All Stories

  1. Le virus d’Epstein-Barr, déclencheur du lupus érythémateux systémique

    Article • médecine/sciences, May 2026, EDP Sciences

    Dr Henri V Gruffat

  2. Le virus d’Epstein-Barr

    Article • médecine/sciences, May 2022, EDP Sciences

    Dr Henri V Gruffat

  3. Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein–Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development

    Article • Cancers, March 2022, MDPI AG

    Dr Henri V Gruffat

  4. Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein

    Article • Nucleic Acids Research, September 2021, Oxford University Press (OUP)

    Dr Henri V Gruffat

  5. Massive clonal expansion of polycytotoxic skin and blood CD8 + T cells in patients with toxic epidermal necrolysis

    Article • Science Advances, March 2021, American Association for the Advancement of Science

    Dr Henri V Gruffat

  6. Translational control of coronaviruses

    Article • Nucleic Acids Research, December 2020, Oxford University Press (OUP)

    Dr Henri V Gruffat

  7. To something, Covid is good: SFV 2.0

    Article • Virologie, June 2020, John Libbey Eurotext

    Dr Henri V Gruffat

  8. BHRF1, a BCL2 viral homolog, disturbs mitochondrial dynamics and stimulates mitophagy to dampen type I IFN induction

    Article • Autophagy, May 2020, Taylor & Francis

    Dr Henri V Gruffat

  9. The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation

    Article • PLoS Pathogens, October 2019, PLOS

    Dr Henri V Gruffat

  10. Cell-to-cell expression dispersion of B-cell surface proteins displays genetic variation among humans

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Dr Henri V Gruffat

  11. Viral oncogenesis and genomic instability: the centr(osom)al connection

    Article • Virologie, October 2019, John Libbey Eurotext

    Dr Henri V Gruffat

  12. Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection

    Article • Journal of Virology, July 2019, ASM Journals

    Dr Henri V Gruffat

  13. SRSF3

    Article • médecine/sciences, February 2019, EDP Sciences

    Dr Henri Gruffat, Dr Henri V Gruffat

  14. The splicing factor SRSF3 is functionally connected to the nuclear RNA exosome for intronless mRNA decay

    Article • Scientific Reports, August 2018, Springer Science + Business Media

    Dr Henri V Gruffat

  15. EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers

    Article • Cancers, April 2018, MDPI AG

    Dr Henri V Gruffat

  16. Co-infection EBV/KSHV

    Article • médecine/sciences, January 2018, EDP Sciences

    Dr Henri Gruffat, Dr Henri V Gruffat

  17. Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G

    Article • Journal of Virology, November 2017, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  18. Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs

    Article • PLoS Pathogens, September 2017, PLOS

    Dr. Louis-Marie Bloyet, Dr Henri V Gruffat

  19. Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines

    Article • Scientific Reports, July 2017, Springer Science + Business Media

    Dr Henri V Gruffat

  20. Epstein–Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle

    Article • Journal of General Virology, February 2017, Society for General Microbiology

    Dr Henri V Gruffat

  21. Herpesvirus Late Gene Expression: A Viral-Specific Pre-initiation Complex Is Key

    Article • Frontiers in Microbiology, June 2016, Frontiers

    Dr Henri V Gruffat

  22. The mycotoxin aflatoxin B1 stimulates Epstein–Barr virus-induced B-cell transformation in in vitro and in vivo experimental models

    Article • Carcinogenesis, September 2015, Oxford University Press (OUP)

    Dr Henri V Gruffat

  23. In vitro translation of mRNAs that are in their native ribonucleoprotein complexes

    Article • Biochemical Journal, September 2015, Portland Press Ltd.

    Dr Henri V Gruffat

  24. TLR9 Transcriptional Regulation in Response to Double-Stranded DNA Viruses

    Article • The Journal of Immunology, September 2014, The American Association of Immunologists

    Dr Henri Gruffat, Dr Henri V Gruffat

  25. vPIC: A viral specific Pre-Initiation Complex

    Article • Journal of Virology, August 2014, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  26. Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1

    Article • Nucleic Acids Research, August 2014, Oxford University Press (OUP)

    Dr Henri Gruffat, Dr Henri V Gruffat

  27. Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression

    Article • PLoS Pathogens, May 2014, PLOS

    Dr Henri Gruffat, Dr Henri V Gruffat

  28. Epstein - Barr Virus Transforming Protein LMP-1 Alters B Cells Gene Expression by Promoting Accumulation of the Oncoprotein ΔNp73α

