All Stories

  1. A Fluorescent Protein-Tagged Scorpion Toxin with Picomolar Affinity for the Kv1.3 K + Channel
  2. Interplay Between Dysregulated Immune System and the Footprints of Blood-Borne miRNAs in Treatment Naive Crohn’s Disease and Ulcerative Colitis Patients
  3. Adipokines as Prognostic Biomarkers in Multiple Myeloma: A Case–Control Study
  4. Comparison of the Effect of CFTR Modulators elexacaftor/tezacaftor/ivacaftor and lumacaftor/ivacaftor via Serum Human Epididymis Protein 4 Concentration in p.Phe508del-CFTR Homozygous Cystic Fibrosis Patients
  5. Cvill6 and Cvill7: Potent and Selective Peptide Blockers of Kv1.2 Ion Channel Isolated from Mexican Scorpion Centruroides villegasi
  6. Look Beyond Plasma Membrane Biophysics: Revealing Considerable Variability of the Dipole Potential Between Plasma and Organelle Membranes of Living Cells
  7. Inhibition of K+ Channels Affects the Target Cell Killing Potential of CAR T Cells
  8. Novel insights into the modulation of the voltage-gated potassium channel KV1.3 activation gating by membrane ceramides
  9. A synthetic flavonoid derivate in the plasma membrane transforms the voltage‐clamp fluorometry signal of CiHv1
  10. Activity of Potassium Channels in CD8+ T Lymphocytes: Diagnostic and Prognostic Biomarker in Ovarian Cancer?
  11. Introducing NZ-58, a potent inhibitor of the human voltage-gated proton channel
  12. Structural and functional characterisation of Tst2, a novel TRPV1 inhibitory peptide from the Australian sea anemone Telmatactis stephensoni
  13. Of Seven New K+ Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2
  14. Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides
  15. Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels
  16. 5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human HV1 Channel
  17. The Voltage-Gated Hv1 H+ Channel Is Expressed in Tumor-Infiltrating Myeloid-Derived Suppressor Cells
  18. Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1
  19. Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?
  20. Recombinant Expression in Pichia pastoris System of Three Potent Kv1.3 Channel Blockers: Vm24, Anuroctoxin, and Ts6
  21. Effects of One-Year Tofacitinib Therapy on Lipids and Adipokines in Association with Vascular Pathophysiology in Rheumatoid Arthritis
  22. The hEag1 K+ Channel Inhibitor Astemizole Stimulates Ca2+ Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures
  23. Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity
  24. sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity
  25. Role of C-Terminal Domain and Membrane Potential in the Mobility of Kv1.3 Channels in Immune Synapse Forming T Cells
  26. Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
  27. Peptide Inhibitors of Kv1.5: An Option for the Treatment of Atrial Fibrillation
  28. Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction
  29. Immune Synapse Residency of Orai1 Alters Ca2+ Response of T Cells
  30. Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin
  31. KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology
  32. A disulfide-stabilised helical hairpin fold in acrorhagin I: An emerging structural motif in peptide toxins
  33. Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation
  34. Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells
  35. The Kv1.3 K+ channel in the immune system and its “precision pharmacology” using peptide toxins
  36. Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells
  37. Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels
  38. The activation gate controls steady-state inactivation and recovery from inactivation in Shaker
  39. The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells
  40. Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom
  41. Weaponisation ‘on the fly’: Convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies
  42. Periodic Membrane Potential and Ca2+ Oscillations in T Cells Forming an Immune Synapse
  43. N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis
  44. Pore-modulating toxins exploit inherent slow inactivation to block K + channels
  45. Determining the target of membrane sterols on voltage-gated potassium channels
  46. Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death
  47. Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold
  48. Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells
  49. The C-terminal HRET sequence of Kv1.3 regulates gating rather than targeting of Kv1.3 to the plasma membrane
  50. Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K + -channels
  51. Optimization of the Synthesis of Flavone–Amino Acid and Flavone–Dipeptide Hybrids via Buchwald–Hartwig Reaction
  52. A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore
  53. Sterol Regulation of Voltage-Gated K+ Channels
  54. Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions
  55. 7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome
  56. Erratum to: Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes
  57. Isolation, chemical and functional characterization of several new K+-channel blocking peptides from the venom of the scorpion Centruroides tecomanus
  58. Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes
  59. The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation
  60. Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds
  61. An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility
  62. Mesenchymal Stromal Cell-Like Cells Set the Balance of Stimulatory and Inhibitory Signals in Monocyte-Derived Dendritic Cells
  63. Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels
  64. Structure, Molecular Modeling, and Function of the Novel Potassium Channel Blocker Urotoxin Isolated from the Venom of the Australian Scorpion Urodacus yaschenkoi
