All Stories

  1. Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction

    Article • JCI Insight, November 2025, American Society for Clinical Investigation

    M.Sc. Ph.D. Gregoire Ruffenach

  2. SOX17 in pulmonary arterial hypertension: from development to clinical phenotype

    Article • European Respiratory Review, July 2025, European Respiratory Society (ERS)

    M.Sc. Ph.D. Gregoire Ruffenach

  3. Ca 2+ Cycling Alteration in a Porcine Model of Right Ventricular Dysfunction

    Article • Circulation Heart Failure, May 2025, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  4. Correction to: Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

    Article • Circulation, April 2025, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  5. Intestinal IFNα4 promotes 15-HETE diet-induced pulmonary hypertension

    Article • Respiratory Research, November 2024, Springer Science + Business Media

    M.Sc. Ph.D. Gregoire Ruffenach

  6. Transcriptome analyses reveal common immune system dysregulation in PAH patients and Kcnk3‐deficient rats

    Article • Pulmonary Circulation, October 2024, Wiley

    M.Sc. Ph.D. Gregoire Ruffenach

  7. Dissecting the lung transcriptome of pulmonary fibrosis-associated pulmonary hypertension

    Article • AJP Lung Cellular and Molecular Physiology, October 2024, American Physiological Society

    M.Sc. Ph.D. Gregoire Ruffenach

  8. Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

    Article • Circulation, August 2024, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  9. Functions of RNA-Binding Proteins in Cardiovascular Disease

    Article • Cells, December 2023, MDPI AG

    M.Sc. Ph.D. Gregoire Ruffenach

  10. Myocardial fibrosis and calcification are attenuated by microRNA–129-5p targeting Asporin and Sox9 in cardiac fibroblasts

    Article • JCI Insight, May 2023, American Society for Clinical Investigation

    M.Sc. Ph.D. Gregoire Ruffenach

  11. Tm4sf1-marked Endothelial Subpopulation Is Dysregulated in Pulmonary Arterial Hypertension

    Article • American Journal of Respiratory Cell and Molecular Biology, April 2023, American Thoracic Society

    M.Sc. Ph.D. Gregoire Ruffenach

  12. HNRNPA2B1: RNA-Binding Protein That Orchestrates Smooth Muscle Cell Phenotype in Pulmonary Arterial Hypertension

    Article • Circulation, October 2022, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  13. Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines

    Article • American Review of Respiratory Disease, July 2022, American Thoracic Society

    M.Sc. Ph.D. Gregoire Ruffenach

  14. Role of miRNA-1 and miRNA-21 in Acute Myocardial Ischemia-Reperfusion Injury and Their Potential as Therapeutic Strategy

    Article • International Journal of Molecular Sciences, January 2022, MDPI AG

    M.Sc. Ph.D. Gregoire Ruffenach

  15. Pulmonary hypertension secondary to pulmonary fibrosis: clinical data, histopathology and molecular insights

    Article • November 2020, Springer Science + Business Media

    M.Sc. Ph.D. Gregoire Ruffenach

  16. Sex differences underlying preexisting cardiovascular disease and cardiovascular injury in COVID-19

    Article • Journal of Molecular and Cellular Cardiology, November 2020, Elsevier

    M.Sc. Ph.D. Gregoire Ruffenach

  17. Single-cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning

    Article • American Review of Respiratory Disease, October 2020, American Thoracic Society

    M.Sc. Ph.D. Gregoire Ruffenach

  18. Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell–Dependent Endothelial Cell Apoptosis

    Article • Hypertension, September 2020, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  19. The Role of Estrogen Receptors in Cardiovascular Disease

    Article • International Journal of Molecular Sciences, June 2020, MDPI AG

    M.Sc. Ph.D. Gregoire Ruffenach

  20. Histological hallmarks and role of Slug/ PIP axis in pulmonary hypertension secondary to pulmonary fibrosis

    Article • EMBO Molecular Medicine, August 2019, EMBO

    M.Sc. Ph.D. Gregoire Ruffenach

  21. Radiation Mitigation of the Intestinal Acute Radiation Injury in Mice by 1‐[(4‐Nitrophenyl)Sulfonyl]‐4‐Phenylpiperazine

    Article • Stem Cells Translational Medicine, August 2019, Wiley

    M.Sc. Ph.D. Gregoire Ruffenach

  22. Enhanced Pulmonary Artery Radiodensity in Pulmonary Arterial Hypertension: A Sign of Early Calcification?

    Article • American Review of Respiratory Disease, March 2019, American Thoracic Society

    M.Sc. Ph.D. Gregoire Ruffenach

  23. Estrogen rescues heart failure through estrogen receptor Beta activation

    Article • Biology of Sex Differences, October 2018, Springer Science + Business Media

    M.Sc. Ph.D. Gregoire Ruffenach

  24. Identity crisis in pulmonary arterial hypertension

    Article • December 2017, SAGE Publications

    Dr Frédéric Perros, M.Sc. Ph.D. Gregoire Ruffenach

  25. Autonomic nervous system involvement in pulmonary arterial hypertension

    Article • December 2017, Springer Science + Business Media

    M.Sc. Ph.D. Gregoire Ruffenach

  26. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

    Article • Biology of Sex Differences, October 2017, Springer Science + Business Media

    M.Sc. Ph.D. Gregoire Ruffenach

  27. Advances in treatment of pulmonary arterial hypertension: patent review

    Article • Expert Opinion on Therapeutic Patents, April 2017, Taylor & Francis

    M.Sc. Ph.D. Gregoire Ruffenach

  28. Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy

    Article • Biology of Sex Differences, March 2017, Springer Science + Business Media

    M.Sc. Ph.D. Gregoire Ruffenach

  29. Intralipid protects the heart in late pregnancy against ischemia/reperfusion injury via Caveolin2/STAT3/GSK-3β pathway

    Article • Journal of Molecular and Cellular Cardiology, January 2017, Elsevier

    M.Sc. Ph.D. Gregoire Ruffenach

  30. Role of Oxidized Lipids in Pulmonary Arterial Hypertension

    Article • Pulmonary Circulation, September 2016, SAGE Publications

    M.Sc. Ph.D. Gregoire Ruffenach

  31. Novel biomarkers for pulmonary arterial hypertension

    Article • July 2016, Springer Science + Business Media

    M.Sc. Ph.D. Gregoire Ruffenach

  32. Role for RUNX2 in Proliferative and Calcified Vascular Lesions in Pulmonary Arterial Hypertension

    Article • American Review of Respiratory Disease, May 2016, American Thoracic Society

    M.Sc. Ph.D. Gregoire Ruffenach

  33. Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension

    Article • Circulation, April 2016, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  34. Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial Hypertension

    Article • Circulation, September 2015, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  35. Bromodomain-Containing Protein 4

    Article • Circulation Research, August 2015, Wolters Kluwer Health

    M.Sc. Ph.D. Gregoire Ruffenach

  36. Adaptation and Remodelling of the Pulmonary Circulation in Pulmonary Hypertension

    Article • Canadian Journal of Cardiology, April 2015, Elsevier

    M.Sc. Ph.D. Gregoire Ruffenach