    Article • PLoS Pathogens, March 2013, PLOS

    Dr Henri Gruffat, Dr Henri V Gruffat

  29. Interaction of Ubinuclein-1, a nuclear and adhesion junction protein, with the 14-3-3 epsilon protein in epithelial cells: Implication of the PKA pathway

    Article • European Journal of Cell Biology, March 2013, Elsevier

    Dr Henri Gruffat, Dr Julien Lupo, Dr Henri V Gruffat

  30. Drosophila Yemanuclein and HIRA Cooperate for De Novo Assembly of H3.3-Containing Nucleosomes in the Male Pronucleus

    Article • PLoS Genetics, February 2013, PLOS

    Dr Henri Gruffat, Dr Henri V Gruffat

  31. Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs

    Article • Nucleic Acids Research, April 2012, Oxford University Press (OUP)

    Dr Henri Gruffat, Dr Henri V Gruffat

  32. The Epstein-Barr Virus BcRF1 Gene Product Is a TBP-Like Protein with an Essential Role in Late Gene Expression

    Article • Journal of Virology, March 2012, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  33. Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1)

    Article • Experimental Cell Research, March 2012, Elsevier

    Dr Henri Gruffat, Dr Julien Lupo, Dr Henri V Gruffat

  34. Functional mechanisms of the cellular prion protein (PrPC) associated anti-HIV-1 properties

    Article • Cellular and Molecular Life Sciences, November 2011, Springer Science + Business Media

    Dr Henri Gruffat, Dr Ricardo Soto-Rifo, Dr Henri V Gruffat

  35. Homozygous deletion of EPB41 genuine AUG-containing exons results in mRNA splicing defects, NMD activation and protein 4.1R complete deficiency in hereditary elliptocytosis

    Article • Blood Cells Molecules and Diseases, October 2011, Elsevier

    Dr Henri Gruffat, Dr Henri V Gruffat

  36. The Nuclear and Adherent Junction Complex Component Protein Ubinuclein Negatively Regulates the Productive Cycle of Epstein-Barr Virus in Epithelial Cells

    Article • Journal of Virology, November 2010, ASM Journals

    Dr Henri Gruffat, Dr Julien Lupo, Dr Henri V Gruffat

  37. EBV Latent Membrane Protein 1 Is a Negative Regulator of TLR9

    Article • The Journal of Immunology, October 2010, The American Association of Immunologists

    Dr Henri Gruffat, Dr Henri V Gruffat

  38. Epstein-Barr Virus Protein EB2 Contains an N-Terminal Transferable Nuclear Export Signal That Promotes Nucleocytoplasmic Export by Directly Binding TAP/NXF1

    Article • Journal of Virology, September 2009, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  39. Translation of intronless RNAs is strongly stimulated by the Epstein-Barr virus mRNA export factor EB2

    Article • Nucleic Acids Research, June 2009, Oxford University Press (OUP)

    Dr Henri Gruffat, Dr Henri V Gruffat

  40. Ubinuclein, a new member of the NACos protein familly

    Article • Biology of the Cell, June 2009, Wiley

    Dr Henri Gruffat, Dr Julien Lupo, Dr Henri V Gruffat

  41. Methylation-Dependent Binding of the Epstein-Barr Virus BZLF1 Protein to Viral Promoters

    Article • PLoS Pathogens, March 2009, PLOS

    Dr Henri Gruffat, Dr Henri V Gruffat

  42. Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: Two individual consequences of CUG trinucleotide repeats

    Article • Experimental Neurology, April 2008, Elsevier

    Dr Henri Gruffat, Dr Henri V Gruffat

  43. The Epstein-Barr virus (EBV) protein EB is an mRNA export factor essential for virus production

    Article • Frontiers in Bioscience, January 2008, IMR Press

    Dr Henri V Gruffat

  44. Protein Kinase CK2 Phosphorylation of EB2 Regulates Its Function in the Production of Epstein-Barr Virus Infectious Viral Particles

    Article • Journal of Virology, August 2007, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  45. Epstein-Barr Virus mRNA Export Factor EB2 Is Essential for Intranuclear Capsid Assembly and Production of gp350

