All Stories

  1. Female sex is a risk factor for exacerbated lipid peroxidation and disease in murine retinitis pigmentosa

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Dr Henri Olavi Leinonen

  2. Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

    Article • FEBS Letters, July 2025, Wiley

    Dr Henri Olavi Leinonen

  3. Computational drug repurposing: approaches, evaluation of in silico resources and case studies

    Article • Nature Reviews Drug Discovery, March 2025, Springer Science + Business Media

    Dr Henri Olavi Leinonen

  4. Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics

    Article • March 2025, Cold Spring Harbor Laboratory Press

    Dr Henri Olavi Leinonen

  5. Retinal Proteome Profiling of Inherited Retinal Degeneration Across Three Different Mouse Models Suggests Common Drug Targets in Retinitis Pigmentosa

    Article • Molecular & Cellular Proteomics, November 2024, Elsevier

    Dr Henri Olavi Leinonen

  6. Biomimic opto-nanobiointerface enables multiscale biomodulation

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr Henri Olavi Leinonen

  7. A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models

    Article • Nature Communications, July 2024, Springer Science + Business Media

    Dr Henri Olavi Leinonen

  8. Synthesis and Biological Analysis of Iso-dimethyltryptamines in a Model of Light-Induced Retinal Degeneration

    Article • ACS Medicinal Chemistry Letters, June 2024, American Chemical Society (ACS)

    Dr Henri Olavi Leinonen

  9. Synthesis of Iso-Dimethyltryptamines and Biological Analysis in a Model of Light-Induced Retinal Degeneration

    Article • March 2024, American Chemical Society (ACS)

    Dr Henri Olavi Leinonen

  10. Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice

    Article • Pflügers Archiv - European Journal of Physiology, February 2024, Springer Science + Business Media

    Dr Henri Olavi Leinonen

  11. Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice

    Article • Journal of Alzheimer’s Disease, January 2024, IOS Press

    Dr Henri Olavi Leinonen

  12. Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition

    Article • Proceedings of the National Academy of Sciences, May 2023, Proceedings of the National Academy of Sciences

    Krzysztof Palczewski, Dr Henri Olavi Leinonen

  13. Neural and Müller glial adaptation of the retina to photoreceptor degeneration

    Article • Neural Regeneration Research, January 2023, Medknow

    Dr Henri Olavi Leinonen

  14. Editorial: Regulation of inflammation and metabolism in retinal neurodegenerative disorders

    Article • Frontiers in Neuroscience, December 2022, Frontiers

    Dr Henri Olavi Leinonen

  15. Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration

    Article • Current Biology, October 2022, Elsevier

    Dr Henri Olavi Leinonen

  16. Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice

    Article • eNeuro, May 2022, Society for Neuroscience

    Dr Henri Olavi Leinonen

  17. In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

    Article • Nature Communications, April 2022, Springer Science + Business Media

    Dr Henri Olavi Leinonen

  18. Inhibition of ceramide accumulation in AdipoR1–/– mice increases photoreceptor survival and improves vision

    Article • JCI Insight, February 2022, American Society for Clinical Investigation

    Dr Henri Olavi Leinonen

  19. VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy

    Article • Journal of Translational Medicine, January 2022, Springer Science + Business Media

    Dr Henri Olavi Leinonen

  20. Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies

    Article • Molecular Pharmacology, November 2021, Elsevier

    Dr Henri Olavi Leinonen

  21. A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6

    Article • Journal of Pharmacology and Experimental Therapeutics, July 2021, Elsevier

    Dr Henri Olavi Leinonen

  22. An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease

    Article • JCI Insight, May 2021, American Society for Clinical Investigation

    Dr Henri Olavi Leinonen

  23. Retinoids in the visual cycle: role of the retinal G protein-coupled receptor

    Article • Journal of Lipid Research, January 2021, Elsevier

    Dr Henri Olavi Leinonen

  24. Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

    Article • Nature Biomedical Engineering, October 2020, Springer Science + Business Media

    Dr Henri Olavi Leinonen

  25. Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

    Article • Nature Biomedical Engineering, October 2020, Springer Science + Business Media

    Dr Henri Olavi Leinonen

  26. Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease

    Article • eLife, September 2020, eLife

    Dr Henri Olavi Leinonen

  27. Homeostatic plasticity triggered by rod photoreceptor degenerative disease is associated with maintenance of sensitive night vision

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Dr Henri Olavi Leinonen

  28. Photic generation of 11-cis-retinal in bovine retinal pigment epithelium

    Article • Journal of Biological Chemistry, November 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Henri Olavi Leinonen

  29. Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

    Article • Human Molecular Genetics, July 2019, Oxford University Press (OUP)

    Dr Henri Olavi Leinonen

  30. Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice

    Article • Neuropharmacology, July 2019, Elsevier

    Dr Henri Olavi Leinonen

  31. A Mixture of U.S. Food and Drug Administration–Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness

    Article • Investigative Ophthalmology & Visual Science, April 2019, Association for Research in Vision and Ophthalmology (ARVO)

    Dr Henri Olavi Leinonen

  32. Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

    Article • Redox Biology, January 2019, Elsevier

    Dr Henri Olavi Leinonen, Professor Heping Xu

  33. A Combination of G Protein–Coupled Receptor Modulators Protects Photoreceptors from Degeneration

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Henri Olavi Leinonen

  34. Vision in laboratory rodents—Tools to measure it and implications for behavioral research

    Article • Behavioural Brain Research, July 2017, Elsevier

    Dr Henri Olavi Leinonen

  35. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy

    Article • Scientific Reports, May 2017, Nature

    Dr Henri Olavi Leinonen

  36. Corrigendum: Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

    Article • Frontiers in Aging Neuroscience, March 2017, Frontiers

    Dr Henri Olavi Leinonen

  37. Lack of P4H-TM in mice results in age-related retinal and renal alterations

    Article • Human Molecular Genetics, July 2016, Oxford University Press (OUP)

    Dr Henri Olavi Leinonen

  38. Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke

    Article • Glia, June 2016, Wiley

    Dr Henri Olavi Leinonen

  39. Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice

    Article • Frontiers in Aging Neuroscience, March 2016, Frontiers

    Dr Henri Olavi Leinonen

  40. Normal gain of retinal responses but subtly changed kinetics in a common mouse model of AD

    Article • Journal of Alzheimer’s Disease, February 2016, IOS Press

    Dr Henri Olavi Leinonen

  41. Cone photoreceptor dysfunction may precede other measurable symptoms in Huntington´s Disease mice

    Article • PLOS One, December 2014, PLOS

    Dr Henri Olavi Leinonen