  65. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Signalling Exerts Chondrogenesis Promoting and Protecting Effects: Implication of Calcineurin as a Downstream Target
  66. Ion channels and anti-cancer immunity
  67. OcyKTx2, a new K+-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum
  68. The role of PSD-95 in the rearrangement of Kv1.3 channels to the immunological synapse
  69. Transient receptor potential vanilloid‐2 mediates the effects of transient heat shock on endocytosis of human monocyte‐derived dendritic cells
  70. Analysis of the K+ current in human CD4+ T lymphocytes in hypercholesterolemic state
  71. Membrane microdomain organization, calcium signal, and NFAT activation as an important axis in polarized Th cell function
  72. Vm24, a Natural Immunosuppressive Peptide, Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells
  73. Structure, Function, and Chemical Synthesis of Vaejovis mexicanus Peptide 24: A Novel Potent Blocker of Kv1.3 Potassium Channels of Human T Lymphocytes
  74. Switch of Voltage-Gated K+ Channel Expression in the Plasma Membrane of Chondrogenic Cells Affects Cytosolic Ca2+-Oscillations and Cartilage Formation
  75. Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced Migration of a Monocyte-Derived Dendritic Cell Subset
  76. Intact rat superior mesenteric artery endothelium is an electrical syncytium and expresses strong inward rectifier K+ conductance
  77. Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF 109203X) on delayed rectifier K+ currents
  78. Ion channels in T lymphocytes: An update on facts, mechanisms and therapeutic targeting in autoimmune diseases
  79. Answer to the “Comment on functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse” by Stefan Bittner et al. [Immunol. Lett. 125 (Aug 15 (2)) (2009) 156–157]
  80. Developmental Switch of the Expression of Ion Channels in Human Dendritic Cells
  81. Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus
  82. Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse
  83. Potassium channel expression in human CD4+ regulatory and naïve T cells from healthy subjects and multiple sclerosis patients
  84. Special Issue from the International Conference on Molecular Recognition, Pécs; and Regional Biophysics Meeting, Balatonfüred; August 2007
  85. A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus
  86. IV. International conference on molecular recognition
  87. Effects of changes in extracellular pH and potassium concentration on Kv1.3 inactivation
  88. Involvement of Membrane Channels in Autoimmune Disorders
  89. Nutrition and immune system: Certain fatty acids differently modify membrane composition and consequently kinetics of KV1.3 channels of human peripheral lymphocytes
  90. Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels
  91. Cross Talk between Activation and Slow Inactivation Gates of Shaker Potassium Channels
  92. Changes in Purinoceptor Distribution and Intracellular Calcium Levels following Noise Exposure in the Outer Hair Cells of the Guinea Pig
  93. K+ Channel Blockers: Novel Tools to Inhibit T Cell Activation Leading to Specific Immunosuppression
  94. Death or survival: Membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration
  95. Differential expression of potassium currents in Deiters cells of the guinea pig cochlea
  96. Novel α-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells
  97. The EBSA prize lecture
  98. Anuroctoxin, a New Scorpion Toxin of the α-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes
  99. Regulation of the lateral wall stiffness by acetylcholine and GABA in the outer hair cells of the guinea pig
  100. Looking through ion channels: recharged concepts in T-cell signaling
  101. Differential expression of purinergic receptor subtypes in the outer hair cells of the guinea pig
  102. An Alternative to Conventional Immunosuppression: Small-Molecule Inhibitors of Kv1.3 Channels
  103. pH-dependent modulation of Kv1.3 inactivation: role of His399
  104. Ion channels and lymphocyte activation
  105. New phenotypic, functional and electrophysiological characteristics of KG-1 cells
  106. Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells
  107. Active and passive behaviour in the regulation of stiffness of the lateral wall in outer hair cells of the guinea-pig
  108. Drug- and mutagenesis-induced changes in the selectivity filter of a cardiac two-pore background K channel
  109. Cholesterol modifies the gating of Kv1.3 in human T lymphocytes
  110. Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes
  111. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K+-channels with distinctly different affinities
  112. Multiple Binding Sites for Melatonin on Kv1.3
  113. Effects of Toxins Pi2 and Pi3 on Human T Lymphocyte Kv1.3 Channels: The Role of Glu7 and Lys24
  114. Blockage of Human T Lymphocyte Kv1.3 Channels by Pi1, a Novel Class of Scorpion Toxin
  115. Pandinus imperatorScorpion Venom Blocks Voltage-Gated K+Channels in Human Lymphocytes
  116. Immunosuppressors Inhibit Voltage-Gated Potassium Channels in Human Peripheral Blood Lymphocytes
  117. Assembly and suppression of endogenous Kv1.3 channels in human T cells.
  118. C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanism
  119. Plasma-membrane-Bound mcromoleculas are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?
  120. Ion-channel activities regulate transmembrane signaling in thymocyte apoptosis and T-cell activation
  121. Peripheral Blood Lymphocytes Display Reduced K+ Channel Activity in Aged Humans
  122. A Ca2+-dependent K+-channel in freshly isolated and cultured chick osteoclasts
  123. Biphasic Effect of Extracellular ATP on the Membrane Potential of Mouse Thymocytes
  124. Effect of cyclosporin A on the membrane potential and Ca2+ level of human lymphoid cell lines and mouse thymocytes