    Article • Journal of Virology, November 2005, ASM Journals

    Dr Henri Gruffat, prof.dr. (emeritus professor) Jaap Michiel Middeldorp, Dr Henri V Gruffat

  46. Interaction of the Epstein-Barr Virus mRNA Export Factor EB2 with Human Spen Proteins SHARP, OTT1, and a Novel Member of the Family, OTT3, Links Spen Proteins with Splicing Regulation and mRNA Export

    Article • Journal of Biological Chemistry, November 2005, Elsevier

    Dr Henri V Gruffat

  47. Cellular uptake of the EBV transcription factor EB1/Zta

    Article • Virus Research, June 2005, Elsevier

    Dr Henri Gruffat, Dr Henri V Gruffat

  48. The BRRF1 Early Gene of Epstein-Barr Virus Encodes a Transcription Factor That Enhances Induction of Lytic Infection by BRLF1

    Article • Journal of Virology, May 2004, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  49. Transcription factor cCP2 controls gene expression in chicken embryonic stem cells

    Article • Nucleic Acids Research, April 2004, Oxford University Press (OUP)

    Dr Henri V Gruffat

  50. Persistance ou cycle productif du virus d'Epstein-Barr : la régulation de l'expression d'un gène viral en est la clé

    Article • Pathologie Biologie, March 2004, Elsevier

    Dr Henri Gruffat, Dr Henri V Gruffat

  51. Differential Hyperacetylation of Histones H3 and H4 upon Promoter-Specific Recruitment of EBNA2 in Epstein-Barr Virus Chromatin

    Article • Journal of Virology, July 2003, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  52. A Region of the Epstein-Barr Virus (EBV) mRNA Export Factor EB2 Containing an Arginine-rich Motif Mediates Direct Binding to RNA

    Article • Journal of Biological Chemistry, July 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Henri Gruffat, Dr Henri V Gruffat

  53. A novel function for the Epstein–Barr virus transcription factor EB1/Zta: induction of transcription of the hIL-10 gene

    Article • Journal of General Virology, April 2003, Society for General Microbiology

    Dr Henri V Gruffat

  54. A Novel Nuclear Export Signal and a REF Interaction Domain Both Promote mRNA Export by the Epstein-Barr Virus EB2 Protein

    Article • Journal of Biological Chemistry, January 2003, Elsevier

    Dr Henri V Gruffat

  55. Epstein-Barr Virus mRNA Export Factor EB2 Is Essential for Production of Infectious Virus

    Article • Journal of Virology, October 2002, ASM Journals

    Dr Henri Gruffat, Dr Henri V Gruffat

  56. MEF2-mediated recruitment of class II HDAC at the EBV immediate early gene BZLF1 links latency and chromatin remodeling

    Article • EMBO Reports, February 2002, EMBO

    Dr Henri Gruffat, Dr Henri V Gruffat

  57. Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma

    Article • Microbes and Infection, May 2000, Elsevier

    Dr Henri Gruffat, Dr Henri V Gruffat

  58. Ubinuclein, a Novel Nuclear Protein Interacting with Cellular and Viral Transcription Factors

    Article • Journal of Cell Biology, March 2000, Rockefeller University Press

    Dr Henri V Gruffat

  59. A particular DNA structure is required for the function of a cis-acting component of the Epstein-Barr virus OriLyt origin of replication

    Article • Nucleic Acids Research, April 1997, Oxford University Press (OUP)

    Dr Henri V Gruffat

  60. Repression by RAZ of Epstein--Barr virus bZIP transcription factor EB1 is dimerization independent

    Article • Journal of General Virology, July 1996, Society for General Microbiology

    Dr Henri Gruffat, Dr Henri V Gruffat

  61. Characterization of the DNA-binding site repertoire for the Epstein - Barr virus transcription factor R

    Article • Nucleic Acids Research, January 1994, Oxford University Press (OUP)

    Dr Henri Gruffat, Dr Henri V Gruffat

  62. Domains of the Epstein-Barr virus (EBV) transcription factor R required for dimerization, DNA binding and activation

    Article • Nucleic Acids Research, May 1991, Oxford University Press (OUP)

    Dr Henri Gruffat, Dr Henri V Gruffat

  63. The enhancer factor R of Epstein-Barr virus (EBV) Is a sequence-specific DNA binding protein

    Article • Nucleic Acids Research, January 1990, Oxford University Press (OUP)

    Dr Henri Gruffat, Dr Henri V Gruffat