B, November 2005, Elsevier

    Professor Hilmi Orhan

  44. Erythrocyte antioxidant defense response against cigarette smoking in humans—the glutathione S-transferase vulnerability

    Article • Journal of Biochemical and Molecular Toxicology, January 2005, Wiley

    Professor Chris Evelo, Professor Hilmi Orhan

  45. Evaluation of a Multi-parameter Biomarker Set for Oxidative Damage in Man: Increased Urinary Excretion of Lipid, Protein and DNA Oxidation Products after One Hour of Exercise

    Article • Free Radical Research, December 2004, Taylor & Francis

    Professor Hilmi Orhan

  46. Use of19F-nuclear magnetic resonance and gas chromatography-electron capture detection in the quantitative analysis of fluorine-containing metabolites in urine of sevoflurane-anaesthetized patients

    Article • Xenobiotica, March 2004, Taylor & Francis

    Professor Hilmi Orhan

  47. Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography–tandem mass spectrometry as non-invasive biomarkers for oxidative damage

    Article • Journal of Chromatography B, January 2004, Elsevier

    Professor Hilmi Orhan

  48. Characterization of Thioether Compounds Formed from Alkaline Degradation Products of Enflurane

    Article • Anesthesiology, July 2001, Wolters Kluwer Health

    Professor Hilmi Orhan

  49. Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control

    Article • Clinical Biochemistry, February 2001, Elsevier

    Professor Hilmi Orhan

  50. In vitro effects of NSAIDS and paracetamolon oxidative stress-related parameters of human erythrocytes

    Article • Experimental and Toxicologic Pathology, January 2001, Elsevier

    Professor Hilmi Orhan

  51. Effects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in rats

    Article • Toxicology, December 1999, Elsevier

    Professor Hilmi Orhan

  52. In vivo effects of non-steroidal antiinflammatory drugs on oxidative stress-related parameters of human erythrocytes

    Article • Experimental and Toxicologic Pathology, July 1999, Elsevier

    Professor Hilmi Orhan

  53. The in vitro effects of new non-steroidal antiinflammatory compounds on antioxidant system of human erythrocytes

    Article • Experimental and Toxicologic Pathology, July 1999, Elsevier

    Professor Hilmi Orhan